Douglas L. Brutlag

11.7k citations

98 papers · 9.2k indexed · 6 hit papers · h-index 46

Co-authors: Arthur Kornberg Jun S. Liu Serge Saxonov Paul BergX. LiuTao‐shih Hsieh Earl R. Shelton X. Shirley Liu
Topics: DNA and Nucleic Acid Chemistry (24 papers)RNA and protein synthesis mechanisms (23 papers)Protein Structure and Dynamics (22 papers)
Cited by: Molecular Biology Genetics Toxicology
Journals: Cell Proceedings of the National Academy of Sciences Nucleic Acids Research
Partner nations: United States Australia Poland

In The Last Decade

Douglas L. Brutlag

98 papers receiving 8.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters

2006 961 citations Douglas L. Brutlag et al. Proceedings of the National Academy of Sciences profile →
BIOPROSPECTOR: DISCOVERING CONSERVED DNA MOTIFS IN UPSTREAM REGULATORY REGIONS OF CO-EXPRESSED GENES

2000 608 citations Douglas L. Brutlag, Jun S. Liu et al. profile →
An algorithm for finding protein–DNA binding sites with applications to chromatin- immunoprecipitation microarray experiments

2002 514 citations Douglas L. Brutlag, Jun S. Liu et al. profile →
Enzymatic Synthesis of Deoxyribonucleic Acid

1972 509 citations Douglas L. Brutlag et al. profile →
RNA Synthesis Initiates In Vitro Conversion of M13 DNA to Its Replicative Form

1972 249 citations Douglas L. Brutlag et al. Proceedings of the National Academy of Sciences profile →
A Possible Role for RNA Polymerase in the Initiation of M13 DNA Synthesis

1971 217 citations Douglas L. Brutlag et al. Proceedings of the National Academy of Sciences profile →

Peers

Countries citing papers authored by Douglas L. Brutlag

Since Specialization

Citations

This map shows the geographic impact of Douglas L. Brutlag's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Douglas L. Brutlag with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Douglas L. Brutlag more than expected).

Fields of papers citing papers by Douglas L. Brutlag

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Douglas L. Brutlag. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Douglas L. Brutlag. The network helps show where Douglas L. Brutlag may publish in the future.

Co-authorship network of co-authors of Douglas L. Brutlag

This figure shows the co-authorship network connecting the top 25 collaborators of Douglas L. Brutlag. A scholar is included among the top collaborators of Douglas L. Brutlag based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Douglas L. Brutlag. Douglas L. Brutlag is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Nucleotide Channel of RNA-dependent RNA Polymerase used for Intermolecular Uridylylation of Protein Primer 2006 ·Journal of Molecular Biology ·(unknown),(unknown),Jeannie F. Spagnolo,Aaron A. Thompson,Olve B. Peersen,Douglas L. Brutlag,Karla Kirkegaard	25
2	Dynamic use of multiple parameter sets in sequence alignment 2006 ·Nucleic Acids Research ·Xiaoqiu Huang,Douglas L. Brutlag	19
3	Identifying Protein-Protein Interaction Sites on a Genome-Wide Scale 2004 ·Neural Information Processing Systems ·Haidong Wang,Eran Segal,Asa Ben‐Hur,Daphne Koller,Douglas L. Brutlag	14
4	A suite of web-based programs to search for transcriptional regulatory motifs 2004 ·Nucleic Acids Research ·Ying Liu,Liping Wei,Serafim Batzoglou,Douglas L. Brutlag,Jun S. Liu,(unknown)	29
5	3motif: visualizing conserved protein sequence motifs in the protein structure database 2003 ·Bioinformatics ·Steven Bennett,Craig G. Nevill-Manning,Douglas L. Brutlag	5
6	FoldMiner: Structural motif discovery using an improved superposition algorithm 2003 ·Protein Science ·(unknown),Douglas L. Brutlag	28
7	Stochastic roadmap simulation for the study ofligand-protein interactions 2002 ·Bioinformatics ·Mehmet Serkan Apaydın,Carlos Guestrin,Chris Varma,Douglas L. Brutlag,Jean‐Claude Latombe	25
8	Fast probabilistic analysis of sequence function using scoring matrices 2000 ·Bioinformatics ·Thomas D. Wu,Craig G. Nevill-Manning,Douglas L. Brutlag	41
9	Proceedings of the Seventh International Conference on Intelligent Systems for Molecular Biology 1999 ·Thomas Lengauer,Reinhard Schneider,Peer Bork,Douglas L. Brutlag,Janice Glasgow,Hans‐Werner Mewes,Ralf Zimmer	95
10	Genomics and computational molecular biology 1998 ·Current Opinion in Microbiology ·Douglas L. Brutlag	15
11	Directions for Clinical Research and Genomic Research into the Next Decade: Implications for Informatics 1998 ·Journal of the American Medical Informatics Association ·Thomas C. Rindfleisch,Douglas L. Brutlag	13
12	Regression Analysis of Multiple Protein Structures 1998 ·Journal of Computational Biology ·Thomas D. Wu,Scott C. Schmidler,Trevor Hastie,Douglas L. Brutlag	16
13	Introns and reading frames: correlation between splicing sites and their codon positions 1996 ·Molecular Biology and Evolution ·Motowo Tomita,Nobutaka Shimizu,Douglas L. Brutlag	45
14	Discovering structural correlations in α‐helices 1994 ·Protein Science ·Tod M. Klingler,Douglas L. Brutlag	55
15	Knowledge-based simulation of DNA metabolism: Prediction of action and envisionment of pathways 1993 ·Adam Galper,Douglas L. Brutlag,(unknown)	7
16	BLAZE™: An implementation of the Smith-Waterman sequence comparison algorithm on a massively parallel computer 1993 ·Computers & Chemistry ·Douglas L. Brutlag,(unknown),(unknown),(unknown),(unknown),(unknown)	31
17	Improved sensitivity of biological sequence database searches 1990 ·Computer applications in the biosciences ·Douglas L. Brutlag,(unknown),(unknown),(unknown)	90
18	Expression of the Drosophila type II topoisomerase is developmentally regulated 1988 ·Biochemistry ·Robert Fairman,Douglas L. Brutlag	40
19	Multiplicity of satellite DNA sequences in Drosophila melanogaster. 1986 ·Proceedings of the National Academy of Sciences ·Allan R. Lohe,Douglas L. Brutlag	97
20	GENESIS, a knowledge-based genetic engineering simulation system for represntation of genetic data and experiment planning 1982 ·Nucleic Acids Research ·Peter Friedland,Larry Kedes,Douglas L. Brutlag,Yumi Iwasaki,(unknown)	16

About Douglas L. Brutlag

Douglas L. Brutlag is a scholar working on Molecular Biology, Information Systems and Management and Computational Theory and Mathematics, having authored 98 papers that have together received 9.2k indexed citations. Recurring topics across this work include DNA and Nucleic Acid Chemistry (24 papers), RNA and protein synthesis mechanisms (23 papers) and Protein Structure and Dynamics (22 papers). The work is most often cited by research in Molecular Biology (7.7k citations), Genetics (1.8k citations) and Toxicology (157 citations). Douglas L. Brutlag has collaborated with scholars based in United States, Australia and Poland. Frequent co-authors include Arthur Kornberg, Jun S. Liu, Serge Saxonov, Paul Berg, X. Liu, Tao‐shih Hsieh, Earl R. Shelton, X. Shirley Liu, Randy Schekman and Neil Osheroff. Their work appears in journals such as Cell, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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