Ed S. Lein

50.5k total citations · 4 hit papers
65 papers, 10.3k citations indexed

About

Ed S. Lein is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Neurology. According to data from OpenAlex, Ed S. Lein has authored 65 papers receiving a total of 10.3k indexed citations (citations by other indexed papers that have themselves been cited), including 40 papers in Molecular Biology, 16 papers in Cellular and Molecular Neuroscience and 16 papers in Neurology. Recurrent topics in Ed S. Lein's work include Single-cell and spatial transcriptomics (31 papers), Neuroinflammation and Neurodegeneration Mechanisms (16 papers) and Cell Image Analysis Techniques (13 papers). Ed S. Lein is often cited by papers focused on Single-cell and spatial transcriptomics (31 papers), Neuroinflammation and Neurodegeneration Mechanisms (16 papers) and Cell Image Analysis Techniques (13 papers). Ed S. Lein collaborates with scholars based in United States, Sweden and United Kingdom. Ed S. Lein's co-authors include Susan M. Sunkin, Hongkui Zeng, Michael Hawrylycz, Allan R. Jones, Lydia Ng, Hatim A. Zariwala, Richard D. Palmiter, Theresa A. Zwingman, Linda Madisen and Hong Gu and has published in prestigious journals such as Science, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

In The Last Decade

Ed S. Lein

65 papers receiving 10.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

2009 4.8k citations Susan M. Sunkin, Lydia Ng et al. profile →
Functional organization of the hippocampal longitudinal axis

2014 1.2k citations Ed S. Lein et al. profile →
Patches of Disorganization in the Neocortex of Children with Autism

2014 507 citations Maggie Chow, Maureen P. Boyle et al. New England Journal of Medicine profile →
Genetic identification of brain cell types underlying schizophrenia

2018 326 citations Trygve E. Bakken, Rebecca D. Hodge et al. profile →

Peers

Countries citing papers authored by Ed S. Lein

Since Specialization

Citations

This map shows the geographic impact of Ed S. Lein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ed S. Lein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ed S. Lein more than expected).

Fields of papers citing papers by Ed S. Lein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ed S. Lein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ed S. Lein. The network helps show where Ed S. Lein may publish in the future.

Co-authorship network of co-authors of Ed S. Lein

This figure shows the co-authorship network connecting the top 25 collaborators of Ed S. Lein. A scholar is included among the top collaborators of Ed S. Lein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ed S. Lein. Ed S. Lein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Interneuron-specific dual-AAV SCN1A gene replacement corrects epileptic phenotypes in mouse models of Dravet syndrome 2025 ·Science Translational Medicine ·John K. Mich, (unknown), Aguan Wei, Bryan B. Gore, (unknown), (unknown), Refugio A. Martinez, (unknown), (unknown), Yemeserach Bishaw, (unknown), Luíz M. Oliveira, Nicole D. Miranda, Jan‐Marino Ramirez, Jonathan T. Ting, Ed S. Lein, Boaz P. Levi, Franck Kalume	4
2	SEA-AD is a multimodal cellular atlas and resource for Alzheimer’s disease 2024 ·Nature Aging ·Michael Hawrylycz, Eitan S Kaplan, Kyle J. Travaglini, Mariano I. Gabitto, Jeremy A. Miller, Lydia Ng, Jennie Close, Rebecca D. Hodge, Brian Long, Tyler Mollenkopf, Shoaib Mufti, Nicole M. Gatto, Eric B. Larson, Paul K. Crane, Thomas J. Grabowski, C. Dirk Keene, Ed S. Lein	5
3	Brain Data Standards - A method for building data-driven cell-type ontologies 2023 ·Scientific Data ·Shawn Zheng Kai Tan, (unknown), Brian D. Aevermann, Tom Gillespie, Nomi L. Harris, Michael Hawrylycz, Nikolas L. Jorstad, Ed S. Lein, Nicolas Matentzoglu, Jeremy A. Miller, Tyler Mollenkopf, Chris Mungall, (unknown), Raymond Sanchez, Brian Staats, (unknown), (unknown), Yun Zhang, Richard H. Scheuermann, David Osumi-Sutherland	7
4	Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types 2023 ·Nature Communications ·(unknown), Anna A. Galakhova, Djai B. Heyer, (unknown), René Wilbers, Eline J. Mertens, (unknown), Tim S. Heistek, (unknown), J. Meijer, Sander Idema, Philip C. De Witt Hamer, David P. Noske, Christiaan P. J. de Kock, Brian Lee, Kimberly A. Smith, Jonathan T. Ting, Ed S. Lein, Huibert D. Mansvelder, Natalia A. Goriounova	5
5	A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases 2023 ·PLoS Biology ·Yashar Zeighami, Trygve E. Bakken, Thomas Nickl‐Jockschat, (unknown), Anil G. Jegga, Jeremy A. Miller, Jay Schulkin, Alan C. Evans, Ed S. Lein, Michael Hawrylycz	17
6	Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH 2022 ·Science ·Rongxin Fang, Chenglong Xia, Jennie Close, Meng Zhang, Jiang He, (unknown), Aaron R. Halpern, Brian Long, Jeremy A. Miller, Ed S. Lein, Xiaowei Zhuang	136
7	A machine learning method for the discovery of minimum marker gene combinations for cell type identification from single-cell RNA sequencing 2021 ·Genome Research ·Brian D. Aevermann, Yun Zhang, Mark Novotny, (unknown), Trygve E. Bakken, Jeremy A. Miller, Rebecca D. Hodge, Boudewijn P. F. Lelieveldt, Ed S. Lein, Richard H. Scheuermann	38
8	Comprehensive in situ mapping of human cortical transcriptomic cell types 2021 ·Communications Biology ·Christoffer Mattsson Langseth, Daniel Gyllborg, Jeremy A. Miller, Jennie Close, Brian Long, Ed S. Lein, Markus M. Hilscher, Mats Nilsson	20
9	Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue 2020 ·Nucleic Acids Research ·Daniel Gyllborg, Christoffer Mattsson Langseth, Xiaoyan Qian, Eun‐Kyoung Choi, Sergio Marco Salas, Markus M. Hilscher, Ed S. Lein, Mats Nilsson	172
10	FR-Match: robust matching of cell type clusters from single cell RNA sequencing data using the Friedman–Rafsky non-parametric test 2020 ·Briefings in Bioinformatics ·Yun Zhang, Brian D. Aevermann, Trygve E. Bakken, Jeremy A. Miller, Rebecca D. Hodge, Ed S. Lein, Richard H. Scheuermann	9
11	Parallel RNA and DNA analysis after deep sequencing (PRDD-seq) reveals cell type-specific lineage patterns in human brain 2020 ·Proceedings of the National Academy of Sciences ·August Yue Huang, Pengpeng Li, Rachel E. Rodin, Sonia N. Kim, Yanmei Dou, Connor Kenny, Shyam K. Akula, Rebecca D. Hodge, Trygve E. Bakken, Jeremy A. Miller, Ed S. Lein, Peter J. Park, Eunjung Alice Lee, Christopher A. Walsh	29
12	Common cell type nomenclature for the mammalian brain 2020 ·eLife ·Jeremy A. Miller, Nathan W. Gouwens, Bosiljka Tasic, Forrest Collman, Cindy T. J. van Velthoven, Trygve E. Bakken, Michael Hawrylycz, Hongkui Zeng, Ed S. Lein, Amy Bernard	38
13	Single-cell transcriptomic evidence for dense intracortical neuropeptide networks 2019 ·eLife ·Stephen J Smith, Uygar Sümbül, Lucas T. Graybuck, Forrest Collman, Sharmishtaa Seshamani, Rohan Gala, Olga Gliko, Leila Elabbady, Jeremy A. Miller, Trygve E. Bakken, Jean Rossier, Zizhen Yao, Ed S. Lein, Hongkui Zeng, Bosiljka Tasic, Michael Hawrylycz	90
14	Cell type discovery using single-cell transcriptomics: implications for ontological representation 2018 ·Human Molecular Genetics ·Brian D. Aevermann, Mark Novotny, Trygve E. Bakken, Jeremy A. Miller, Alexander D. Diehl, David Osumi-Sutherland, Roger S. Lasken, Ed S. Lein, Richard H. Scheuermann	33
15	Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex 2018 ·eNeuro ·Kristina D. Micheva, Edward F. Chang, Alissa L. Nana, William W. Seeley, Jonathan T. Ting, Charles Cobbs, Ed S. Lein, Stephen J Smith, Richard J. Weinberg, Daniel V. Madison	26
16	STRT-seq-2i: dual-index 5ʹ single cell and nucleus RNA-seq on an addressable microwell array 2017 ·Scientific Reports ·Hannah Hochgerner, Peter Lönnerberg, Rebecca D. Hodge, Jaromír Mikeš, (unknown), (unknown), (unknown), Simone Picelli, Gioele La Manno, Michael Ratz, (unknown), (unknown), Ed S. Lein, Maithreyan Srinivasan, Amit Zeisel, Sten Linnarsson	57
17	Patches of Disorganization in the Neocortex of Children with Autism breakdown → 2014 ·New England Journal of Medicine ·(unknown), Maggie Chow, Maureen P. Boyle, Susan M. Sunkin, Peter R. Mouton, Subhojit Roy, Anthony Wynshaw‐Boris, Sophia A. Colamarino, Ed S. Lein, Eric Courchesne	507
18	Multi-scale correlation structure of gene expression in the brain 2011 ·Neural Networks ·Mike Hawrylycz, Lydia Ng, Damon T. Page, John C. Morris, Chris Lau, Sky Faber, Vance Faber, Susan M. Sunkin, Vilas Menon, Ed S. Lein, Allan R. Jones	27
19	Shifting the paradigm: new approaches for characterizing and classifying neurons 2009 ·Current Opinion in Neurobiology ·Amy Bernard, Staci A. Sorensen, Ed S. Lein	21
20	Genomic Anatomy of the Hippocampus 2008 ·Neuron ·Carol L. Thompson, Dev S. Pathak, Andreas Jeromin, Lydia Ng, Cameron Ross MacPherson, Marty Mortrud, (unknown), Zackery L. Riley, Susan M. Sunkin, Amy Bernard, Ralph B. Puchalski, Fred H. Gage, Allan R. Jones, Vladimir B. Bajić, Michael Hawrylycz, Ed S. Lein	304

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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