Paul A. Roche

10.4k citations

120 papers · 8.4k indexed · 2 hit papers · h-index 49

Impact in

Immunology top 0.5%
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
Cell Biology top 0.5%
- Cellular transport and secretion

Papers in

Immunology 63
- Immunotherapy and Immune Responses 48
- Immune Cell Function and Interaction 38
- T-cell and B-cell Immunology 32
Cell Biology 34
- Cellular transport and secretion 28

Co-authors: Peter Cresswell Kazuyuki Furuta Zhenzhen Liu Niti Puri Elizabeth M. Hiltbold Howard A. Anderson Sharad K. Mittal Michael S. Marks
Journals: Journal of Biological Chemistry (19 papers)The Journal of Immunology (13 papers)Proceedings of the National Academy of Sciences (10 papers)Biochemistry (6 papers)Biochemical Journal (5 papers)
Partner nations: United States Japan Canada

In The Last Decade

Paul A. Roche

117 papers receiving 8.3k citations

Hit Papers

align trajectories log scale

The ins and outs of MHC class II-mediated antigen processing and presentation 2015 · 755 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Nature reviews. Immunology
2015 Frontiers in Physiology

Peers

Countries citing papers authored by Paul A. Roche

Since Specialization

Citations

This map shows the geographic impact of Paul A. Roche's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul A. Roche with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul A. Roche more than expected).

Fields of papers citing papers by Paul A. Roche

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul A. Roche. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul A. Roche. The network helps show where Paul A. Roche may publish in the future.

Co-authors

The 25 scholars most cited alongside Paul A. Roche, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Paul A. Roche Line = papers co-authored together Paul A. Roche links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	CD83 suppresses endogenous March-I-dependent MHC class II ubiquitination, endocytosis, and degradation Proceedings of the National Academy of Sciences ·聂桂兰, Nelson B. Cole, Sheridan JF, Young Lae Jung, Elena Tondini, Even Walseng, Paul A. Roche	2025	0
2	Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth Cell Reports ·Sheridan JF, Yoshinaga Ito, Kai W. Wucherpfennig, Paul A. Roche	2025	3
3	TRAF6 and TRAF2/3 Binding Motifs in CD40 Differentially Regulate B Cell Function in T-Dependent Antibody Responses and Dendritic Cell Function in Experimental Autoimmune Encephalomyelitis The Journal of Immunology ·Young Lae Jung, Jeffrey Chiang, Ray Zhang, Paul A. Roche, Richard J. Hodes	2023	2
4	Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes Autophagy ·Subhankar Dolai, Toshimasa Takahashi, Tairan Qin, Tao Liang, Li Xie, Fei Kang, Yifan Miao, Huanli Xie, Youhou Kang, Justin Manuel, Erin Winter, Paul A. Roche, Mark S. Cattral, Herbert Y. Gaisano	2020	26
5	Monitoring MHC-II Endocytosis and Recycling Using Cell-Surface Protein Biotinylation-Based Assays Methods in molecular biology ·Kyungjin Cho, Paul A. Roche	2019	5
6	Interleukin 10 (IL-10)-mediated Immunosuppression Journal of Biological Chemistry ·Sharad K. Mittal, Kyungjin Cho, Satoshi Ishido, Paul A. Roche	2015	119
7	Expression of the SNARE Protein SNAP-23 Is Essential for Cell Survival PLoS ONE ·Sunil C. Kaul, Sharad K. Mittal, Lionel Feigenbaum, Michael J. Kruhlak, Paul A. Roche	2015	16
8	The ins and outs of MHC class II-mediated antigen processing and presentation Nature reviews. Immunology ·Paul A. Roche, Kazuyuki Furuta Hit paper breakdown →	2015	755
9	TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation Cell ·Gleevoĭ Ni, Alessia Baccarini, Navpreet Tung, Paul Edward Smith, Oliver Florey, Yunjie Huang, Meenakshi Banerjee, Michael Overholtzer, Paul A. Roche, Robert Tampé, Brian D. Brown, Derk Amsen, Sidney W. Whiteheart, J. Magarian Blander	2014	250
10	Internalizing MHC class II–peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation Proceedings of the National Academy of Sciences ·Kazuyuki Furuta, Even Walseng, Paul A. Roche	2013	35
11	Pillars Article: Proteolysis of the Class II-Associated Invariant Chain Generates a Peptide Binding Site in Intracellular HLA-DR Molecules. Proc. Natl. Acad. Sci. USA. 1991. 88: 3150-3154 The Journal of Immunology ·Paul A. Roche, Peter Cresswell	2011	5
12	Phosphorylation of SNAP-23 Regulates Exocytosis from Mast Cells Journal of Biological Chemistry ·Régine Hepp, Niti Puri, Anita C. Hohenstein, Garland L. Crawford, Sidney W. Whiteheart, Paul A. Roche	2004	104
13	MHC Class II-Peptide Complexes and APC Lipid Rafts Accumulate at the Immunological Synapse The Journal of Immunology ·Elizabeth M. Hiltbold, Neil J. Poloso, Paul A. Roche	2003	115
14	Mast Cell Degranulation Requires N -Ethylmaleimide-Sensitive Factor-Mediated SNARE Disassembly The Journal of Immunology ·Niti Puri, Michael J. Kruhlak, Sidney W. Whiteheart, Paul A. Roche	2003	62
15	Phosphorylation of SNAP-23 by the Novel Kinase SNAK Regulates t-SNARE Complex Assembly Molecular Biology of the Cell ·Jean‐Pierre Cabaniols, Ravichandran Veerasamy, Paul A. Roche	1999	27
16	Targeting of SNAP-23 and SNAP-25 in Polarized Epithelial Cells Journal of Biological Chemistry ·Seng Hui Low, Paul A. Roche, Howard A. Anderson, Sven C.D. van IJzendoorn, Min Zhang, Keith E. Mostov, Thomas Weimbs	1998	87
17	SNAP-23 Is Not Cleaved by Botulinum Neurotoxin E and Can Replace SNAP-25 in the Process of Insulin Secretion Journal of Biological Chemistry ·Karin Sadoul, Sahena Rameez, Heiner Niemann, Ulrich Weller, Paul A. Roche, Amira Klip, William S. Trimble, Romano Regazzi, Stefan Catsicas, Philippe A. Halban	1997	89
18	Identification of a Novel Syntaxin- and Synaptobrevin/VAMP-binding Protein, SNAP-23, Expressed in Non-neuronal Tissues Journal of Biological Chemistry ·Ravichandran Veerasamy, O.L.J. Stoelinga, Paul A. Roche	1996	296
19	A conserved region in .alpha.-macroglobulins participates in binding to the mammalian .alpha.-macroglobulin receptor Biochemistry ·Jan J. Enghild, Ida B. Thøgersen, Paul A. Roche, Salvatore V. Pizzo	1989	68
20	Analysis of thiolester bond cleavage-dependent conformational changes in binary α2-macroglobulin-proteinase complexes Archives of Biochemistry and Biophysics ·Paul A. Roche, Salvatore V. Pizzo	1988	12

About Paul A. Roche

Paul A. Roche is a scholar working on Immunology, Cell Biology, Hematology, Molecular Biology and Physiology, having authored 120 papers that have together received 8.4k indexed citations. Recurring topics across this work include Immunotherapy and Immune Responses (48 papers), Immune Cell Function and Interaction (38 papers), T-cell and B-cell Immunology (32 papers), Cellular transport and secretion (28 papers), Monoclonal and Polyclonal Antibodies Research (14 papers), Lipid Membrane Structure and Behavior (14 papers), Glycosylation and Glycoproteins Research (9 papers) and Protein purification and stability (9 papers). The work is most often cited by research in Immunology (4.3k citations), Cell Biology (1.7k citations), Physiology (300 citations), Immunology and Allergy (363 citations) and Molecular Biology (3.5k citations). Paul A. Roche has collaborated with scholars based in United States, Japan and Canada. Frequent co-authors include Peter Cresswell, Kazuyuki Furuta, Zhenzhen Liu, Niti Puri, Elizabeth M. Hiltbold, Howard A. Anderson, Sharad K. Mittal, Michael S. Marks, Ravichandran Veerasamy and Oddmund Bakke. Their work appears in journals such as Journal of Biological Chemistry, The Journal of Immunology, Proceedings of the National Academy of Sciences, Biochemistry and Biochemical Journal.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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