Richard N. Perham

15.5k citations

262 papers · 13.0k indexed · 3 hit papers · h-index 60

Co-authors: J. Ieuan Harris Nigel S. Scrutton Alan Berry Leonard C. Packman H. B. F. Dixon G Hale Anne E. Willis Adolfo Borges
Topics: Biochemical Acid Research Studies (132 papers)Metabolism and Genetic Disorders (99 papers)Enzyme Structure and Function (55 papers)
Cited by: Biochemistry Clinical Biochemistry Molecular Biology
Journals: Nature Science Cell
Partner nations: United Kingdom United States South Sudan

In The Last Decade

Richard N. Perham

260 papers receiving 12.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering

1990 646 citations Nigel S. Scrutton, Alan Berry et al. profile →
Glyceraldehyde 3-phosphate dehydrogenases

1965 421 citations J. Ieuan Harris, Richard N. Perham Journal of Molecular Biology profile →
Reversible blocking of amino groups with citraconic anhydride

1968 392 citations H. B. F. Dixon, Richard N. Perham profile →

Peers

Countries citing papers authored by Richard N. Perham

Since Specialization

Citations

This map shows the geographic impact of Richard N. Perham's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard N. Perham with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard N. Perham more than expected).

Fields of papers citing papers by Richard N. Perham

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard N. Perham. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard N. Perham. The network helps show where Richard N. Perham may publish in the future.

Co-authorship network of co-authors of Richard N. Perham

This figure shows the co-authorship network connecting the top 25 collaborators of Richard N. Perham. A scholar is included among the top collaborators of Richard N. Perham based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard N. Perham. Richard N. Perham is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Crystal Structure of the E1 Component of the Escherichia coli 2-Oxoglutarate Dehydrogenase Multienzyme Complex 2007 ·Journal of Molecular Biology ·René Frank,Amanda J. Price,F.D. Northrop,Richard N. Perham,Ben F. Luisi	73
2	The Molecular Origins of Specificity in the Assembly of a Multienzyme Complex 2005 ·Structure ·René Frank,J. Venkatesh Pratap,Xue Pei,Richard N. Perham,Ben F. Luisi	60
3	Processing of Filamentous Bacteriophage Virions in Antigen-Presenting Cells Targets Both HLA Class I and Class II Peptide Loading Compartments 2003 ·DNA and Cell Biology ·(unknown),Cristina Fanutti,Zohar Mishal,Antoine Dürrbach,Piergiuseppe De Berardinis,Rossella Sartorius,Giovanna Del Pozzo,John Guardiola,Richard N. Perham,Dominique Piatier‐Tonneau	59
4	Multiple Display of Peptides and Proteins on a Macromolecular Scaffold Derived from a Multienzyme Complex 2001 ·Journal of Molecular Biology ·Gonzalo J. Domingo,Stefania Orrù,Richard N. Perham	61
5	Heteronuclear NMR studies of the specificity of the post‐translational modification of biotinyl domains by biotinyl protein ligase 2000 ·FEBS Letters ·Pedro A. Reche,Mark J. Howard,R. William Broadhurst,Richard N. Perham	18
6	Structural determinants of post-translational modification and catalytic specificity for the lipoyl domains of the pyruvate dehydrogenase multienzyme complex of Escherichia coli 2000 ·Journal of Molecular Biology ·Rochelle D. Ahmed,(unknown),Pedro A. Reche,Richard N. Perham	26
7	Interaction of the Globular Domains of pIII Protein of Filamentous Bacteriophage fd with the F-Pilus ofEscherichia coli 1999 ·Virology ·Lih‐Wen Deng,Pratap Malik,Richard N. Perham	42
8	Three-dimensional structure of the major autoantigen in primary biliary cirrhosis 1998 ·Gastroenterology ·Mark J. Howard,Christopher Fuller,R. William Broadhurst,Richard N. Perham,(unknown),Janet Quinn,Austin G. Diamond,Stephen J. Yeaman	64
9	A Synthesis of Acylphosphonic Acids and of 1-Aminoalkylphosphonic Acids: The Action of Pyruvate Dehydrogenase and Lactate Dehydrogenase on Acetylphosphonic Acid 1991 ·Journal of enzyme inhibition ·H. B. F. Dixon,(unknown),R. A. Harrison,Christopher E. Henderson,(unknown),David M. Parker,Richard N. Perham,P. Slater,(unknown)	7
10	Cloning and sequence analysis of the genes encoding the dihydrolipoamide acetyltransferase and dihydrolipoamide dehydrogenase components of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus 1990 ·European Journal of Biochemistry ·Adolfo Borges,Christopher F. Hawkins,Leonard C. Packman,Richard N. Perham	51
11	2‐Oxo Acid Dehydrogenase Multienzyme Complexes: Domains, Dynamics, and Design^a 1989 ·Annals of the New York Academy of Sciences ·Richard N. Perham,Leonard C. Packman	77
12	Identification, molecular cloning and sequence analysis of a gene cluster encoding the Class II fructose 1,6‐bisphosphate aldolase, 3‐phosphoglycerate kinase and a putative second glyceraldehyde 3‐phosphate dehydrogenase of Escherichia coli 1989 ·Molecular Microbiology ·Peter R. Alefounder,Richard N. Perham	102
13	Alternative proton donors/acceptors in the catalytic mechanism of the glutathione reductase of Escherichia coli: the role of histidine-439 and tyrosine-99 1989 ·Biochemistry ·Mahendra P. Deonarain,Alan Berry,(unknown),Richard N. Perham	43
14	Engineering of an intersubunit disulphide bridge in glutathione reductase from Escherichia coli 1988 ·FEBS Letters ·Nigel S. Scrutton,Alan Berry,Richard N. Perham	30
15	Investigation of the mechanism of active site coupling in the pyruvate dehydrogenase multienzyme complex of Escherichia coli by protein engineering 1988 ·Journal of Molecular Biology ·John S. Miles,John R. Guest,Sheena E. Radford,Richard N. Perham	54
16	The pyruvate dehydrogenase multi-enzyme complex of Escherichia coli : genetic reconstruction and functional analysis of the lipoyl domains 1986 ·Philosophical Transactions of the Royal Society of London Series A Mathematical and Physical Sciences ·Lloyd D. Graham,John R. Guest,Hilary Lewis,J S Miles,Leonard C. Packman,Richard N. Perham,Sheena E. Radford	15
17	Domain structure and1H-n.m.r. spectroscopy of the pyruvate dehydrogenase complex of Bacillus stearothermophilus 1984 ·Biochemical Journal ·Leonard C. Packman,Richard N. Perham,Gordon C. K. Roberts	45
18	Rapid removal of acetimidoyl groups from proteins and peptides. Applications to primary structure determination 1981 ·Biochemical Journal ·G C Dubois,Elizabeth A. Robinson,John K. Inman,Richard N. Perham,Ettore Appella	6
19	INNER CORE AND DOMAIN-STRUCTURE OF THE PYRUVATE-DEHYDROGENASE MULTI-ENZYME COMPLEX OF BACILLUS-STEAROTHERMOPHILUS 1980 ·Richard N. Perham,(unknown)	2
20	Glyceraldehyde 3-phosphate dehydrogenases: I. The protein chains in glyceraldehyde 3-phosphate dehydrogenase from pig muscle 1965 ·Journal of Molecular Biology ·J. Ieuan Harris,Richard N. Perham	174

About Richard N. Perham

Richard N. Perham is a scholar working on Biochemistry, Clinical Biochemistry and Molecular Biology, having authored 262 papers that have together received 13.0k indexed citations. Recurring topics across this work include Biochemical Acid Research Studies (132 papers), Metabolism and Genetic Disorders (99 papers) and Enzyme Structure and Function (55 papers). The work is most often cited by research in Biochemistry (5.3k citations), Clinical Biochemistry (3.5k citations) and Molecular Biology (7.7k citations). Richard N. Perham has collaborated with scholars based in United Kingdom, United States and South Sudan. Frequent co-authors include J. Ieuan Harris, Nigel S. Scrutton, Alan Berry, Leonard C. Packman, H. B. F. Dixon, G Hale, Anne E. Willis, Adolfo Borges, Michael J. Danson and I. R. Gibbons. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact