René E. M. Toes

48.2k citations

490 papers · 30.9k indexed · 6 hit papers · h-index 90

Impact in

Rheumatology top 0.01%
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
Immunology top 0.02%
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction

Papers in

Rheumatology 237
- Rheumatoid Arthritis Research and Therapies 175
- Systemic Lupus Erythematosus Research 147
Immunology 256
- T-cell and B-cell Immunology 118
- Immunotherapy and Immune Responses 89
- Immune Cell Function and Interaction 67

Co-authors: T. Huizinga Rienk Offringa Ellen I. H. van der Voort Annette H M van der Helm–van Mil Cornelis J.M. Melief Andreea Ioan‐Facsinay Stephen P. Schoenberger Leendert A. Trouw
Journals: Annals of the Rheumatic Diseases (102 papers)Arthritis Research & Therapy (34 papers)The Journal of Immunology (30 papers)European Journal of Immunology (20 papers)Arthritis & Rheumatology (12 papers)
Partner nations: Netherlands United States United Kingdom

In The Last Decade

René E. M. Toes

482 papers receiving 30.3k citations

Hit Papers

6 papers align trajectories log scale

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review 2012 · 544 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2012 Osteoarthritis and Cartilage
2012 Journal of Clinical Investigation
2011 Proceedings of the National Academy of Sciences
2006 European Journal of Immunology
2001 The Journal of Experimental Medicine
1998 Nature

Peers

Countries citing papers authored by René E. M. Toes

Since Specialization

Citations

This map shows the geographic impact of René E. M. Toes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by René E. M. Toes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites René E. M. Toes more than expected).

Fields of papers citing papers by René E. M. Toes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by René E. M. Toes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by René E. M. Toes. The network helps show where René E. M. Toes may publish in the future.

Co-authors

The 25 scholars most cited alongside René E. M. Toes, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with René E. M. Toes Line = papers co-authored together René E. M. Toes links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	The Autoantibody response in rheumatoid arthritis; what makes it unique? Seminars in Arthritis and Rheumatism ·René E. M. Toes	2025	0
2	Increased Phosphorylation of Intracellular Signaling Molecules Indicates Continuous Activation of Human Autoreactive B‐Cells European Journal of Immunology ·Sanne Kroos, N. Blomberg, Joanneke C. Kwekkeboom, Rudi W. Hendriks, Odilia B. J. Corneth, René E. M. Toes, Hans Ulrich Scherer	2025	0
3	Variable domain glycosylation as a marker and modulator of immune responses: Insights into autoimmunity and B-cell malignancies Seminars in Immunology ·Roxane Biersteker, Øjvind Larsen, Manfred Wuhrer, T. Huizinga, René E. M. Toes, Lise Hafkenscheid	2025	0
4	Development of bispecific antibodies that drive selective targeted local complement inhibition on rheumatoid arthritis-related antigens Annals of the Rheumatic Diseases ·Haiyu Wang, Sandrine Nugteren, Rick J. Groenland, Stef van der Meulen, Hanneke Kapsenberg, Christoph Gstöttner, Elena Domínguez‐Vega, Jan Piet van Hamburg, Sander W. Tas, René E. M. Toes, Paul W.H.I. Parren, Leendert A. Trouw	2025	1
5	Multitiered Proteome Analysis Displays the Hyperpermeability of the Rheumatoid Synovial Compartment for Plasma Proteins Molecular & Cellular Proteomics ·Eva Maria Stork, Sofia Kalaidopoulou Nteak, Danique M.H. van Rijswijck, J Damen, Hans Ulrich Scherer, René E. M. Toes, Albert Bondt, T. Huizinga, Albert J. R. Heck	2024	0
6	N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line Nature Communications ·Theresa Kissel, V. Derksen, Arthur E. H. Bentlage, Carolien A. M. Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson, René E. M. Toes	2024	4
7	Anti-carbamylated protein antibodies in systemic sclerosis Arthritis Research & Therapy ·Sophie I E Liem, Eva M. Hoekstra, E. W. Nivine Levarht, Annemarie L Dorjée, Hans Ulrich Scherer, René E. M. Toes, T. Huizinga, Jeska K de Vries‐Bouwstra, Cynthia M. Fehres	2023	1
8	Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis RMD Open ·C. Wortel, Sophie I E Liem, Nina M. van Leeuwen, Maaike Boonstra, Cynthia M. Fehres, J. Lauran Stöger, T. Huizinga, René E. M. Toes, Jeska de Vries‐Bouwstra, Hans Ulrich Scherer	2023	9
9	Effect of Antigen Valency on Autoreactive B-Cell Targeting Molecular Pharmaceutics ·Margot J. van Weijsten, Kevin R. Venrooij, Lianne P. W. M. Lelieveldt, Theresa Kissel, Erik van Buijtenen, Floris J. van Dalen, Martijn Verdoes, René E. M. Toes, Kimberly M. Bonger	2023	1
10	Benchmarking computational methods for B-cell receptor reconstruction from single-cell RNA-seq data NAR Genomics and Bioinformatics ·Tommaso Andreani, Linda M. Slot, Samuel Gabillard, Carsten Strübing, C. Reimertz, Yaligara Veeranagouda, Aleida M. Bakker, Reza Olfati-Saber, René E. M. Toes, Hans Ulrich Scherer, Franck Augé, Deimantė Šimaitė	2022	8
11	IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross‐Sectional Study Encompassing ~1,500 Samples Arthritis & Rheumatology ·Theresa Kissel, Lise Hafkenscheid, Tineke J van Wesemael, Mami Tamai, Shin‐ya Kawashiri, Atsushi Kawakami, Hani El‐Gabalawy, Dirkjan van Schaardenburg, Solbritt Rantapää‐Dahlqvist, Manfred Wuhrer, Annette H M van der Helm–van Mil, Cornelia F Allaart, Diane van der Woude, Hans Ulrich Scherer, René E. M. Toes, T. Huizinga	2022	35
12	Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens RSC Chemical Biology ·Tyrza van Leeuwen, Can Araman, Linda Pieper-Pournara, Arieke S. B. Kampstra, Thomas Bakkum, Mikkel H. S. Marqvorsen, Clarissa R. Nascimento, G. J. Mirjam Groenewold, Willemijn van der Wulp, Marcel Camps, George M. C. Janssen, Peter A. van Veelen, Gerard J. P. van Westen, Antonius P. A. Janssen, Bogdan I. Florea, Herman S. Overkleeft, Ferry Ossendorp, René E. M. Toes, Sander I. van Kasteren	2021	6
13	Anticentromere Antibody Levels and Isotypes and the Development of Systemic Sclerosis Arthritis & Rheumatology ·Nina M. van Leeuwen, Maaike Boonstra, Jaap Bakker, Annette Grummels, Suzana Jordan, Sophie I E Liem, Oliver Distler, Anna‐Maria Hoffmann‐Vold, Karin Melsens, Vanessa Smith, Marie‐Elise Truchetet, Hans Ulrich Scherer, René E. M. Toes, T. Huizinga, Jeska K de Vries‐Bouwstra	2021	18
14	Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis Science Translational Medicine ·Hendy Kristyanto, N. Blomberg, Linda M. Slot, Ellen I. H. van der Voort, Priscilla F. Kerkman, Aleida M. Bakker, L.E. Burgers, Robin M. ten Brinck, Annette H M van der Helm–van Mil, Hergen Spits, Dominique Baeten, T. Huizinga, René E. M. Toes, Hans Ulrich Scherer	2020	73
15	Association Between Centromere- and Topoisomerase-specific Immune Responses and the Degree of Microangiopathy in Systemic Sclerosis The Journal of Rheumatology ·Nina M. van Leeuwen, C. Wortel, Cynthia M. Fehres, Jaap Bakker, Hans Ulrich Scherer, René E. M. Toes, T. Huizinga, Jeska K de Vries‐Bouwstra	2020	11
16	Adaptive antibody diversification through N -linked glycosylation of the immunoglobulin variable region Proceedings of the National Academy of Sciences ·Fleur S. van de Bovenkamp, Ninotska I. L. Derksen, Pleuni Ooijevaar‐de Heer, Karin A. van Schie, Simone Kruithof, Magdalena A. Berkowska, C. Ellen van der Schoot, Hanna IJspeert, Mirjam van der Burg, Ann Gils, Lise Hafkenscheid, René E. M. Toes, Yoann Rombouts, Rosina Plomp, Manfred Wuhrer, S. Marieke van Ham, Gestur Vidarsson, Theo Rispens	2018	99
17	Autoantibody Development under Treatment with Immune-Checkpoint Inhibitors Cancer Immunology Research ·Emma C. de Moel, Elisa A. Rozeman, Ellen Kapiteijn, Els M.E. Verdegaal, Annette Grummels, Jaap Bakker, T. Huizinga, John B.A.G. Haanen, René E. M. Toes, Diane van der Woude	2018	129
18	A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis The Journal of Experimental Medicine ·S.W. Scally, Jan Petersen, Soi Cheng Law, Nadine L. Dudek, Hendrik J. Nel, Khai Lee Loh, Lakshmi C. Wijeyewickrema, Sidonia B. G. Eckle, Jurgen van Heemst, Robert N. Pike, James McCluskey, René E. M. Toes, Nicole L. La Gruta, Anthony W. Purcell, Hugh H. Reid, Ranjeny Thomas, Jamie Rossjohn	2013	308
19	Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients Arthritis & Rheumatism ·Omri Snir, Mona Widhe, Monika Hermansson, Caroline von Spee-Mayer, Johan Lindberg, Sanne M.M. Hensen, Karin Lundberg, Åke Engström, Patrick J Venables, René E. M. Toes, Rikard Holmdahl, Lars Klareskog, Vivianne Malmström	2009	171
20	Fibroblast-like synoviocytes from patients with rheumatoid arthritis are more sensitive to apoptosis induced by the viral protein, apoptin, than fibroblast-like synoviocytes from trauma patients. PubMed ·Tanja C. A. Tolboom, YH Zhang, N. Henriquez, Rob G. H. H. Nelissen, René E. M. Toes, Mathieu H. M. Noteborn, T. Huizinga	2006	7

About René E. M. Toes

René E. M. Toes is a scholar working on Rheumatology, Immunology, Radiology, Nuclear Medicine and Imaging, Immunology and Allergy and Genetics, having authored 490 papers that have together received 30.9k indexed citations. Recurring topics across this work include Monoclonal and Polyclonal Antibodies Research (192 papers), Rheumatoid Arthritis Research and Therapies (175 papers), Systemic Lupus Erythematosus Research (147 papers), T-cell and B-cell Immunology (118 papers), Immunotherapy and Immune Responses (89 papers), Immune Cell Function and Interaction (67 papers), Glycosylation and Glycoproteins Research (28 papers) and Cell Adhesion Molecules Research (28 papers). The work is most often cited by research in Rheumatology (12.6k citations), Immunology (15.6k citations), Radiology, Nuclear Medicine and Imaging (6.4k citations), Immunology and Allergy (1.3k citations) and Hematology (2.2k citations). René E. M. Toes has collaborated with scholars based in Netherlands, United States and United Kingdom. Frequent co-authors include T. Huizinga, Rienk Offringa, Ellen I. H. van der Voort, Annette H M van der Helm–van Mil, Cornelis J.M. Melief, Andreea Ioan‐Facsinay, Stephen P. Schoenberger, Leendert A. Trouw, René R. P. de Vries and Hans Ulrich Scherer. Their work appears in journals such as Annals of the Rheumatic Diseases, Arthritis Research & Therapy, The Journal of Immunology, European Journal of Immunology and Arthritis & Rheumatology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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