Giles E. Hardingham

17.8k total citations · 5 hit papers
133 papers, 12.5k citations indexed

About

Giles E. Hardingham is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Neurology. According to data from OpenAlex, Giles E. Hardingham has authored 133 papers receiving a total of 12.5k indexed citations (citations by other indexed papers that have themselves been cited), including 96 papers in Molecular Biology, 74 papers in Cellular and Molecular Neuroscience and 22 papers in Neurology. Recurrent topics in Giles E. Hardingham's work include Neuroscience and Neuropharmacology Research (60 papers), Neuroinflammation and Neurodegeneration Mechanisms (21 papers) and Ion channel regulation and function (20 papers). Giles E. Hardingham is often cited by papers focused on Neuroscience and Neuropharmacology Research (60 papers), Neuroinflammation and Neurodegeneration Mechanisms (21 papers) and Ion channel regulation and function (20 papers). Giles E. Hardingham collaborates with scholars based in United Kingdom, United States and India. Giles E. Hardingham's co-authors include Hilmar Bading, Yuko Fukunaga, Sangeeta Chawla, David J. A. Wyllie, Sofia Papadia, Paul Baxter, Fiona J. L. Arnold, Francesc X. Soriano, Claire M. Johnson and Marc‐André Martel and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Giles E. Hardingham

130 papers receiving 12.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 1.4k citations Giles E. Hardingham, Hilmar Bading et al. Nature Neuroscience profile →
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

2010 1.3k citations Giles E. Hardingham, Hilmar Bading Nature reviews. Neuroscience profile →
Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression

1997 634 citations Giles E. Hardingham, Hilmar Bading et al. profile →
The Yin and Yang of NMDA receptor signalling

2003 522 citations Giles E. Hardingham, Hilmar Bading profile →
Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

2023 279 citations Rickie Patani, Giles E. Hardingham et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Giles E. Hardingham United Kingdom	55	7.2k	6.6k	2.0k	1.8k	1.4k	133	12.5k
Hilmar Bading Germany	52	8.1k 1.1×	8.2k 1.3×	1.6k 0.8×	1.8k 1.0×	1.2k 0.9×	134	13.9k
Carlos Matute Spain	64	4.1k 0.6×	5.4k 0.8×	4.2k 2.0×	2.0k 1.1×	2.3k 1.7×	245	13.1k
Robert Nitsch Germany	61	5.4k 0.8×	3.8k 0.6×	3.5k 1.7×	1.4k 0.8×	2.4k 1.8×	176	13.1k
Valeria Bruno Italy	55	3.9k 0.5×	5.5k 0.8×	1.7k 0.8×	1.6k 0.9×	884 0.7×	164	8.6k
Mike Dragunow New Zealand	72	7.4k 1.0×	9.2k 1.4×	3.1k 1.5×	2.7k 1.5×	2.2k 1.6×	231	18.2k
Mónica Di Luca Italy	62	3.7k 0.5×	5.0k 0.8×	2.4k 1.1×	3.9k 2.2×	710 0.5×	233	11.6k
Steven Mennerick United States	54	4.5k 0.6×	6.1k 0.9×	839 0.4×	2.0k 1.1×	902 0.7×	187	10.3k
Niels C. Danbolt Norway	61	8.1k 1.1×	13.8k 2.1×	2.9k 1.4×	2.6k 1.5×	2.0k 1.5×	121	18.8k
Bernhard Bettler Switzerland	72	9.8k 1.4×	12.2k 1.9×	1.2k 0.6×	1.7k 0.9×	701 0.5×	205	16.9k
Stefano Vicini United States	62	6.4k 0.9×	10.0k 1.5×	1.5k 0.7×	1.2k 0.7×	1.3k 1.0×	204	13.1k

Countries citing papers authored by Giles E. Hardingham

Since Specialization

Citations

This map shows the geographic impact of Giles E. Hardingham's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Giles E. Hardingham with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Giles E. Hardingham more than expected).

Fields of papers citing papers by Giles E. Hardingham

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Giles E. Hardingham. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Giles E. Hardingham. The network helps show where Giles E. Hardingham may publish in the future.

Co-authorship network of co-authors of Giles E. Hardingham

This figure shows the co-authorship network connecting the top 25 collaborators of Giles E. Hardingham. A scholar is included among the top collaborators of Giles E. Hardingham based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Giles E. Hardingham. Giles E. Hardingham is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Hor, Kahyee, et al.. (2025). Maternal high fat and high sugar diet impacts on key DNA methylation enzymes in offspring brain in a sex‐specific manner. Journal of Neuroendocrinology. 37(8). e70046–e70046. 1 indexed citations

Dawson, John C., Virginia Álvarez-García, Morwenna Muir, et al.. (2025). FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation. Disease Models & Mechanisms. 18(11).

Dando, Owen, et al.. (2024). Laboratory Automated Interrogation of Data: an interactive web application for visualization of multilevel data from biological experiments. Brain Communications. 6(2). fcae074–fcae074.

Dando, Owen, Jamie McQueen, Karen Burr, et al.. (2024). A comparison of basal and activity-dependent exon splicing in cortical-patterned neurons of human and mouse origin. Frontiers in Molecular Neuroscience. 17. 1392408–1392408.

Hardingham, Giles E., et al.. (2023). Long-term plasticity of astrocytic phenotypes and their control by neurons in health and disease. Essays in Biochemistry. 67(1). 39–47. 2 indexed citations

Jiwaji, Zoeb, Nóra M. Márkus, Jamie McQueen, et al.. (2023). General anesthesia alters CNS and astrocyte expression of activity-dependent and activity-independent genes. PubMed. 3. 1216366–1216366. 2 indexed citations

Tzioras, Makis, Michael J. Daniels, C. T. M. Davies, et al.. (2021). A role for astrocytes and microglia in synapse loss in Alzheimer’s disease. Alzheimer s & Dementia. 17(S4). 2 indexed citations

Zhao, Chen, Amit K. Chouhan, Bhuvaneish T. Selvaraj, et al.. (2019). Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology. Glia. 68(5). 1046–1064. 83 indexed citations

Marwick, Katie, Kasper B. Hansen, Paul Skehel, Giles E. Hardingham, & David J. A. Wyllie. (2019). Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy. The Journal of Physiology. 597(6). 1691–1704. 20 indexed citations

10.

Mehta, Arpan R., Bhuvaneish T. Selvaraj, Owen Dando, et al.. (2019). 229 Dysregulated axonal homeostasis in C9orf72 iPSC-derived motor neurones. Journal of Neurology Neurosurgery & Psychiatry. 90(12). e57.3–e57. 2 indexed citations

11.

Zanato, Chiara, Katie Marwick, Monica Piras, et al.. (2017). Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers. Organic & Biomolecular Chemistry. 15(9). 2086–2096. 4 indexed citations

12.

Hardingham, Giles E., Priit Pruunsild, Michael E. Greenberg, & Hilmar Bading. (2017). Lineage divergence of activity-driven transcription and evolution of cognitive ability. Nature reviews. Neuroscience. 19(1). 9–15. 28 indexed citations

13.

Baxter, Paul & Giles E. Hardingham. (2016). Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes. Free Radical Biology and Medicine. 100. 147–152. 186 indexed citations

14.

Baxter, Paul, Karen Bell, Philip Hasel, et al.. (2015). Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system. Nature Communications. 6(1). 6761–6761. 118 indexed citations

15.

Lewerenz, Jan, Paul Baxter, Philipp Albrecht, et al.. (2013). Phosphoinositide 3-Kinases Upregulate System x _c ⁻ via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy. Antioxidants and Redox Signaling. 20(18). 2907–2922. 60 indexed citations

16.

Bilican, Bilada, Andrea Serio, Sami J. Barmada, et al.. (2012). Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proceedings of the National Academy of Sciences. 109(15). 5803–5808. 257 indexed citations

17.

Patani, Rickie, Patrick A. Lewis, Daniah Trabzuni, et al.. (2012). Investigating the utility of human embryonic stem cell‐derived neurons to model ageing and neurodegenerative disease using whole‐genome gene expression and splicing analysis. Journal of Neurochemistry. 122(4). 738–751. 45 indexed citations

18.

Bell, Karen & Giles E. Hardingham. (2010). CNS Peroxiredoxins and Their Regulation in Health and Disease. Antioxidants and Redox Signaling. 14(8). 1467–1477. 59 indexed citations

19.

Hardingham, Giles E. & Stuart A. Lipton. (2010). Regulation of Neuronal Oxidative and Nitrosative Stress by Endogenous Protective Pathways and Disease Processes. Antioxidants and Redox Signaling. 14(8). 1421–1424. 49 indexed citations

20.

Hardingham, Giles E., Fiona J. L. Arnold, & Hilmar Bading. (2001). Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nature Neuroscience. 4(3). 261–267. 433 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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