Sandaruwan Geeganage

1.9k citations

21 papers · 1.0k indexed · h-index 11

Geriatrics and Gerontology top 5%
- Sirtuins and Resveratrol in Medicine 2
Biological Psychiatry top 10%
- Tryptophan and brain disorders 4
Oncology top 10%
Cancer Research top 10%
Genetics top 10%
Clinical Biochemistry
- Metabolism and Genetic Disorders 5
Molecular Biology
- PI3K/AKT/mTOR signaling in cancer 5
- Biochemical and Molecular Research 3
- Protein Degradation and Inhibitors 2
Biochemistry
- Amino Acid Enzymes and Metabolism 4
Materials Chemistry
- Enzyme Structure and Function 3

Co-authors: Liandong Ma Michael Flagella Jennifer D. Davidson Christopher A. Slapak Lawrence M. Gelbert Karen Huss Perry A. Frey Lillian Sams
Cited by: Geriatrics and Gerontology Biological Psychiatry Oncology
Journals: Cancer Research (9 papers)Biochemistry (4 papers)Journal of Biological Chemistry (2 papers)
Partner nations: United States Canada United Kingdom

In The Last Decade

Sandaruwan Geeganage

21 papers receiving 997 citations

Peers

Countries citing papers authored by Sandaruwan Geeganage

Since Specialization

Citations

This map shows the geographic impact of Sandaruwan Geeganage's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sandaruwan Geeganage with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sandaruwan Geeganage more than expected).

Fields of papers citing papers by Sandaruwan Geeganage

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sandaruwan Geeganage. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sandaruwan Geeganage. The network helps show where Sandaruwan Geeganage may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Sandaruwan Geeganage, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Sandaruwan Geeganage Line = papers co-authored together Sandaruwan Geeganage links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	A Phase I Study of an IDO-1 Inhibitor (LY3381916) as Monotherapy and in Combination With an Anti-PD-L1 Antibody (LY3300054) in Patients With Advanced Cancer Journal of Immunotherapy ·Nuria Kotecki,Perrine Vuagnat,Bert H. O’Neil,Shadia I. Jalal,Sylvie Rottey,Hans Prenen,Karim A. Benhadji,Meng Xia,Anna M. Szpurka,Abhijoy Saha,Johan Wallin,Jinhai Zhao,Violeta Régnier Galvão,Sandaruwan Geeganage,Thompson N. Doman,Leena Gandhi,Xiaojian Xu,Johanna C. Bendell	2021	29
2	Abstract 2187: Tryptophan Metabolism Plays a Central Role in Immunosuppression Sandaruwan Geeganage,Lillian Sams,James L. Henry,Frank C. Dorsey,Kenneth Roth,Alexander Nikolayev,Karim A. Benhadji,Raymond Gilmour,Ana Cerezo,Vimal Verma,Rebecca L. Ticker,Ramón Campos‐Olivas,Juan M. Funes,ALVES H.M.,Susana Velasco-Miguel	2019	1
3	Abstract 2187: Tryptophan Metabolism Plays a Central Role in Immunosuppression Cancer Research ·Sandaruwan Geeganage,Lillian Sams,James R. Henry,Frank C. Dorsey,Kenneth D. Roth,Alexander Nikolayev,Karim A. Benhadji,Raymond Gilmour,Ana Cerezo,Vimal Verma,Rebecca L. Ticker,Ramón Campos‐Olivas,Juan M. Funes,ALVES H.M.,Susana Velasco-Miguel	2019	2
4	Abstract LB-274: Identification and characterization of LY3410738, a novel covalent inhibitor of cancer-associated mutant Isocitrate Dehydrogenase 1 (IDH1) Cancer Research ·Nathan A. Brooks,Leny Metrics,U.K. Kussebayev,J. Li,Lisa Kays,Ana Marta Hernández García,宋岩君,John Strelow,Dexter Mk,Kenneth D. Roth,Renato A. Bauer,Stephen Antonysamy,Patric J. Hahn,Zoran Ranković,Denis McCann,Gary Mo,Ramón V. Tiu,Timothy P. Burkholder,Sandaruwan Geeganage,Raymond Gilmour	2019	9
5	Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT Bioorganic & Medicinal Chemistry Letters ·Vicente Riccio Neto,Kenneth J. Henry,S.S. Dr. Kadek Eva Krishna Adnyani,Mary E. Okelo,V. I. Pereyaslavskii,Raad Hoobi,Óscar de Frutos,Pablo D. García,Carlos Mateos,周次明,Yong Wang,Sun Zi-jian,Bradley Condon,X. M. Zhang,Lillian M. Firestone-Johansen,William J. Ehlhardt,Isaias Reyes Ramirez,Mei Lai,Sandaruwan Geeganage,Timothy P. Burkholder	2018	9
6	Abstract 4549: Pemetrexed enhances anti-tumor efficacy of PD1 pathway blockade by promoting intra tumor immune response via immunogenic tumor cell death and T cell intrinsic mechanisms Cancer Research ·Ruslan D. Novosiadly,David Schaer,Nelusha Amaladas,Erik Rasmussen,장만식,Manuel Millán-Vázquez,Carmine Carpenito,Yanxia Li,Shuang Luo,Andrew Capen,Catalina M. Meyer,Xiaodong Huang,Jason R. Manro,Gregory P. Donoho,Thompson N. Doman,Gerald E. Hall,Sandaruwan Geeganage,Michael Kalos	2018	8
7	Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916 Cancer Research ·Frank C. Dorsey,Karim A. Benhadji,Lillian Sams,Debra A. Young,John F. Schindler,Karen Huss,Alexander Nikolayev,Carmine Carpenito,David K. Clawson,Marjan Javanmard,Andrew L. Faber,James E. Thomas,Steven A. Haney,Bojan Kuzmič,William T. McMillen,Tod Smeal,Daniel J. Sall,Michael Kalos,Sandaruwan Geeganage,James R. Henry	2018	13
8	Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells Journal of Biological Chemistry ·Bo Tan,Sucai Dong,Robert L. Shepard,Lisa Kays,Kenneth D. Roth,Sandaruwan Geeganage,Ming‐Shang Kuo,Genshi Zhao	2015	38
9	Akt1 and Akt3 Exert Opposing Roles in the Regulation of Vascular Tumor Growth Cancer Research ·Thuy L. Phung,Wa Du,Qi Xue,Bilghis Elkhair Elshafie,Damien Gerald,Zeus A. Antonello,Michael Kühnlein,Carole Perruzzi,Wenlu Ma,Borzoo Taami,Paul Rodriguez‐Waitkus,Joseph I. Thoms,Marcelo Hochman,Dina Lev,Sandaruwan Geeganage,Laura E. Benjamin	2014	40
10	A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours European Journal of Cancer ·Anthony W. Tolcher,Jonathan H. Goldman,Amita Patnaik,Kyriakos P. Papadopoulos,Paul Westwood,Fred F Achem,María Blasco Marhuenda,Lillian Sams,Sandaruwan Geeganage,Tao Wang,Andrew Capen,Jianping Huang,En-Ze Zhu,J. A. Miller,Karim A. Benhadji,Les Brail,Lee S. Rosen	2014	45
11	Basics of Enzymatic Assays for HTS Harold B. Brooks,Sandaruwan Geeganage,Steven D. Kahl,Chahrzad Montrose,治彦永井,H. Schmidt,Jeffrey R. Weidner	2012	24
12	Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, in Human Cancer Cells Journal of Biological Chemistry ·Bo Tan,Debra A. Young,Iliana Underwood-Holbrook,Tao Wang,Timothy I. Meier,Robert L. Shepard,Kenneth D. Roth,Yan Zhai,Karen Huss,Ming‐Shang Kuo,James R. Gillig,Saravanan Parthasarathy,Timothy P. Burkholder,Michèle C. Smith,Sandaruwan Geeganage,Genshi Zhao	2012	135
13	Abstract 352: Preclinical evaluation of LYS6K1, a novel, highly selective, orally bioavailable inhibitor of p70 S6 kinase currently in phase I clinical trials for cancer Cancer Research ·Sandaruwan Geeganage,Lillian Sams,En-Ze Zhu,Leslie H. Brail,Tao Wang,George H. Rodgers,IP Villarosa,Jianping Huang,E.J. Perkins,Rose T. Ajamie	2010	1
14	The Protein Kinase Cβ–Selective Inhibitor, Enzastaurin (LY317615.HCl), Suppresses Signaling through the AKT Pathway, Induces Apoptosis, and Suppresses Growth of Human Colon Cancer and Glioblastoma Xenografts Cancer Research ·Jeremy R. Graff,Ann M. McNulty,仁西澤,Bruce W. Konicek,Rebecca L. Lynch,Shao Hua Dang,Raluca Botezatu,Andrew Capen,Robin L. Goode,Chika Akinseye,Lillian Sams,Karen Huss,Robert M. Campbell,Philip W. Iversen,Blake Lee Neubauer,Thomas J. Brown,Luna Musib,Sandaruwan Geeganage,Donald Thornton	2005	362
15	An Increase in the Expression of Ribonucleotide Reductase Large Subunit 1 Is Associated with Gemcitabine Resistance in Non-Small Cell Lung Cancer Cell Lines Cancer Research ·Jennifer D. Davidson,Liandong Ma,Michael Flagella,Sandaruwan Geeganage,Lawrence M. Gelbert,Christopher A. Slapak	2004	249
16	Galactose-1-Phosphate Uridylyltransferase: Kinetics of Formation and Reaction of Uridylyl-Enzyme Intermediate in Wild-Type and Specifically Mutated Uridylyltransferases Methods in enzymology on CD-ROM/Methods in enzymology ·Sandaruwan Geeganage,Perry A. Frey	2002	2
17	Roles of Two Conserved Amino Acid Residues in the Active Site of Galactose-1-Phosphate Uridylyltransferase: An Essential Serine and a Nonessential Cysteine Biochemistry ·Sandaruwan Geeganage,Badavannavar Anand,Perry A. Frey	2000	6
18	Significance of Metal Ions in Galactose-1-Phosphate Uridylyltransferase: An Essential Structural Zinc and a Nonessential Structural Iron Biochemistry ·Sandaruwan Geeganage,Perry A. Frey	1999	20
19	Transient Kinetics of Formation and Reaction of the Uridylyl-Enzyme Form of Galactose-1-P Uridylyltransferase and Its Q168R-Variant: Insight into the Molecular Basis of Galactosemia Biochemistry ·Sandaruwan Geeganage,Perry A. Frey	1998	23
20	Kinetic Mechanism of UDP-Hexose Synthase, a Point Variant of Hexose-1-Phosphate Uridylyltransferase from Escherichia coli Biochemistry ·Frank J. Ruzicka,Sandaruwan Geeganage,Perry A. Frey	1998	4

About Sandaruwan Geeganage

Sandaruwan Geeganage is a scholar working on Biological Psychiatry, Clinical Biochemistry and Biochemistry, having authored 21 papers that have together received 1.0k indexed citations. Recurring topics across this work include Metabolism and Genetic Disorders (5 papers), PI3K/AKT/mTOR signaling in cancer (5 papers), Amino Acid Enzymes and Metabolism (4 papers), Tryptophan and brain disorders (4 papers), Biochemical and Molecular Research (3 papers), Enzyme Structure and Function (3 papers), Sirtuins and Resveratrol in Medicine (2 papers) and Protein Degradation and Inhibitors (2 papers). The work is most often cited by research in Geriatrics and Gerontology (84 citations), Biological Psychiatry (34 citations) and Oncology (361 citations). Sandaruwan Geeganage has collaborated with scholars based in United States, Canada and United Kingdom. Frequent co-authors include Liandong Ma, Michael Flagella, Jennifer D. Davidson, Christopher A. Slapak, Lawrence M. Gelbert, Karen Huss, Perry A. Frey, Lillian Sams, Andrew Capen and Jeremy R. Graff. Their work appears in journals such as Cancer Research, Biochemistry, Journal of Biological Chemistry, Journal of Immunotherapy and Bioorganic & Medicinal Chemistry Letters.

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