J. John Holbrook

5.7k total citations
138 papers, 4.8k citations indexed

About

J. John Holbrook is a scholar working on Molecular Biology, Materials Chemistry and Cell Biology. According to data from OpenAlex, J. John Holbrook has authored 138 papers receiving a total of 4.8k indexed citations (citations by other indexed papers that have themselves been cited), including 104 papers in Molecular Biology, 59 papers in Materials Chemistry and 33 papers in Cell Biology. Recurrent topics in J. John Holbrook's work include Enzyme Structure and Function (59 papers), Protein Structure and Dynamics (57 papers) and Amino Acid Enzymes and Metabolism (26 papers). J. John Holbrook is often cited by papers focused on Enzyme Structure and Function (59 papers), Protein Structure and Dynamics (57 papers) and Amino Acid Enzymes and Metabolism (26 papers). J. John Holbrook collaborates with scholars based in United Kingdom, United States and Germany. J. John Holbrook's co-authors include Anthony R. Clarke, Tony Atkinson, Robert A. Stinson, David A. Barstow, William Chia, Dale B. Wigley, David Halsall, Richard B. Sessions, Keith Hart and H. Gutfreund and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

J. John Holbrook

138 papers receiving 4.5k citations

Peers

Countries citing papers authored by J. John Holbrook

Since Specialization

Citations

This map shows the geographic impact of J. John Holbrook's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by J. John Holbrook with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites J. John Holbrook more than expected).

Fields of papers citing papers by J. John Holbrook

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by J. John Holbrook. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by J. John Holbrook. The network helps show where J. John Holbrook may publish in the future.

Co-authorship network of co-authors of J. John Holbrook

This figure shows the co-authorship network connecting the top 25 collaborators of J. John Holbrook. A scholar is included among the top collaborators of J. John Holbrook based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with J. John Holbrook. J. John Holbrook is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Estimating the energetic contribution of hydrogen bonding to the stability of Candida methylica formate dehydrogenase by using double mutant cycle 2004 ·Biotechnology Letters ·Nevin Gül Karagüler, Richard B. Sessions, Kathleen M. Moreton, Anthony R. Clarke, J. John Holbrook	6
2	Production of an activated form of Bacillus stearothermophilus L-2-hydroxyacid dehydrogenase by directed evolution 2000 ·Protein Engineering Design and Selection ·Stuart J. Allen, J. John Holbrook	18
3	A general method for relieving substrate inhibition in lactate dehydrogenases 1999 ·Protein Engineering Design and Selection ·(unknown), (unknown), Richard B. Sessions, (unknown), Timothy R. Dafforn, Jiro Takei, Christopher E. Dempsey, Alan R. Clarke, J. John Holbrook	47
4	D‐2‐Hydroxy‐4‐Methylvalerate Dehydrogenase from Lactobacillus Delbrueckii Subsp. Bulgaricus— I. Kinetic Mechanism and pH Dependence of Kinetic Parameters, Coenzyme Binding and Substrate Inhibition 1997 ·European Journal of Biochemistry ·(unknown), Josep Lluís Gelpí, (unknown), Nathalie Bernard, Jean Delcour, Anthony R. Clarke, J. John Holbrook, Antonio Cortés	9
5	A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia 1997 ·Protein Engineering Design and Selection ·Richard B. Sessions, (unknown), Alan R. Clarke, J. John Holbrook	30
6	Protein engineering tests of a homology model of Plasmodium falciparum lactate dehydrogenase 1997 ·Protein Engineering Design and Selection ·(unknown), Richard B. Sessions, Timothy R. Dafforn, J. John Holbrook	22
7	D175 Discriminates Between NADH and NADPH in the Coenzyme Binding Site of Lactobacillus delbrueckii subsp. Bulgaricus D-Lactate Dehydrogenase 1995 ·Biochemical and Biophysical Research Communications ·Nathalie Bernard, (unknown), J. John Holbrook, Jean Delcour	38
8	Isolation, sequence and overexpression of the gene encoding NAD-dependent formate dehydrogenase from the methylotrophic yeast Candida methylica 1995 ·Gene ·Stuart J. Allen, J. John Holbrook	34
9	NAD⁺‐Dependent d‐2‐Hydroxyisocaproate Dehydrogenase of Lactobacillus Delbrueckii subsp. Bulgaricus 1994 ·European Journal of Biochemistry ·Nathalie Bernard, (unknown), Thierry Ferain, Dominique Garmyn, Pascal Hols, J. John Holbrook, Jean Delcour	57
10	The energetics and cooperativity of protein folding: a simple experimental analysis based upon the solvation of internal residues 1993 ·Biochemistry ·Rosemary A. Staniforth, Steven G. Burston, Corinne J. Smith, Graham S. Jackson, Ian G. Badcoe, Tony Atkinson, J. John Holbrook, Anthony R. Clarke	55
11	Opportunities and limits in creating new enzymes: experiences with the NAD-dependent lactate dehydrogenase frameworks of humans and bacteria 1992 ·Bristol Research (University of Bristol) ·(unknown), Antoni Cortés, (unknown), (unknown), Alan R. Clarke, J. John Holbrook	1
12	A prediction of the three-dimensional structure of maize NADP+-dependent malate dehydrogenase which explains aspects of light-dependent regulation unique to plant enzymes 1992 ·Journal of Computer-Aided Molecular Design ·Richard M. Jackson, Richard B. Sessions, J. John Holbrook	20
13	The importance of arginine 102 for the substrate specificity of Escherichia coli malate dehydrogenase 1992 ·Biochemical and Biophysical Research Communications ·David Nicholls, Julie Ann Miller, Michael D. Scawen, Anthony R. Clarke, J. John Holbrook, Tony Atkinson, Christopher R. Goward	43
14	Structure of a ternary complex of an allosteric lactate dehydrogenase from Bacillus stearothermophilus at 2·5 Å resolution 1992 ·Journal of Molecular Biology ·Dale B. Wigley, S.J. Gamblin, J.P. Turkenburg, E.J. Dodson, Klaus Piontek, H. Muirhead, J. John Holbrook	116
15	Charge balance in the α‐hydroxyacid dehydrogenase vacuole: An acid test 1992 ·Protein Science ·Antonio Cortés, David C. Emery, David Halsall, Richard M. Jackson, Anthony R. Clarke, J. John Holbrook	16
16	Genetic and spectroscopic characterisation of structural changes in dehydrogenase enzymes and their substrates during enzyme catalysis 1991 ·Bristol Research (University of Bristol) ·Alan R. Clarke, Álvaro Cortés-Cabrera, (unknown), (unknown), J. John Holbrook	2
17	Design and synthesis of new enzymes based on the lactate dehydrogenase framework 1991 ·Philosophical Transactions of the Royal Society B Biological Sciences ·(unknown), (unknown), David Halsall, Tony Atkinson, Anthony R. Clarke, Hilary Muirhead, J. John Holbrook	116
18	Detection and characterization of intermediates in the folding of large proteins by the use of genetically inserted tryptophan probes 1991 ·Biochemistry ·Corinne J. Smith, Alan R. Clarke, W. Chia, (unknown), Tony Atkinson, J. John Holbrook	51
19	Approaches to the study of enzyme mechanisms lactate dehydrogenase 1973 ·FEBS Letters ·J. John Holbrook, H. Gutfreund	98
20	The reactivities of the lysine, cysteine and tyrosine residues of pig heart lactate dehydrogenase in the presence of sulphite 1968 ·FEBS Letters ·Gerhard Pfleiderer, J. John Holbrook, (unknown), D Jeckel	15

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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