Graham Rena

7.5k total citations · 4 hit papers
52 papers, 5.7k citations indexed

About

Graham Rena is a scholar working on Molecular Biology, Surgery and Endocrinology, Diabetes and Metabolism. According to data from OpenAlex, Graham Rena has authored 52 papers receiving a total of 5.7k indexed citations (citations by other indexed papers that have themselves been cited), including 45 papers in Molecular Biology, 17 papers in Surgery and 14 papers in Endocrinology, Diabetes and Metabolism. Recurrent topics in Graham Rena's work include Metabolism, Diabetes, and Cancer (22 papers), Pancreatic function and diabetes (15 papers) and FOXO transcription factor regulation (14 papers). Graham Rena is often cited by papers focused on Metabolism, Diabetes, and Cancer (22 papers), Pancreatic function and diabetes (15 papers) and FOXO transcription factor regulation (14 papers). Graham Rena collaborates with scholars based in United Kingdom, United States and Switzerland. Graham Rena's co-authors include Ewan R. Pearson, D. Grahame Hardie, Philip Cohen, Terry G. Unterman, Shaodong Guo, Kei Sakamoto, Chim C. Lang, Alan R. Prescott, Xiaowei He and Miles D. Houslay and has published in prestigious journals such as Nucleic Acids Research, Journal of Biological Chemistry and Circulation.

In The Last Decade

Graham Rena

51 papers receiving 5.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The mechanisms of action of metformin

2017 1.6k citations Graham Rena, D. Grahame Hardie et al. Diabetologia profile →
Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 606 citations Graham Rena, Philip Cohen et al. Journal of Biological Chemistry profile →
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

2016 519 citations Amy Cameron, Mohapradeep Mohan et al. profile →
Molecular mechanism of action of metformin: old or new insights?

2013 369 citations Graham Rena, Ewan R. Pearson et al. Diabetologia profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Graham Rena United Kingdom	25	4.0k	1.1k	1.0k	867	499	52	5.7k
Shaodong Guo United States	42	4.9k 1.2×	1.1k 1.0×	1.2k 1.2×	1.7k 2.0×	416 0.8×	92	7.3k
Judy Fenyk‐Melody United States	10	3.9k 1.0×	1.4k 1.3×	1.7k 1.6×	1.1k 1.3×	499 1.0×	10	5.5k
Jocelyne Leclerc France	19	2.7k 0.7×	901 0.8×	1.2k 1.2×	1.0k 1.2×	372 0.7×	20	4.0k
Yasuo Ido United States	47	4.3k 1.1×	1.4k 1.2×	1.2k 1.1×	3.7k 4.2×	364 0.7×	93	9.5k
Mengwei Zang United States	30	3.3k 0.8×	1.1k 1.0×	986 1.0×	1.6k 1.8×	402 0.8×	42	6.1k
Carmen Argmann United States	32	3.3k 0.8×	409 0.4×	764 0.7×	2.8k 3.2×	414 0.8×	65	6.8k
Fawaz G. Haj United States	42	3.0k 0.8×	923 0.8×	628 0.6×	1.5k 1.7×	380 0.8×	87	5.7k
John Ventre United States	14	4.3k 1.1×	1.5k 1.4×	1.8k 1.7×	1.6k 1.8×	506 1.0×	18	6.2k
Zhijun Luo United States	47	5.5k 1.4×	849 0.8×	1.1k 1.1×	1.5k 1.7×	1.0k 2.0×	108	8.3k
Nico Mitro Italy	45	2.9k 0.7×	627 0.6×	1.2k 1.2×	1.3k 1.5×	911 1.8×	144	6.1k

Countries citing papers authored by Graham Rena

Since Specialization

Citations

This map shows the geographic impact of Graham Rena's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Graham Rena with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Graham Rena more than expected).

Fields of papers citing papers by Graham Rena

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Graham Rena. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Graham Rena. The network helps show where Graham Rena may publish in the future.

Co-authorship network of co-authors of Graham Rena

This figure shows the co-authorship network connecting the top 25 collaborators of Graham Rena. A scholar is included among the top collaborators of Graham Rena based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Graham Rena. Graham Rena is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

McNeilly, Alison D., et al.. (2025). In-depth proteomic profiling identifies potentiation of the LPS response by 7-ketocholesterol. PubMed. 11. 100285–100285. 1 indexed citations

Booth, David, et al.. (2024). Defining Activity Thresholds Triggering a “Stand Hour” for Apple Watch Users: Cross-Sectional Study. JMIR Formative Research. 8. e53806–e53806.

Rena, Graham, et al.. (2023). Metformin: evidence from preclinical and clinical studies for potential novel applications in cardiovascular disease. Expert Opinion on Investigational Drugs. 32(4). 291–299. 12 indexed citations

Arthur, J. Simon C., et al.. (2023). Inflammation as a therapeutic target in heart failure with preserved ejection fraction. Frontiers in Cardiovascular Medicine. 10. 1125687–1125687. 20 indexed citations

Mohan, Mohapradeep, et al.. (2021). Left Ventricular Hypertrophy in Diabetic Cardiomyopathy: A Target for Intervention. Frontiers in Cardiovascular Medicine. 8. 746382–746382. 43 indexed citations

Rena, Graham, Ify Mordi, & Chim C. Lang. (2020). Metformin: still the sweet spot for CV protection in diabetes?. Current Opinion in Pharmacology. 54. 202–208. 8 indexed citations

Mohan, Mohapradeep, et al.. (2019). Metformin and its potential for heart failure with preserved ejection fraction. Discovery Research Portal (University of Dundee). 1 indexed citations

Rena, Graham, D. Grahame Hardie, & Ewan R. Pearson. (2017). The mechanisms of action of metformin. Diabetologia. 60(9). 1577–1585. 1597 indexed citations breakdown →

Cameron, Amy, Lisa Logie, Kashyap Patel, et al.. (2017). Metformin selectively targets redox control of complex I energy transduction. Redox Biology. 14. 187–197. 117 indexed citations

10.

Rena, Graham & Kei Sakamoto. (2014). Salicylic acid: old and new implications for the treatment of type 2 diabetes?. Diabetology International. 5(4). 212–218. 20 indexed citations

11.

Rena, Graham, Ewan R. Pearson, & Kei Sakamoto. (2013). Molecular mechanism of action of metformin: old or new insights?. Diabetologia. 56(9). 1898–1906. 369 indexed citations breakdown →

12.

Cameron, Amy, et al.. (2009). Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes. Metallomics. 2(3). 195–203. 21 indexed citations

13.

Cameron, Amy, et al.. (2007). Black tea polyphenols mimic insulin/insulin‐like growth factor‐1 signalling to the longevity factor FOXO1a. Aging Cell. 7(1). 69–77. 46 indexed citations

14.

Rena, Graham, Jenny Bain, Matthew Elliott, & Philip Cohen. (2004). D4476, a cell‐permeant inhibitor of CK1, suppresses the site‐specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Reports. 5(1). 60–65. 217 indexed citations

15.

Patel, Satish, Pamela A. Lochhead, Graham Rena, et al.. (2002). Insulin Regulation of Insulin-like Growth Factor-binding Protein-1 Gene Expression Is Dependent on the Mammalian Target of Rapamycin, but Independent of Ribosomal S6 Kinase Activity. Journal of Biological Chemistry. 277(12). 9889–9895. 39 indexed citations

16.

Rena, Graham. (2002). Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. The EMBO Journal. 21(9). 2263–2271. 194 indexed citations

17.

Rena, Graham, Annette H. Ross, Ian McPhee, et al.. (2001). Molecular Cloning, Genomic Positioning, Promoter Identification, and Characterization of the Novel Cyclic AMP-Specific Phosphodiesterase PDE4A10. Molecular Pharmacology. 59(5). 996–1011. 57 indexed citations

18.

Patel, Satish, Pamela A. Lochhead, Graham Rena, & Calum Sutherland. (2001). Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression. Biochemical Journal. 359(3). 611–611. 14 indexed citations

19.

Shakur, Yasmin, Kazuyo Takeda, Zu‐Xi Yu, et al.. (2000). Membrane Localization of Cyclic Nucleotide Phosphodiesterase 3 (PDE3). Journal of Biological Chemistry. 275(49). 38749–38761. 92 indexed citations

20.

Kostić, Milena, Suat Erdoğan, Graham Rena, et al.. (1997). Altered Expression of PDE1 and PDE4 Cyclic Nucleotide Phosphodiesterase Isoforms in 7-oxo-prostacyclin-preconditioned Rat Heart. Journal of Molecular and Cellular Cardiology. 29(11). 3135–3146. 69 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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