Michael P. Hughes

2.1k citations

20 papers · 1.4k indexed · 2 hit papers · h-index 13

Co-authors: David Eisenberg M.R. Sawaya José A. Rodríguez David R. Boyer Duilio Cascio Roland Riek Lukasz Goldschmidt Lisa D. Chong
Topics: RNA Research and Splicing (9 papers)Protein Structure and Dynamics (5 papers)Alzheimer's disease research and treatments (5 papers)
Cited by: Neurology Physiology Molecular Biology
Journals: Nature Science Cell
Partner nations: United States China Bulgaria

In The Last Decade

Michael P. Hughes

20 papers receiving 1.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

2018 343 citations Michael P. Hughes, M.R. Sawaya et al. Science profile →
The expanding amyloid family: Structure, stability, function, and pathogenesis

2021 267 citations M.R. Sawaya, Michael P. Hughes et al. Cell profile →

Peers

Countries citing papers authored by Michael P. Hughes

Since Specialization

Citations

This map shows the geographic impact of Michael P. Hughes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael P. Hughes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael P. Hughes more than expected).

Fields of papers citing papers by Michael P. Hughes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael P. Hughes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael P. Hughes. The network helps show where Michael P. Hughes may publish in the future.

Co-authorship network of co-authors of Michael P. Hughes

This figure shows the co-authorship network connecting the top 25 collaborators of Michael P. Hughes. A scholar is included among the top collaborators of Michael P. Hughes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael P. Hughes. Michael P. Hughes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Rethinking Cellular Organization: Phase Separation as a Unifying Principle in Molecular Biology 2025 ·Journal of Molecular Biology ·Michael P. Hughes	1
2	Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation 2023 ·Journal of Biological Chemistry ·Jiahui Lu,P. Ge,M.R. Sawaya,Michael P. Hughes,David R. Boyer,Qin Cao,Romany Abskharon,Duilio Cascio,Einav Tayeb-Fligelman,David Eisenberg	4
3	A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins 2022 ·eLife ·(unknown),(unknown),(unknown),Peter Mastrangelo,(unknown),Hao Cai,(unknown),Michael P. Hughes,(unknown),Xiaoquan Chu,Jianfeng Pei,Vince Grolmusz,Małgorzata Kotulska,Julie D. Forman‐Kay,Peter J. Roy	13
4	Bioinformatic identification of previously unrecognized amyloidogenic proteins 2022 ·Journal of Biological Chemistry ·Gregory M. Rosenberg,Kevin A. Murray,Łukasz Salwiński,Michael P. Hughes,Romany Abskharon,David Eisenberg	8
5	Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies 2022 ·Nature Structural & Molecular Biology ·Kevin A. Murray,Michael P. Hughes,(unknown),M.R. Sawaya,Łukasz Salwiński,Hope Pan,Samuel W. French,Paul M. Seidler,David Eisenberg	22
6	Extended β-Strands Contribute to Reversible Amyloid Formation 2022 ·ACS Nano ·Kevin A. Murray,Declan Evans,Michael P. Hughes,M.R. Sawaya,(unknown),K. N. Houk,David Eisenberg	18
7	The expanding amyloid family: Structure, stability, function, and pathogenesisbreakdown → 2021 ·Cell ·M.R. Sawaya,Michael P. Hughes,José A. Rodríguez,Roland Riek,David Eisenberg	267
8	Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils 2021 ·Journal of Biological Chemistry ·Michael P. Hughes,Lukasz Goldschmidt,David Eisenberg	29
9	The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure 2020 ·Proceedings of the National Academy of Sciences ·David R. Boyer,Binsen Li,Chuanqi Sun,(unknown),Kang Zhou,Michael P. Hughes,M.R. Sawaya,Lin Jiang,David Eisenberg	137
10	CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid 2020 ·Nature Communications ·Jiahui Lu,Qin Cao,Michael P. Hughes,M.R. Sawaya,David R. Boyer,Duilio Cascio,David Eisenberg	78
11	Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation 2019 ·Nature Structural & Molecular Biology ·E.L. Guenther,Qin Cao,Hamilton Trinh,Jiahui Lu,M.R. Sawaya,Duilio Cascio,David R. Boyer,José A. Rodríguez,Michael P. Hughes,David Eisenberg	1
12	DNA Facilitates Oligomerization and Prevents Aggregation via DNA Networks 2019 ·Biophysical Journal ·(unknown),(unknown),Michael P. Hughes,Jennifer N. Bourne,Scott Horowitz	12
13	Estimating the Global Epidemiology of Amyloid Light-Chain Amyloidosis With an Incidence-to-Prevalence Model 2019 ·Clinical Lymphoma Myeloma & Leukemia ·Nicole Zhang,Dasha Cherepanov,Dorothy Romanus,Nishant Kumar,Michael P. Hughes,Douglas V. Faller	2
14	Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networksbreakdown → 2018 ·Science ·Michael P. Hughes,M.R. Sawaya,David R. Boyer,Lukasz Goldschmidt,José A. Rodríguez,Duilio Cascio,Lisa D. Chong,Tamir Gonen,David Eisenberg	343
15	Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation 2018 ·Nature Structural & Molecular Biology ·E.L. Guenther,Qin Cao,Hamilton Trinh,Jiahui Lu,M.R. Sawaya,Duilio Cascio,David R. Boyer,José A. Rodríguez,Michael P. Hughes,David Eisenberg	183
16	TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle 2018 ·Nature ·Thomas O. Vogler,Joshua Wheeler,Éric Nguyen,Michael P. Hughes,Kyla A. Britson,Evan Lester,Bhalchandra S. Rao,Nicole Dalla Betta,Oscar N. Whitney,(unknown),Edward Gomes,James Shorter,Thomas E. Lloyd,David Eisenberg,J. Paul Taylor,Aaron M. Johnson,Bradley B. Olwin,Roy Parker	145
17	Atomic structures of corkscrew‐forming segments of SOD1 reveal varied oligomer conformations 2018 ·Protein Science ·Smriti Sangwan,M.R. Sawaya,Kevin A. Murray,Michael P. Hughes,David Eisenberg	23
18	The Amyloid State of Proteins 2015 ·The FASEB Journal ·David Eisenberg,M.R. Sawaya,Rebecca A. Nelson,Alice Soragni,José A. Rodríguez,Lin Jiang,Smriti Sangwan,Lisa M. Johnson,Arthur Laganowsky,Cong Liu,A.B. Soriaga,Meytal Landau,Duilio Cascio,Stuart A. Sievers,(unknown),E.L. Guenther,Michael P. Hughes	2
19	Correction: Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta 2013 ·eLife ·Lin Jiang,Cong Liu,D.J. Leibly,Meytal Landau,Minglei Zhao,Michael P. Hughes,David Eisenberg	3
20	Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta 2013 ·eLife ·Lin Jiang,Cong Liu,D.J. Leibly,Meytal Landau,Minglei Zhao,Michael P. Hughes,David Eisenberg	102

About Michael P. Hughes

Michael P. Hughes is a scholar working on Aging, Neurology and Molecular Biology, having authored 20 papers that have together received 1.4k indexed citations. Recurring topics across this work include RNA Research and Splicing (9 papers), Protein Structure and Dynamics (5 papers) and Alzheimer's disease research and treatments (5 papers). The work is most often cited by research in Neurology (356 citations), Physiology (456 citations) and Molecular Biology (1.0k citations). Michael P. Hughes has collaborated with scholars based in United States, China and Bulgaria. Frequent co-authors include David Eisenberg, M.R. Sawaya, José A. Rodríguez, David R. Boyer, Duilio Cascio, Roland Riek, Lukasz Goldschmidt, Lisa D. Chong, Tamir Gonen and Lin Jiang. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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