J.N. Champness

2.2k citations

26 papers · 1.8k indexed · h-index 19

Impact in

Structural Biology top 10%
Infectious Diseases top 5%
- HIV/AIDS drug development and treatment

Papers in

Structural Biology 1
Infectious Diseases 11
- HIV/AIDS drug development and treatment 11

Co-authors: D.K. Stammers A. C. Bloomer G. Bricogne A. Klug C.R. Beddell Rodger Staden Aniruddha Achari D.O. Somers
Journals: FEBS Letters (6 papers)Journal of Medicinal Chemistry (5 papers)Journal of Molecular Biology (3 papers)Nature (2 papers)Bioorganic & Medicinal Chemistry (1 paper)
Partner nations: United Kingdom United States Belgium

In The Last Decade

J.N. Champness

26 papers receiving 1.7k citations

Peers

Countries citing papers authored by J.N. Champness

Since Specialization

Citations

This map shows the geographic impact of J.N. Champness's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by J.N. Champness with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites J.N. Champness more than expected).

Fields of papers citing papers by J.N. Champness

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by J.N. Champness. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by J.N. Champness. The network helps show where J.N. Champness may publish in the future.

Co-authorship network

The 25 scholars most cited alongside J.N. Champness, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with J.N. Champness Line = papers co-authored together J.N. Champness links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Crystal structure of Escherichia coli UvrB C‐terminal domain, and a model for UvrB‐UvrC interaction FEBS Letters ·Maninder K. Sohi, Alexander Alexandrovich, Geri F. Moolenaar, Rob Visse, Nora Goosen, X. Vernède, Juan C. Fontecilla‐Camps, J.N. Champness, Mark R. Sanderson	2000	38
2	Structure to 1.9 Å resolution of a complex with herpes simplex virus type‐1 thymidine kinase of a novel, non‐substrate inhibitor: X‐ray crystallographic comparison with binding of aciclovir FEBS Letters ·Matthew Bennett, Frank Wien, J.N. Champness, Minggao Zheng, Thomas Rutherford, William C. Summers, Hongmao Sun, George E. Wright, Mark R. Sanderson	1999	57
3	2.0 Å X‐ray structure of the ternary complex of 7,8‐dihydro‐6‐hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue FEBS Letters ·D.K. Stammers, Aniruddha Achari, D.O. Somers, よしこみわ, Leonardo Gónzalez-Galli, David L. Scott, J.N. Champness	1999	48
4	Herpesviral thymidine kinases: laxity and resistance by design. Journal of General Virology ·James S. Evans, J.N. Champness, Mark R. Sanderson, S. Sarkar, N.M. Prangsma deRijk, T. R. Kiran, A. Buchan, William C. Summers	1998	31
5	Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands Proteins Structure Function and Bioinformatics ·J.N. Champness, Matthew Bennett, Frank Wien, Rob Visse, William C. Summers, Piet Herdewijn, Erik De Clercq, Tomasz Ostrowski, Richard L. Jarvest, Mark R. Sanderson	1998	118
6	5-Substituted Pyrimidines with a 1,5-Anhydro-2,3-dideoxy-d-arabino-hexitol Moiety at N-1: Synthesis, Antiviral Activity, Conformational Analysis, and Interaction with Viral Thymidine Kinase Journal of Medicinal Chemistry ·Tomasz Ostrowski, Berthold Wroblowski, Roger Busson, Jef Rozenski, Erik De Clercq, Matthew Bennett, J.N. Champness, William C. Summers, Mark R. Sanderson, Piet Herdewijn	1998	47
7	Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase Nature Structural Biology ·Aniruddha Achari, D.O. Somers, J.N. Champness, よしこみわ, Leonardo Gónzalez-Galli, D.K. Stammers	1997	236
8	Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim Bioorganic & Medicinal Chemistry ·Lee F. Kuyper, Janice M Garvey, David P. Baccanari, J.N. Champness, D.K. Stammers, C.R. Beddell	1996	44
9	Preliminary Crystallographic Data for Pneumocystis carinii Dihydrofolate Reductase Journal of Molecular Biology ·D.K. Stammers, C. J. Delves, S. Ballantine, E. Yvonne Jones, David I. Stuart, A. Achari, よしこみわ, J.N. Champness	1993	4
10	Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses Journal of Medicinal Chemistry ·David L. Selwood, S. R. Challand, J.N. Champness, Chun Guo Wang, I Prandzhev, Pascale Bosch, Denise Lowe, Michael J. Pether, Yongjian Ma, Martin S Maron	1993	14
11	2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes Journal of Medicinal Chemistry ·Barbara Roth, Barbara S. Rauckman, Robert Ferone, David P. Baccanari, J.N. Champness, Richard M. Hyde	1987	29
12	Crystallographic investigation of the cooperative interaction between trimethoprim, reduced cofactor and dihydrofolate reductase FEBS Letters ·J.N. Champness, D.K. Stammers, C.R. Beddell	1986	46
13	ChemInform Abstract: RECEPTOR‐BASED DESIGN OF DIHYDROFOLATE REDUCTASE INHIBITORS: COMPARISON OF CRYSTALLOGRAPHICALLY DETERMINED ENZYME BINDING WITH ENZYME AFFINITY IN A SERIES OF CARBOXY‐SUBSTITUTED TRIMETHOPRIM ANALOGS Chemischer Informationsdienst ·Lee F. Kuyper, Barbara Roth, David P. Baccanari, Robert Ferone, C.R. Beddell, J.N. Champness, D.K. Stammers, John G. Dann, F. E. Norrington, David Baker, P. J. Goodford	1983	16
14	Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs Journal of Medicinal Chemistry ·Lee F. Kuyper, Barbara Roth, David P. Baccanari, Robert Ferone, C.R. Beddell, J.N. Champness, D.K. Stammers, John G. Dann, F. E. Norrington	1982	57
15	The binding of trimethoprim to bacterial dihydrofolate reductase FEBS Letters ·T. Gaudeny, C.R. Beddell, J.N. Champness, P. J. Goodford, F. E. Norrington, Douglas R. Smith, D.K. Stammers	1981	68
16	A new automatic flat-bed microdensitometer for use in X-ray crystallography Journal of Physics E Scientific Instruments ·Hiram Alvin. from old catalog Reid, J.N. Champness, A.R. Faruqi, (unknown)	1977	12
17	The hand of the stacked-disk aggregate of tobacco mosaic virus protein Journal of Molecular Biology ·A. C. Bloomer, J.N. Champness, P.N.T. Unwin	1976	3
18	The structure of the protein disk of tobacco mosaic virus to 5 Å resolution Nature ·J.N. Champness, A. C. Bloomer, G. Bricogne, P.J.G. Butler, A. Klug	1976	149
19	A single-crystal oscillation camera for large unit cells Journal of Applied Crystallography ·U. W. Arndt, J.N. Champness, R. P. Phizackerley, Alan J. Wonacott	1973	39
20	X-ray and optical diffraction studies of bacterial flagella Journal of Molecular Biology ·J.N. Champness	1971	35

About J.N. Champness

J.N. Champness is a scholar working on Structural Biology, Infectious Diseases, Endocrinology, Molecular Medicine and Epidemiology, having authored 26 papers that have together received 1.8k indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (11 papers), Biochemical and Molecular Research (9 papers), Pneumocystis jirovecii pneumonia detection and treatment (4 papers), Herpesvirus Infections and Treatments (4 papers), Cytomegalovirus and herpesvirus research (4 papers), Bacteriophages and microbial interactions (3 papers), Plant and Fungal Interactions Research (3 papers) and Plant Virus Research Studies (3 papers). The work is most often cited by research in Structural Biology (24 citations), Infectious Diseases (315 citations), Endocrinology (83 citations), Molecular Biology (1.0k citations) and Molecular Medicine (62 citations). J.N. Champness has collaborated with scholars based in United Kingdom, United States and Belgium. Frequent co-authors include D.K. Stammers, A. C. Bloomer, G. Bricogne, A. Klug, C.R. Beddell, Rodger Staden, Aniruddha Achari, D.O. Somers, D.K. Stammers and Mark R. Sanderson. Their work appears in journals such as FEBS Letters, Journal of Medicinal Chemistry, Journal of Molecular Biology, Nature and Bioorganic & Medicinal Chemistry.

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