Giuseppina De Simone

11.1k citations

166 papers · 8.5k indexed · 1 hit paper · h-index 47

Impact in

Physical and Theoretical Chemistry top 0.2%
- Chemical Reactions and Mechanisms
Organic Chemistry top 0.2%
- Synthesis and Catalytic Reactions
- Synthesis and Biological Evaluation

Papers in

Physical and Theoretical Chemistry 32
- Chemical Reactions and Mechanisms 31
Organic Chemistry 80
- Synthesis and Catalytic Reactions 67

Co-authors: Claudiu T. Supuran Anna Di Fiore Vincenzo Alterio Simona Maria Monti Katia D’Ambrosio Andrea Scozzafava Carlo Pedone Seppo Parkkila
Journals: Bioorganic & Medicinal Chemistry Letters (17 papers)Journal of Medicinal Chemistry (12 papers)Journal of Enzyme Inhibition and Medicinal Chemistry (9 papers)Journal of Molecular Biology (8 papers)Biopolymers (8 papers)
Partner nations: Italy France Finland

In The Last Decade

Giuseppina De Simone

161 papers receiving 8.4k citations

Hit Papers

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Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms? 2012 · 1.0k citations

Peers

Countries citing papers authored by Giuseppina De Simone

Since Specialization

Citations

This map shows the geographic impact of Giuseppina De Simone's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Giuseppina De Simone with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Giuseppina De Simone more than expected).

Fields of papers citing papers by Giuseppina De Simone

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Giuseppina De Simone. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Giuseppina De Simone. The network helps show where Giuseppina De Simone may publish in the future.

Co-authors

The 25 scholars most cited alongside Giuseppina De Simone, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Giuseppina De Simone Line = papers co-authored together Giuseppina De Simone links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Exploring the binding mode of phenyl and vinyl boronic acids to human carbonic anhydrases International Journal of Biological Macromolecules ·Davide Esposito, Simona Maria Monti, Claudiu T. Supuran, Jean‐Yves Winum, Giuseppina De Simone, Vincenzo Alterio	2024	1
2	Multiple Binding Modes of Inhibitors to Human Carbonic Anhydrases: An Update on the Design of Isoform-Specific Modulators of Activity Chemical Reviews ·Katia D’Ambrosio, Anna Di Fiore, Vincenzo Alterio, Joseph Ponera, Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone	2024	15
3	6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography Journal of Medicinal Chemistry ·Alessio Nocentini, Alessandro Bonardi, Carla Bazzicalupi, Vincenzo Alterio, Davide Esposito, Simona Maria Monti, Michaël Smietana, Giuseppina De Simone, Claudiu T. Supuran, Paola Gratteri, Jean‐Yves Winum	2023	13
4	Biochemical, structural, and computational studies of a γ-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei Computational and Structural Biotechnology Journal ·Anna Di Fiore, Viviana De Luca, Emma Langella, Alessio Nocentini, Martina Buonanno, Simona Maria Monti, Claudiu T. Supuran, Clemente Capasso, Giuseppina De Simone	2022	18
5	Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII Bioorganic & Medicinal Chemistry ·Merve Tatu, Anna Di Fiore, Laura De Luca, Andrea Angeli, Giuseppina De Simone, Claudiu T. Supuran, Rosaria Gitto	2021	5
6	Benzyl alcohol inhibits carbonic anhydrases by anchoring to the zinc coordinated water molecule Biochemical and Biophysical Research Communications ·Giuseppina De Simone, Silvia Bua, Claudiu T. Supuran, Vincenzo Alterio	2021	10
7	Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy Journal of Medicinal Chemistry ·Alessio Nocentini, Vincenzo Alterio, Silvia Bua, Laura Micheli, Davide Esposito, Martina Buonanno, Gianluca Bartolucci, Sameh M. Osman, Zeid A. ALOthman, Roberto Cirilli, Marco Pierini, Simona Maria Monti, Lorenzo Di Cesare Mannelli, Paola Gratteri, Carla Ghelardini, Giuseppina De Simone, Claudiu T. Supuran	2020	28
8	Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides Journal of Enzyme Inhibition and Medicinal Chemistry ·Florencia Haase, Andrea Angeli, Vesa P. Hytönen, Anna Di Fiore, Giuseppina De Simone, Seppo Parkkila, Claudiu T. Supuran	2020	6
9	Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment Metabolites ·Andrea Angeli, Fabrizio Carta, Alessio Nocentini, Jean‐Yves Winum, Raivis Žalubovskis, Atilla Akdemir, Valentina Onnis, Wagdy M. Eldehna, Clemente Capasso, Giuseppina De Simone, Simona Maria Monti, Simone Carradori, William A. Donald, Shoukat Dedhar, Claudiu T. Supuran	2020	141
10	Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms ACS Medicinal Chemistry Letters ·Merve Tatu, Anna Di Fiore, Laura De Luca, Andrea Angeli, Simona Maria Monti, Giuseppina De Simone, Claudiu T. Supuran, Rosaria Gitto	2020	9
11	Are Carbonic Anhydrases Suitable Targets to Fight Protozoan Parasitic Diseases? Current Medicinal Chemistry ·Katia D’Ambrosio, Claudiu T. Supuran, Giuseppina De Simone	2018	26
12	Protective Role of Carbonic Anhydrases III and VII in Cellular Defense Mechanisms upon Redox Unbalance Oxidative Medicine and Cellular Longevity ·Anna Di Fiore, Daria Maria Monti, Andrea Scaloni, Giuseppina De Simone, Simona Maria Monti	2018	35
13	Anticancer carbonic anhydrase inhibitors: a patent review (2008 – 2013) Expert Opinion on Therapeutic Patents ·Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone	2013	230
14	Recent Advances in Structural Studies of the Carbonic Anhydrase Family: The Crystal Structure of Human CA IX and CA XIII Current Pharmaceutical Design ·Claudiu T. Supuran, Anna Di Fiore, Vincenzo Alterio, Simona Maria Monti, Giuseppina De Simone	2010	34
15	Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography Molecular Cancer Therapeutics ·L. W. Lawrence Woo, Delphine S. Fischer, Hee-Sun Cho, Ahsan Sharif, Paul Foster, Surinder K. Chander, Anna Di Fiore, Claudiu T. Supuran, Giuseppina De Simone, Atul Purohit, Michael Reed, Barry V. L. Potter	2008	35
16	Functional and structural features of the oxyanion hole in a thermophilic esterase from Alicyclobacillus acidocaldarius Proteins Structure Function and Bioinformatics ·Luigi Mandrich, Valeria Menchise, Vincenzo Alterio, Giuseppina De Simone, Carlo Pedone, Mosé Rossi, Giuseppe Manco	2007	31
17	Insights on a New PDI-like Family: Structural and Functional Analysis of a Protein Disulfide Oxidoreductase from the Bacterium Aquifex aeolicus Journal of Molecular Biology ·Emilia Pedone, Katia D’Ambrosio, Giuseppina De Simone, Mosé Rossi, Carlo Pedone, Simonetta Bartolucci	2005	23
18	Crystallization and preliminary X-ray diffraction studies of a protein disulfide oxidoreductase fromAquifex aeolicus Acta Crystallographica Section D Biological Crystallography ·Katia D’Ambrosio, Giuseppina De Simone, Emilia Pedone, Mosé Rossi, Simonetta Bartolucci, Carlo Pedone	2004	7
19	Crystallization and preliminary X-ray diffraction studies of aD-lysine-based chiral PNA–DNA duplex Acta Crystallographica Section D Biological Crystallography ·Valeria Menchise, Giuseppina De Simone, Roberto Corradini, Stefano Sforza, Anna Sofia Rossholm, Alessandra Romanelli, Michele Saviano, Carlo Pedone	2002	6
20	The crystal structure of aDcp-containing peptide Biopolymers ·Giuseppina De Simone, Angela Lombardi, Stefania Galdiero, Flavia Nastri, Luigi Di Costanzo, Shin Gohda, R. Nacken, Takashi Yamada, Vincenzo Pavone	2000	12

About Giuseppina De Simone

Giuseppina De Simone is a scholar working on Physical and Theoretical Chemistry, Organic Chemistry, Pharmacology, Molecular Biology and Hematology, having authored 166 papers that have together received 8.5k indexed citations. Recurring topics across this work include Enzyme function and inhibition (113 papers), Synthesis and Catalytic Reactions (67 papers), Cholinesterase and Neurodegenerative Diseases (40 papers), Chemical Reactions and Mechanisms (31 papers), Phenothiazines and Benzothiazines Synthesis and Activities (17 papers), Enzyme Catalysis and Immobilization (15 papers), Enzyme Structure and Function (12 papers) and Chemical Synthesis and Analysis (10 papers). The work is most often cited by research in Physical and Theoretical Chemistry (1.7k citations), Organic Chemistry (4.6k citations), Pharmacology (2.4k citations), Molecular Biology (7.5k citations) and Biochemistry (158 citations). Giuseppina De Simone has collaborated with scholars based in Italy, France and Finland. Frequent co-authors include Claudiu T. Supuran, Anna Di Fiore, Vincenzo Alterio, Simona Maria Monti, Katia D’Ambrosio, Andrea Scozzafava, Carlo Pedone, Seppo Parkkila, Valeria Menchise and Andrea Scaloni. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Journal of Enzyme Inhibition and Medicinal Chemistry, Journal of Molecular Biology and Biopolymers.

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