Kirk E. Hevener

2.4k citations

44 papers · 1.8k indexed · 1 hit paper · h-index 19

Impact in

Computational Theory and Mathematics top 1%
- Computational Drug Discovery Methods
Toxicology top 2%

Papers in

Molecular Medicine 5
- Antibiotic Resistance in Bacteria 5
Critical Care and Intensive Care Medicine 5
- Nosocomial Infections in ICU 5

Co-authors: Richard Lee Stephen W. White David M. Ball Jianjun Qi Kerim Babaoglu Michael E. Johnson Wei Zhao Shahila Mehboob
Journals: Journal of Medicinal Chemistry (6 papers)Antimicrobial Agents and Chemotherapy (4 papers)ACS Infectious Diseases (4 papers)Bioorganic & Medicinal Chemistry (3 papers)Protein Expression and Purification (3 papers)
Partner nations: United States Spain Canada

In The Last Decade

Kirk E. Hevener

43 papers receiving 1.8k citations

Hit Papers

align trajectories log scale

Validation of Molecular Docking Programs for Virtual Screening against Dihydropteroate Synthase 2009 · 459 citations

Peers

Countries citing papers authored by Kirk E. Hevener

Since Specialization

Citations

This map shows the geographic impact of Kirk E. Hevener's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kirk E. Hevener with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kirk E. Hevener more than expected).

Fields of papers citing papers by Kirk E. Hevener

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kirk E. Hevener. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kirk E. Hevener. The network helps show where Kirk E. Hevener may publish in the future.

Co-authors

The 25 scholars most cited alongside Kirk E. Hevener, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Kirk E. Hevener Line = papers co-authored together Kirk E. Hevener links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Biophysical library screening using a Thermo-FMN assay to identify and characterize Clostridioides difficile FabK inhibitors Biochemical and Biophysical Research Communications ·Huabin Ling, Glen E. Palmer, Kirk E. Hevener	2024	2
2	Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents Bioorganic & Medicinal Chemistry ·Jang Youngnam, Huabin Ling, Z. Chen, Vera Marin, Chetna Dureja, Julian G. Hurdle, Kirk E. Hevener, Dianqing Sun	2023	3
3	Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile Nature Communications ·Abiola Olumuyiwa Olaitan, Chetna Dureja, Horst Brandstatter, Madeline A. Topf, Wan‐Jou Shen, Anne J Gonzales-Luna, Shen Liu, Kirk E. Hevener, Jane Freeman, Mark H. Wilcox, Kelli L. Palmer, Kevin W. Garey, Caitlin S. Pepperell, Julian G. Hurdle	2023	30
4	Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701 Phytochemistry ·G. Ivetich, Xiaohua Wu, Zhenquan Hu, Wesley Y. Yoshida, Shaobin Hou, Jennifer A. Saito, Amber Ickes, Kirk E. Hevener, John N. Alumasa, Shugeng Cao	2020	9
5	Small-Molecule Inhibition of the C. difficile FAS-II Enzyme, FabK, Results in Selective Activity ACS Chemical Biology ·刘家贺, Allan M. Prior, Ravi K. R. Marreddy, Ai Zhipin, Julian G. Hurdle, Dianqing Sun, Kirk E. Hevener	2019	9
6	Crystal structure of the 65-kilodalton amino-terminal fragment of DNA topoisomerase I from the gram-positive model organism Streptococcus mutans Biochemical and Biophysical Research Communications ·刘家贺, Kirk E. Hevener	2019	4
7	Second-Generation Antidiabetic Sulfonylureas Inhibit Candida albicans and Candidalysin-Mediated Activation of the NLRP3 Inflammasome Antimicrobial Agents and Chemotherapy ·David J. Lowes, Kirk E. Hevener, Brian M. Peters	2019	25
8	Hit-to-Lead: Hit Validation and Assessment Methods in enzymology on CD-ROM/Methods in enzymology ·Kirk E. Hevener, R MULHEARN, F Bosch-Albareda, Hyun Lee, Kiira Ratia, Michael E. Johnson	2018	24
9	Structural characterization ofPorphyromonas gingivalisenoyl-ACP reductase II (FabK) Acta Crystallographica Section F Structural Biology Communications ·Kirk E. Hevener, Bernard D. Santarsiero, Hyun Lee, 刘家贺, 成美鄭, Michael E. Johnson, Shahila Mehboob	2018	11
10	Computational Toxicology Methods in Chemical Library Design and High-Throughput Screening Hit Validation Methods in molecular biology ·Kirk E. Hevener	2018	17
11	Recent developments in topoisomerase-targeted cancer chemotherapy Acta Pharmaceutica Sinica B ·Kirk E. Hevener, Takeshita Toshiaki, E. Paterniani, Chainiyom Sinthorn, 史明小菅	2018	182
12	A simplified protocol for high-yield expression and purification of bacterial topoisomerase I Protein Expression and Purification ·刘家贺, Emily Price, A. García, Kirk E. Hevener	2016	2
13	Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI) Bioorganic & Medicinal Chemistry Letters ·Shahila Mehboob, Jinhua Song, Kirk E. Hevener, 坂口一成, 成美鄭, Julia A. Karpenko, 晃一松下, David Paganin, Jiangping Deng, James L. Cook, Bernard D. Santarsiero, Arun K. Ghosh, Michael E. Johnson	2015	19
14	High-Throughput Screening (HTS) and Hit Validation to Identify Small Molecule Inhibitors with Activity against NS3/4A proteases from Multiple Hepatitis C Virus Genotypes PLoS ONE ·Hyun Lee, Tian Ran Zhu, Ibrahim Tag Al Deen, Yanyan Zhang, 晃一松下, Kirk E. Hevener, Rahila Bhatt, Gitanjali Subramanya, Hyunyoung Jeong, Susan L. Uprichard, Michael E. Johnson	2013	17
15	Synergistic Inhibitor Binding to the Papain‐Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications ChemMedChem ·Hyun Lee, Josip Grbelja, Kirk E. Hevener, 晃一松下, Rahila Bhatt, Ibrahim Tag Al Deen, Arun K. Ghosh, Michael E. Johnson	2013	19
16	Expression, purification and characterization of enoyl-ACP reductase II, FabK, from Porphyromonas gingivalis Protein Expression and Purification ·Kirk E. Hevener, Shahila Mehboob, 成美鄭, Kent Truong, Bernard D. Santarsiero, Michael E. Johnson	2012	6
17	High-level expression, purification, and characterization of Staphylococcus aureus dihydroorotase (PyrC) as a cleavable His-SUMO fusion Protein Expression and Purification ·晃一松下, Kirk E. Hevener, Exu Anton Mates, Ibrahim Tag Al Deen, Michael E. Johnson, Hyun Lee	2012	15
18	A statistical framework to evaluate virtual screening BMC Bioinformatics ·Wei Zhao, Kirk E. Hevener, Stephen W. White, Richard Lee, James M. Boyett	2009	80
19	Quantitative structure–activity relationship studies on nitrofuranyl anti-tubercular agents Bioorganic & Medicinal Chemistry ·Kirk E. Hevener, David M. Ball, John K. Buolamwini, Richard Lee	2008	45
20	The Structure of the Pantothenate Kinase·ADP·Pantothenate Ternary Complex Reveals the Relationship between the Binding Sites for Substrate, Allosteric Regulator, and Antimetabolites Journal of Biological Chemistry ·Robert A. Ivey, Carlos Emilio Bernal Rodríguez, Kristopher G. Virga, Kirk E. Hevener, Richard Lee, Charles O. Rock, Suzanne Jackowski, Hee Won Park	2004	48

About Kirk E. Hevener

Kirk E. Hevener is a scholar working on Molecular Medicine, Critical Care and Intensive Care Medicine, Infectious Diseases, Periodontics and Toxicology, having authored 44 papers that have together received 1.8k indexed citations. Recurring topics across this work include Cancer therapeutics and mechanisms (8 papers), Clostridium difficile and Clostridium perfringens research (8 papers), Biochemical and Molecular Research (7 papers), Antimicrobial agents and applications (6 papers), Computational Drug Discovery Methods (6 papers), Pneumocystis jirovecii pneumonia detection and treatment (5 papers), Antibiotic Resistance in Bacteria (5 papers) and Nosocomial Infections in ICU (5 papers). The work is most often cited by research in Computational Theory and Mathematics (530 citations), Toxicology (80 citations), Infectious Diseases (335 citations), Molecular Medicine (82 citations) and Organic Chemistry (471 citations). Kirk E. Hevener has collaborated with scholars based in United States, Spain and Canada. Frequent co-authors include Richard Lee, Stephen W. White, David M. Ball, Jianjun Qi, Kerim Babaoglu, Michael E. Johnson, Wei Zhao, Shahila Mehboob, Julian G. Hurdle and Tian Ran Zhu. Their work appears in journals such as Journal of Medicinal Chemistry, Antimicrobial Agents and Chemotherapy, ACS Infectious Diseases, Bioorganic & Medicinal Chemistry and Protein Expression and Purification.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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