James P. Lees‐Miller

2.7k citations

38 papers · 2.2k indexed · h-index 26

Molecular Biology top 5%
Cardiology and Cardiovascular Medicine top 2%
Cell Biology top 5%
Cellular and Molecular Neuroscience top 5%
Immunology and Allergy top 10%

Co-authors: David M. Helfman Henry J. Duff Guoqi Teng Jiqing Guo Leslie O. Goodwin Yufeng Duan Trina A. Schroer David H. Heeley
Topics: Cardiac electrophysiology and arrhythmias (19 papers)Ion channel regulation and function (16 papers)Cardiomyopathy and Myosin Studies (7 papers)
Cited by: Cardiology and Cardiovascular Medicine Molecular Biology Cell Biology
Journals: Nature Proceedings of the National Academy of Sciences Journal of Biological Chemistry
Partner nations: Canada United States Germany

In The Last Decade

James P. Lees‐Miller

38 papers receiving 2.2k citations

Peers

Countries citing papers authored by James P. Lees‐Miller

Since Specialization

Citations

This map shows the geographic impact of James P. Lees‐Miller's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James P. Lees‐Miller with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James P. Lees‐Miller more than expected).

Fields of papers citing papers by James P. Lees‐Miller

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James P. Lees‐Miller. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James P. Lees‐Miller. The network helps show where James P. Lees‐Miller may publish in the future.

Co-authorship network of co-authors of James P. Lees‐Miller

This figure shows the co-authorship network connecting the top 25 collaborators of James P. Lees‐Miller. A scholar is included among the top collaborators of James P. Lees‐Miller based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James P. Lees‐Miller. James P. Lees‐Miller is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	The voltage-sensing domain of a hERG1 mutant is a cation-selective channel 2022 ·Biophysical Journal ·(unknown),Jiqing Guo,Hanif M. Khan,James P. Lees‐Miller,(unknown),(unknown),Van A. Ngo,Sergei Y. Noskov,D. Peter Tieleman,Henry J. Duff	4
2	Lipid regulation of hERG1 channel function 2021 ·Nature Communications ·(unknown),Jiqing Guo,(unknown),Valentina Corradi,James P. Lees‐Miller,D. Peter Tieleman,Henry J. Duff,Sergei Y. Noskov	13
3	Structural insights into the role of DNA-PK as a master regulator in NHEJ 2021 ·PubMed ·Siyu Chen,James P. Lees‐Miller,Yuan He,Susan P. Lees‐Miller	28
4	Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade 2020 ·Frontiers in Pharmacology ·(unknown),Jiqing Guo,Hanif M. Khan,(unknown),James P. Lees‐Miller,Sergei Y. Noskov,Henry J. Duff	8
5	The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain 2019 ·Molecular Pharmacology ·Laura L. Perissinotti,Jiqing Guo,(unknown),James P. Lees‐Miller,Marina V. Ol’khovich,Angelica Sharapova,German L. Perlovich,Daniel A. Muruve,Brenda Gerull,Sergei Y. Noskov,Henry J. Duff	24
6	Role of the pH in state-dependent blockade of hERG currents 2016 ·Scientific Reports ·Yibo Wang,Jiqing Guo,Laura L. Perissinotti,James P. Lees‐Miller,Guoqi Teng,Serdar Durdağı,Henry J. Duff,Sergei Y. Noskov	24
7	NS1643 Interacts around L529 of hERG to Alter Voltage Sensor Movement on the Path to Activation 2015 ·Biophysical Journal ·Jiqing Guo,(unknown),James P. Lees‐Miller,Laura L. Perissinotti,Tom W. Claydon,Christina M. Hull,Samrat Thouta,Daniel E. Roach,Serdar Durdağı,Sergei Y. Noskov,Henry J. Duff	24
8	Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4 2015 ·Journal of Molecular and Cellular Cardiology ·James P. Lees‐Miller,Jiqing Guo,Yibo Wang,Laura L. Perissinotti,Sergei Y. Noskov,Henry J. Duff	52
9	Structure-Guided Topographic Mapping and Mutagenesis to Elucidate Binding Sites for the Human Ether-a-Go-Go-Related Gene 1 Potassium Channel (KCNH2) Activator NS1643 2012 ·Journal of Pharmacology and Experimental Therapeutics ·Serdar Durdağı,Jiqing Guo,James P. Lees‐Miller,Sergei Y. Noskov,Henry J. Duff	26
10	Structural refinement of the hERG1 pore and voltage‐sensing domains with ROSETTA‐membrane and molecular dynamics simulations 2010 ·Proteins Structure Function and Bioinformatics ·Julia Subbotina,Vladimir Yarov‐Yarovoy,James P. Lees‐Miller,Serdar Durdağı,Jiqing Guo,Henry J. Duff,Sergei Y. Noskov	46
11	Interactions of H562 in the S5 Helix with T618 and S621 in the Pore Helix Are Important Determinants of hERG1 Potassium Channel Structure and Function 2009 ·Biophysical Journal ·James P. Lees‐Miller,Julia Subbotina,Jiqing Guo,Vladimir Yarov‐Yarovoy,Sergei Y. Noskov,Henry J. Duff	33
12	Homozygous Missense N629D hERG (KCNH2) Potassium Channel Mutation Causes Developmental Defects in the Right Ventricle and Its Outflow Tract and Embryonic Lethality 2008 ·Circulation Research ·(unknown),(unknown),James P. Lees‐Miller,F. Russell Quinn,Pin Li,Derrick E. Rancourt,Barry London,James C. Cross,Henry J. Duff	43
13	Decrease in density of I_Na is in the common final pathway to heart block in murine hearts overexpressing calcineurin 2006 ·American Journal of Physiology-Heart and Circulatory Physiology ·Jia Guo,Zhan Shu,(unknown),R. Westenbroek,William A. Catterall,(unknown),Robert S. Sheldon,James P. Lees‐Miller,(unknown),Y. Shimoni,Henry J. Duff	14
14	Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37°C and 42°C 2005 ·Heart Rhythm ·Jiqing Guo,Zhan Shu,James P. Lees‐Miller,Guoqi Teng,Henry J. Duff	45
15	Selective Knockout of Mouse ERG1 B Potassium Channel Eliminates I _Kr in Adult Ventricular Myocytes and Elicits Episodes of Abrupt Sinus Bradycardia 2003 ·Molecular and Cellular Biology ·James P. Lees‐Miller,Jiqing Guo,(unknown),(unknown),Robert S. Sheldon,Derrick E. Rancourt,Henry J. Duff	43
16	[3H]Dofetilide Binding to Cardiac Myocytes: Modulation by Extracellular Potassium 1997 ·Journal of Molecular and Cellular Cardiology ·Henry J. Duff,Zhong‐Ping Feng,Céline Fiset,Li Wang,James P. Lees‐Miller,Robert S. Sheldon	9
17	Electrophysiological Characterization of an Alternatively Processed ERG K⁺Channel in Mouse and Human Hearts 1997 ·Circulation Research ·James P. Lees‐Miller,Colleen Kondo,Li Wang,Henry J. Duff	163
18	The molecular basis for tropomyosin isoform diversity 1991 ·BioEssays ·James P. Lees‐Miller,David M. Helfman	306
19	Three Novel Brain Tropomyosin Isoforms Are Expressed from the Rat α-Tropomyosin Gene through the Use of Alternative Promoters and Alternative RNA Processing 1990 ·Molecular and Cellular Biology ·James P. Lees‐Miller,Leslie O. Goodwin,David M. Helfman	25
20	Structure and complete nucleotide sequence of the gene encoding rat fibroblast tropomyosin 4 1990 ·Journal of Molecular Biology ·James P. Lees‐Miller,Albert C. Yan,David M. Helfman	37

About James P. Lees‐Miller

James P. Lees‐Miller is a scholar working on Cardiology and Cardiovascular Medicine, Immunology and Allergy and Molecular Biology, having authored 38 papers that have together received 2.2k indexed citations. Recurring topics across this work include Cardiac electrophysiology and arrhythmias (19 papers), Ion channel regulation and function (16 papers) and Cardiomyopathy and Myosin Studies (7 papers). The work is most often cited by research in Cardiology and Cardiovascular Medicine (1.2k citations), Molecular Biology (1.8k citations) and Cell Biology (370 citations). James P. Lees‐Miller has collaborated with scholars based in Canada, United States and Germany. Frequent co-authors include David M. Helfman, Henry J. Duff, Guoqi Teng, Jiqing Guo, Leslie O. Goodwin, Yufeng Duan, Trina A. Schroer, David H. Heeley, L. B. Smillie and Sergei Y. Noskov. Their work appears in journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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