John Hines

6.0k total citations · 4 hit papers
42 papers, 4.6k citations indexed

About

John Hines is a scholar working on Molecular Biology, Hematology and Oncology. According to data from OpenAlex, John Hines has authored 42 papers receiving a total of 4.6k indexed citations (citations by other indexed papers that have themselves been cited), including 33 papers in Molecular Biology, 9 papers in Hematology and 8 papers in Oncology. Recurrent topics in John Hines's work include Protein Degradation and Inhibitors (20 papers), Ubiquitin and proteasome pathways (16 papers) and Multiple Myeloma Research and Treatments (9 papers). John Hines is often cited by papers focused on Protein Degradation and Inhibitors (20 papers), Ubiquitin and proteasome pathways (16 papers) and Multiple Myeloma Research and Treatments (9 papers). John Hines collaborates with scholars based in United States, France and Taiwan. John Hines's co-authors include Craig M. Crews, Saul Jaime‐Figueroa, Jing Wang, Yimin Qian, Hanqing Dong, George M. Burslem, Momar Toure, Kanak Raina, Andrew P. Crew and Daniel P. Bondeson and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Angewandte Chemie International Edition.

In The Last Decade

John Hines

39 papers receiving 4.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

2015 849 citations Jing Lü, Yimin Qian et al. Chemistry & Biology profile →
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

2017 636 citations Daniel P. Bondeson, Blake E. Smith et al. Cell chemical biology profile →
Modular PROTAC Design for the Degradation of Oncogenic BCR‐ABL

2015 492 citations Momar Toure, Doris Hellerschmied et al. Angewandte Chemie International Edition profile →
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

2017 488 citations George M. Burslem, Blake E. Smith et al. Cell chemical biology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
John Hines United States	24	4.1k	1.7k	1.2k	343	144	42	4.6k
George M. Burslem United States	20	2.8k 0.7×	1.1k 0.6×	699 0.6×	425 1.2×	114 0.8×	54	3.2k
Dennis L. Buckley United States	22	5.8k 1.4×	1.7k 1.0×	1.4k 1.1×	272 0.8×	199 1.4×	35	6.2k
Danette L. Daniels United States	29	3.7k 0.9×	788 0.5×	523 0.4×	244 0.7×	283 2.0×	46	4.1k
Taavi K. Neklesa United States	18	2.0k 0.5×	784 0.5×	380 0.3×	141 0.4×	155 1.1×	25	2.2k
Stephen C. Cosenza United States	23	1.1k 0.3×	571 0.3×	296 0.2×	460 1.3×	316 2.2×	55	2.0k
Pingda Ren United States	21	2.3k 0.5×	570 0.3×	248 0.2×	636 1.9×	166 1.2×	49	3.2k
Joshiawa Paulk United States	14	3.4k 0.8×	998 0.6×	845 0.7×	138 0.4×	86 0.6×	18	3.6k
A Levitzki Israel	21	1.8k 0.4×	1.1k 0.7×	395 0.3×	202 0.6×	269 1.9×	26	3.1k
Kanak Raina United States	14	2.8k 0.7×	996 0.6×	828 0.7×	166 0.5×	135 0.9×	23	3.0k
Antonia Lopez‐Girona United States	22	3.1k 0.8×	1.1k 0.6×	1.2k 1.0×	61 0.2×	587 4.1×	58	3.6k

Countries citing papers authored by John Hines

Since Specialization

Citations

This map shows the geographic impact of John Hines's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Hines with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Hines more than expected).

Fields of papers citing papers by John Hines

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Hines. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Hines. The network helps show where John Hines may publish in the future.

Co-authorship network of co-authors of John Hines

This figure shows the co-authorship network connecting the top 25 collaborators of John Hines. A scholar is included among the top collaborators of John Hines based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John Hines. John Hines is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

1.

Hu, Zhenyi, Po‐Han Chen, Jacques Saarbach, et al.. (2024). EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Science Advances. 10(13). eadj7251–eadj7251. 18 indexed citations

2.

Nalawansha, Dhanusha A., Ke Li, John Hines, & Craig M. Crews. (2022). Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation. Journal of the American Chemical Society. 144(12). 5594–5605. 28 indexed citations

3.

Alabi, Shanique, Saul Jaime‐Figueroa, Zhan Yao, et al.. (2021). Mutant-selective degradation by BRAF-targeting PROTACs. Nature Communications. 12(1). 920–920. 105 indexed citations

4.

Jaime‐Figueroa, Saul, Alexandru D. Buhimschi, Momar Toure, John Hines, & Craig M. Crews. (2019). Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. Bioorganic & Medicinal Chemistry Letters. 30(3). 126877–126877. 73 indexed citations

5.

Burslem, George M., Jayoung Song, Xin Chen, John Hines, & Craig M. Crews. (2018). Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. Journal of the American Chemical Society. 140(48). 16428–16432. 137 indexed citations

6.

Hines, John, et al.. (2018). MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53. Cancer Research. 79(1). 251–262. 258 indexed citations

7.

Burslem, George M., Blake E. Smith, Saul Jaime‐Figueroa, et al.. (2017). The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell chemical biology. 25(1). 67–77.e3. 488 indexed citations breakdown →

8.

Lü, Jing, Yimin Qian, Martha Altieri, et al.. (2015). Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chemistry & Biology. 22(6). 755–763. 849 indexed citations breakdown →

9.

Gustafson, Jeffrey L., Taavi K. Neklesa, Anke G. Roth, et al.. (2015). Small‐Molecule‐Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. Angewandte Chemie International Edition. 54(33). 9659–9662. 165 indexed citations

10.

Toure, Momar, Doris Hellerschmied, Saul Jaime‐Figueroa, et al.. (2015). Modular PROTAC Design for the Degradation of Oncogenic BCR‐ABL. Angewandte Chemie International Edition. 55(2). 807–810. 492 indexed citations breakdown →

11.

Gustafson, Jeffrey L., Taavi K. Neklesa, Anke G. Roth, et al.. (2015). Small‐Molecule‐Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. Angewandte Chemie. 127(33). 9795–9798. 25 indexed citations

12.

Tae, Hyun Seop, et al.. (2011). Unexpected stereochemical tolerance for the biological activity of tyroscherin. Bioorganic & Medicinal Chemistry. 19(5). 1708–1713. 4 indexed citations

13.

Hines, John, Rong Ju, Ginger E. Dutschman, Yung‐Chi Cheng, & Craig M. Crews. (2010). Reversal of TNP-470-Induced Endothelial Cell Growth Arrest by Guanine and Guanine Nucleosides. Journal of Pharmacology and Experimental Therapeutics. 334(3). 729–738. 8 indexed citations

14.

Hines, John, M. Groll, Margaret Fahnestock, & Craig M. Crews. (2008). Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis. Chemistry & Biology. 15(5). 501–512. 91 indexed citations

15.

Hines, John, et al.. (2006). Myriaporone 3/4 structure–activity relationship studies define a pharmacophore targeting eukaryotic protein synthesis. Molecular BioSystems. 2(8). 371–379. 11 indexed citations

16.

Zhang, Yi, Jing-Ruey Joanna Yeh, Andrew Mara, et al.. (2006). A Chemical and Genetic Approach to the Mode of Action of Fumagillin. Chemistry & Biology. 13(9). 1001–1009. 62 indexed citations

17.

Schneekloth, John S., John L. Sanders, John Hines, & Craig M. Crews. (2006). Neurotrophic peptide aldehydes: Solid phase synthesis of fellutamide B and a simplified analog. Bioorganic & Medicinal Chemistry Letters. 16(14). 3855–3858. 32 indexed citations

18.

Hines, John. (2005). Small Molecules Driving Myotube Fission. Chemistry & Biology. 12(10). 1058–1060. 5 indexed citations

19.

Mandal, Amit Kumar, John Hines, Kouji Kuramochi, & Craig M. Crews. (2005). Developing microcolin A analogs as biological probes. Bioorganic & Medicinal Chemistry Letters. 15(18). 4043–4047. 28 indexed citations

20.

Hines, John & Dexter M. Easton. (1971). EFFLUX OF ENDOGENOUS PROTEIN FROM NON‐MYELINATED OLFACTORY NERVE AS MONITORED BY TRYPTOPHAN FLUORESCENCE. Journal of Neurochemistry. 18(11). 2155–2169. 4 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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