Rocco Moretti

3.6k citations

48 papers · 1.7k indexed · 2 hit papers · h-index 20

Impact in

Molecular Biology top 5%
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Chemical Synthesis and Analysis
Biotechnology top 10%

Papers in

Information Systems 12
- Service-Oriented Architecture and Web Services 9
Computational Theory and Mathematics 8
- Computational Drug Discovery Methods 8

Co-authors: David Baker Nihan Çelebi‐Ölçüm K. N. Houk Gert Kiss Lucas G. Nivón Jon S. Thorson Jens Meiler Aseem Z. Ansari
Journals: Journal of Biological Chemistry (3 papers)Proceedings of the National Academy of Sciences (3 papers)Journal of Chemical Information and Modeling (3 papers)PLoS ONE (2 papers)Rapid Communications in Mass Spectrometry (1 paper)
Partner nations: United States Germany Italy

In The Last Decade

Rocco Moretti

44 papers receiving 1.7k citations

Hit Papers

align trajectories log scale

Engineering an allosteric transcription factor to respond to new ligands 2015 · 253 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Nature Methods
2013 Angewandte Chemie International Edition

Peers

Countries citing papers authored by Rocco Moretti

Since Specialization

Citations

This map shows the geographic impact of Rocco Moretti's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Rocco Moretti with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Rocco Moretti more than expected).

Fields of papers citing papers by Rocco Moretti

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Rocco Moretti. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Rocco Moretti. The network helps show where Rocco Moretti may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Rocco Moretti, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Rocco Moretti Line = papers co-authored together Rocco Moretti links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	RosettaHDX: Predicting antibody-antigen interaction from hydrogen-deuterium exchange mass spectrometry data Journal of Structural Biology ·Minh H. Tran, Irensiana Pote, Rocco Moretti, علی کاظمی, Kevin L. Schey, Jens Meiler	2025	2
2	Self-supervised machine learning methods for protein design improve sampling but not the identification of high-fitness variants Science Advances ·Жамшид Иброҳимов, Rocco Moretti, Jens Meiler, Clara T. Schoeder	2025	6
3	Ultra-large library screening with an evolutionary algorithm in Rosetta (REvoLd) Communications Chemistry ·J. Valcarce Pérez, Claudia Hemeltjen, Rocco Moretti, Jens Meiler	2025	0
4	Cache: Utilizing ultra-large library screening in Rosetta to identify novel binders of the WD-repeat domain of Leucine-Rich Repeat Kinase 2 Journal of Cheminformatics ·Claudia Hemeltjen, J. Valcarce Pérez, Victor de Ory Guimera, Bobbi J. Estabrook, Rocco Moretti, Jens Meiler	2025	0
5	Posttranslationally modified self-peptides promote hypertension in mouse models Journal of Clinical Investigation ·Nathaniel Bloodworth, Wei Chen, Nurul Arifah, David M. Patrick, O. А. Artyukhova, Elizabeth J. Phillips, Caiyun Zhong, Markus Kalkum, S. Mallal, Sean S. Davies, Mingfang Ao, Rocco Moretti, Jens Meiler, David G. Harrison	2024	0
6	Combining machine learning with structure-based protein design to predict and engineer post-translational modifications of proteins PLoS Computational Biology ·Жамшид Иброҳимов, Vikram Khipple Mulligan, Jack B. Maguire, Sergey Lyskov, Rocco Moretti, Torben Schiffner, Jens Meiler, Clara T. Schoeder	2024	12
7	Interpretable Chirality-Aware Graph Neural Network for Quantitative Structure Activity Relationship Modeling in Drug Discovery Proceedings of the AAAI Conference on Artificial Intelligence ·M. Postaire, Yu Wang, Bobbi J. Estabrook, Rocco Moretti, I. B. Orlova, Jens Meiler, Tyler Derr	2023	16
8	Rosetta FlexPepDock to predict peptide-MHC binding: An approach for non-canonical amino acids PLoS ONE ·Nathaniel Bloodworth, Natália R. Barbaro, Rocco Moretti, David G. Harrison, Jens Meiler	2022	10
9	Integrative model of the FSH receptor reveals the structural role of the flexible hinge region Structure ·علی کاظمی, Rocco Moretti, Ralf Paschke, Martin von Bergen�, Jens Meiler, Stefan Kalkhof	2022	1
10	Delineating the Molecular Basis of the Calmodulin–bMunc13-2 Interaction by Cross-Linking/Mass Spectrometry—Evidence for a Novel CaM Binding Motif in bMunc13-2 Cells ·Christine Piotrowski, Rocco Moretti, Christian Ihling, Tie-Gan Jia, Thomas Liepold, Noa Lipstein, Jens Meiler, Olaf Jahn, Andrea Sinz	2020	9
11	Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation Journal of Biological Chemistry ·Jörg Schaarschmidt, علی کاظمی, Santosh Prabhu, Holger Jaeschke, Rocco Moretti, Vera Hintze, Martin von Bergen�, Stefan Kalkhof, Jens Meiler, Ralf Paschke	2016	16
12	Rosetta and the Design of Ligand Binding Sites Methods in molecular biology ·Rocco Moretti, Brian J. Bender, Xin Yoong Tan, Jens Meiler	2016	24
13	Engineering an allosteric transcription factor to respond to new ligands Nature Methods ·Noah D. Taylor, Alexander S. Garruss, Rocco Moretti, Sum Chan, Mark A. Arbing, Duilio Cascio, Jameson K. Rogers, Farren J. Isaacs, Sriram Kosuri, David Baker, Stanley Fields, George M. Church, Srivatsan Raman Hit paper breakdown →	2015	253
14	Computational Enzyme Design Angewandte Chemie International Edition ·Gert Kiss, Nihan Çelebi‐Ölçüm, Rocco Moretti, David Baker, K. N. Houk Hit paper breakdown →	2013	401
15	Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution Journal of Biological Chemistry ·Rocco Moretti, Aram Chang, Pauline Peltier‐Pain, C.A. Bingman, G.N. Phillips, Jon S. Thorson	2011	38
16	A comparison of sugar indicators enables a universal high-throughput sugar-1-phosphate nucleotidyltransferase assay Analytical Biochemistry ·Rocco Moretti, Jon S. Thorson	2008	53
17	The in vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI ChemBioChem ·Changsheng Zhang, Rocco Moretti, Jiqing Jiang, Jon S. Thorson	2008	26
18	Expanding the specificity of DNA targeting by harnessing cooperative assembly Biochimie ·Rocco Moretti, Aseem Z. Ansari	2008	24
19	Towards a language for a satisfaction-based selection of Grid services Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) ·(unknown), Paolo Ciancarini, Danilo Montesi, Rocco Moretti	2006	0
20	Towards a Framework for Web Sites Quality Evaluation. Software Engineering and Knowledge Engineering ·Paolo Ciancarini, Rocco Moretti	2003	2

About Rocco Moretti

Rocco Moretti is a scholar working on Information Systems, Computational Theory and Mathematics, Management Information Systems, Molecular Biology and Spectroscopy, having authored 48 papers that have together received 1.7k indexed citations. Recurring topics across this work include Service-Oriented Architecture and Web Services (9 papers), Protein Structure and Dynamics (8 papers), Computational Drug Discovery Methods (8 papers), RNA and protein synthesis mechanisms (7 papers), Distributed and Parallel Computing Systems (6 papers), Glycosylation and Glycoproteins Research (5 papers), Enzyme Structure and Function (4 papers) and Business Process Modeling and Analysis (4 papers). The work is most often cited by research in Molecular Biology (1.4k citations), Biotechnology (88 citations), Computational Theory and Mathematics (133 citations), Organic Chemistry (190 citations) and Structural Biology (9 citations). Rocco Moretti has collaborated with scholars based in United States, Germany and Italy. Frequent co-authors include David Baker, Nihan Çelebi‐Ölçüm, K. N. Houk, Gert Kiss, Lucas G. Nivón, Jon S. Thorson, Jens Meiler, Aseem Z. Ansari, Iain H. Moal and Noah D. Taylor. Their work appears in journals such as Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, Journal of Chemical Information and Modeling, PLoS ONE and Rapid Communications in Mass Spectrometry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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