John Isaac

13.9k citations

134 papers · 10.7k indexed · 4 hit papers · h-index 49

Impact in

Cellular and Molecular Neuroscience top 0.05%
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
Cognitive Neuroscience top 0.5%
- Neural dynamics and brain function
- Memory and Neural Mechanisms

Papers in ⓘ

Cellular and Molecular Neuroscience 88
- Neuroscience and Neuropharmacology Research 84
- Photoreceptor and optogenetics research 25
Hepatology 29
- Hepatocellular Carcinoma Treatment and Prognosis 16
- Liver Disease and Transplantation 15

Co-authors: Graham L. Collingridge (24 shared papers)Robert C. Malenka (8 shared papers)Roger A. Nicoll (1 shared paper)Michael C. Ashby (7 shared papers)Yu Tian Wang (2 shared papers)Chris J. McBain (3 shared papers)Zuner A. Bortolotto (9 shared papers)Roger A. Nicoll (6 shared papers)
Journals: Neuron (22 papers)HPB (10 papers)Journal of Neuroscience (10 papers)Nature Neuroscience (8 papers)Neuropharmacology (7 papers)
Partner nations: United Kingdom United States Singapore

In The Last Decade

John Isaac

132 papers receiving 10.6k citations

Hit Papers

align trajectories log scale

The Role of the GluR2 Subunit in AMPA Receptor Function and Synaptic Plasticity 2007 · 634 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2007 Neuron
2007 Neuron
2004 Nature reviews. Neuroscience
1995 Neuron

Peers

Countries citing papers authored by John Isaac

Since Specialization

Citations

This map shows the geographic impact of John Isaac's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Isaac with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Isaac more than expected).

Fields of papers citing papers by John Isaac

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Isaac. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Isaac. The network helps show where John Isaac may publish in the future.

Co-authors

The 25 scholars most cited alongside John Isaac, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John Isaac Line = papers co-authored together John Isaac links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 134 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Evidence for silent synapses: Implications for the expression of LTP Neuron ·John Isaac, Roger A. Nicoll, Robert C. Malenka Hit paper breakdown →	1995	1019
2	Receptor trafficking and synaptic plasticity Nature reviews. Neuroscience ·Graham L. Collingridge, John Isaac, Yu Tian Wang Hit paper breakdown →	2004	819
3	The Role of the GluR2 Subunit in AMPA Receptor Function and Synaptic Plasticity Neuron ·John Isaac, Michael C. Ashby, Chris J. McBain Hit paper breakdown →	2007	634
4	LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β Neuron ·Stéphane Peineau, Changiz Taghibiglou, Clarrisa A. Bradley, Tak Pan Wong, Lidong Liu, Jie Lu, Edmond Lo, Dong Wu, Emilia Saule, Tristan Bouschet, Paul M. Matthews, John Isaac, Zuner A. Bortolotto, Yu Tian Wang, Graham L. Collingridge Hit paper breakdown →	2007	593
5	NSF Binding to GluR2 Regulates Synaptic Transmission Neuron ·Atsushi Nishimune, John Isaac, Elek Molnár, Jacques Noël, S. Russell Nash, Mitsuo Tagaya, Graham L. Collingridge, Shigetada Nakanishi, Jeremy M. Henley	1998	450
6	Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation Nature Neuroscience ·Karen Plant, Kenneth A. Pelkey, Zuner A. Bortolotto, Daiju Morita, Akira Terashima, Chris J. McBain, Graham L. Collingridge, John Isaac	2006	439
7	Silent Synapses during Development of Thalamocortical Inputs Neuron ·John Isaac, Michael C. Crair, Roger A. Nicoll, Robert C. Malenka	1997	411
8	Modulation of AMPA receptor unitary conductance by synaptic activity Nature ·Tim A. Benke, Andreas Lüthi, John Isaac, Graham L. Collingridge	1998	411
9	PDZ Proteins Interacting with C-Terminal GluR2/3 Are Involved in a PKC-Dependent Regulation of AMPA Receptors at Hippocampal Synapses Neuron ·Michael I. Daw, Ramesh Chittajallu, Zuner A. Bortolotto, Kumlesh K. Dev, Fabrice Duprat, Jeremy M. Henley, Graham L. Collingridge, John Isaac	2000	278
10	Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction Neuron ·Andreas Lüthi, Ramesh Chittajallu, Fabrice Duprat, Mary J. Palmer, Tim A. Benke, Fleur L. Kidd, Jeremy M. Henley, John Isaac, Graham L. Collingridge	1999	245
11	Developmental and activity- dependent regulation of kainate receptors at thalamocortical synapses Nature ·Fleur L. Kidd, John Isaac	1999	189
12	Rapid and Differential Regulation of AMPA and Kainate Receptors at Hippocampal Mossy Fibre Synapses by PICK1 and GRIP Neuron ·Hélène Hirbec, Joanna C Francis, Sari E. Lauri, Steven P. Braithwaite, Françoise Coussen, Christophe Mulle, Kumlesh K. Dev, Victoria Couthino, Guido R.Y. De Meyer, John Isaac, Graham L. Collingridge, Jeremy M. Henley	2003	178
13	Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome Nature Neuroscience ·Lina Chakrabarti, Tyler K. Best, Nathan Cramer, Rosalind S.E. Carney, John Isaac, Zygmunt Galdzicki, Tarik F. Haydar	2010	170
14	Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors Neuron ·Antonio Sanz-Clemente, José A. Matta, John Isaac, Katherine W. Roche	2010	164
15	A Critical Role of a Facilitatory Presynaptic Kainate Receptor in Mossy Fiber LTP Neuron ·Sari E. Lauri, Zuner A. Bortolotto, David Bleakman, Paul L. Ornstein, David Lodge, John Isaac, Graham L. Collingridge	2001	162
16	A Role for Ca2+ Stores in Kainate Receptor-Dependent Synaptic Facilitation and LTP at Mossy Fiber Synapses in the Hippocampus Neuron ·Sari E. Lauri, Zuner A. Bortolotto, Robert Nisticò, David Bleakman, Paul L. Ornstein, David Lodge, John Isaac, Graham L. Collingridge	2003	159
17	The UK DCD Risk Score: A new proposal to define futility in donation-after-circulatory-death liver transplantation Journal of Hepatology ·Andrea Schlegel, Marit Kalisvaart, Irene Scalera, Richard W. Laing, Hynek Mergental, Darius F. Mirza, M. Thamara P. R. Perera, John Isaac, Philipp Dutkowski, Paolo Muiesan	2017	158
18	mGluR5 and NMDA Receptors Drive the Experience- and Activity-Dependent NMDA Receptor NR2B to NR2A Subunit Switch Neuron ·José A. Matta, Michael C. Ashby, Antonio Sanz-Clemente, Katherine W. Roche, John Isaac	2011	154
19	Long-Term Depression at Thalamocortical Synapses in Developing Rat Somatosensory Cortex Neuron ·Daniel E. Feldman, Roger A. Nicoll, Robert C. Malenka, John Isaac	1998	148
20	An Essential Role for PICK1 in NMDA Receptor-Dependent Bidirectional Synaptic Plasticity Neuron ·Akira Terashima, Kenneth A. Pelkey, Jong‐Cheol Rah, Young Ho Suh, Katherine W. Roche, Graham L. Collingridge, Chris J. McBain, John Isaac	2008	143

About John Isaac

John Isaac is a scholar working on Cellular and Molecular Neuroscience, Hepatology, Cognitive Neuroscience, Transplantation and Neurology, having authored 134 papers that have together received 10.7k indexed citations. Recurring topics across this work include Neuroscience and Neuropharmacology Research (84 papers), Neural dynamics and brain function (32 papers), Photoreceptor and optogenetics research (25 papers), Ion channel regulation and function (20 papers), Organ Transplantation Techniques and Outcomes (20 papers), Memory and Neural Mechanisms (18 papers), Hepatocellular Carcinoma Treatment and Prognosis (16 papers) and Liver Disease and Transplantation (15 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (8.2k citations), Cognitive Neuroscience (3.7k citations), Developmental Neuroscience (633 citations), Neurology (1.2k citations) and Molecular Biology (5.0k citations). John Isaac has collaborated with scholars based in United Kingdom, United States and Singapore. Frequent co-authors include Graham L. Collingridge, Robert C. Malenka, Roger A. Nicoll, Michael C. Ashby, Yu Tian Wang, Chris J. McBain, Zuner A. Bortolotto, Roger A. Nicoll, Katherine W. Roche and Tim A. Benke. Their work appears in journals such as Neuron, HPB, Journal of Neuroscience, Nature Neuroscience and Neuropharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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