Ignacio Varela

33.1k citations

54 papers · 3.3k indexed · 2 hit papers · h-index 23

Impact in

Aging top 2%
Hematology top 2%
- Acute Myeloid Leukemia Research

Papers in ⓘ

Molecular Biology 32
- Nuclear Structure and Function 10
- Genomics and Chromatin Dynamics 9
- RNA Research and Splicing 7
- Chromatin Remodeling and Cancer 4
- DNA Repair Mechanisms 4
- Epigenetics and DNA Methylation 4
Cancer Research 15
- Cancer Genomics and Diagnostics 11

Co-authors: Carlos López-Otı́n (13 shared papers)José M.P. Freije (13 shared papers)Juan Cadiñanos (11 shared papers)Alejandro P. Ugalde (5 shared papers)Fernando G. Osorio (4 shared papers)Laura González-Silva (5 shared papers)Alberto M. Pendás (3 shared papers)Colin L. Stewart (3 shared papers)
Journals: Haematologica (3 papers)Journal of Biological Chemistry (3 papers)Oncotarget (3 papers)Blood (2 papers)Cell Reports (2 papers)
Partner nations: Spain United States United Kingdom

In The Last Decade

Ignacio Varela

52 papers receiving 3.3k citations

Hit Papers

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Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis 2015 · 357 citations

Peers

Countries citing papers authored by Ignacio Varela

Since Specialization

Citations

This map shows the geographic impact of Ignacio Varela's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ignacio Varela with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ignacio Varela more than expected).

Fields of papers citing papers by Ignacio Varela

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ignacio Varela. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ignacio Varela. The network helps show where Ignacio Varela may publish in the future.

Co-authors

The 25 scholars most cited alongside Ignacio Varela, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ignacio Varela Line = papers co-authored together Ignacio Varela links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 54 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells Nature ·Kosuke Yusa, S. Tamir Rashid, Hélène Strick‐Marchand, Ignacio Varela, Pei-Qi Liu, David E. Paschon, Elena Miranda, A. Ordóñez, Nicholas R. F. Hannan, Foad J. Rouhani, Sylvie Darche, Graeme Alexander, Stefan J. Marciniak, Noemi Fusaki, Mamoru Hasegawa, Michael C. Holmes, James P. Di Santo, David A. Lomas, Allan Bradley, Ludovic Vallier Hit paper breakdown →	2011	472
2	Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation Nature ·Ignacio Varela, Juan Cadiñanos, Alberto M. Pendás, Ana Gutiérrez‐Fernández, Alicia R. Folgueras, Luis Sánchez‐Pulido, Zhongjun Zhou, Francisco Rodríguez, Colin L. Stewart, José A. Vega, Karl Tryggvason, José M.P. Freije, Carlos López-Otı́n	2005	367
3	Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis Cell Reports ·Thomas McKerrell, Naomi Park, Thaidy Moreno-Rodriguez, Carolyn Grove, Hannes Ponstingl, Jonathan Stephens, Charles Crawley, Jenny I. O. Craig, Mike Scott, Clare Hodkinson, E. Joanna Baxter, Roland Rad, Duncan R. Forsyth, Michael A. Quail, Eleftheria Zeggini, Willem H. Ouwehand, Ignacio Varela, George S. Vassiliou Hit paper breakdown →	2015	357
4	Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging Nature Medicine ·Ignacio Varela, Sandrine Pereira, Alejandro P. Ugalde, Claire Navarro, María F. Suárez, Pierre Cau, Juan Cadiñanos, Fernando G. Osorio, Nicolas Foray, Juan Cobo, Félix de Carlos Villafranca, Nicolas Lévy, José M.P. Freije, Carlos López-Otı́n	2008	308
5	Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging Science Translational Medicine ·Fernando G. Osorio, Claire Navarro, Juan Cadiñanos, Isabel C. López‐Mejía, Pedro M. Quirós, Catherine Bartoli, José Rivera, Jamal Tazi, Gabriela Guzmán, Ignacio Varela, D. Depétris, Félix de Carlos Villafranca, Juan Cobo, Vicente Andrés, Annachiara De Sandre‐Giovannoli, José M.P. Freije, Nicolas Lévy, Carlos López-Otı́n	2011	301
6	Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53 The EMBO Journal ·Alejandro P. Ugalde, Andrew Ramsay, Jorge de la Rosa, Ignacio Varela, Guillermo Mariño, Juan Cadiñanos, Jun Lü, José M.P. Freije, Carlos López-Otı́n	2011	198
7	Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis Cell Reports ·Fernando G. Osorio, Axel Rosendahl Huber, Rurika Oka, Mark Verheul, Sachin Patel, Karlijn Hasaart, Lisanne de la Fonteijne, Ignacio Varela, Fernando D. Camargo, Ruben van Boxtel	2018	151
8	Tumor Functional Heterogeneity Unraveled by scRNA-seq Technologies Trends in cancer ·Laura González-Silva, Laura Quevedo, Ignacio Varela	2020	140
9	Nuclear envelope defects cause stem cell dysfunction in premature-aging mice The Journal of Cell Biology ·Jesús Espada, Ignacio Varela, Ignacio Flores, Alejandro P. Ugalde, Juan Cadiñanos, Alberto M. Pendás, Colin L. Stewart, Karl Tryggvason, Marı́a A. Blasco, José M.P. Freije, Carlos López-Otı́n	2008	133
10	Premature aging in mice activates a systemic metabolic response involving autophagy induction Human Molecular Genetics ·Guillermo Mariño, Alejandro P. Ugalde, Natalia Salvador-Montoliu, Ignacio Varela, Pedro M. Quirós, Juan Cadiñanos, Ingrid van der Pluijm, José M.P. Freije, Carlos López-Otı́n	2008	123
11	Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions Cellular and Molecular Life Sciences ·César Luis Janeiro Ramírez, Juan Cadiñanos, Ignacio Varela, José M.P. Freije, Carlos López-Otı́n	2006	65
12	Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis Haematologica ·Antonio Agraz-Doblás, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Giovanni Cazzaniga, Thaidy Moreno-Rodriguez, Carlos Revilla, Marta Gut, Maria Grazia Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menéndez, Ronald W. Stam	2019	60
13	Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia Blood ·Oliver M. Dovey, Jonathan Cooper, Annalisa Mupo, Carolyn Grove, Claire Lynn, Nathalie Conte, Robert Andrews, Suruchi Pacharne, Konstantinos Tzelepis, M. S. Vijayabaskar, Paul Green, Roland Rad, Mark J. Arends, Penny Wright, Kosuke Yusa, Allan Bradley, Ignacio Varela, George S. Vassiliou	2017	52
14	Nuclear envelope alterations generate an aging‐like epigenetic pattern in mice deficient in Zmpste24 metalloprotease Aging Cell ·Fernando G. Osorio, Ignacio Varela, Ester Lara, Xosé S. Puente, Jesús Espada, Raffaella Santoro, José M.P. Freije, Mario F. Fraga, Carlos López-Otı́n	2010	44
15	A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis Arthritis Research & Therapy ·Silvia Torices, Antonio Julià, Pedro Muñoz, Ignacio Varela, Alejandro Balsa, Sara Marsal, Antonio Fernández‐Nebro, Francisco J. Blanco, Marcos López‐Hoyos, Víctor M. Martínez‐Taboada, José L. Fernández-Luna	2016	39
16	JAK2 V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics Blood Advances ·Thomas McKerrell, Naomi Park, Jianxiang Chi, Grace Collord, Thaidy Moreno-Rodriguez, Hannes Ponstingl, João M.L. Dias, Petroula Gerasimou, Kiki Melanthiou, Chrystalla Prokopiou, Marios Antoniades, Ignacio Varela, Paul Costeas, George S. Vassiliou	2017	38
17	Characterization of gene mutations and copy number changes in acute myeloid leukemia using a rapid target enrichment protocol Haematologica ·Niccolò Bolli, Nicla Manes, Thomas McKerrell, Jufang Chi, N. Park, Gunes Gundem, Michael A. Quail, Vijitha Sathiaseelan, Bram Herman, Charles Crawley, J Craig, Nathalie Conte, Carolyn Grove, Elli Papaemmanuil, Peter J. Campbell, Ignacio Varela, Paul Costeas, George S. Vassiliou	2014	37
18	AtFACE-2, a functional Prenylated Protein Protease from Arabidopsis thaliana Related to Mammalian Ras-converting Enzymes Journal of Biological Chemistry ·Juan Cadiñanos, Ignacio Varela, Daniel Mandel, Walter K. Schmidt, Araceli Díaz‐Perales, Carlos López-Otı́n, José M.P. Freije	2003	36
19	Analysis of the mutational landscape of classic Hodgkin lymphoma identifies disease heterogeneity and potential therapeutic targets Oncotarget ·Elena Mata, Antonio Díaz‐López, Ana M. Martín‐Moreno, Margarita Sánchez‐Beato, Ignacio Varela, María J. Mestre, Carlos Santonja, Fernando Burgos, Javier Menárguez, Mónica Estévez, Mariano Provencio, Beatriz Sánchez‐Espiridión, Eva Díaz, Carlos Montalbán, Miguel Á. Piris, Juan F. Garcı́a	2017	27
20	Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate Leukemia Cancer Research ·Cristina Prieto, Ronald W. Stam, Antonio Agraz-Doblás, Paola Ballerini, Mireia Camós, Julio Castaño, Rolf Marschalek, A Bursen, Ignacio Varela, Clara Bueno, Pablo Menéndez	2016	27

About Ignacio Varela

Ignacio Varela is a scholar working on Molecular Biology, Cancer Research, Hematology, Oncology and Pathology and Forensic Medicine, having authored 54 papers that have together received 3.3k indexed citations. Recurring topics across this work include Cancer Genomics and Diagnostics (11 papers), Nuclear Structure and Function (10 papers), Acute Myeloid Leukemia Research (10 papers), Genomics and Chromatin Dynamics (9 papers), RNA Research and Splicing (7 papers), Chromatin Remodeling and Cancer (4 papers), DNA Repair Mechanisms (4 papers) and Epigenetics and DNA Methylation (4 papers). The work is most often cited by research in Aging (142 citations), Hematology (599 citations), Cancer Research (569 citations), Molecular Biology (2.4k citations) and Genetics (343 citations). Ignacio Varela has collaborated with scholars based in Spain, United States and United Kingdom. Frequent co-authors include Carlos López-Otı́n, José M.P. Freije, Juan Cadiñanos, Alejandro P. Ugalde, Fernando G. Osorio, Laura González-Silva, Alberto M. Pendás, Colin L. Stewart, Karl Tryggvason and Félix de Carlos Villafranca. Their work appears in journals such as Haematologica, Journal of Biological Chemistry, Oncotarget, Blood and Cell Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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