Gerhard Heßler

2.9k citations

56 papers · 2.1k indexed · h-index 22

Impact in

Computational Theory and Mathematics top 0.5%
- Computational Drug Discovery Methods
Health Informatics top 5%

Papers in

Computational Theory and Mathematics 29
- Computational Drug Discovery Methods 29
Molecular Biology 36
- Chemical Synthesis and Analysis 12
- Protein Structure and Dynamics 8
- Receptor Mechanisms and Signaling 6

Co-authors: Thomas Klabunde Karl‐Heinz Baringhaus Hans Matter Horst Kessler Matthias Hoffmann Andreas Evers Gerhard Müller Erich Graf von Roedern
Journals: Journal of Chemical Information and Modeling (9 papers)Journal of Medicinal Chemistry (7 papers)ChemMedChem (4 papers)Angewandte Chemie International Edition (3 papers)Journal of Cheminformatics (3 papers)
Partner nations: Germany France United States

In The Last Decade

Gerhard Heßler

54 papers receiving 2.0k citations

Peers

Countries citing papers authored by Gerhard Heßler

Since Specialization

Citations

This map shows the geographic impact of Gerhard Heßler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gerhard Heßler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gerhard Heßler more than expected).

Fields of papers citing papers by Gerhard Heßler

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gerhard Heßler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gerhard Heßler. The network helps show where Gerhard Heßler may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Gerhard Heßler, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Gerhard Heßler Line = papers co-authored together Gerhard Heßler links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo Journal of Medicinal Chemistry ·Morgan R Light, Kerstin Jahn‐Hofmann, Bodo Brunner, Mike W. Helms, W. Emboden, Gupta SS, Gernot Zech, Ziyu Li, Gerhard Heßler, Herman Schreuder, Bettina Elshorst, Megan Lechleitner, Michael Kurz, Bakul Tikoo, Sabine Scheidler	2025	0
2	Modern machine‐learning for binding affinity estimation of protein–ligand complexes: Progress, opportunities, and challenges Wiley Interdisciplinary Reviews Computational Molecular Science ·E. Peiper, 耿淑芳, Christoph Grebner, Gerhard Heßler, Matthias Rarey	2024	8
3	Task‐Similarity is a Crucial Factor for Few‐Shot Meta‐Learning of Structure‐Activity Relationships ChemBioChem ·А. V. Zamoryakhin, 新本洋士, Christoph Grebner, Hans Matter, Jan A. Hiss, Gisbert Schneider, Gerhard Heßler	2024	1
4	Back in Person: Frontiers in Medicinal Chemistry 2023 ChemMedChem ·Matthias Gehringer, E. Koumpia, Marı́a Méndez, Florian Gremme, M. R. Tagajdid, Julien Lefranc, Franca‐Maria Klingler, Gerhard Heßler, Thierry Langer, Eleonora Diamanti, Matthias Schiedel	2023	0
5	Optimizing interactions to protein binding sites by integrating docking-scoring strategies into generative AI methods Frontiers in Chemistry ·张永芳, Hans Matter, Gerhard Heßler, Christoph Grebner	2022	9
6	The PROTACtable genome Nature Reviews Drug Discovery ·Melanie Schneider, Chris J. Radoux, Emisa Koguma, David Ochoa, Ian Dunham, Lykourgos‐Panagiotis Zalmas, Gerhard Heßler, Sven Ruf, Veerabahu Shanmugasundaram, Michael M. Hann, 胡家驿, Markus A. Queisser, Andrew B. Benowitz, Anne Langlois-Lafitte, Andrew R. Leach	2021	162
7	Artificial Intelligence in Compound Design Methods in molecular biology ·Christoph Grebner, Hans Matter, Gerhard Heßler	2021	6
8	Quantum–mechanical property prediction of solvated drug molecules: what have we learned from a decade of SAMPL blind prediction challenges? Journal of Computer-Aided Molecular Design ·慎二宮澤, Vora Nancy Jayeshbhai, Gerhard Heßler, Friedemann Schmidt, Stefan Güssregen, Stefan M. Kast	2020	13
9	Using Graph Databases to Investigate Trends in Structure–Activity Relationship Networks Journal of Chemical Information and Modeling ·Hans Matter, Christian Buning, Man Foon Chau, Sven Ruf, Gerhard Heßler	2020	6
10	Peptide Optimization at the Drug Discovery-Development Interface: Tailoring of Physicochemical Properties Toward Specific Formulation Requirements Journal of Pharmaceutical Sciences ·Andreas Evers, Stefania Pfeiffer‐Marek, Martin Bossart, Bakul Tikoo, Mengpo Zhao, 郑轶民, Z Conić, Bettina Elshorst, Anja Pfenninger, Adriana BORDINO, Gerhard Heßler, Walter Kamm, Michael Wagner	2018	20
11	The hpCADD NDDO Hamiltonian: Parametrization Journal of Chemical Information and Modeling ·Inna Pavlova, Matthias Hennemann, Wm. H. Fennen, Franziska Hoffgaard, Stefan Güssregen, Gerhard Heßler, Stefan M. Kast, Timothy Clark	2017	9
12	Thermodynamic Characterization of Hydration Sites from Integral Equation-Derived Free Energy Densities: Application to Protein Binding Sites and Ligand Series Journal of Chemical Information and Modeling ·Stefan Güssregen, Hans Matter, Gerhard Heßler, Sathish Kumar M, Zhao Yu-kun, Stefan M. Kast	2017	20
13	A Combination of Spin Diffusion Methods for the Determination of Protein–Ligand Complex Structural Ensembles Angewandte Chemie International Edition ·Jens Pilger, Artur Mazur, Peter Monecke, Herman Schreuder, Bettina Elshorst, Stefan Bartoschek, Thomas Langer, A Froufe Sánchez, Isabelle Krimm, 森修一, Donghan Lee, Gerhard Heßler, K. Ulrich Wendt, Stefan Becker, Christian Griesinger	2015	16
14	Fractal Dimensions of Macromolecular Structures Molecular Informatics ·Matilda Sjöblom, Jens Kunze, Herman Schreuder, Gerhard Heßler, Karl‐Heinz Baringhaus, Gisbert Schneider	2014	14
15	Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules Bioorganic & Medicinal Chemistry ·Hans Matter, Lennart T. Anger, 李鹏宇, Stefan Güssregen, Gerhard Heßler, Karl‐Heinz Baringhaus	2012	29
16	Identification and Application of Antitarget Activity Hotspots to Guide Compound Optimization Molecular Informatics ·Gerhard Heßler, Hans Matter, Friedemann Schmidt, 李鹏宇, L Gulitz, Stefan Güssregen, Karl‐Heinz Baringhaus	2011	4
17	The scaffold hopping potential of pharmacophores Drug Discovery Today Technologies ·Gerhard Heßler, Karl‐Heinz Baringhaus	2010	53
18	Drug Design Strategies for Targeting G-Protein-Coupled Receptors ChemBioChem ·Thomas Klabunde, Gerhard Heßler	2002	390
19	Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent α4β1 integrin antagonists Bioorganic & Medicinal Chemistry Letters ·Gerhard Müller, 백맹언, R. X. Fischer, Gerhard Heßler, Thomas E. Lehmann, R. Bröttcher, Masaomi Tajimi, Kevin B. Bacon, Thomas Rölle	2001	13
20	Structure of a stereoregular phosphorothioate DNA/RNA duplex Nature Structural Biology ·O. Chinnappa Reddy, Gerhard Heßler, 美奈子岡, J. Hacia, Peter B. Dervan, Horst Kessler	1998	41

About Gerhard Heßler

Gerhard Heßler is a scholar working on Computational Theory and Mathematics, Molecular Biology, Environmental Chemistry, Organic Chemistry and Spectroscopy, having authored 56 papers that have together received 2.1k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (29 papers), Chemical Synthesis and Analysis (12 papers), Machine Learning in Materials Science (10 papers), Protein Structure and Dynamics (8 papers), Receptor Mechanisms and Signaling (6 papers), Microbial Natural Products and Biosynthesis (4 papers), Analytical Chemistry and Chromatography (4 papers) and Chemistry and Chemical Engineering (4 papers). The work is most often cited by research in Computational Theory and Mathematics (642 citations), Health Informatics (31 citations), Molecular Biology (1.5k citations), Organic Chemistry (456 citations) and Sensory Systems (69 citations). Gerhard Heßler has collaborated with scholars based in Germany, France and United States. Frequent co-authors include Thomas Klabunde, Karl‐Heinz Baringhaus, Hans Matter, Horst Kessler, Matthias Hoffmann, Andreas Evers, Gerhard Müller, Erich Graf von Roedern, Elisabeth Lohof and Christoph Grebner. Their work appears in journals such as Journal of Chemical Information and Modeling, Journal of Medicinal Chemistry, ChemMedChem, Angewandte Chemie International Edition and Journal of Cheminformatics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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