Fraser P. Coxon

21.3k citations

68 papers · 8.4k indexed · 5 hit papers · h-index 35

Oncology top 0.2%
Molecular Biology top 2%
Orthopedics and Sports Medicine top 0.1%
Radiology, Nuclear Medicine and Imaging top 1%
Rheumatology top 1%

Co-authors: Michael J. Rogers Steven P. Luckman R.G.G. Russell Frank H. Ebetino Jukka Mönkkönen Keith Thompson Miep Helfrich Helena L. Benford
Topics: Bone health and treatments (50 papers)Bone Metabolism and Diseases (27 papers)Radiopharmaceutical Chemistry and Applications (14 papers)
Cited by: Orthopedics and Sports Medicine Oncology Radiology, Nuclear Medicine and Imaging
Journals: Journal of Biological Chemistry Journal of Clinical Investigation Molecular Cell
Partner nations: United Kingdom United States Poland

In The Last Decade

Fraser P. Coxon

68 papers receiving 8.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras

1998 977 citations Steven P. Luckman, Fraser P. Coxon et al. profile →
Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates

2001 726 citations James E. Dunford, Keith Thompson et al. profile →
Cellular and molecular mechanisms of action of bisphosphonates

2000 720 citations Michael J. Rogers, Sharon Gordon et al. Cancer profile →
Cellular and molecular mechanisms of action of bisphosphonates

2000 571 citations Michael J. Rogers, Sharon Gordon et al. Cancer profile →
PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

2014 431 citations David G. McEwan, Doris Popovic et al. Molecular Cell profile →

Peers

Countries citing papers authored by Fraser P. Coxon

Since Specialization

Citations

This map shows the geographic impact of Fraser P. Coxon's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Fraser P. Coxon with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Fraser P. Coxon more than expected).

Fields of papers citing papers by Fraser P. Coxon

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Fraser P. Coxon. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Fraser P. Coxon. The network helps show where Fraser P. Coxon may publish in the future.

Co-authorship network of co-authors of Fraser P. Coxon

This figure shows the co-authorship network connecting the top 25 collaborators of Fraser P. Coxon. A scholar is included among the top collaborators of Fraser P. Coxon based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Fraser P. Coxon. Fraser P. Coxon is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure 2023 ·Platelets ·(unknown),Claire S. Whyte,Fraser P. Coxon,Nicola J. Mutch	6
2	PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteinsbreakdown → 2014 ·Molecular Cell ·David G. McEwan,Doris Popovic,Andrea Gubaš,Seigo Terawaki,H. Suzuki,Daniela Stadel,Fraser P. Coxon,(unknown),Sagar Bhogaraju,Karthik Maddi,(unknown),Evelina Gatti,Miep Helfrich,Soichi Wakatsuki,Christian Behrends,Philippe Pierre,Ivan Đikić	431
3	Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT 2014 ·European Journal of Medicinal Chemistry ·Fraser P. Coxon,(unknown),Arafath K. Najumudeen,(unknown),(unknown),(unknown),(unknown),James E. Dunford,Daniel Abankwa,K. M. Błażewska	23
4	Jaw bone marrow-derived osteoclast precursors internalize more bisphosphonate than long-bone marrow precursors 2013 ·Bone ·Jenny A. F. Vermeer,Ineke D.C. Jansen,(unknown),Fraser P. Coxon,Charles E. McKenna,Shuting Sun,Teun J. de Vries,Vincent Everts	37
5	The regulation of osteoclast function and bone resorption by small GTPases 2011 ·Small GTPases ·Cécile Itzstein,Fraser P. Coxon,Michael J. Rogers	119
6	Generation of Human Osteoclasts from Peripheral Blood 2011 ·Methods in molecular biology ·Kim Henriksen,M.A. Karsdal,Adam Taylor,(unknown),Fraser P. Coxon	33
7	The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates 2011 ·Bone ·Fraser P. Coxon,Adam Taylor,(unknown),Rudi Baron,Miguel C. Seabra,Frank H. Ebetino,Michael J. Rogers	7
8	Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function 2011 ·Small GTPases ·Adam Taylor,Emilie H. Mules,Miguel C. Seabra,Miep Helfrich,Michael J. Rogers,Fraser P. Coxon	23
9	Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors 2011 ·European Journal of Medicinal Chemistry ·K. M. Błażewska,Feng Ni,Ralf Haiges,B. A. Kashemirov,Fraser P. Coxon,(unknown),Rudi Baron,Michael J. Rogers,Miguel C. Seabra,Frank H. Ebetino,Charles E. McKenna	24
10	Biochemical and molecular mechanisms of action of bisphosphonates 2010 ·Bone ·Michael J. Rogers,Julie C. Crockett,Fraser P. Coxon,Jukka Mönkkönen	400
11	Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase 2008 ·Journal of Biological Chemistry ·Rudi Baron,Richard Tavaré,Ana C. Figueiredo,K. M. Błażewska,B. A. Kashemirov,Charles E. McKenna,Frank H. Ebetino,Adam Taylor,Michael J. Rogers,Fraser P. Coxon,Miguel C. Seabra	46
12	Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells 2008 ·Bone ·Fraser P. Coxon,Keith Thompson,Anke J. Roelofs,Frank H. Ebetino,Michael J. Rogers	190
13	A Novel Method for Efficient Generation of Transfected Human Osteoclasts 2007 ·Calcified Tissue International ·Adam Taylor,Michael J. Rogers,(unknown),Fraser P. Coxon	19
14	Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans 2007 ·Journal of Clinical Investigation ·Liesbeth Van Wesenbeeck,Paul R. Odgren,Fraser P. Coxon,Annalisa Frattini,Pierre Moens,Bram Perdu,Carole A. MacKay,Els Van Hul,Jean‐Pierre Timmermans,Filip Vanhoenacker,Reinhilde Jacobs,Barbara Peruzzi,Anna Teti,Miep Helfrich,Michael J. Rogers,Anna Villa,Wim Van Hul	163
15	Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo 2005 ·Bone ·Fraser P. Coxon,Frank H. Ebetino,Emilie H. Mules,Miguel C. Seabra,Charles E. McKenna,Michael J. Rogers	86
16	Pharmacoeconomic analysis of Capecitabine in the adjuvant setting. Results from the X-ACT trial comparing capecitabine with 5-FU/LV in patients with Dukes' C colon cancer 2004 ·Annals of Oncology ·(unknown),C.J. Twelves,J McKendrick,Oscar Bertetto,Fraser P. Coxon,Eduardo Díaz‐Rubio,P. Dufour,(unknown),Werner Scheithauer,Howard A. Burris	7
17	The Role of Prenylated Small GTP-Binding Proteins in the Regulation of Osteoclast Function 2003 ·Calcified Tissue International ·Fraser P. Coxon,Michael J. Rogers	72
18	Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages 2001 ·Journal of Biological Chemistry ·Fraser P. Coxon,Miep Helfrich,Banafshé Larijani,M Muzylak,James E. Dunford,Deborah Marshall,Alastair McKinnon,Stephen A. Nesbitt,Michael A. Horton,Miguel C. Seabra,Frank H. Ebetino,Michael J. Rogers	136
19	Cellular and molecular mechanisms of action of bisphosphonatesbreakdown → 2000 ·Cancer ·Michael J. Rogers,Sharon Gordon,Helena L. Benford,Fraser P. Coxon,Steven P. Luckman,Jukka Mönkkönen,Julie C. Frith	720
20	Molecular mechanisms of action of bisphosphonates 1999 ·Bone ·Michael J. Rogers,Julie C. Frith,Steven P. Luckman,Fraser P. Coxon,Helena L. Benford,Jukka Mönkkönen,Seppo Auriola,(unknown),R.G.G. Russell	181

About Fraser P. Coxon

Fraser P. Coxon is a scholar working on Orthopedics and Sports Medicine, Oncology and Radiology, Nuclear Medicine and Imaging, having authored 68 papers that have together received 8.4k indexed citations. Recurring topics across this work include Bone health and treatments (50 papers), Bone Metabolism and Diseases (27 papers) and Radiopharmaceutical Chemistry and Applications (14 papers). The work is most often cited by research in Orthopedics and Sports Medicine (2.9k citations), Oncology (5.7k citations) and Radiology, Nuclear Medicine and Imaging (1.4k citations). Fraser P. Coxon has collaborated with scholars based in United Kingdom, United States and Poland. Frequent co-authors include Michael J. Rogers, Steven P. Luckman, R.G.G. Russell, Frank H. Ebetino, Jukka Mönkkönen, Keith Thompson, Miep Helfrich, Helena L. Benford, Julie C. Frith and Julie C. Crockett. Their work appears in journals such as Journal of Biological Chemistry, Journal of Clinical Investigation and Molecular Cell.

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