Gregory Hook

1.5k total citations
21 papers, 1.2k citations indexed

About

Gregory Hook is a scholar working on Physiology, Molecular Biology and Nutrition and Dietetics. According to data from OpenAlex, Gregory Hook has authored 21 papers receiving a total of 1.2k indexed citations (citations by other indexed papers that have themselves been cited), including 14 papers in Physiology, 13 papers in Molecular Biology and 5 papers in Nutrition and Dietetics. Recurrent topics in Gregory Hook's work include Alzheimer's disease research and treatments (14 papers), S100 Proteins and Annexins (7 papers) and Trace Elements in Health (5 papers). Gregory Hook is often cited by papers focused on Alzheimer's disease research and treatments (14 papers), S100 Proteins and Annexins (7 papers) and Trace Elements in Health (5 papers). Gregory Hook collaborates with scholars based in United States, Israel and Germany. Gregory Hook's co-authors include Vivian Hook, Mark S. Kindy, Thomas Toneff, Christoph Peters, Thomas Reinheckel, Michael C. Yoon, Anthony J. O’Donoghue, J. Steven Jacobsen, Hans‐Ulrich Demuth and Kenneth H. Grabstein and has published in prestigious journals such as Journal of Biological Chemistry, Biochemistry and Biochemical and Biophysical Research Communications.

In The Last Decade

Gregory Hook

21 papers receiving 1.1k citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Gregory Hook United States	17	612	537	213	196	146	21	1.2k
Sacha Uljon United States	16	659 1.1×	952 1.8×	249 1.2×	117 0.6×	191 1.3×	34	1.6k
Yasuhiro Nakagami Japan	20	296 0.5×	577 1.1×	203 1.0×	72 0.4×	102 0.7×	44	1.3k
CL Masters Australia	11	660 1.1×	910 1.7×	105 0.5×	142 0.7×	141 1.0×	18	1.4k
Athina Tzinia Greece	21	270 0.4×	494 0.9×	89 0.4×	186 0.9×	66 0.5×	35	1.2k
Leonid Tarassishin United States	19	293 0.5×	668 1.2×	83 0.4×	299 1.5×	90 0.6×	41	1.6k
Ha‐Na Woo South Korea	18	378 0.6×	830 1.5×	180 0.8×	130 0.7×	150 1.0×	38	1.5k
Juan R. Peinado Spain	24	544 0.9×	954 1.8×	250 1.2×	193 1.0×	63 0.4×	57	1.8k
Seung‐Yong Yoon South Korea	18	380 0.6×	520 1.0×	146 0.7×	61 0.3×	117 0.8×	28	1.2k
Patricia V. Burgos Chile	26	470 0.8×	889 1.7×	629 3.0×	107 0.5×	89 0.6×	52	1.8k
Isabell Greeve Germany	12	277 0.5×	402 0.7×	88 0.4×	65 0.3×	114 0.8×	21	1.1k

Countries citing papers authored by Gregory Hook

Since Specialization

Citations

This map shows the geographic impact of Gregory Hook's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gregory Hook with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gregory Hook more than expected).

Fields of papers citing papers by Gregory Hook

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gregory Hook. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gregory Hook. The network helps show where Gregory Hook may publish in the future.

Co-authorship network of co-authors of Gregory Hook

This figure shows the co-authorship network connecting the top 25 collaborators of Gregory Hook. A scholar is included among the top collaborators of Gregory Hook based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Gregory Hook. Gregory Hook is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

1.

Hook, Gregory, Mark S. Kindy, & Vivian Hook. (2023). Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer’s Disease Condition. Journal of Alzheimer s Disease. 93(1). 33–46. 12 indexed citations

2.

Hook, Gregory, Thomas Reinheckel, Junjun Ni, et al.. (2022). Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders. Pharmacological Reviews. 74(3). 600–629. 60 indexed citations

3.

Yoon, Michael C., Mitchell P. Christy, William H. Gerwick, et al.. (2022). Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B. Biochemistry. 61(4). 228–238. 20 indexed citations

4.

Yoon, Michael C., Zhenze Jiang, Mitchell P. Christy, et al.. (2021). Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions. ACS Chemical Biology. 16(9). 1628–1643. 42 indexed citations

5.

Hook, Vivian, Michael C. Yoon, Charles Mosier, et al.. (2020). Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1868(8). 140428–140428. 113 indexed citations

6.

Boutté, Angela M., Vivian Hook, George Anis Sarkis, et al.. (2020). Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid. Journal of Neurotrauma. 37(13). 1574–1586. 18 indexed citations

7.

Meng, Jie, Hong Qing, Gregory Hook, et al.. (2020). Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling. Journal of Neurochemistry. 155(3). 300–312. 24 indexed citations

8.

Hook, Gregory, J. Steven Jacobsen, Kenneth H. Grabstein, Mark S. Kindy, & Vivian Hook. (2015). Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate. Frontiers in Neurology. 6. 178–178. 83 indexed citations

9.

Hook, Gregory, Jin Yu, Thomas Toneff, Mark S. Kindy, & Vivian Hook. (2014). Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic. Journal of Alzheimer s Disease. 41(1). 129–149. 62 indexed citations

10.

Hook, Gregory, Vivian Hook, & Mark S. Kindy. (2011). The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-β and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, β-Secretase Activity. Journal of Alzheimer s Disease. 26(2). 387–408. 95 indexed citations

11.

Hook, Vivian, Lydiane Funkelstein, Jill Wegrzyn, et al.. (2011). Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1824(1). 89–104. 55 indexed citations

12.

Hook, Vivian, Gregory Hook, & Mark S. Kindy. (2010). Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce β-amyloid related to Alzheimer's disease. Biological Chemistry. 391(8). 861–72. 38 indexed citations

13.

Hook, Vivian, Mark S. Kindy, Thomas Reinheckel, Christoph Peters, & Gregory Hook. (2009). Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochemical and Biophysical Research Communications. 386(2). 284–288. 82 indexed citations

14.

Hook, Vivian, Mark S. Kindy, & Gregory Hook. (2008). Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein. Journal of Biological Chemistry. 283(12). 7745–7753. 177 indexed citations

15.

Hook, Vivian, Israël Schechter, Hans‐Ulrich Demuth, & Gregory Hook. (2008). Alternative pathways for production of β-amyloid peptides of Alzheimer's disease. Biological Chemistry. 389(8). 993–1006. 65 indexed citations

16.

Hook, Vivian, Israël Schechter, Hans‐Ulrich Demuth, & Gregory Hook. (2008). Alternative pathways for production of β-amyloid peptides of Alzheimer's disease. Biological Chemistry. 0(ja). 2555420020–37. 1 indexed citations

17.

Hook, Vivian, Mark S. Kindy, & Gregory Hook. (2007). Cysteine protease inhibitors effectively reduce in vivo levels of brain β-amyloid related to Alzheimer's disease. Biological Chemistry. 388(2). 247–52. 39 indexed citations

18.

Hook, Gregory, Vivian Hook, & Mark S. Kindy. (2007). Cysteine protease inhibitors reduce brain β-amyloid and β-secretase activity in vivo and are potential Alzheimer's disease therapeutics. Biological Chemistry. 388(9). 979–983. 33 indexed citations

19.

Hook, Vivian, Thomas Toneff, Matthew Bogyo, et al.. (2005). Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease. Biological Chemistry. 386(9). 931–40. 137 indexed citations

20.

Hook, Gregory, J. Bastacky, Thomas Hayes, Robert L. Conhaim, & Norman C. Staub. (1982). Frozen-Hydrated Lung Preparation for Low Temperature Scanning Electron Microscopy. Proceedings annual meeting Electron Microscopy Society of America. 40. 372–373. 6 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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