Holger Heine

11.2k total citations · 2 hit papers
114 papers, 8.2k citations indexed

About

Holger Heine is a scholar working on Immunology, Molecular Biology and Microbiology. According to data from OpenAlex, Holger Heine has authored 114 papers receiving a total of 8.2k indexed citations (citations by other indexed papers that have themselves been cited), including 72 papers in Immunology, 29 papers in Molecular Biology and 26 papers in Microbiology. Recurrent topics in Holger Heine's work include Immune Response and Inflammation (61 papers), Antimicrobial Peptides and Activities (23 papers) and Pediatric health and respiratory diseases (15 papers). Holger Heine is often cited by papers focused on Immune Response and Inflammation (61 papers), Antimicrobial Peptides and Activities (23 papers) and Pediatric health and respiratory diseases (15 papers). Holger Heine collaborates with scholars based in Germany, United States and Austria. Holger Heine's co-authors include Egil Lien, Artur J. Ulmer, Douglas T. Golenbock, Ulrich Zähringer, Brian G. Monks, Karl‐Heinz Wiesmüller, Buko Lindner, Alla Zamyatina, Atsutoshi Yoshimura and Ute Buwitt‐Beckmann and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Angewandte Chemie International Edition.

In The Last Decade

Holger Heine

112 papers receiving 8.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

2000 655 citations Holger Heine et al. profile →
LPS-induced Cytokine Production in Human Monocytes and Macrophages

2011 507 citations Holger Heine et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Holger Heine Germany	45	4.2k	2.5k	1.1k	1.1k	1.0k	114	8.2k
David C. Morrison United States	58	6.2k 1.5×	3.3k 1.3×	1.5k 1.4×	814 0.8×	1.3k 1.2×	212	11.1k
Xiaolong He China	27	5.0k 1.2×	2.4k 1.0×	1.3k 1.2×	458 0.4×	802 0.8×	119	8.9k
Irina Smirnova United States	21	6.0k 1.4×	2.0k 0.8×	1.5k 1.4×	395 0.4×	907 0.9×	38	8.2k
John C. Mathison United States	39	7.1k 1.7×	3.5k 1.4×	2.1k 1.9×	755 0.7×	1.3k 1.2×	67	11.6k
Alexander Poltorak United States	31	7.8k 1.9×	3.3k 1.3×	1.9k 1.7×	522 0.5×	1.1k 1.1×	66	11.0k
Tomohiko Ogawa Japan	33	7.2k 1.7×	2.1k 0.9×	1.6k 1.5×	542 0.5×	1.3k 1.3×	67	10.2k
Marina Sironi Italy	59	7.0k 1.7×	3.4k 1.3×	1.4k 1.3×	930 0.9×	312 0.3×	168	13.1k
Andrej Tarkowski Sweden	51	3.1k 0.7×	3.4k 1.4×	1.6k 1.4×	886 0.8×	927 0.9×	138	9.7k
Simon R. Carding United Kingdom	62	6.0k 1.4×	5.0k 2.0×	2.4k 2.2×	1.4k 1.3×	696 0.7×	197	14.0k
Robert S. Munford United States	52	3.6k 0.9×	2.0k 0.8×	1.9k 1.7×	487 0.5×	937 0.9×	118	7.5k

Countries citing papers authored by Holger Heine

Since Specialization

Citations

This map shows the geographic impact of Holger Heine's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Holger Heine with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Holger Heine more than expected).

Fields of papers citing papers by Holger Heine

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Holger Heine. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Holger Heine. The network helps show where Holger Heine may publish in the future.

Co-authorship network of co-authors of Holger Heine

This figure shows the co-authorship network connecting the top 25 collaborators of Holger Heine. A scholar is included among the top collaborators of Holger Heine based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Holger Heine. Holger Heine is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Krause, Kathrin, Matteo Ugolini, Tonya Kueck, et al.. (2025). Streptococcus pyogenes EVs induce the alternative inflammasome via caspase-4/-5 in human monocytes. EMBO Reports. 26(19). 4847–4885. 1 indexed citations

Kumpitsch, Christina, et al.. (2024). Exploring the human archaeome: its relevance for health and disease, and its complex interplay with the human immune system. FEBS Journal. 292(6). 1316–1329. 8 indexed citations

Strobl, Herbert, et al.. (2023). Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids. Molecules. 28(16). 5948–5948. 2 indexed citations

Bagola, Katrin, et al.. (2023). Investigating pyroptosis as a mechanism of L. major cell‐to‐cell spread in the human BLaER1 infection model. Molecular Microbiology. 121(3). 453–469. 6 indexed citations

Herster, Franziska, Zsofia Bittner, Nathan K. Archer, et al.. (2020). Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis. Nature Communications. 11(1). 105–105. 191 indexed citations

Wang, Zhongjie, et al.. (2020). Complete Genome Sequence of Lactococcus lactis subsp. lactis G121, an Isolate with Allergy-Protective Features Derived from a Farming Environment. Microbiology Resource Announcements. 9(41). 1 indexed citations

Zamyatina, Alla & Holger Heine. (2020). Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways. Frontiers in Immunology. 11. 585146–585146. 140 indexed citations

Burkhardt, Lia, Michael Spohn, Iris Bruchhaus, et al.. (2019). An EGFR-Induced Drosophila Lung Tumor Model Identifies Alternative Combination Treatments. Molecular Cancer Therapeutics. 18(9). 1659–1668. 13 indexed citations

Boutin, Sébastien, Annika Kötter, Florian Pichot, et al.. (2019). 2′-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms. RNA. 25(7). 869–880. 29 indexed citations

10.

Gárate, José Antonio, et al.. (2018). Disaccharide‐Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide‐Induced Inflammation. ChemMedChem. 13(21). 2317–2331. 15 indexed citations

11.

Shi, Jianjin, et al.. (2018). Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics. Chemical Science. 9(16). 3957–3963. 23 indexed citations

12.

Bartel, Sabine, et al.. (2017). Influences of environmental bacteria and their metabolites on allergies, asthma, and host microbiota. Allergy. 72(12). 1859–1867. 48 indexed citations

13.

Brand, Stéphanie, Anna M. Sigmund, Zhijian J. Chen, et al.. (2016). Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects. Journal of Allergy and Clinical Immunology. 139(2). 667–678.e5. 23 indexed citations

14.

Hogendorf, Wouter F. J., Nicolas Gisch, Dominik Schwudke, et al.. (2014). Total Synthesis of Five Lipoteichoic acids of Clostridium difficile. Chemistry - A European Journal. 20(42). 13511–13516. 7 indexed citations

15.

Haase, Hajo, Julia L. Ober-Blöbaum, Gabriela Engelhardt, et al.. (2008). Zinc Signals Are Essential for Lipopolysaccharide-Induced Signal Transduction in Monocytes. The Journal of Immunology. 181(9). 6491–6502. 236 indexed citations

16.

Bülow, Verena von, Gabriela Engelhardt, Silke Hebel, et al.. (2007). Zinc-Dependent Suppression of TNF-α Production Is Mediated by Protein Kinase A-Induced Inhibition of Raf-1, IκB Kinase β, and NF-κB. The Journal of Immunology. 179(6). 4180–4186. 118 indexed citations

17.

Löseke, Stefan, Evelin Grage‐Griebenow, Holger Heine, et al.. (2006). In vitro‐Generated Viral Double‐Stranded RNA in Contrast to Polyinosinic : Polycytidylic Acid Induces Interferon‐α in Human Plasmacytoid Dendritic Cells. Scandinavian Journal of Immunology. 63(4). 264–274. 23 indexed citations

18.

Fricke, Ingo, et al.. (2006). Mycobacteria Induce IFN-γ Production in Human Dendritic Cells via Triggering of TLR2. The Journal of Immunology. 176(9). 5173–5182. 67 indexed citations

19.

Schröder, Nicolas W.J., Holger Heine, Christian Alexander, et al.. (2004). Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses. The Journal of Immunology. 173(4). 2683–2691. 131 indexed citations

20.

Ulmer, A.J., E. Rietschel, Ulrich Zähringer, & Holger Heine. (2002). Lipopolysaccharide: Structure, Bioactivity, Receptors, and Signal Transduction.. Trends in Glycoscience and Glycotechnology. 14(76). 53–68. 59 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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