Nancy A. Speck

20.0k total citations · 4 hit papers
163 papers, 14.6k citations indexed

About

Nancy A. Speck is a scholar working on Molecular Biology, Hematology and Immunology. According to data from OpenAlex, Nancy A. Speck has authored 163 papers receiving a total of 14.6k indexed citations (citations by other indexed papers that have themselves been cited), including 91 papers in Molecular Biology, 68 papers in Hematology and 57 papers in Immunology. Recurrent topics in Nancy A. Speck's work include Acute Myeloid Leukemia Research (61 papers), Zebrafish Biomedical Research Applications (46 papers) and Epigenetics and DNA Methylation (25 papers). Nancy A. Speck is often cited by papers focused on Acute Myeloid Leukemia Research (61 papers), Zebrafish Biomedical Research Applications (46 papers) and Epigenetics and DNA Methylation (25 papers). Nancy A. Speck collaborates with scholars based in United States, United Kingdom and Netherlands. Nancy A. Speck's co-authors include Elaine Dzierzak, Terryl Stacy, Michael Binder, Qing Wang, Arlene H. Sharpe, Michael Chen, Marella de Bruijn, D. Gary Gilliland, Tomomasa Yokomizo and David Baltimore and has published in prestigious journals such as Nature, New England Journal of Medicine and Cell.

In The Last Decade

Nancy A. Speck

160 papers receiving 14.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 1.0k citations Nancy A. Speck et al. profile →
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

2009 750 citations Nancy A. Speck et al. profile →
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters

1999 537 citations Nancy A. Speck et al. Development profile →
The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 532 citations Ting-Lei Gu, John H. Bushweller et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Nancy A. Speck United States	65	9.6k	5.7k	4.0k	3.9k	1.5k	163	14.6k
Elaine Dzierzak Netherlands	54	7.7k 0.8×	4.3k 0.8×	6.9k 1.7×	4.2k 1.1×	752 0.5×	151	13.6k
Warren S. Pear United States	74	11.7k 1.2×	3.3k 0.6×	1.6k 0.4×	5.4k 1.4×	3.1k 2.1×	181	18.8k
Ana Cumano France	57	6.6k 0.7×	1.9k 0.3×	2.2k 0.6×	8.6k 2.2×	1.9k 1.3×	162	16.3k
Atsushi Iwama Japan	64	7.6k 0.8×	3.6k 0.6×	945 0.2×	2.5k 0.6×	2.2k 1.4×	251	12.1k
Bruno Calabretta United States	65	8.6k 0.9×	3.4k 0.6×	1.1k 0.3×	1.6k 0.4×	2.6k 1.7×	237	13.2k
Scott W. Hiebert United States	70	14.1k 1.5×	5.2k 0.9×	1.5k 0.4×	2.5k 0.6×	5.4k 3.6×	176	19.1k
Guy Sauvageau Canada	52	7.4k 0.8×	3.9k 0.7×	852 0.2×	1.8k 0.5×	1.7k 1.1×	210	10.3k
Thalia Papayannopoulou United States	62	6.9k 0.7×	5.8k 1.0×	1.1k 0.3×	3.0k 0.8×	2.2k 1.5×	224	14.9k
Peter Besmer United States	65	6.5k 0.7×	2.5k 0.4×	1.2k 0.3×	4.8k 1.2×	2.4k 1.6×	119	16.6k
Gerd A. Blobel United States	71	13.0k 1.4×	2.0k 0.4×	1.2k 0.3×	1.1k 0.3×	1.2k 0.8×	185	15.7k

Countries citing papers authored by Nancy A. Speck

Since Specialization

Citations

This map shows the geographic impact of Nancy A. Speck's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nancy A. Speck with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nancy A. Speck more than expected).

Fields of papers citing papers by Nancy A. Speck

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nancy A. Speck. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nancy A. Speck. The network helps show where Nancy A. Speck may publish in the future.

Co-authorship network of co-authors of Nancy A. Speck

This figure shows the co-authorship network connecting the top 25 collaborators of Nancy A. Speck. A scholar is included among the top collaborators of Nancy A. Speck based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Nancy A. Speck. Nancy A. Speck is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Chen, Xiaowen, Joanna Tober, Martin H. Dominguez, et al.. (2025). Lineage tracing studies suggest that the placenta is not a de novo source of hematopoietic stem cells. PLoS Biology. 23(1). e3003003–e3003003. 1 indexed citations

Ye, Darwin, Elizabeth D. Howell, Erica Bresciani, et al.. (2023). RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. Genes & Development. 37(13-14). 605–620. 14 indexed citations

Yang, Yi‐Qing, Melanie Mumau, Joanna Tober, et al.. (2022). Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis. Blood. 139(19). 2942–2957. 11 indexed citations

Bennett, Laura, Melanie Mumau, Yan Li, & Nancy A. Speck. (2022). MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo. Development. 149(8). 5 indexed citations

Speck, Nancy A.. (2022). A Pernicious Cycle Affecting Premalignant Stem Cells. New England Journal of Medicine. 386(6). 596–598. 4 indexed citations

Howell, Elizabeth D., Amanda D. Yzaguirre, Peng Gao, et al.. (2021). Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. Genes & Development. 35(21-22). 1475–1489. 15 indexed citations

Estevez, Brian, Danuta Jarocha, Michael V. Gonzalez, et al.. (2021). RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells. Blood. 137(19). 2662–2675. 21 indexed citations

Zhu, Qin, Sumedha Bagga, Bing He, et al.. (2020). Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling. Blood Advances. 4(6). 1145–1158. 50 indexed citations

Zhu, Qin, Peng Gao, Joanna Tober, et al.. (2020). Developmental trajectory of prehematopoietic stem cell formation from endothelium. Blood. 136(7). 845–856. 107 indexed citations

10.

Yzaguirre, Amanda D., Elizabeth D. Howell, Yan Li, Zijing Liu, & Nancy A. Speck. (2018). Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis. Development. 145(2). 33 indexed citations

11.

Gao, Long, Joanna Tober, Peng Gao, et al.. (2018). RUNX1 and the endothelial origin of blood. Experimental Hematology. 68. 2–9. 62 indexed citations

12.

Zhen, Tao, Erika M. Kwon, Ling Zhao, et al.. (2017). Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11. Blood. 130(22). 2431–2442. 20 indexed citations

13.

Tober, Joanna, Yan Li, Long Gao, et al.. (2017). Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1. The Journal of Experimental Medicine. 215(2). 645–659. 14 indexed citations

14.

Sinenko, Sergey, et al.. (2010). Genetic manipulation of AML1-ETO–induced expansion of hematopoietic precursors in a Drosophila model. Blood. 116(22). 4612–4620. 46 indexed citations

15.

Roudaia, Liya, Matthew D. Cheney, Wei Chen, et al.. (2009). CBFβ is critical for AML1-ETO and TEL-AML1 activity. Blood. 113(13). 3070–3079. 40 indexed citations

16.

Goetz, Tamara L., Ting-Lei Gu, Nancy A. Speck, & Barbara J. Graves. (2000). Auto-Inhibition of Ets-1 Is Counteracted by DNA Binding Cooperativity with Core-Binding Factor α2. Molecular and Cellular Biology. 20(1). 81–90. 121 indexed citations

17.

Gu, Ting-Lei, Tamara L. Goetz, Barbara J. Graves, & Nancy A. Speck. (2000). Auto-Inhibition and Partner Proteins, Core-Binding Factor β (CBFβ) and Ets-1, Modulate DNA Binding by CBFα2 (AML1). Molecular and Cellular Biology. 20(1). 91–103. 132 indexed citations

18.

Wotton, David, Jacques Ghysdael, Shuwen Wang, Nancy A. Speck, & Michael J. Owen. (1994). Cooperative binding of Ets-1 and core binding factor to DNA. Molecular and Cellular Biology. 14(1). 840–850. 70 indexed citations

19.

Wang, Shuwen, Qing Wang, Barbara E. Crute, et al.. (1993). Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor. Molecular and Cellular Biology. 13(6). 3324–3339. 378 indexed citations

20.

Redondo, Juan Miguel, et al.. (1992). Indistinguishable Nuclear Factor Binding to Functional Core Sites of the T-Cell Receptor δ and Murine Leukemia Virus Enhancers. Molecular and Cellular Biology. 12(11). 4817–4823. 22 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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