Michael C. Holmes

23.3k total citations · 9 hit papers
104 papers, 14.7k citations indexed

About

Michael C. Holmes is a scholar working on Molecular Biology, Genetics and Oncology. According to data from OpenAlex, Michael C. Holmes has authored 104 papers receiving a total of 14.7k indexed citations (citations by other indexed papers that have themselves been cited), including 84 papers in Molecular Biology, 44 papers in Genetics and 28 papers in Oncology. Recurrent topics in Michael C. Holmes's work include CRISPR and Genetic Engineering (70 papers), Virus-based gene therapy research (42 papers) and CAR-T cell therapy research (27 papers). Michael C. Holmes is often cited by papers focused on CRISPR and Genetic Engineering (70 papers), Virus-based gene therapy research (42 papers) and CAR-T cell therapy research (27 papers). Michael C. Holmes collaborates with scholars based in United States, Italy and Spain. Michael C. Holmes's co-authors include Philip D. Gregory, Fyodor D. Urnov, Edward J. Rebar, Jeffrey C. Miller, Jianbin Wang, H. Steve Zhang, Christian Beauséjour, Ya-Li Lee, Luigi Naldini and David E. Paschon and has published in prestigious journals such as Nature, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

In The Last Decade

Michael C. Holmes

102 papers receiving 14.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Genome editing with engineered zinc finger nucleases

2010 1.6k citations Fyodor D. Urnov, Edward J. Rebar et al. profile →
A TALE nuclease architecture for efficient genome editing

2010 1.6k citations Jeffrey C. Miller, Jianbin Wang et al. Nature Biotechnology profile →
Highly efficient endogenous human gene correction using designed zinc-finger nucleases

2005 1.2k citations Fyodor D. Urnov, Jeffrey C. Miller et al. profile →
Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

2014 973 citations Pablo Tebas, David Stein et al. New England Journal of Medicine profile →
An improved zinc-finger nuclease architecture for highly specific genome editing

2007 804 citations Jeffrey C. Miller, Michael C. Holmes et al. Nature Biotechnology profile →
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

2007 647 citations Angelo Lombardo, Pietro Genovese et al. Nature Biotechnology profile →
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

2010 534 citations Nathalia Holt, Jianbin Wang et al. Nature Biotechnology profile →
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

2011 472 citations David E. Paschon, Michael C. Holmes et al. profile →
Targeted genome editing in human repopulating haematopoietic stem cells

2014 434 citations Pietro Genovese, Giulia Schiroli et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Michael C. Holmes United States	45	12.5k	5.3k	2.4k	1.2k	1.1k	104	14.7k
Philip D. Gregory United States	61	18.6k 1.5×	6.7k 1.3×	2.6k 1.1×	1.9k 1.6×	1.1k 1.0×	138	21.9k
Edward J. Rebar United States	40	11.7k 0.9×	3.6k 0.7×	1.4k 0.6×	1.3k 1.1×	208 0.2×	77	13.3k
Ophir Shalem United States	21	11.6k 0.9×	2.3k 0.4×	1.1k 0.5×	935 0.8×	173 0.2×	42	13.1k
Fyodor D. Urnov United States	39	11.6k 0.9×	3.6k 0.7×	832 0.3×	1.4k 1.2×	211 0.2×	84	13.4k
Prashant Mali United States	40	16.4k 1.3×	3.3k 0.6×	888 0.4×	1.4k 1.2×	135 0.1×	96	17.8k
Toni Cathomen Germany	44	5.3k 0.4×	2.2k 0.4×	721 0.3×	610 0.5×	307 0.3×	161	7.0k
Silvana Konermann United States	18	15.2k 1.2×	2.7k 0.5×	795 0.3×	1.7k 1.4×	163 0.1×	26	16.3k
Neville E. Sanjana United States	35	10.3k 0.8×	1.7k 0.3×	1.3k 0.5×	470 0.4×	143 0.1×	74	12.5k
Donald B. Kohn United States	69	9.8k 0.8×	7.8k 1.5×	3.6k 1.5×	143 0.1×	1.1k 1.0×	361	16.0k
Theodore Friedmann United States	50	7.4k 0.6×	4.5k 0.8×	1.7k 0.7×	780 0.7×	588 0.5×	175	11.2k

Countries citing papers authored by Michael C. Holmes

Since Specialization

Citations

This map shows the geographic impact of Michael C. Holmes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael C. Holmes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael C. Holmes more than expected).

Fields of papers citing papers by Michael C. Holmes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael C. Holmes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael C. Holmes. The network helps show where Michael C. Holmes may publish in the future.

Co-authorship network of co-authors of Michael C. Holmes

This figure shows the co-authorship network connecting the top 25 collaborators of Michael C. Holmes. A scholar is included among the top collaborators of Michael C. Holmes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael C. Holmes. Michael C. Holmes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Cotta‐Ramusino, Cecilia, James B. Rottman, Donghui Li, et al.. (2025). Targeted lnp delivery of an RNA gene writer In Vivo enables generation of functional CAR-T cells. Blood. 146(Supplement 1). 6097–6097.

Iaco, Alberto De, James B. Rottman, Donghui Liu, et al.. (2024). Targeted Lipid Nanoparticle Delivery of an RNA Gene Writer In Vivo Enables Generation of CAR-T Cells in a Humanized Mouse Model. Blood. 144(Supplement 1). 4799–4799. 2 indexed citations

Magee, Michael S., Alberto De Iaco, James B. Rottman, et al.. (2023). Deploying an RNA-Based Gene Writer System and Lipid Nanoparticle (LNP) Delivery to Generate Functional Chimeric Antigen Receptor (CAR) T Cells with in Vitro and In Vivo Anti-Tumor Activity. Blood. 142(Supplement 1). 2073–2073. 3 indexed citations

Conway, Anthony, Matthew Mendel, Kenneth H. Kim, et al.. (2019). Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets. Molecular Therapy. 27(4). 866–877. 69 indexed citations

Ou, Li, Russell C. DeKelver, Michelle Rohde, et al.. (2018). ZFN-Mediated In Vivo Genome Editing Corrects Murine Hurler Syndrome. Molecular Therapy. 27(1). 178–187. 64 indexed citations

Leibman, Rachel S., Max W. Richardson, Christoph T. Ellebrecht, et al.. (2017). Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor. PLoS Pathogens. 13(10). e1006613–e1006613. 94 indexed citations

Díez, Begoña, Pietro Genovese, Francisco J Roman‐Rodriguez, et al.. (2017). Therapeutic gene editing in CD 34 ⁺ hematopoietic progenitors from Fanconi anemia patients. EMBO Molecular Medicine. 9(11). 1574–1588. 44 indexed citations

Schiroli, Giulia, Samuele Ferrari, Anthony Conway, et al.. (2017). Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1. Science Translational Medicine. 9(411). 159 indexed citations

Annoni, Andrea, Mauro Biffi, Fabio Russo, et al.. (2017). Genome editing for scalable production of alloantigen‐free lentiviral vectors for in vivo gene therapy. EMBO Molecular Medicine. 9(11). 1558–1573. 44 indexed citations

10.

Leslie, George J., Jianbin Wang, Max W. Richardson, et al.. (2016). Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus. PLoS Pathogens. 12(11). e1005983–e1005983. 33 indexed citations

11.

Wang, Jianbin, Samuel B. Hayward, David A. Shivak, et al.. (2015). Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery. Nucleic Acids Research. 44(3). e30–e30. 100 indexed citations

12.

Tebas, Pablo, David Stein, Winson W. Tang, et al.. (2014). Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV. New England Journal of Medicine. 370(10). 901–910. 973 indexed citations breakdown →

13.

Benabdallah, Basma, Joël Rousseau, Pierre Chapdelaine, et al.. (2013). Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation. Molecular Therapy — Nucleic Acids. 2. e68–e68. 16 indexed citations

14.

Brennan, Andrea, Shuguang Jiang, Gwendolyn Binder-Scholl, et al.. (2013). Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease–Targeted Disruption of the HIV Co-receptor CCR5. Human Gene Therapy. 24(3). 245–258. 91 indexed citations

15.

Rensburg, Ruan van, Ines Beyer, Oleg Denisenko, et al.. (2012). Chromatin structure of two genomic sites for targeted transgene integration in induced pluripotent stem cells and hematopoietic stem cells. Gene Therapy. 20(2). 201–214. 35 indexed citations

16.

Simsek, Deniz, Erika Brunet, Sunnie Wong, et al.. (2011). DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation. PLoS Genetics. 7(6). e1002080–e1002080. 237 indexed citations

17.

Benabdallah, Basma, Shuyuan Yao, Philip D. Gregory, et al.. (2010). Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform. Cytotherapy. 12(3). 394–399. 48 indexed citations

18.

Orlando, Salvatore J., Yolanda Santiago, Russell C. DeKelver, et al.. (2010). Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology. Nucleic Acids Research. 38(15). e152–e152. 147 indexed citations

19.

Holt, Nathalia, Jianbin Wang, Kenneth Kim, et al.. (2010). Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nature Biotechnology. 28(8). 839–847. 534 indexed citations breakdown →

20.

Jamieson, Andrew C., Bo Guan, Thomas J. Cradick, et al.. (2006). Controlling gene expression in Drosophila using engineered zinc finger protein transcription factors. Biochemical and Biophysical Research Communications. 348(3). 873–879. 6 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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