Inge R. Holtman

6.7k total citations · 3 hit papers
34 papers, 3.7k citations indexed

About

Inge R. Holtman is a scholar working on Neurology, Immunology and Physiology. According to data from OpenAlex, Inge R. Holtman has authored 34 papers receiving a total of 3.7k indexed citations (citations by other indexed papers that have themselves been cited), including 23 papers in Neurology, 20 papers in Immunology and 13 papers in Physiology. Recurrent topics in Inge R. Holtman's work include Neuroinflammation and Neurodegeneration Mechanisms (23 papers), Immune cells in cancer (12 papers) and Alzheimer's disease research and treatments (9 papers). Inge R. Holtman is often cited by papers focused on Neuroinflammation and Neurodegeneration Mechanisms (23 papers), Immune cells in cancer (12 papers) and Alzheimer's disease research and treatments (9 papers). Inge R. Holtman collaborates with scholars based in Netherlands, United States and United Kingdom. Inge R. Holtman's co-authors include Bart J. L. Eggen, Erik Boddeke, Christopher K. Glass, Thomas Möller, Dylan Skola, Nieske Brouwer, Paul D. Wes, Divya Raj, Zhuoran Yin and David Gosselin and has published in prestigious journals such as Science, Journal of Clinical Investigation and Nature Medicine.

In The Last Decade

Inge R. Holtman

32 papers receiving 3.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

An environment-dependent transcriptional network specifies human microglia identity

2017 795 citations David Gosselin, Dylan Skola et al. Science profile →
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

2017 510 citations Thais Fernanda de Almeida Galatro, Inge R. Holtman et al. Nature Neuroscience profile →
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

2015 437 citations Inge R. Holtman, Divya Raj et al. Acta Neuropathologica Communications profile →

Peers

Inge R. Holtman

NEURO

IMMUN

PHYSI

Diego Gómez‐Nicola United Kingdom

Chotima Böttcher Germany

Orit Matcovitch-Natan Israel

Samuel E. Marsh United States

Hendrikus Boddeke Netherlands

Brad A. Friedman United States

Allison R. Najafi United States

Michael A. Wheeler United States

Rachel Rice United States

Luke M. Healy Canada

Diego Gómez‐Nicola United Kingdom

Inge R. Holtman

2.7k ×1.0

NEURO

1.4k ×0.8

IMMUN

939 ×1.0

1.2k ×1.4

PHYSI

602 ×1.4

Citations per year, relative to Inge R. Holtman Inge R. Holtman (= 1×) peers Diego Gómez‐Nicola

Countries citing papers authored by Inge R. Holtman

Since Specialization

Citations

This map shows the geographic impact of Inge R. Holtman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Inge R. Holtman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Inge R. Holtman more than expected).

Fields of papers citing papers by Inge R. Holtman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Inge R. Holtman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Inge R. Holtman. The network helps show where Inge R. Holtman may publish in the future.

Co-authorship network of co-authors of Inge R. Holtman

This figure shows the co-authorship network connecting the top 25 collaborators of Inge R. Holtman. A scholar is included among the top collaborators of Inge R. Holtman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Inge R. Holtman. Inge R. Holtman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Kracht, Laura, Yi Wu, Abel Soto-Gamez, et al.. (2025). Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage. The EMBO Journal. 45(2). 374–393. 1 indexed citations

Brouwer, Nieske, et al.. (2025). Microglia endotoxin tolerance is retained after enforced repopulation. Brain Behavior and Immunity. 128. 512–528.

Wehrens, Sophie M. T., Megan K. Herbert, Annemieke J.M. Rozemüller, et al.. (2024). Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing. Nature Medicine. 30(4). 1143–1153. 22 indexed citations

Bosch, Aletta M.R. van den, Nina L. Fransen, Jörg Hamann, et al.. (2024). Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions. Acta Neuropathologica. 147(1). 90–90. 10 indexed citations

Holtman, Inge R., Christopher K. Glass, & Alexi Nott. (2024). Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types. Advances in neurobiology. 37. 531–544. 1 indexed citations

Jiang, Yuting, Luiza Reali Nazario, Hilmar R. J. van Weering, et al.. (2024). Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state. Cell Reports. 43(2). 113764–113764. 10 indexed citations

Tan, Manuela, et al.. (2022). Dissecting the limited genetic overlap of Parkinson's and Alzheimer's disease. Annals of Clinical and Translational Neurology. 9(8). 1289–1295. 9 indexed citations

Hoeksema, Marten A., Zeyang Shen, Inge R. Holtman, et al.. (2021). Mechanisms underlying divergent responses of genetically distinct macrophages to IL-4. Science Advances. 7(25). 27 indexed citations

Bandrés‐Ciga, Sara, Regina H. Reynolds, John Hardy, et al.. (2021). Heritability Enrichment Implicates Microglia in Parkinson's Disease Pathogenesis. Annals of Neurology. 89(5). 942–951. 36 indexed citations

10.

Włodarczyk, Agnieszka, Inge R. Holtman, Martin Krueger, et al.. (2017). A novel microglial subset plays a key role in myelinogenesis in developing brain. The EMBO Journal. 36(22). 3292–3308. 372 indexed citations

11.

Gosselin, David, Dylan Skola, Nicole G. Coufal, et al.. (2017). An environment-dependent transcriptional network specifies human microglia identity. Science. 356(6344). 795 indexed citations breakdown →

12.

Raj, Divya, Zhuoran Yin, Marjolein Breur, et al.. (2017). Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain. Frontiers in Molecular Neuroscience. 10. 206–206. 128 indexed citations

13.

Galatro, Thais Fernanda de Almeida, Inge R. Holtman, Antônio Marcondes Lerário, et al.. (2017). Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. Nature Neuroscience. 20(8). 1162–1171. 510 indexed citations breakdown →

14.

Jagessar, S. Anwar, Inge R. Holtman, Sam Hofman, et al.. (2016). Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein. The Journal of Immunology. 197(4). 1074–1088. 40 indexed citations

15.

Scheffold, Annika, Inge R. Holtman, Sandra Dieni, et al.. (2016). Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model. Acta Neuropathologica Communications. 4(1). 87–87. 41 indexed citations

16.

Vainchtein, Ilia D., et al.. (2015). Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease. Data Archiving and Networked Services (DANS). 1 indexed citations

17.

Wes, Paul D., Inge R. Holtman, Erik Boddeke, Thomas Möller, & Bart J. L. Eggen. (2015). Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease. Glia. 64(2). 197–213. 109 indexed citations

18.

Szulzewsky, Frank, Andreas Pelz, Xi Feng, et al.. (2015). Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1. PLoS ONE. 10(2). e0116644–e0116644. 317 indexed citations

19.

Holtman, Inge R., Divya Raj, Jeremy A. Miller, et al.. (2015). Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta Neuropathologica Communications. 3(1). 31–31. 437 indexed citations breakdown →

20.

Raj, Divya, Dick Jaarsma, Inge R. Holtman, et al.. (2014). Priming of microglia in a DNA-repair deficient model of accelerated aging. Neurobiology of Aging. 35(9). 2147–2160. 101 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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