Hiroyuki Koshio

689 total citations
35 papers, 581 citations indexed

About

Hiroyuki Koshio is a scholar working on Hematology, Cardiology and Cardiovascular Medicine and Pulmonary and Respiratory Medicine. According to data from OpenAlex, Hiroyuki Koshio has authored 35 papers receiving a total of 581 indexed citations (citations by other indexed papers that have themselves been cited), including 18 papers in Hematology, 11 papers in Cardiology and Cardiovascular Medicine and 8 papers in Pulmonary and Respiratory Medicine. Recurrent topics in Hiroyuki Koshio's work include Blood Coagulation and Thrombosis Mechanisms (18 papers), Atrial Fibrillation Management and Outcomes (10 papers) and Vitamin K Research Studies (6 papers). Hiroyuki Koshio is often cited by papers focused on Blood Coagulation and Thrombosis Mechanisms (18 papers), Atrial Fibrillation Management and Outcomes (10 papers) and Vitamin K Research Studies (6 papers). Hiroyuki Koshio collaborates with scholars based in Japan, Norway and Netherlands. Hiroyuki Koshio's co-authors include Yuzo Matsumoto, Tomihisa Kawasaki, Fukushi Hirayama, Kazuo Sato, Yuta Taniuchi, Chiaki Kuroda, Takeyuki Yatsu, Seiji Kaku, Shin‐ichi Tsukamoto and Tsukasa Ishihara and has published in prestigious journals such as Blood, Cancer Research and Journal of Medicinal Chemistry.

In The Last Decade

Hiroyuki Koshio

35 papers receiving 498 citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Hiroyuki Koshio Japan	16	261	191	175	127	106	35	581
Taketoshi Ogawa Japan	14	166 0.6×	541 2.8×	146 0.8×	98 0.8×	71 0.7×	30	827
Christopher L. Heran United States	14	122 0.5×	162 0.8×	48 0.3×	121 1.0×	56 0.5×	22	503
Thomas E. Steinbacher United States	15	184 0.7×	180 0.9×	38 0.2×	100 0.8×	108 1.0×	30	469
Jacqueline Agans-Fantuzzi United States	6	171 0.7×	164 0.9×	112 0.6×	85 0.7×	68 0.6×	7	392
Stan Kurowski United States	8	129 0.5×	175 0.9×	58 0.3×	71 0.6×	47 0.4×	14	362
Martin F. Haslanger United States	13	26 0.1×	193 1.0×	157 0.9×	235 1.9×	51 0.5×	26	766
H Weisenberger Germany	13	78 0.3×	214 1.1×	38 0.2×	82 0.6×	14 0.1×	21	463
Gillian M. Olins United States	21	44 0.2×	403 2.1×	134 0.8×	411 3.2×	41 0.4×	37	877
Keizo Sugasawa Japan	9	144 0.6×	40 0.2×	105 0.6×	53 0.4×	37 0.3×	13	330
Jian‐Ke Tie United States	19	55 0.2×	50 0.3×	42 0.2×	264 2.1×	66 0.6×	41	978

Countries citing papers authored by Hiroyuki Koshio

Since Specialization

Citations

This map shows the geographic impact of Hiroyuki Koshio's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroyuki Koshio with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroyuki Koshio more than expected).

Fields of papers citing papers by Hiroyuki Koshio

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroyuki Koshio. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroyuki Koshio. The network helps show where Hiroyuki Koshio may publish in the future.

Co-authorship network of co-authors of Hiroyuki Koshio

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroyuki Koshio. A scholar is included among the top collaborators of Hiroyuki Koshio based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroyuki Koshio. Hiroyuki Koshio is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Tanaka, Hiroaki, Hideki Sakagami, Naoki Kaneko, et al.. (2019). Mutant-Selective Irreversible EGFR Inhibitor, Naquotinib, Inhibits Tumor Growth in NSCLC Models with EGFR-Activating Mutations, T790M Mutation, and AXL Overexpression. Molecular Cancer Therapeutics. 18(8). 1366–1373. 15 indexed citations

Hirayama, Fukushi, Hiroyuki Koshio, Tsukasa Ishihara, et al.. (2011). Discovery of N -[2-Hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (Darexaban, YM150) as a Potent and Orally Available Factor Xa Inhibitor. Journal of Medicinal Chemistry. 54(23). 8051–8065. 27 indexed citations

Koshio, Hiroyuki, et al.. (2009). Synthesis and structure–activity relationships of amide derivatives of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetic acid as selective arginine vasopressin V2 receptor agonists. Bioorganic & Medicinal Chemistry. 17(8). 3130–3141. 12 indexed citations

Koshio, Hiroyuki, et al.. (2009). Optimization of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists and discussion of their binding modes. Bioorganic & Medicinal Chemistry. 17(24). 8161–8167. 1 indexed citations

Koshio, Hiroyuki, et al.. (2008). Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists. Bioorganic & Medicinal Chemistry. 16(21). 9524–9535. 7 indexed citations

Kaku, Seiji, Toshiyuki Funatsu, Hiroyuki Koshio, et al.. (2007). Comparison of YM150, an Oral, Direct Factor Xa Inhibitor, with Other Antithrombotic Agents in Rodent Venous and Arterial Thrombosis Models.. Blood. 110(11). 3155–3155. 7 indexed citations

Ishihara, Tsukasa, Norio Seki, Fukushi Hirayama, et al.. (2007). Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors. Bioorganic & Medicinal Chemistry. 15(12). 4175–4192. 7 indexed citations

Koshio, Hiroyuki, et al.. (2005). An Easy Access to 7-Methyl-2-naphthalenecarbonitrile. Chemical and Pharmaceutical Bulletin. 53(4). 448–450. 2 indexed citations

Koshio, Hiroyuki, Fukushi Hirayama, Tsukasa Ishihara, et al.. (2004). Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. Bioorganic & Medicinal Chemistry. 12(9). 2179–2191. 14 indexed citations

10.

Koshio, Hiroyuki, Fukushi Hirayama, Tsukasa Ishihara, et al.. (2004). Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives. Bioorganic & Medicinal Chemistry. 12(20). 5415–5426. 12 indexed citations

11.

Kuroda, Chiaki, et al.. (2003). Synthesis of spiro[4.5]decane and bicyclo[4.3.0]nonane ring systems by self-cyclization of (Z)- and (E)-2-(trimethylsilylmethyl)pentadienal derivative. Tetrahedron. 60(2). 319–331. 10 indexed citations

12.

Hirayama, Fukushi, Hiroyuki Koshio, Naoko Katayama, et al.. (2003). Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template. Bioorganic & Medicinal Chemistry. 11(3). 367–381. 13 indexed citations

13.

Hirayama, Fukushi, Hiroyuki Koshio, Tsukasa Ishihara, et al.. (2002). Design, synthesis and biological activity of YM-60828 derivatives: potent and orally-Bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates. Bioorganic & Medicinal Chemistry. 10(8). 2597–2610. 17 indexed citations

14.

Hirayama, Fukushi, Hiroyuki Koshio, Naoko Katayama, et al.. (2002). The Discovery of YM-60828: A Potent, Selective and Orally-Bioavailable Factor Xa Inhibitor. Bioorganic & Medicinal Chemistry. 10(5). 1509–1523. 31 indexed citations

15.

Matsuhisa, Akio, Naoyuki Taniguchi, Hiroyuki Koshio, Takeyuki Yatsu, & Akihiro Tanaka. (2000). Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 4'-(1,4,5,6-Tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl)benzanilide Derivatives and 4'-(5,6-Dihydro-4H-thiazolo[5,4-d][1]benzoazepine-6-carbonyl)benzanilide Derivatives.. Chemical and Pharmaceutical Bulletin. 48(1). 21–31. 27 indexed citations

16.

Matsuhisa, Akira, et al.. (1998). Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 2-Phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-carbonyl)benzanilide Derivatives.. Chemical and Pharmaceutical Bulletin. 46(10). 1566–1579. 30 indexed citations

17.

Sato, Kazuo, Tomihisa Kawasaki, Yuta Taniuchi, et al.. (1998). Antithrombotic effects of YM-60828 in three thrombosis models in guinea pigs. European Journal of Pharmacology. 350(1). 87–91. 22 indexed citations

18.

Sato, Kazuo, Yuta Taniuchi, Tomihisa Kawasaki, et al.. (1998). Relationship between the antithrombotic effect of YM-75466, a novel factor Xa inhibitor, and coagulation parameters in rats. European Journal of Pharmacology. 347(2-3). 231–236. 29 indexed citations

19.

Sato, Kazuo, et al.. (1997). YM-60828, a novel factor Xa inhibitor: Separation of its antithrombotic effects from its prolongation of bleeding time. European Journal of Pharmacology. 339(2-3). 141–146. 48 indexed citations

20.

Okamoto, Yoshinori, Hiroyuki Koshio, Mitsuaki Ohta, et al.. (1996). Biological Activity of Analogues of YM022. Novel (3-Amino Substituted Phenyl)urea Derivatives of 1,4-Benzodiazepin-2-one as Gastrin/Cholecystokinin-B Receptor Antagonists.. Chemical and Pharmaceutical Bulletin. 44(7). 1412–1414. 4 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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