Hidetsugu Tsubouchi

1.6k total citations · 1 hit paper
34 papers, 1.3k citations indexed

About

Hidetsugu Tsubouchi is a scholar working on Organic Chemistry, Molecular Biology and Dermatology. According to data from OpenAlex, Hidetsugu Tsubouchi has authored 34 papers receiving a total of 1.3k indexed citations (citations by other indexed papers that have themselves been cited), including 16 papers in Organic Chemistry, 11 papers in Molecular Biology and 6 papers in Dermatology. Recurrent topics in Hidetsugu Tsubouchi's work include Synthesis and Catalytic Reactions (7 papers), Dermatology and Skin Diseases (6 papers) and Synthesis of β-Lactam Compounds (6 papers). Hidetsugu Tsubouchi is often cited by papers focused on Synthesis and Catalytic Reactions (7 papers), Dermatology and Skin Diseases (6 papers) and Synthesis of β-Lactam Compounds (6 papers). Hidetsugu Tsubouchi collaborates with scholars based in Japan, Spain and South Korea. Hidetsugu Tsubouchi's co-authors include Makoto Matsumoto, Hirofumi Sasaki, Hiroyuki Hashizume, Makoto Komatsu, Masanori Kawasaki, Yoshihiko Shimokawa, Hidehisa Saeki, Daisuke Yokota, Hiroshi Ishikawa and Naoko Baba and has published in prestigious journals such as Journal of Medicinal Chemistry, PLoS Medicine and Journal of the American Academy of Dermatology.

In The Last Decade

Hidetsugu Tsubouchi

34 papers receiving 1.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

OPC-67683, a Nitro-Dihydro-Imidazooxazole Derivative with Promising Action against Tuberculosis In Vitro and In Mice

2006 578 citations Makoto Matsumoto, Hiroyuki Hashizume et al. PLoS Medicine profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Hidetsugu Tsubouchi Japan	15	617	463	458	224	153	34	1.3k
Hiroshi Kawakami Japan	19	295 0.5×	207 0.4×	455 1.0×	276 1.2×	51 0.3×	68	1.4k
Mary E. Fling United States	16	377 0.6×	293 0.6×	330 0.7×	52 0.2×	51 0.3×	16	1.4k
Joachim Seipelt Austria	17	226 0.4×	181 0.4×	308 0.7×	47 0.2×	36 0.2×	22	972
Garbiñe Roy Spain	22	55 0.1×	423 0.9×	488 1.1×	58 0.3×	35 0.2×	58	1.7k
Patricia A. McKernan United States	19	225 0.4×	218 0.5×	440 1.0×	349 1.6×	37 0.2×	33	1.2k
Ruchi Pandey United States	16	260 0.4×	333 0.7×	549 1.2×	63 0.3×	16 0.1×	28	1.6k
David P. Jacobus United States	20	319 0.5×	223 0.5×	396 0.9×	360 1.6×	15 0.1×	59	1.3k
Tatsuya Akaki Japan	14	214 0.3×	296 0.6×	89 0.2×	41 0.2×	130 0.8×	22	612
Paul E. Steele United States	20	286 0.5×	490 1.1×	379 0.8×	102 0.5×	54 0.4×	54	1.2k
G. Lopez‐Berestein United States	17	267 0.4×	195 0.4×	548 1.2×	38 0.2×	13 0.1×	38	1.3k

Countries citing papers authored by Hidetsugu Tsubouchi

Since Specialization

Citations

This map shows the geographic impact of Hidetsugu Tsubouchi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hidetsugu Tsubouchi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hidetsugu Tsubouchi more than expected).

Fields of papers citing papers by Hidetsugu Tsubouchi

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hidetsugu Tsubouchi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hidetsugu Tsubouchi. The network helps show where Hidetsugu Tsubouchi may publish in the future.

Co-authorship network of co-authors of Hidetsugu Tsubouchi

This figure shows the co-authorship network connecting the top 25 collaborators of Hidetsugu Tsubouchi. A scholar is included among the top collaborators of Hidetsugu Tsubouchi based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hidetsugu Tsubouchi. Hidetsugu Tsubouchi is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Saeki, Hidehisa, Yukihiro Ohya, Naoko Baba, et al.. (2024). An Interim Report of a Phase 3, Long-Term, Open-Label Study to Evaluate Efficacy and Safety of Difamilast Ointment in Japanese Infants with Atopic Dermatitis. Dermatology and Therapy. 14(9). 2443–2455. 1 indexed citations

Saeki, Hidehisa, Tomomi Imamura, Daisuke Yokota, & Hidetsugu Tsubouchi. (2022). Difamilast Ointment in Japanese Adult and Pediatric Patients with Atopic Dermatitis: A Phase III, Long-Term, Open-Label Study. Dermatology and Therapy. 12(7). 1589–1601. 19 indexed citations

Saeki, Hidehisa, et al.. (2021). Difamilast ointment in adult patients with atopic dermatitis: A phase 3 randomized, double-blind, vehicle-controlled trial. Journal of the American Academy of Dermatology. 86(3). 607–614. 52 indexed citations

Saeki, Hidehisa, Naoko Baba, Kazuhide Oshiden, Yuji Abe, & Hidetsugu Tsubouchi. (2019). Phase 2, randomized, double‐blind, placebo‐controlled, 4‐week study to evaluate the safety and efficacy of OPA‐ 15406 (difamilast), a new topical selective phosphodiesterase type‐4 inhibitor, in Japanese pediatric patients aged 2–14 years with atopic dermatitis. The Journal of Dermatology. 47(1). 17–24. 29 indexed citations

Muto, Satoru, et al.. (2017). Long-term safety profile of tolvaptan in autosomal dominant polycystic kidney disease patients: TEMPO Extension Japan Trial. Drug Healthcare and Patient Safety. Volume 9. 93–104. 15 indexed citations

Sakaida, Isao, Koji Nakajima, Kiwamu Okita, et al.. (2015). Can serum albumin level affect the pharmacological action of tolvaptan in patients with liver cirrhosis? A post hoc analysis of previous clinical trials in Japan. Journal of Gastroenterology. 50(10). 1047–1053. 29 indexed citations

Matsumoto, Makoto, Hiroyuki Hashizume, Hidetsugu Tsubouchi, et al.. (2007). Screening for Novel Antituberculosis Agents that are Effective Against Multidrug Resistant Tuberculosis. Current Topics in Medicinal Chemistry. 7(5). 499–507. 28 indexed citations

Sasaki, Hirofumi, Hiroyuki Hashizume, Masanori Kawasaki, et al.. (2006). Synthesis and Antituberculosis Activity of a Novel Series of Optically Active 6-Nitro-2,3-dihydroimidazo[2,1-b]oxazoles. Journal of Medicinal Chemistry. 49(26). 7854–7860. 144 indexed citations

Matsumoto, Makoto, Hiroyuki Hashizume, Masanori Kawasaki, et al.. (2006). OPC-67683, a Nitro-Dihydro-Imidazooxazole Derivative with Promising Action against Tuberculosis In Vitro and In Mice. PLoS Medicine. 3(11). e466–e466. 578 indexed citations breakdown →

10.

Tsubouchi, Hidetsugu, et al.. (1997). Synthesis and structure-activity relationships of novel antiseptics. Bioorganic & Medicinal Chemistry Letters. 7(13). 1721–1724. 27 indexed citations

11.

Tsubouchi, Hidetsugu, et al.. (1996). Synthesis and structure-activity relationships of cephalosporins, 2-isocephems, and 2-oxaisocephems with C-3′ or C-7 catechol or related aromatics. Bioorganic & Medicinal Chemistry. 4(12). 2135–2149. 6 indexed citations

12.

Tsubouchi, Hidetsugu & Hiroshi Ishikawa. (1995). Synthesis and biological properties of a series of optically active 2-oxaisocephems. Bioorganic & Medicinal Chemistry. 3(2). 143–150. 4 indexed citations

13.

Tsubouchi, Hidetsugu, et al.. (1995). Synthesis and Antibacterial Activities of Optically Active Substituted 1,2-Dihydro-6-oxo-6H-pyrrolo(3,2,1-ij)quinoline-5-carboxylic Acids.. Chemical and Pharmaceutical Bulletin. 43(10). 1678–1682. 9 indexed citations

14.

Ishikawa, Hiroshi, Hidetsugu Tsubouchi, & KOICHI YASUMURA. (1994). Synthesis and biological activity of new optically active 2-oxaisocephems: 3-(N-alkylpyridinium-4′-thio)methyl derivatives. Bioorganic & Medicinal Chemistry Letters. 4(9). 1147–1152. 8 indexed citations

15.

Tsubouchi, Hidetsugu, K. Tsuji, KOICHI YASUMURA, & Hiroshi Ishikawa. (1994). Synthesis and Antibacterial Activities of 2-Oxaisocephems.. Chemical and Pharmaceutical Bulletin. 42(10). 2084–2089. 4 indexed citations

16.

Matsuoka, Hiroki, et al.. (1994). [Psoriasis exacerbated by alpha-interferon therapy in a case of chronic myelogenous leukemia].. PubMed. 35(3). 309–11. 2 indexed citations

17.

Tsubouchi, Hidetsugu, et al.. (1994). Use of 4- Nitro-N-phthalimide as Protective Group of Primary Amines. Synlett. 1994(1). 63–64. 14 indexed citations

18.

Horinouchi, Michiko, et al.. (1993). [Successful chronic daily administration of oral etoposide for a case of adult T cell leukemia].. PubMed. 20(10). 1387–90. 1 indexed citations

19.

Tamura, Yasumitsu, et al.. (1983). 1,3-Dipolar cycloaddition reaction of 1-methylperimidine 3-ylides with dimethyl acetylenedicarboxylate.. Chemical and Pharmaceutical Bulletin. 31(4). 1378–1381. 3 indexed citations

20.

Tamura, Yoshinori, et al.. (1982). イリド中間体を経由する複素環化合物の環の変換テトラヒドロ-γ-カルボリンからヘキサヒドロ-2,3-ジアゼピノ〔5,4-b〕インドールの合成. Heterocycles. 17. 163–166. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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