David Fram

1.7k citations

30 papers · 1.0k indexed · 1 hit paper · h-index 16

Impact in

Toxicology top 0.5%
- Pharmacovigilance and Adverse Drug Reactions
Applied Microbiology and Biotechnology top 2%
- Antibiotic Use and Resistance

Papers in ⓘ

Toxicology 10
- Pharmacovigilance and Adverse Drug Reactions 10
Applied Microbiology and Biotechnology 3
- Antibiotic Use and Resistance 3

Co-authors: William DuMouchel (10 shared papers)Sameer S. Kadri (10 shared papers)Michael Klompas (10 shared papers)Chanu Rhee (10 shared papers)June S. Almenoff (7 shared papers)Huai-Chun Chen (5 shared papers)Robert L. Danner (1 shared paper)Rui Wang (1 shared paper)
Journals: Critical Care Medicine (4 papers)JAMA Network Open (3 papers)Drug Safety (2 papers)Pharmacoepidemiology and Drug Safety (2 papers)Clinical Infectious Diseases (1 paper)
Partner nations: United States United Kingdom Canada

In The Last Decade

David Fram

30 papers receiving 1.0k citations

Hit Papers

align trajectories log scale

Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use 2020 · 232 citations

Peers

Countries citing papers authored by David Fram

Since Specialization

Citations

This map shows the geographic impact of David Fram's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Fram with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Fram more than expected).

Fields of papers citing papers by David Fram

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Fram. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Fram. The network helps show where David Fram may publish in the future.

Co-authors

The 25 scholars most cited alongside David Fram, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David Fram Line = papers co-authored together David Fram links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 30 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use JAMA Network Open ·Chanu Rhee, Sameer S. Kadri, John P. Dekker, Robert L. Danner, Huai-Chun Chen, David Fram, Fang Zhang, Rui Wang, Michael Klompas Hit paper breakdown →	2020	232
2	Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients* Critical Care Medicine ·Dominique J. Pepper, Cumhur Y. Demirkale, Junfeng Sun, Chanu Rhee, David Fram, Peter Q. Eichacker, Michael Klompas, Anthony F. Suffredini, Sameer S. Kadri	2019	111
3	Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria* Critical Care Medicine ·Chanu Rhee, Zilu Zhang, Sameer S. Kadri, David J. Murphy, Greg S. Martin, Elizabeth Overton, Christopher Seymour, Derek C. Angus, Raymund Dantes, Lauren Epstein, David Fram, Richard Schaaf, Rui Wang, Michael Klompas	2019	91
4	Disproportionality analysis using empirical Bayes data mining: a tool for the evaluation of drug interactions in the post‐marketing setting Pharmacoepidemiology and Drug Safety ·June S. Almenoff, William DuMouchel, L. Allen Kindman, Xionghu Yang, David Fram	2003	90
5	Comparative Performance of Two Quantitative Safety Signalling Methods Drug Safety ·June S. Almenoff, Karol LaCroix, Nancy A. Yuen, David Fram, William DuMouchel	2006	81
6	Epidemiology of Hospital-Onset Versus Community-Onset Sepsis in U.S. Hospitals and Association With Mortality: A Retrospective Analysis Using Electronic Clinical Data Critical Care Medicine ·Chanu Rhee, Rui Wang, Zilu Zhang, David Fram, Sameer S. Kadri, Michael Klompas	2019	66
7	Association of asthma therapy and churg-strauss syndrome: An analysis of postmarketing surveillance data Clinical Therapeutics ·William DuMouchel, Eric T. Smith, Richard Beasley, Harold S. Nelson, Xionghu Yang, David Fram, June S. Almenoff	2004	49
8	Association Between Implementation of the Severe Sepsis and Septic Shock Early Management Bundle Performance Measure and Outcomes in Patients With Suspected Sepsis in US Hospitals JAMA Network Open ·Chanu Rhee, Tingting Yu, Rui Wang, Sameer S. Kadri, David Fram, Huai-Chun Chen, Michael Klompas	2021	45
9	Empirical Bayesian data mining for discovering patterns in post-marketing drug safety David Fram, June S. Almenoff, William DuMouchel	2003	34
10	Antipsychotics, Glycemic Disorders, and Life-Threatening Diabetic Events: A Bayesian Data-Mining Analysis of the FDA Adverse Event Reporting System (1968-2004) Annals of Clinical Psychiatry ·William DuMouchel, David Fram, Xionghu Yang, Ramy Mahmoud, Amy Grogg, Luella Engelhart, Krishnan Ramaswamy	2008	31
11	Adaptation of Bayesian Data Mining Algorithms to Longitudinal Claims Data Medical Care ·Jeffrey R. Curtis, Hong Cheng, Elizabeth Delzell, David Fram, Meredith L. Kilgore, Kenneth G. Saag, Huifeng Yun, William DuMouchel	2008	30
12	Signal detection methodologies to support effective safety management Expert Opinion on Drug Safety ·Robbert P. van Manen, David Fram, William DuMouchel	2007	27
13	The implementation of the PROPHET system Paul A. Castleman, Channing H. Russell, Frederick N. Webb, C. A. Hollister, Jakob Siegel, S. R. Zdoxik, David Fram	1974	25
14	Using simulation to assess the sensitivity and specificity of a signal detection tool for multidimensional public health surveillance data Statistics in Medicine ·Henry Rolka, D Bracy, Channing Russell, David Fram, Robert Ball	2005	21
15	Trends in Empiric Broad-Spectrum Antibiotic Use for Suspected Community-Onset Sepsis in US Hospitals JAMA Network Open ·Chanu Rhee, Tom Chen, Sameer S. Kadri, Alexander Lawandi, Christina Yek, Morgan Walker, Sarah Warner, David Fram, Huai-Chun Chen, Claire Shappell, Laura DelloStritto, Michael Klompas	2024	19
16	Psychogenic camptocormia Movement Disorders ·Frank M. Skidmore, Karen E. Anderson, David Fram, William J. Weiner	2007	17
17	Development of a mother-child database for drug exposure and adverse event detection in the Military Health System Pharmacoepidemiology and Drug Safety ·Lockwood G. Taylor, Rosenie Thelus Jean, Geoff Gordon, David Fram, Trinka S. Coster	2015	12
18	Risk Adjustment for Sepsis Mortality to Facilitate Hospital Comparisons Using Centers for Disease Control and Prevention’s Adult Sepsis Event Criteria and Routine Electronic Clinical Data Critical Care Explorations ·Chanu Rhee, Rui Wang, Song Yue, Zilu Zhang, Sameer S. Kadri, Edward Septimus, David Fram, Robert Jin, Russell E. Poland, Jason Hickok, Kenneth Sands, Michael Klompas	2019	11
19	Molecular clinical safety intelligence: a system for bridging clinically focused safety knowledge to early-stage drug discovery – the GSK experience Drug Discovery Today ·Dana E. Vanderwall, Nancy Yuen, Mohammad Basim Al-Ansari, James M. Bailey, David Fram, Darren V. S. Green, Stephen D. Pickett, Giovanni Vitulli, Juan I. Luengo, June S. Almenoff	2011	8
20	Impact of Risk Adjustment Using Clinical vs Administrative Data on Hospital Sepsis Mortality Comparisons Open Forum Infectious Diseases ·Chanu Rhee, Zhonghe Li, Rui Wang, Song Yue, Sameer S. Kadri, Edward Septimus, Huai-Chun Chen, David Fram, Robert Jin, Russell E. Poland, Kenneth Sands, Michael Klompas	2020	8

About David Fram

David Fram is a scholar working on Toxicology, Applied Microbiology and Biotechnology, Critical Care and Intensive Care Medicine, Statistics and Probability and Family Practice, having authored 30 papers that have together received 1.0k indexed citations. Recurring topics across this work include Pharmacovigilance and Adverse Drug Reactions (10 papers), Sepsis Diagnosis and Treatment (9 papers), Nosocomial Infections in ICU (6 papers), Statistical Methods in Clinical Trials (6 papers), Computational Drug Discovery Methods (5 papers), Health Systems, Economic Evaluations, Quality of Life (4 papers), Pharmaceutical Economics and Policy (4 papers) and Antibiotic Use and Resistance (3 papers). The work is most often cited by research in Toxicology (267 citations), Applied Microbiology and Biotechnology (117 citations), Critical Care and Intensive Care Medicine (153 citations), Family Practice (57 citations) and Clinical Biochemistry (101 citations). David Fram has collaborated with scholars based in United States, United Kingdom and Canada. Frequent co-authors include William DuMouchel, Sameer S. Kadri, Michael Klompas, Chanu Rhee, June S. Almenoff, Huai-Chun Chen, Robert L. Danner, Rui Wang, John P. Dekker and Fang Zhang. Their work appears in journals such as Critical Care Medicine, JAMA Network Open, Drug Safety, Pharmacoepidemiology and Drug Safety and Clinical Infectious Diseases.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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