Izumi Horikawa

8.4k total citations · 3 hit papers
78 papers, 6.7k citations indexed

About

Izumi Horikawa is a scholar working on Molecular Biology, Physiology and Oncology. According to data from OpenAlex, Izumi Horikawa has authored 78 papers receiving a total of 6.7k indexed citations (citations by other indexed papers that have themselves been cited), including 50 papers in Molecular Biology, 44 papers in Physiology and 24 papers in Oncology. Recurrent topics in Izumi Horikawa's work include Telomeres, Telomerase, and Senescence (43 papers), Cancer-related Molecular Pathways (22 papers) and DNA Repair Mechanisms (16 papers). Izumi Horikawa is often cited by papers focused on Telomeres, Telomerase, and Senescence (43 papers), Cancer-related Molecular Pathways (22 papers) and DNA Repair Mechanisms (16 papers). Izumi Horikawa collaborates with scholars based in United States, Japan and United Kingdom. Izumi Horikawa's co-authors include J. Carl Barrett, Eriko Michishita, Curtis C. Harris, Jean Y. Park, William M. Bonner, Olga A. Sedelnikova, Drazen B. Zimonjic, Nicholas C. Popescu, Cynthia A. Afshari and Kaori Fujita and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

Izumi Horikawa

76 papers receiving 6.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins

2005 1.1k citations J. Carl Barrett, Izumi Horikawa et al. profile →
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

2004 623 citations Olga A. Sedelnikova, Izumi Horikawa et al. profile →
HIF‐1α induces cell cycle arrest by functionally counteracting Myc

2004 507 citations Minori Koshiji, Yukio Kageyama et al. The EMBO Journal profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Izumi Horikawa United States	40	4.1k	2.4k	1.5k	1.3k	1.0k	78	6.7k
Tej K. Pandita United States	36	5.2k 1.3×	1.0k 0.4×	1.2k 0.8×	1.8k 1.4×	1.0k 1.0×	70	7.1k
Marta Cañamero Spain	43	5.6k 1.4×	1.6k 0.7×	1.2k 0.8×	2.6k 1.9×	703 0.7×	67	8.4k
Shomit Sengupta United States	13	4.6k 1.1×	925 0.4×	705 0.5×	1.4k 1.0×	896 0.9×	16	6.5k
Akihiro Kurimasa Japan	36	4.8k 1.2×	775 0.3×	1.2k 0.8×	1.6k 1.2×	597 0.6×	90	6.3k
Noboru Motoyama Japan	36	5.1k 1.3×	739 0.3×	1.1k 0.8×	1.8k 1.4×	617 0.6×	63	7.6k
John Manis United States	41	6.2k 1.5×	684 0.3×	979 0.6×	2.3k 1.7×	1.1k 1.1×	78	9.3k
Christopher K. Patil United States	11	3.8k 0.9×	2.0k 0.8×	1.3k 0.8×	693 0.5×	875 0.9×	17	6.5k
Kevin M. Haigis United States	42	3.9k 1.0×	540 0.2×	1.0k 0.7×	2.5k 1.9×	581 0.6×	105	6.8k
Karthik B. Jeganathan United States	26	3.9k 1.0×	1.8k 0.8×	630 0.4×	936 0.7×	404 0.4×	39	6.0k
Mila E. McCurrach United States	20	7.3k 1.8×	2.1k 0.9×	1.3k 0.9×	3.6k 2.7×	510 0.5×	21	9.6k

Countries citing papers authored by Izumi Horikawa

Since Specialization

Citations

This map shows the geographic impact of Izumi Horikawa's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Izumi Horikawa with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Izumi Horikawa more than expected).

Fields of papers citing papers by Izumi Horikawa

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Izumi Horikawa. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Izumi Horikawa. The network helps show where Izumi Horikawa may publish in the future.

Co-authorship network of co-authors of Izumi Horikawa

This figure shows the co-authorship network connecting the top 25 collaborators of Izumi Horikawa. A scholar is included among the top collaborators of Izumi Horikawa based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Izumi Horikawa. Izumi Horikawa is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Joruiz, Sebastien M., Delphine Lissa, Natalia von Muhlinen, et al.. (2025). Pharmacologic activation of delta133p53α reduces cellular senescence in progeria patients-derived cells. PubMed. 7(3). 231–238.

Beck, Jessica A., et al.. (2022). Δ133p53α Protects Human Astrocytes from Amyloid-beta Induced Senescence and Neurotoxicity. Neuroscience. 498. 190–202. 11 indexed citations

Joruiz, Sebastien M., Jessica A. Beck, Izumi Horikawa, & Curtis C. Harris. (2020). The Δ133p53 Isoforms, Tuners of the p53 Pathway. Cancers. 12(11). 3422–3422. 26 indexed citations

Mondal, Abdul M., Hua Zhou, Izumi Horikawa, et al.. (2018). Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells. Cell Death and Disease. 9(7). 750–750. 25 indexed citations

Muhlinen, Natalia von, Izumi Horikawa, Kazunobu Isogaya, et al.. (2018). p53 isoforms regulate premature aging in human cells. Oncogene. 37(18). 2379–2393. 47 indexed citations

Mondal, Abdul M., Izumi Horikawa, Sharon R. Pine, et al.. (2013). p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. Journal of Clinical Investigation. 123(12). 5247–5257. 123 indexed citations

Sohn, Jane J., Aaron J. Schetter, Harris G. Yfantis, et al.. (2012). Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease. PLoS ONE. 7(9). e44156–e44156. 56 indexed citations

Liu, Shuang, Yanfeng Qi, Yubin Ge, et al.. (2010). Telomerase as an Important Target of Androgen Signaling Blockade for Prostate Cancer Treatment. Molecular Cancer Therapeutics. 9(7). 2016–2025. 30 indexed citations

Kumamoto, Kensuke, Elisa A. Spillare, Kaori Fujita, et al.. (2008). Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence. Cancer Research. 68(9). 3193–3203. 185 indexed citations

10.

Yang, Qin, Ran Zhang, Izumi Horikawa, et al.. (2007). Functional Diversity of Human Protection of Telomeres 1 Isoforms in Telomere Protection and Cellular Senescence. Cancer Research. 67(24). 11677–11686. 28 indexed citations

11.

Sedelnikova, Olga A., Izumi Horikawa, Christophe E. Redon, et al.. (2007). Delayed kinetics of DNA double‐strand break processing in normal and pathological aging. Aging Cell. 7(1). 89–100. 176 indexed citations

12.

Tanaka, Hiromi, Izumi Horikawa, J. Carl Barrett, & Mitsuo Oshimura. (2005). Evidence for inactivation of distinct telomerase repressor genes in different types of human cancers. International Journal of Cancer. 115(4). 653–657. 7 indexed citations

13.

Koshiji, Minori, et al.. (2004). HIF‐1α induces cell cycle arrest by functionally counteracting Myc. The EMBO Journal. 23(9). 1949–1956. 507 indexed citations breakdown →

14.

Horikawa, Izumi & J. Carl Barrett. (2003). Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms. Carcinogenesis. 24(7). 1167–1176. 165 indexed citations

15.

Horikawa, Izumi, Toshio Yawata, & J. Carl Barrett. (2000). Cellular Senescence Mechanisms Independent of Telomere Shortening and Telomerase: Other Barriers to Cell Immortalization and Carcinogenesis. 3(4). 373–382. 8 indexed citations

16.

Kugoh, Hiroyuki, Mutsunori Fujiwara, Kazunori Kihara, et al.. (2000). Cellular Senescence of a Human Bladder Carcinoma Cell Line (JTC-32) Induced by a Normal Chromosome 11. Cancer Genetics and Cytogenetics. 116(2). 158–163. 6 indexed citations

17.

Choi, Chan, Sunghee Cho, Izumi Horikawa, et al.. (1997). Loss of heterozygosity at chromosome segment Xq25‐26.1 in advanced human ovarian carcinomas. Genes Chromosomes and Cancer. 20(3). 234–242. 3 indexed citations

18.

Horikawa, Izumi, Hideto Yamada, Hiroyuki Kugoh, et al.. (1995). Subchromosomal Mapping of a Putative Transformation Suppressor Gene on Human Chromosome 1. Japanese Journal of Cancer Research. 86(5). 444–450. 1 indexed citations

19.

Horikawa, Izumi, Hiromi Tanaka, Yoshihiro Yuasa, et al.. (1995). Forced Expression of YL-1 Protein Suppresses the Anchorage-Independent Growth of Kirsten Sarcoma Virus-Transformed NIH3T3 Cells. Experimental Cell Research. 220(1). 11–17. 11 indexed citations

20.

Horikawa, Izumi, Mikio Suzuki, Mitsuaki A. Yoshida, & Mitsuo Oshimura. (1995). Frame-shift mutation and reduced transcript of p53 gene in a renal cell carcinoma cell line, RCC23. Human Molecular Genetics. 4(4). 771–773. 2 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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