David Shire

9.3k citations

73 papers · 7.8k indexed · 4 hit papers · h-index 33

Impact in

Pharmacology top 0.05%
- Cannabis and Cannabinoid Research
Cellular and Molecular Neuroscience top 0.5%
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior

Papers in

Cellular and Molecular Neuroscience 21
- Neuroscience and Neuropharmacology Research 14
- Neurotransmitter Receptor Influence on Behavior 8
Pharmacology 15
- Cannabis and Cannabinoid Research 15

Co-authors: Gérard Le Fur Pierre Casellas Monsif Bouaboula Pascual Ferrara Daniel Caput Bernard Calandra Murielle Rinaldi‐Carmona Francis Barth
Journals: Journal of Biological Chemistry (8 papers)European Journal of Pharmacology (6 papers)Gene (5 papers)FEBS Letters (4 papers)European Journal of Biochemistry (4 papers)
Partner nations: France United Kingdom United States

In The Last Decade

David Shire

70 papers receiving 7.6k citations

Hit Papers

align trajectories log scale

SR 144528, the First Potent and Selective Antagonist of the CB2 Cannabinoid Receptor 1998 · 593 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1998 Journal of Pharmacology and Experimental Therapeutics
1995 European Journal of Biochemistry
1994 FEBS Letters
1993 Nature

Peers

Countries citing papers authored by David Shire

Since Specialization

Citations

This map shows the geographic impact of David Shire's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Shire with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Shire more than expected).

Fields of papers citing papers by David Shire

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Shire. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Shire. The network helps show where David Shire may publish in the future.

Co-authorship network

The 25 scholars most cited alongside David Shire, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David Shire Line = papers co-authored together David Shire links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Brain–body mitochondrial distribution patterns lack coherence and point to tissue-specific regulatory mechanisms PubMed ·Jack Devine, Anna S. Monzel, David Shire, Jorge Moyolema Yuquilema, Alex Junker, Alan A. Cohen, Martin Picard	2025	0
2	Mitochondrial health, prenatal distress, and gestational age: investigation of cf-mtDNA and GDF15 in two pregnancy studies from the USA and Turkey Mitochondrion ·M Emilio, David Shire, Fiona Hollis, Christian Altamirano, Martin Picard, Catherine Monk, Sergey K Yusupov, Caroline Trumpff	2025	2
3	Toward the active conformations of rhodopsin and the β₂‐adrenergic receptor Proteins Structure Function and Bioinformatics ·Paul R. Gouldson, Oğuz Çoban, Robert P. Bywater, Eridei Amakiri, Fl vio W. Cavaleri, B Gadjanski, David Shire, Christopher A. Reynolds	2004	67
4	Gene Expression Analysis Using Quantitative Reverse Transcription-Polymerase Chain Reaction and a Multispecific Internal Control Humana Press eBooks ·David Shire, Pascale Legoux	2003	3
5	Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia Brain Research ·Anne Rémaury, Natalio Vita, Min Long, M. Jung, Rohit Goel, Martine Poncelet, Jean‐Michel Culouscou, Gérard Le Fur, Philippe Soubrié, Daniel Caput, David Shire, Manfred Köpf, Pascual Ferrara	2002	113
6	Cannabinoid receptor interactions with the antagonists SR 141716A and SR 144528 Life Sciences ·David Shire, Bernard Calandra, Monsif Bouaboula, Francis Barth, Murielle Rinaldi‐Carmona, Pierre Casellas, Pascual Ferrara	1999	80
7	Topological Analysis of the Peripheral Benzodiazepine Receptor in Yeast Mitochondrial Membranes Supports a Five-transmembrane Structure Journal of Biological Chemistry ·Evelyne Joseph-Liauzun, Pascal Delmas, David Shire, Pascual Ferrara	1998	90
8	Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals European Journal of Pharmacology ·Graeme Griffin, Susanthi R. Fernando, Ruth A. Ross, Neil G. McKay, Michael L.J. Ashford, David Shire, John W. Huffman, Shu Yu, Julia A.H. Lainton, Roger G. Pertwee	1997	144
9	Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression ·David Shire, Bernard Calandra, Murielle Rinaldi‐Carmona, Hala Mohammed Salh, Elysa Feigenbaum, mehdi mohammadzadeh, Gérard Le Fur, Daniel Caput, Pascual Ferrara	1996	163
10	Structural Features of the Central Cannabinoid CB1 Receptor Involved in the Binding of the Specific CB1 Antagonist SR 141716A Journal of Biological Chemistry ·David Shire, Bernard Calandra, Boris Burshteyn, Xavier Dumont, Mourad Kaghad, Gérard Le Fur, Daniel Caput, Pascual Ferrara	1996	87
11	An Amino-terminal Variant of the Central Cannabinoid Receptor Resulting from Alternative Splicing Journal of Biological Chemistry ·David Shire, Christine Carillon, Mourad Kaghad, Bernard Calandra, Murielle Rinaldi‐Carmona, Gérard Le Fur, Daniel Caput, Pascual Ferrara	1995	264
12	Molecular basis for the different binding properties of benzodiazepines to human and bovine peripheral‐type benzodiazepine receptors FEBS Letters ·Roseli C. Farges, Evelyne Joseph-Liauzun, David Shire, Daniel Caput, Gérard Le Fur, Gérard Loison, Pascual Ferrara	1993	41
13	lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses Nature ·A Minty, Pascale Chalon, Jean‐Marie Derocq, Xavier Dumont, Jean-Claude Guillemot, Mourad Kaghad, Xiaoqi Lv, Pascal Leplatois, 堀越悠里, Brigitte Miloux, 田惠艳, Pierre Casellas, G. Loison, Jan H. Lupker, David Shire, Pascual Ferrara, Daniel Caput Hit paper breakdown →	1993	758
14	Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin‐1 and phorbol ester activation pathways in the EL4–6.1 thymoma cell line Journal of Cellular Physiology ·Jacques Dornand, Monsif Bouaboula, Arnaud Dupuy d’Angeac, Jean Favero, David Shire, Pierre Casellas	1992	23
15	RNase H-mediated inhibition of translation by antisense oligodeoxyribo-nucleotides: use of backbone modification to improve specificity Gene ·A. Garcia-Lastra, Casimir Blonski, Claudine Boiziau, Б. А. Еспембетов, Serge Moreau, David Shire, Jean‐Jacques Toulmé	1992	50
16	Human interleukin 1β fused to the human growth hormone signal peptide is N-glycosylated and secreted by Chinese hamster ovary cells Gene ·Florence Pecceu, Zhenkun Yu, David Shire, Francisco de Elorza y Rada, Fabiana Ferreira de Souza, Pascual Ferrara, Mourad Kaghad, Xavier Dumont, Jan H. Lupker	1991	18
17	Effect of RNA secondary structure and modified bases on the inhibition of trypanosomatid protein synthesis in cellfree extracts by antisense oligodeoxynucleotides Nucleic Acids Research ·Maud Lecacheur, Nadine Loreau, Nguyen T. Thuong, David Shire, Jean‐Jacques Toulmé	1990	22
18	Synthesis and sequence-specific proteolysis of a hybrid protein (colicin A :: growth hormone releasing factor) produced in Escherichia coli Gene ·Vincent Géli, Daniel Baty, Martine Knibiehler, Roland Lloubès, Elysa Feigenbaum, David Shire, Claude Lazdunski	1989	10
19	Characterization and sequencing of normal and modified oligonucleotides by252Cf plasma desorption mass spectrometry Journal of Mass Spectrometry ·Alain Viari, J.–P. Ballini, Philippe Méléard, Paul Vigny, Zhenkun Yu, Casimir Blonski, David Shire	1988	13
20	Potential memory and hysteretic effects in transcription Journal of Theoretical Biology ·Dominique Job, GAA Hago, Claudette Job, David Shire	1988	5

About David Shire

David Shire is a scholar working on Cellular and Molecular Neuroscience, Pharmacology, Molecular Biology, Endocrine and Autonomic Systems and Biotechnology, having authored 73 papers that have together received 7.8k indexed citations. Recurring topics across this work include Cannabis and Cannabinoid Research (15 papers), Neuroscience and Neuropharmacology Research (14 papers), RNA and protein synthesis mechanisms (12 papers), Receptor Mechanisms and Signaling (10 papers), DNA and Nucleic Acid Chemistry (8 papers), Neurotransmitter Receptor Influence on Behavior (8 papers), Bacterial Genetics and Biotechnology (6 papers) and CRISPR and Genetic Engineering (5 papers). The work is most often cited by research in Pharmacology (4.9k citations), Cellular and Molecular Neuroscience (3.3k citations), Toxicology (569 citations), Endocrine and Autonomic Systems (895 citations) and Biological Psychiatry (156 citations). David Shire has collaborated with scholars based in France, United Kingdom and United States. Frequent co-authors include Gérard Le Fur, Pierre Casellas, Monsif Bouaboula, Pascual Ferrara, Daniel Caput, Bernard Calandra, Murielle Rinaldi‐Carmona, Francis Barth, Pierre Carayon and Christian Congy. Their work appears in journals such as Journal of Biological Chemistry, European Journal of Pharmacology, Gene, FEBS Letters and European Journal of Biochemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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