Frank Grams

2.8k citations

28 papers · 2.1k indexed · 1 hit paper · h-index 19

Impact in

Cancer Research top 1%
- Protease and Inhibitor Mechanisms
Oncology top 5%
- Peptidase Inhibition and Analysis

Papers in

Cancer Research 22
- Protease and Inhibitor Mechanisms 22
Hematology 9
- Blood Coagulation and Thrombosis Mechanisms 9

Co-authors: Peter Reinemer F. Xavier Gomis‐Rüth Wolfram Bode Walter Stöcker Robert Huber Hans‐Willi Krell Harald Tschesche Michael Pieper
Journals: Journal of Biological Chemistry (4 papers)Biological Chemistry (3 papers)Journal of Medicinal Chemistry (3 papers)FEBS Letters (2 papers)European Journal of Biochemistry (2 papers)
Partner nations: Germany United States Switzerland

In The Last Decade

Frank Grams

28 papers receiving 2.0k citations

Hit Papers

align trajectories log scale

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases 1995 · 535 citations

Peers

Countries citing papers authored by Frank Grams

Since Specialization

Citations

This map shows the geographic impact of Frank Grams's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frank Grams with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frank Grams more than expected).

Fields of papers citing papers by Frank Grams

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frank Grams. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frank Grams. The network helps show where Frank Grams may publish in the future.

Co-authors

The 25 scholars most cited alongside Frank Grams, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Frank Grams Line = papers co-authored together Frank Grams links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Stimulation of Matrix Metalloproteinase-9 Expression in Human Fibrosarcoma Cells by Synthetic Matrix Metalloproteinase Inhibitors Experimental Cell Research ·Erik Maquoi, Carine Munaut, Alain Colige, Charles Lambert, Françis Frankenne, Agnès Noël, Frank Grams, Hans‐Willi Krell, Jean‐Michel Foidart	2002	23
2	Pyrimidine-2,4,6-triones: A new effective and selective class of matrix metalloproteinase inhibitors (vol 382, pg 1278, 2001) Biological Chemistry ·Frank Grams, Hans Brandstetter, S. D’Alò, Kenichi Tsukada, H. W. Krell, Herbert Leinert, Brooke Bn, E. MENTA, Ambrogio Oliva, Joanna Strzemecka	2001	2
3	The 1.8-Å Crystal Structure of a Matrix Metalloproteinase 8-Barbiturate Inhibitor Complex Reveals a Previously Unobserved Mechanism for Collagenase Substrate Recognition Journal of Biological Chemistry ·Hans Brandstetter, Frank Grams, Ismailov A.M., R. Voelker, Robert Huber, Wolfram Bode, Hans‐Willi Krell, Richard A. Engh	2001	101
4	Pyrimidine-2,4,6-Triones: A New Effective and Selective Class of Matrix Metalloproteinase Inhibitors Biological Chemistry ·Frank Grams, Hans Brandstetter, S. D’Alò, Kenichi Tsukada, Hans‐Willi Krell, Herbert Leinert, Brooke Bn, Ernesto Menta, Ambrogio Oliva, Gerd W. Zimmermann	2001	122
5	Identification of the 183RWTNNFREY191Region as a Critical Segment of Matrix Metalloproteinase 1 for the Expression of Collagenolytic Activity Journal of Biological Chemistry ·Linda Chung, Ken‐ichi Shimokawa, Deendayal Dinakarpandian, Frank Grams, Gregg B. Fields, Hideaki Nagase	2000	107
6	Type IV Collagen Induces Matrix Metalloproteinase 2 Activation in HT1080 Fibrosarcoma Cells Experimental Cell Research ·Erik Maquoi, Françis Frankenne, Agnès Noël, Hans‐Willi Krell, Frank Grams, Jean‐Michel Foidart	2000	58
7	Paradoxical Stimulation of Matrix Metalloproteinase‐9 Expression in HT1080 Cells by a Broad‐Spectrum Hydroxamate‐Based Matrix Metalloproteinase Inhibitor Annals of the New York Academy of Sciences ·Erik Maquoi, Carine Munaut, Alain Colige, Cécile Lambert, Françis Frankenne, Agnès Noël, Frank Grams, H. W. Krell, Jean‐Michel Foidart	1999	4
8	Insights into MMP‐TIMP Interactions Annals of the New York Academy of Sciences ·Wolfram Bode, C. Fernandez-Catalan, Frank Grams, F. Xavier Gomis‐Rüth, Hideaki Nagase, H. Tschesche, K. Maskos	1999	166
9	Structure of malonic acid‐based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data Protein Science ·Hans Brandstetter, Richard A. Engh, Erich Graf von Roedern, Luis Moroder, Robert Huber, F. P. GAMBRA, Frank Grams	1998	35
10	Diarylsulfonamides as selective, non-peptidic thrombin inhibitors Bioorganic & Medicinal Chemistry Letters ·Irene T. Weber, Richard Neidlein, Wolfgang von der Saal, Frank Grams, Herbert Leinert, K. Strein, Richard A. Engh, Pingwei Zhou	1998	9
11	Non-Peptidic Cysteine Derivatives as Inhibitors of Matrix Metalloproteinases Biological Chemistry ·Clara Armando, Sidnei Francisco do Nascimento, Erich Graf von Roedern, Frank Grams, Hideaki Nagase, Luis Moroder	1997	8
12	The Metzincin-Superfamily of Zinc-Peptidases Advances in experimental medicine and biology ·Wolfram Bode, Frank Grams, Peter Reinemer, F. Xavier Gomis‐Rüth, Ulrich Baumann, Bram Veenhuizen, Walter Stöcker	1996	60
13	A new efficient method for the synthesis of 1,4‐benzodiazepine‐2,5‐dione diversomers Biopolymers ·Luis Moroder, Jürgen Lutz, Frank Grams, Sabine Rudolph‐Böhner, George Ösapay, Murray Goodman, R. Hussa	1996	5
14	Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor Biochemistry ·Frank Grams, Mats Brunström, Ichsan Syuhudi, Philip Huxley, Michael Pieper, Harald Tschesche, Wolfram Bode	1995	146
15	X-ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors. Implications for Substrate Binding and Rational Drug Design European Journal of Biochemistry ·Frank Grams, Peter Reinemer, James C. Powers, T. Kleine, Michael Pieper, Harald Tschesche, Robert Huber, Wolfram Bode	1995	155
16	The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases Protein Science ·Walter Stöcker, Frank Grams, Peter Reinemer, Nagai Susumu, 昭則阿波, F. Xavier Gomis‐Rüth, Cate Hit paper breakdown →	1995	535
17	X-ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors. Implications for Substrate Binding and Rational Drug Design European Journal of Biochemistry ·Frank Grams, Peter Reinemer, James C. Powers, T. Kleine, Michael Pieper, Harald Tschesche, Robert Huber, Wolfram Bode	1995	41
18	ChemInform Abstract: The Synthesis of Phosphonamidate Peptides ChemInform ·Maryam Mohammadlou, Frank Grams, Longhao Yi, Luis Moroder	1995	2
19	Structural implications for the role of the N terminus in the ‘superactivation’ of collagenases FEBS Letters ·Peter Reinemer, Frank Grams, Robert Huber, T. Kleine, Susanne Schnierer, Dunja Brötz, H. Tschesche, Nagai Susumu	1994	116
20	Activation of snake venom metalloproteinases by a cysteine switch‐like mechanism FEBS Letters ·Frank Grams, Robert Huber, Lawrence F. Kress, Luis Moroder, Nagai Susumu	1993	88

About Frank Grams

Frank Grams is a scholar working on Cancer Research, Hematology, Oncology, Immunology and Allergy and Genetics, having authored 28 papers that have together received 2.1k indexed citations. Recurring topics across this work include Protease and Inhibitor Mechanisms (22 papers), Peptidase Inhibition and Analysis (15 papers), Blood Coagulation and Thrombosis Mechanisms (9 papers), S100 Proteins and Annexins (5 papers), Coagulation, Bradykinin, Polyphosphates, and Angioedema (3 papers), Chemical Synthesis and Analysis (3 papers), Venomous Animal Envenomation and Studies (3 papers) and Phosphorus compounds and reactions (2 papers). The work is most often cited by research in Cancer Research (1.1k citations), Oncology (974 citations), Hematology (388 citations), Immunology and Allergy (186 citations) and Biotechnology (143 citations). Frank Grams has collaborated with scholars based in Germany, United States and Switzerland. Frequent co-authors include Peter Reinemer, F. Xavier Gomis‐Rüth, Wolfram Bode, Walter Stöcker, Robert Huber, Hans‐Willi Krell, Harald Tschesche, Michael Pieper, Luis Moroder and Hideaki Nagase. Their work appears in journals such as Journal of Biological Chemistry, Biological Chemistry, Journal of Medicinal Chemistry, FEBS Letters and European Journal of Biochemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact