Douglas Cyr

11.8k citations

113 papers · 9.2k indexed · 2 hit papers · h-index 47

Impact in

Cell Biology top 0.2%
- Endoplasmic Reticulum Stress and Disease
Aging top 1%

Papers in

Cell Biology 39
- Endoplasmic Reticulum Stress and Disease 34
Clinical Biochemistry 8

Co-authors: Cam Patterson Michael G. Douglas Jörg Höhfeld J. Michael Younger Chun-Yang Fan Walter Neupert Meredith F.N. Rosser Zhen Lü
Journals: Journal of Biological Chemistry (19 papers)Molecular Biology of the Cell (13 papers)Trends in Biochemical Sciences (4 papers)EMBO Reports (3 papers)PLoS ONE (3 papers)
Partner nations: United States Germany Brazil

In The Last Decade

Douglas Cyr

107 papers receiving 9.1k citations

Hit Papers

align trajectories log scale

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations 2016 · 422 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2016 Molecular Biology of the Cell
2000 Nature Cell Biology

Peers

Countries citing papers authored by Douglas Cyr

Since Specialization

Citations

This map shows the geographic impact of Douglas Cyr's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Douglas Cyr with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Douglas Cyr more than expected).

Fields of papers citing papers by Douglas Cyr

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Douglas Cyr. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Douglas Cyr. The network helps show where Douglas Cyr may publish in the future.

Co-authors

The 25 scholars most cited alongside Douglas Cyr, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Douglas Cyr Line = papers co-authored together Douglas Cyr links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Type I Hsp40s/ DnaJs aggregates exhibit features reminiscent of amyloidogenic structures FEBS Journal ·Ana O. Tiroli‐Cepeda, Leonardo A. Linhares, Annelize Zambon Barbosa Aragão, Jemmyson Romário de Jesus, Ana Paula Wasilewska‐Sampaio, Fernanda G. De Felice, Sérgio T. Ferreira, Júlio C. Borges, Douglas Cyr, Carlos H.I. Ramos	2024	1
2	Specification of Hsp70 Function by Hsp40 Co-chaperones Sub-cellular biochemistry ·Douglas Cyr, Carlos H.I. Ramos	2022	17
3	Endoplasmic reticulum stress–induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis Journal of Biological Chemistry ·Pattarawut Sopha, Hong Yu Ren, Diane E. Grove, Douglas Cyr	2017	38
4	VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1 Molecular Biology of the Cell ·Hong Yu Ren, Diane E. Grove, Oxana De La Rosa, Scott A. Houck, Pattarawut Sopha, Fredrick Van Goor, Beth J. Hoffman, Douglas Cyr	2013	231
5	Identification of a Consensus Motif in Substrates Bound by a Type I Hsp40 Biophysical Journal ·Pradeep Kota, Daniel W. Summers, Hongyu Ren, Douglas Cyr, Nikolay V. Dokholyan	2010	1
6	Mechanisms for Rescue of Correctable Folding Defects in CFTRΔF508 Molecular Biology of the Cell ·Diane E. Grove, Meredith F.N. Rosser, Hong Yu Ren, Anjaparavanda P. Naren, Douglas Cyr	2009	100
7	Stress-dependent Daxx-CHIP Interaction Suppresses the p53 Apoptotic Program Journal of Biological Chemistry ·Holly McDonough, Peter C. Charles, Eleanor Hilliard, Shu Bing Qian, Jin-Na Min, Andrea L. Portbury, Douglas Cyr, Cam Patterson	2009	28
8	Prion propagation by Hsp40 molecular chaperones Prion ·Daniel W. Summers, Peter M. Douglas, Douglas Cyr	2009	29
9	Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508 Molecular Biology of the Cell ·Daisuke Morito, Kazuyoshi Hirao, Yukako Oda, Nobuko Hosokawa, Fuminori Tokunaga, Douglas Cyr, Keiji Tanaka, Kazuhiro Iwaï, Kazuhiro Nagata	2008	186
10	Conserved Central Domains Control the Quaternary Structure of Type I and Type II Hsp40 Molecular Chaperones Journal of Molecular Biology ·Carlos H.I. Ramos, Cristiano L. P. Oliveira, Chung-Yang Fan, Í. Torriani, Douglas Cyr	2008	40
11	Sequential Quality-Control Checkpoints Triage Misfolded Cystic Fibrosis Transmembrane Conductance Regulator Cell ·J. Michael Younger, Liling Chen, Hong-Yu Ren, Meredith F.N. Rosser, Emma L. Turnbull, Chun-Yang Fan, Cam Patterson, Douglas Cyr	2006	362
12	Ubiquitin-Proteasome Protocols Humana Press eBooks ·Cam Patterson, Douglas Cyr	2005	12
13	Regulation of the Cytoplasmic Quality Control Protein Degradation Pathway by BAG2 Journal of Biological Chemistry ·Qian Dai, Shu-Bing Qian, Huihua Li, Holly McDonough, Christoph H. Borchers, David Huang, Shinichi Takayama, J. Michael Younger, Hong Yu Ren, Douglas Cyr, Cam Patterson	2005	113
14	Distinct Roles for the AAA ATPases NSF and p97 in the Secretory Pathway Molecular Biology of the Cell ·Seema Dalal, Meredith F.N. Rosser, Douglas Cyr, Phyllis I. Hanson	2003	150
15	Protein quality control: U-box-containing E3 ubiquitin ligases join the fold Trends in Biochemical Sciences ·Douglas Cyr, Jörg Höhfeld, Cam Patterson	2002	278
16	The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation Nature Cell Biology ·Geoffrey C. Meacham, Cam Patterson, Wenyue Zhang, J. Michael Younger, Douglas Cyr Hit paper breakdown →	2000	687
17	The crystal structure of the peptide-binding fragment from the yeast Hsp40 protein Sis1 Structure ·Bingdong Sha, Soojin Lee, Douglas Cyr	2000	133
18	Human Hsp70 and Hsp40 Chaperone Proteins Facilitate Human Papillomavirus-11 E1 Protein Binding to the Origin and Stimulate Cell-free DNA Replication Journal of Biological Chemistry ·Jen‐Sing Liu, Shu‐Ru Kuo, Alexander M. Makhov, Douglas Cyr, Jack D. Griffith, Thomas R. Broker, Louise T. Chow	1998	98
19	Protein Folding Activity of Hsp70 Is Modified Differentially by the Hsp40 Co-chaperones Sis1 and Ydj1 Journal of Biological Chemistry ·Zhen Lü, Douglas Cyr	1998	186
20	On the mechanism of inhibition of gluconeogenesis and ureagenesis by sodium benzoate Biochemical Pharmacology ·Douglas Cyr, Sharon G. Egan, Carla M. Brini, George C. Tremblay	1991	22

About Douglas Cyr

Douglas Cyr is a scholar working on Cell Biology, Clinical Biochemistry, Molecular Biology, Physical and Theoretical Chemistry and Endocrinology, having authored 113 papers that have together received 9.2k indexed citations. Recurring topics across this work include Heat shock proteins research (50 papers), Endoplasmic Reticulum Stress and Disease (34 papers), Protein Structure and Dynamics (18 papers), Cystic Fibrosis Research Advances (17 papers), Mitochondrial Function and Pathology (16 papers), Prion Diseases and Protein Misfolding (9 papers), Enzyme Structure and Function (9 papers) and Ubiquitin and proteasome pathways (9 papers). The work is most often cited by research in Cell Biology (2.8k citations), Aging (264 citations), Molecular Biology (7.0k citations), Physical and Theoretical Chemistry (426 citations) and Immunology (834 citations). Douglas Cyr has collaborated with scholars based in United States, Germany and Brazil. Frequent co-authors include Cam Patterson, Michael G. Douglas, Jörg Höhfeld, J. Michael Younger, Chun-Yang Fan, Walter Neupert, Meredith F.N. Rosser, Zhen Lü, Soojin Lee and Hong Yu Ren. Their work appears in journals such as Journal of Biological Chemistry, Molecular Biology of the Cell, Trends in Biochemical Sciences, EMBO Reports and PLoS ONE.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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