Lars Aagaard

3.2k total citations · 1 hit paper
45 papers, 2.4k citations indexed

About

Lars Aagaard is a scholar working on Molecular Biology, Genetics and Cancer Research. According to data from OpenAlex, Lars Aagaard has authored 45 papers receiving a total of 2.4k indexed citations (citations by other indexed papers that have themselves been cited), including 37 papers in Molecular Biology, 19 papers in Genetics and 10 papers in Cancer Research. Recurrent topics in Lars Aagaard's work include Virus-based gene therapy research (16 papers), RNA Interference and Gene Delivery (16 papers) and CRISPR and Genetic Engineering (13 papers). Lars Aagaard is often cited by papers focused on Virus-based gene therapy research (16 papers), RNA Interference and Gene Delivery (16 papers) and CRISPR and Genetic Engineering (13 papers). Lars Aagaard collaborates with scholars based in Denmark, United States and China. Lars Aagaard's co-authors include John J. Rossi, Pål Sætrom, Finn Skou Pedersen, Ola Snøve, Jessica Alluin, Bret S.E. Heale, Arthur D. Riggs, Palle Villesen, Thomas G. Jensen and Carsten Wiuf and has published in prestigious journals such as Nucleic Acids Research, Advanced Drug Delivery Reviews and Cellular and Molecular Life Sciences.

In The Last Decade

Lars Aagaard

45 papers receiving 2.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

RNAi therapeutics: Principles, prospects and challenges

2007 689 citations Lars Aagaard, John J. Rossi Advanced Drug Delivery Reviews profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Lars Aagaard Denmark	20	2.1k	679	374	244	218	45	2.4k
Ayalew Mergia United States	24	1.8k 0.9×	349 0.5×	682 1.8×	149 0.6×	216 1.0×	56	2.9k
Rachel E. Rempel United States	21	2.3k 1.1×	347 0.5×	388 1.0×	141 0.6×	250 1.1×	37	3.0k
Eliezer Calo United States	15	2.1k 1.0×	356 0.5×	256 0.7×	117 0.5×	194 0.9×	26	2.7k
Jacob Giehm Mikkelsen Denmark	35	2.8k 1.4×	542 0.8×	1.2k 3.3×	225 0.9×	876 4.0×	112	3.9k
Ian Pitha United States	21	1.8k 0.9×	1.1k 1.6×	167 0.4×	50 0.2×	629 2.9×	48	2.8k
Jiing‐Kuan Yee United States	26	2.3k 1.1×	207 0.3×	1.2k 3.3×	98 0.4×	310 1.4×	53	3.5k
Jon Karpilow United States	16	2.6k 1.3×	974 1.4×	401 1.1×	137 0.6×	255 1.2×	23	3.0k
Rasmus O. Bak Denmark	30	4.3k 2.1×	535 0.8×	1.4k 3.6×	303 1.2×	628 2.9×	66	5.2k
Haoquan Wu United States	18	2.3k 1.1×	789 1.2×	415 1.1×	98 0.4×	346 1.6×	27	2.9k
David Newsome United States	15	2.0k 1.0×	262 0.4×	713 1.9×	41 0.2×	304 1.4×	23	2.8k

Countries citing papers authored by Lars Aagaard

Since Specialization

Citations

This map shows the geographic impact of Lars Aagaard's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lars Aagaard with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lars Aagaard more than expected).

Fields of papers citing papers by Lars Aagaard

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lars Aagaard. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lars Aagaard. The network helps show where Lars Aagaard may publish in the future.

Co-authorship network of co-authors of Lars Aagaard

This figure shows the co-authorship network connecting the top 25 collaborators of Lars Aagaard. A scholar is included among the top collaborators of Lars Aagaard based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lars Aagaard. Lars Aagaard is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Jensen, Nanna Møller, G.R. Andersen, Steffen Thiel, et al.. (2025). Nanobody-based gene therapy targeting complement component C3 reduces choroidal neovascularization in mice. Molecular Therapy — Methods & Clinical Development. 33(4). 101620–101620. 1 indexed citations

Aagaard, Lars, et al.. (2024). Subretinal AAV delivery of RNAi-therapeutics targeting VEGFA reduces choroidal neovascularization in a large animal model. Molecular Therapy — Methods & Clinical Development. 32(2). 101242–101242. 8 indexed citations

Doktor, Thomas Koed, Anne Louise Askou, Ulvi Ahmadov, et al.. (2022). VEGFA-targeting miR-agshRNAs combine efficacy with specificity and safety for retinal gene therapy. Molecular Therapy — Nucleic Acids. 28. 58–76. 13 indexed citations

Cao, Tianqi, Shengyao Zhi, Yuxi Chen, et al.. (2021). Methylation silencing and reactivation of exogenous genes in lentivirus-mediated transgenic mice. Transgenic Research. 30(1). 63–76. 3 indexed citations

Cao, Tianqi, Yuxi Chen, Shengyao Zhi, et al.. (2021). Single AAV-mediated CRISPR-Nme2Cas9 efficiently reduces mutant hTTR expression in a transgenic mouse model of transthyretin amyloidosis. Molecular Therapy. 30(1). 164–174. 18 indexed citations

Damgaard, Christian Kroun, et al.. (2018). Efficient Knockdown and Lack of Passenger Strand Activity by Dicer-Independent shRNAs Expressed from Pol II-Driven MicroRNA Scaffolds. Molecular Therapy — Nucleic Acids. 14. 318–328. 13 indexed citations

Hollensen, Anne Kruse, Rune Thomsen, Rasmus O. Bak, et al.. (2017). Improved microRNA suppression by WPRE-linked tough decoy microRNA sponges. RNA. 23(8). 1247–1258. 10 indexed citations

Zhou, Yan, Niels Gregersen, Søren Rittig, et al.. (2016). Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene. Stem Cell Research. 19. 37–42. 1 indexed citations

Zhou, Yan, Paula Fernández‐Guerra, Kristine Freude, et al.. (2016). Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency. Stem Cells and Development. 26(3). 166–176. 19 indexed citations

10.

Zhou, Yan, Yong Liu, Dianna Hussmann, et al.. (2016). Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system. Cellular and Molecular Life Sciences. 73(13). 2543–2563. 28 indexed citations

11.

Kang, Ran, Yan Zhou, Shuang Tan, et al.. (2015). Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity. Stem Cell Research & Therapy. 6(1). 144–144. 99 indexed citations

12.

Aagaard, Lars, et al.. (2014). DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1. Nucleic Acids Research. 42(11). 7186–7200. 42 indexed citations

13.

Jakobsen, Maria, Hanne Gissel, Lars Aagaard, et al.. (2014). A Novel Homologous Model for Gene Therapy of Dwarfism by Non-Viral Transfer of the Mouse Growth Hormone Gene into Immunocompetent Dwarf Mice. Current Gene Therapy. 14(1). 44–51. 9 indexed citations

14.

Brudek, Tomasz, Tove Christensen, Lars Aagaard, et al.. (2009). B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity. Retrovirology. 6(1). 104–104. 86 indexed citations

15.

Aagaard, Lars, et al.. (2008). Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs. Gene Therapy. 15(23). 1536–1549. 83 indexed citations

16.

Sætrom, Pål, Bret S.E. Heale, Ola Snøve, et al.. (2007). Distance constraints between microRNA target sites dictate efficacy and cooperativity. Nucleic Acids Research. 35(7). 2333–2342. 278 indexed citations

17.

Aagaard, Lars, Mohammed Amarzguioui, Guihua Sun, et al.. (2007). A Facile Lentiviral Vector System for Expression of Doxycycline-Inducible shRNAs: Knockdown of the Pre-miRNA Processing Enzyme Drosha. Molecular Therapy. 15(5). 938–945. 44 indexed citations

18.

Aagaard, Lars & John J. Rossi. (2007). RNAi therapeutics: Principles, prospects and challenges. Advanced Drug Delivery Reviews. 59(2-3). 75–86. 689 indexed citations breakdown →

19.

Weinberg, Marc S., Louisa M. Villeneuve, Ali A. Ehsani, et al.. (2005). The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA. 12(2). 256–262. 221 indexed citations

20.

Aagaard, Lars, et al.. (2004). Efficient replication of full-length murine leukemia viruses modified at the dimer initiation site regions. Virology. 318(1). 360–370. 13 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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