Nicholas I. Carruthers

5.5k total citations · 1 hit paper
102 papers, 4.2k citations indexed

About

Nicholas I. Carruthers is a scholar working on Molecular Biology, Immunology and Organic Chemistry. According to data from OpenAlex, Nicholas I. Carruthers has authored 102 papers receiving a total of 4.2k indexed citations (citations by other indexed papers that have themselves been cited), including 57 papers in Molecular Biology, 28 papers in Immunology and 24 papers in Organic Chemistry. Recurrent topics in Nicholas I. Carruthers's work include Mast cells and histamine (28 papers), Receptor Mechanisms and Signaling (26 papers) and Phenothiazines and Benzothiazines Synthesis and Activities (15 papers). Nicholas I. Carruthers is often cited by papers focused on Mast cells and histamine (28 papers), Receptor Mechanisms and Signaling (26 papers) and Phenothiazines and Benzothiazines Synthesis and Activities (15 papers). Nicholas I. Carruthers collaborates with scholars based in United States, Belgium and United Kingdom. Nicholas I. Carruthers's co-authors include Timothy W. Lovenberg, Brian Lord, Sandy J. Wilson, Pascal Bonaventure, Curt A. Dvorak, Leah Aluisio, Michael A. Letavic, Wenying Chai, Ann Barbier and Changlu Liu and has published in prestigious journals such as Nature, Journal of Neuroscience and Journal of Medicinal Chemistry.

In The Last Decade

Nicholas I. Carruthers

98 papers receiving 4.1k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Copper-mediated synthesis of drug-like bicyclopentanes

2020 280 citations Xiaheng Zhang, Russell T. Smith et al. Nature profile →

Peers

Countries citing papers authored by Nicholas I. Carruthers

Since Specialization

Citations

This map shows the geographic impact of Nicholas I. Carruthers's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nicholas I. Carruthers with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nicholas I. Carruthers more than expected).

Fields of papers citing papers by Nicholas I. Carruthers

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nicholas I. Carruthers. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nicholas I. Carruthers. The network helps show where Nicholas I. Carruthers may publish in the future.

Co-authorship network of co-authors of Nicholas I. Carruthers

This figure shows the co-authorship network connecting the top 25 collaborators of Nicholas I. Carruthers. A scholar is included among the top collaborators of Nicholas I. Carruthers based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Nicholas I. Carruthers. Nicholas I. Carruthers is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Discovery of a Series of Substituted 1H-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators 2023 ·Journal of Medicinal Chemistry ·Christine F. Gelin, (unknown), Heather Coate, (unknown), (unknown), (unknown), Brian Lord, (unknown), Kevin J. Coe, (unknown), Jesús Alcázar, Christa C. Chrovian, Curt A. Dvorak, Nicholas I. Carruthers, Tatiana Koudriakova, Bartosz Balana, Michael A. Letavic	3
2	Copper-mediated synthesis of drug-like bicyclopentanes breakdown → 2020 ·Nature ·Xiaheng Zhang, Russell T. Smith, Chi “Chip” Le, Stefan J. McCarver, Brock T. Shireman, Nicholas I. Carruthers, David W. C. MacMillan	280
3	Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate 2020 ·Bioorganic & Medicinal Chemistry Letters ·Curt A. Dvorak, (unknown), Diane Nepomuceno, Lisa Dvorak, Brian Lord, Ian Fraser, Pascal Bonaventure, Timothy W. Lovenberg, Nicholas I. Carruthers	3
4	Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists 2015 ·Bioorganic & Medicinal Chemistry Letters ·(unknown), Jesús Alcázar, Michael K. Ameriks, (unknown), Hong Ao, Pascal Bonaventure, Nicholas I. Carruthers, Christa C. Chrovian, Meri De Angelis, Brian Lord, Jason C. Rech, Qi Wang, Anindya Bhattacharya, José Ignacio Andrés, Michael A. Letavic	30
5	A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334 2015 ·European Journal of Pharmacology ·Brian Lord, Michael K. Ameriks, Qi Wang, Lawrence Fourgeaud, (unknown), (unknown), (unknown), Nicholas I. Carruthers, Timothy W. Lovenberg, Pascal Bonaventure, Michael A. Letavic, Anindya Bhattacharya	45
6	Pharmacology of a Novel Central Nervous System–Penetrant P2X7 Antagonist JNJ-42253432 2014 ·Journal of Pharmacology and Experimental Therapeutics ·Brian Lord, Leah Aluisio, James R. Shoblock, Robert A. Neff, Elena I. Varlinskaya, Marc Ceusters, Timothy W. Lovenberg, Nicholas I. Carruthers, Pascal Bonaventure, Michael A. Letavic, Terrence Deak, Wilhelmus Drinkenburg, Anindya Bhattacharya	65
7	Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists 2011 ·European Journal of Pharmacology ·Da‐Thao Tran, Pascal Bonaventure, Michael D. Hack, Taraneh Mirzadegan, Curt A. Dvorak, Michael A. Letavic, Nicholas I. Carruthers, Timothy W. Lovenberg, Steven W. Sutton	25
8	Exploration of Structure-Activity Relationships for Dual Serotonin Transporter Reuptake Inhibitors-Histamine H3 Receptor Antagonists 2010 ·Current Topics in Medicinal Chemistry ·Emily M. Stocking, Michael A. Letavic, Pascal Bonaventure, Nicholas I. Carruthers	6
9	2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists 2008 ·Bioorganic & Medicinal Chemistry Letters ·Brock T. Shireman, Curt A. Dvorak, (unknown), Pascal Bonaventure, Diane Nepomuceno, Lisa Dvorak, Kirsten L. Miller, Timothy W. Lovenberg, Nicholas I. Carruthers	10
10	Novel imidazole-based histamine H3 antagonists 2008 ·Bioorganic & Medicinal Chemistry Letters ·Jill A. Jablonowski, Kiev S. Ly, (unknown), Curt A. Dvorak, Jamin D. Boggs, Lisa Dvorak, Brian Lord, Kirsten L. Miller, Curt Mazur, Sandy J. Wilson, Timothy W. Lovenberg, Nicholas I. Carruthers	7
11	Benzylamine histamine H3 antagonists and serotonin reuptake inhibitors 2007 ·Bioorganic & Medicinal Chemistry Letters ·Michael A. Letavic, Emily M. Stocking, Ann Barbier, Pascal Bonaventure, Jamin D. Boggs, Brian Lord, Kirsten L. Miller, Sandy J. Wilson, Nicholas I. Carruthers	9
12	Lead identification of acetylcholinesterase inhibitors–histamine H3 receptor antagonists from molecular modeling 2007 ·Bioorganic & Medicinal Chemistry ·Scott D. Bembenek, John M. Keith, Michael A. Letavic, Richard L. Apodaca, Ann Barbier, Lisa Dvorak, Leah Aluisio, Kirsten L. Miller, Timothy W. Lovenberg, Nicholas I. Carruthers	48
13	Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors 2007 ·Bioorganic & Medicinal Chemistry Letters ·Kiev S. Ly, Michael A. Letavic, John M. Keith, (unknown), Emily M. Stocking, Ann Barbier, Pascal Bonaventure, Brian Lord, Xiaohui Jiang, Jamin D. Boggs, Lisa Dvorak, Kirsten L. Miller, Diane Nepomuceno, Sandy J. Wilson, Nicholas I. Carruthers	19
14	Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore 2006 ·Bioorganic & Medicinal Chemistry Letters ·John M. Keith, (unknown), Michael A. Letavic, Kiev S. Ly, Jill A. Jablonowski, Mark Seierstad, Ann Barbier, Sandy Wilson, Jamin D. Boggs, Ian Fraser, Curt Mazur, (unknown), Nicholas I. Carruthers	0
15	5 Recent Medicinal Chemistry of the Histamine H3 Receptor 2006 ·Progress in medicinal chemistry ·Michael A. Letavic, Ann Barbier, Curt A. Dvorak, Nicholas I. Carruthers	36
16	Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand 2006 ·Nuclear Medicine and Biology ·Anu J. Airaksinen, Jill A. Jablonowski, (unknown), Ann Barbier, (unknown), (unknown), Robert C. Schuit, Jacobus D. M. Herscheid, Josée E. Leysen, Nicholas I. Carruthers, Adriaan A. Lammertsma, Albert D. Windhorst	24
17	Effects of histamine H3 antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice 2005 ·Neuropharmacology ·Feiyong Jia, Motohisa Kato, Hongmei Dai, (unknown), Tomohiro Okuda, Eiko Sakurai, Nobuyuki Okamura, Timothy W. Lovenberg, Ann Barbier, Nicholas I. Carruthers, Kazuie Iinuma, Kazuhiko Yanai	28
18	Non-imidazole heterocyclic histamine H3 receptor antagonists 2003 ·Bioorganic & Medicinal Chemistry Letters ·Wenying Chai, J. Guy Breitenbucher, Annette K. Kwok, Xiaobing Li, (unknown), Nicholas I. Carruthers, Timothy W. Lovenberg, Curt Mazur, Sandy J. Wilson, Frank U. Axe, Todd K. Jones	101
19	Synthesis and structure–activity relationships of oxime neurokinin antagonists: discovery of potent arylamides 2002 ·Bioorganic & Medicinal Chemistry Letters ·(unknown), (unknown), John C. Anthes, Nicholas I. Carruthers, Cheryl A. Grice, Ling Lin, (unknown), Gregory A. Reichard, (unknown), (unknown), Shing‐Chung Wong, John J. Piwinski	12
20	Cloning and Pharmacological Characterization of a Fourth Histamine Receptor (H₄) Expressed in Bone Marrow 2001 ·Molecular Pharmacology ·Changlu Liu, Xiaojun Ma, Xiaoxia Jiang, Sandy J. Wilson, Claudia L. Hofstra, Jonathan M. Blevitt, Jayashree Pyati, Xiaobing Li, Wenying Chai, Nicholas I. Carruthers, Timothy W. Lovenberg	355

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact