Paul D. Upton

8.0k citations

76 papers · 5.2k indexed · 2 hit papers · h-index 38

Impact in

Pulmonary and Respiratory Medicine top 0.5%
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Genetics top 1%
- Vascular Anomalies and Treatments

Papers in

Pulmonary and Respiratory Medicine 49
- Pulmonary Hypertension Research and Treatments 46
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis 12
Genetics 9
- Vascular Anomalies and Treatments 9

Co-authors: Nicholas W. Morrell Richard C. Trembath Xudong Yang Mark Southwood Lü Long Carl Atkinson Rajiv D. Machado John Wharton
Journals: Circulation (5 papers)Journal of Biological Chemistry (5 papers)American Journal of Physiology-Lung Cellular and Molecular Physiology (5 papers)American Journal of Respiratory Cell and Molecular Biology (5 papers)Human Molecular Genetics (3 papers)
Partner nations: United Kingdom United States Portugal

In The Last Decade

Paul D. Upton

75 papers receiving 5.2k citations

Hit Papers

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Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension 2015 · 347 citations

Peers

Countries citing papers authored by Paul D. Upton

Since Specialization

Citations

This map shows the geographic impact of Paul D. Upton's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul D. Upton with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul D. Upton more than expected).

Fields of papers citing papers by Paul D. Upton

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul D. Upton. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul D. Upton. The network helps show where Paul D. Upton may publish in the future.

Co-authors

The 25 scholars most cited alongside Paul D. Upton, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Paul D. Upton Line = papers co-authored together Paul D. Upton links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport Cardiovascular Research ·Bin Liu, Mujahid Azfar, Ekaterina Legchenko, James A. West, Shaun Martin, Chris Van den Haute, Veerle Baekelandt, John Wharton, Luke Howard, Martin R. Wilkins, Peter Vangheluwe, Nicholas W. Morrell, Paul D. Upton	2024	7
2	SEMA3G regulates BMP9 inhibition of VEGF-mediated migration and network formation in pulmonary endothelial cells Vascular Pharmacology ·Sarah Mirza, Paul D. Upton, Joshua Hodgson, Stefan Gräf, Nicholas W. Morrell, Benjamin J. Dunmore	2024	3
3	Reduced circulating BMP9 and pBMP10 in hospitalized COVID‐19 patients Pulmonary Circulation ·Benjamin J. Dunmore, Paul D. Upton, Kate Auckland, Romit Samanta, (unknown), Paul Lyons, Kenneth G. C. Smith, Stefan Gräf, Charlotte Summers, Nicholas W. Morrell	2023	3
4	High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells Scientific Reports ·Clara Andersson-Rusch, Bin Liu, Ingrid Quist-Løkken, Paul D. Upton, Oddrun Elise Olsen, Hanne Hella, Xudong Yang, Zhen Tong, Nicholas W. Morrell, Toril Holien, Wei Li	2023	2
5	An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis Communications Biology ·Alexander J. Ainscough, Timothy J. N. Smith, Maike Haensel, Christopher J. Rhodes, Adam Fellows, Harry J. Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke Howard, John Wharton, Benjamin J. Dunmore, Paul D. Upton, Martin R. Wilkins, Joshua B. Edel, Beata Wójciak‐Stothard	2022	18
6	Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis EBioMedicine ·Nicola Owen, Graeme Alexander, Sambit Sen, Katherine Bunclark, Gary Polwarth, Joanna Pepke‐Żaba, Anthony P. Davenport, Nicholas W. Morrell, Paul D. Upton	2020	31
7	4PBA Restores Signaling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with Pulmonary Arterial Hypertension American Journal of Respiratory Cell and Molecular Biology ·Benjamin J. Dunmore, Xudong Yang, Alexi Crosby, Stephen D. Moore, Lü Long, Chris Huang, Mark Southwood, Eric D. Austin, Amer A. Rana, Paul D. Upton, Nicholas W. Morrell	2020	17
8	Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10 Peptides ·Nicola Owen, Duuamene Nyimanu, Rhoda E. Kuc, Paul D. Upton, Nicholas W. Morrell, Graeme Alexander, Janet J. Maguire, Anthony P. Davenport	2020	8
9	Bone Morphogenetic Protein Receptor Type II Deficiency and Increased Inflammatory Cytokine Production. A Gateway to Pulmonary Arterial Hypertension American Journal of Respiratory and Critical Care Medicine ·Elaine Soon, Alexi Crosby, Mark Southwood, Peiran Yang, Tamara Tajsic, Mark Toshner, Sarah Appleby, Catherine M. Shanahan, Kenneth D. Bloch, Joanna Pepke‐Żaba, Paul D. Upton, Nicholas W. Morrell	2015	117
10	Transcript Analysis Reveals a Specific HOX Signature Associated with Positional Identity of Human Endothelial Cells PLoS ONE ·Mark Toshner, Benjamin J. Dunmore, Eoin McKinney, Mark Southwood, Paola Caruso, Paul D. Upton, J.P. Waters, Mark L. Ormiston, Jeremy N. Skepper, Gerard B. Nash, Amer A. Rana, Nicholas W. Morrell	2014	51
11	Transforming Growth Factor-β1 Represses Bone Morphogenetic Protein–Mediated Smad Signaling in Pulmonary Artery Smooth Muscle Cells via Smad3 American Journal of Respiratory Cell and Molecular Biology ·Paul D. Upton, Rachel Davies, Tamara Tajsic, Nicholas W. Morrell	2013	46
12	The transforming growth factor‐β–bone morphogenetic protein type signalling pathway in pulmonary vascular homeostasis and disease Experimental Physiology ·Paul D. Upton, Nicholas W. Morrell	2013	38
13	The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations Human Molecular Genetics ·BJ Dunmore, Kylie M. Drake, Paul D. Upton, Mark Toshner, Micheala A. Aldred, Nicholas W. Morrell	2013	85
14	BMP9 Mutations Cause a Vascular-Anomaly Syndrome with Phenotypic Overlap with Hereditary Hemorrhagic Telangiectasia The American Journal of Human Genetics ·Whitney Wooderchak‐Donahue, Jamie McDonald, Brendan O’Fallon, Paul D. Upton, Wei Li, Beth L. Roman, Sarah P. Young, Parker Plant, Gyula T. Fülöp, Carmen Langa, Nicholas W. Morrell, Luisa M. Botella, Carmelo Bernabéu, David A. Stevenson, James Runo, Pınar Bayrak‐Toydemir	2013	226
15	A Role for miR-145 in Pulmonary Arterial Hypertension Circulation Research ·Paola Caruso, Yvonne Dempsie, Hannah Stevens, Robert A. McDonald, Lü Long, Ruifang Lu, Kevin P. White, Kirsty M. Mair, John McClure, Mark Southwood, Paul D. Upton, Mei Xin, Eva van Rooij, Eric N. Olson, Nicholas W. Morrell, Margaret R. MacLean, Andrew H. Baker	2012	226
16	TGF-β and BMPR-II pharmacology—implications for pulmonary vascular diseases Current Opinion in Pharmacology ·Paul D. Upton, Nicholas W. Morrell	2009	45
17	Functional Characterization of Bone Morphogenetic Protein Binding Sites and Smad1/5 Activation in Human Vascular Cells Molecular Pharmacology ·Paul D. Upton, Lu Long, Richard C. Trembath, Nicholas W. Morrell	2007	52
18	BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways American Journal of Physiology-Lung Cellular and Molecular Physiology ·Trina K. Jeffery, Paul D. Upton, Richard C. Trembath, Nicholas W. Morrell	2004	83
19	ETA and ETB Receptors Modulate the Proliferation of Human Pulmonary Artery Smooth Muscle Cells American Journal of Respiratory and Critical Care Medicine ·Neil Davie, STEPHEN J. HALEEN, Paul D. Upton, Julia M. Polak, Magdi H. Yacoub, Nicholas W. Morrell, John Wharton	2002	248
20	Inactivation of platelet‐derived growth factor‐BB following modification by ADP‐ribosyltransferase British Journal of Pharmacology ·Barbara Saxty, Masoud Yadollahi‐Farsani, Paul D. Upton, Stephen R. Johnstone, John MacDermot	2001	26

About Paul D. Upton

Paul D. Upton is a scholar working on Pulmonary and Respiratory Medicine, Genetics, Cellular and Molecular Neuroscience, Hepatology and Molecular Biology, having authored 76 papers that have together received 5.2k indexed citations. Recurring topics across this work include Pulmonary Hypertension Research and Treatments (46 papers), Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis (12 papers), TGF-β signaling in diseases (10 papers), Neuropeptides and Animal Physiology (10 papers), Vascular Anomalies and Treatments (9 papers), Receptor Mechanisms and Signaling (7 papers), Nitric Oxide and Endothelin Effects (5 papers) and Cardiovascular, Neuropeptides, and Oxidative Stress Research (5 papers). The work is most often cited by research in Pulmonary and Respiratory Medicine (3.3k citations), Genetics (711 citations), Cardiology and Cardiovascular Medicine (1.2k citations), Cancer Research (639 citations) and Hepatology (241 citations). Paul D. Upton has collaborated with scholars based in United Kingdom, United States and Portugal. Frequent co-authors include Nicholas W. Morrell, Richard C. Trembath, Xudong Yang, Mark Southwood, Lü Long, Carl Atkinson, Rajiv D. Machado, John Wharton, Rachel Davies and Susan Stewart. Their work appears in journals such as Circulation, Journal of Biological Chemistry, American Journal of Physiology-Lung Cellular and Molecular Physiology, American Journal of Respiratory Cell and Molecular Biology and Human Molecular Genetics.

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