Leslie Z. Benet

37.6k total citations · 8 hit papers
510 papers, 26.5k citations indexed

About

Leslie Z. Benet is a scholar working on Oncology, Pharmacology and Pediatrics, Perinatology and Child Health. According to data from OpenAlex, Leslie Z. Benet has authored 510 papers receiving a total of 26.5k indexed citations (citations by other indexed papers that have themselves been cited), including 186 papers in Oncology, 170 papers in Pharmacology and 135 papers in Pediatrics, Perinatology and Child Health. Recurrent topics in Leslie Z. Benet's work include Drug Transport and Resistance Mechanisms (170 papers), Pharmacogenetics and Drug Metabolism (155 papers) and Pharmacological Effects and Toxicity Studies (103 papers). Leslie Z. Benet is often cited by papers focused on Drug Transport and Resistance Mechanisms (170 papers), Pharmacogenetics and Drug Metabolism (155 papers) and Pharmacological Effects and Toxicity Studies (103 papers). Leslie Z. Benet collaborates with scholars based in United States, Germany and Japan. Leslie Z. Benet's co-authors include Chi‐Yuan Wu, Vincent J. Wacher, Carolyn L. Cummins, Yuanchao Zhang, Tudor I. Oprea, Renato L. Galeazzi, Betty‐Ann Hoener, Uwe Christians, Wolfgang Jacobsen and Malcolm Rowland and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Leslie Z. Benet

506 papers receiving 25.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System

2005 1.0k citations Leslie Z. Benet et al. profile →
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 734 citations Leslie Z. Benet et al. profile →
Noncompartmental Determination of the Steady‐State Volume of Distribution

1979 678 citations Leslie Z. Benet et al. Journal of Pharmaceutical Sciences profile →
Clearance concepts in pharmacokinetics

1973 607 citations Leslie Z. Benet et al. profile →
BDDCS, the Rule of 5 and drugability

2016 597 citations Leslie Z. Benet, Chelsea M. Hosey et al. profile →
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 576 citations Leslie Z. Benet et al. profile →
Changes in plasma protein binding have little clinical relevance

2002 551 citations Leslie Z. Benet et al. profile →
BDDCS Applied to Over 900 Drugs

2011 520 citations Leslie Z. Benet, Fabio Broccatelli et al. The AAPS Journal profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Leslie Z. Benet United States	80	9.5k	8.4k	6.1k	5.0k	3.8k	510	26.5k
Michel Eichelbaum Germany	87	11.4k 1.2×	12.0k 1.4×	6.8k 1.1×	4.7k 1.0×	2.6k 0.7×	335	25.4k
Kenneth E. Thummel United States	73	7.2k 0.8×	11.5k 1.4×	4.7k 0.8×	3.1k 0.6×	1.8k 0.5×	263	20.2k
Yuichi Sugiyama Japan	99	25.4k 2.7×	11.2k 1.3×	13.0k 2.1×	7.8k 1.6×	3.1k 0.8×	831	40.4k
Malcolm Rowland United Kingdom	65	4.7k 0.5×	5.6k 0.7×	2.5k 0.4×	2.9k 0.6×	2.8k 0.7×	293	16.0k
Steven Wrighton United States	71	6.7k 0.7×	11.1k 1.3×	2.6k 0.4×	3.9k 0.8×	1.8k 0.5×	172	17.1k
Jos H. Beijnen Netherlands	111	27.4k 2.9×	6.0k 0.7×	7.5k 1.2×	17.7k 3.5×	3.2k 0.8×	1.5k	57.9k
Pertti J. Neuvonen Finland	84	8.1k 0.8×	10.9k 1.3×	5.7k 0.9×	3.1k 0.6×	4.1k 1.1×	506	26.6k
Amin Rostami‐Hodjegan United Kingdom	71	4.9k 0.5×	6.5k 0.8×	3.7k 0.6×	2.7k 0.5×	2.1k 0.6×	324	16.0k
Magnus Ingelman‐Sundberg Sweden	96	7.8k 0.8×	18.2k 2.2×	3.0k 0.5×	10.8k 2.2×	3.1k 0.8×	527	35.5k
F. Peter Guengerich United States	127	16.8k 1.8×	37.6k 4.5×	3.2k 0.5×	27.2k 5.5×	5.1k 1.3×	941	68.3k

Countries citing papers authored by Leslie Z. Benet

Since Specialization

Citations

This map shows the geographic impact of Leslie Z. Benet's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leslie Z. Benet with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leslie Z. Benet more than expected).

Fields of papers citing papers by Leslie Z. Benet

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leslie Z. Benet. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leslie Z. Benet. The network helps show where Leslie Z. Benet may publish in the future.

Co-authorship network of co-authors of Leslie Z. Benet

This figure shows the co-authorship network connecting the top 25 collaborators of Leslie Z. Benet. A scholar is included among the top collaborators of Leslie Z. Benet based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Leslie Z. Benet. Leslie Z. Benet is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Benet, Leslie Z. & Jasleen K. Sodhi. (2025). Net Influx Rather Than Directional Rates: Re-evaluating Transporter Characterization In Vivo and In Vitro for Renal and Hepatic Clearance. The AAPS Journal. 28(1). 3–3.

Sodhi, Jasleen K., et al.. (2024). An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing. The AAPS Journal. 26(1). 22–22. 8 indexed citations

Benet, Leslie Z. & Jasleen K. Sodhi. (2024). Evaluating in vivo data for drug metabolism and transport: lessons from Kirchhoff’s Laws. Frontiers in Pharmacology. 15. 1456677–1456677. 2 indexed citations

Liu, Wei, Ziyu Wang, Yidong Chen, et al.. (2024). Is there a possibility that P‐glycoprotein reduces reproductive toxicity in males but breast cancer resistance protein does not?. Clinical and Translational Science. 17(10). e70027–e70027. 1 indexed citations

Benet, Leslie Z. & Jasleen K. Sodhi. (2024). Commentary: Pharmacokinetic Theory Must Consider Published Experimental Data. Drug Metabolism and Disposition. 52(9). 932–938. 8 indexed citations

Benet, Leslie Z.. (2023). Solubility-Permeability Interplay in Facilitating the Prediction of Drug Disposition Routes, Extent of Absorption, Food Effects, Brain Penetration and Drug Induced Liver Injury Potential. Journal of Pharmaceutical Sciences. 112(9). 2326–2331. 2 indexed citations

Liu, Wei, Tingting Yan, Ken Chen, et al.. (2020). Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System. Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy. 40(4). 274–290. 9 indexed citations

Tagawa, Yoshihiko, et al.. (2019). The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats. Drug Metabolism and Disposition. 47(9). 1004–1012. 5 indexed citations

Koss, Catherine A., Peter Bacchetti, Sharon L. Hillier, et al.. (2017). Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. AIDS Research and Human Retroviruses. 33(8). 778–783. 50 indexed citations

10.

Gandhi, Monica, David V. Glidden, Kenneth H. Mayer, et al.. (2016). Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. The Lancet HIV. 3(11). e521–e528. 60 indexed citations

11.

Hosey, Chelsea M., Fabio Broccatelli, & Leslie Z. Benet. (2014). Predicting when Biliary Excretion of Parent Drug is a Major Route of Elimination in Humans. The AAPS Journal. 16(5). 1085–1096. 22 indexed citations

12.

Frymoyer, Adam, Adam L. Hersh, Zlatan Coralic, Leslie Z. Benet, & B. Joseph Guglielmo. (2010). Prediction of vancomycin pharmacodynamics in children with invasive methicillin-resistant Staphylococcus aureus infections: A Monte Carlo simulation. Clinical Therapeutics. 32(3). 534–542. 47 indexed citations

13.

Wolfe, Alan R., Leslie Z. Benet, B. Joseph Guglielmo, et al.. (2009). In vitro inhibitory effects of Hypoxis obtusa and Dicoma anomala on cyp450 enzymes and p-glycoprotein. African Journal of Pharmacy and Pharmacology. 3(11). 539–546. 18 indexed citations

14.

Qiu, Yongchang, Alma L. Burlingame, & Leslie Z. Benet. (1998). Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry.. PubMed. 26(3). 246–56. 69 indexed citations

15.

Sambol, Nancy C., J Chiang, Emil T. Lin, et al.. (1996). Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Subjects and Patients with Noninsulin‐Dependent Diabetes Mellitus. The Journal of Clinical Pharmacology. 36(11). 1012–1021. 139 indexed citations

16.

Iwaki, Masahiro, et al.. (1995). Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin.. Drug Metabolism and Disposition. 23(9). 900–903. 13 indexed citations

17.

Benet, Leslie Z.. (1994). Pharmacy Education in an Era of Health Care Reform. American Journal of Pharmaceutical Education. 58(4). 399–401. 3 indexed citations

18.

Han, Chao, et al.. (1994). Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration. Biopharmaceutics & Drug Disposition. 15(2). 179–183. 5 indexed citations

19.

Spahn, H., et al.. (1988). Measurement of carprofen enantiomer concentrations in plasma and urine using l-leucinamide as the chiral coupling component. Journal of Chromatography B Biomedical Sciences and Applications. 433. 331–338. 18 indexed citations

20.

Benet, Leslie Z.. (1976). The Effect of disease states on drug pharmacokinetics : a symposium, 123rd annual meeting, American Pharmaceutical Association, New Orleans, Louisiana, April, 1976. 6 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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