David E. Nichols

16.4k citations

213 papers · 11.2k indexed · 4 hit papers · h-index 53

Impact in

Toxicology top 0.01%
- Forensic Toxicology and Drug Analysis
Cellular and Molecular Neuroscience top 0.1%
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research

Papers in

Toxicology 24
- Forensic Toxicology and Drug Analysis 24
Cellular and Molecular Neuroscience 124
- Neurotransmitter Receptor Influence on Behavior 115
- Neuroscience and Neuropharmacology Research 30

Co-authors: Charles D. Nichols Danuta Marona‐Lewicka Richard B. Mailman Andrew J. Hoffman Michael P. Johnson Jon E. Sprague Robert Oberlender G.K.W. Yim
Journals: Journal of Medicinal Chemistry (48 papers)Journal of Pharmacology and Experimental Therapeutics (13 papers)Psychopharmacology (11 papers)European Journal of Pharmacology (10 papers)Pharmacology Biochemistry and Behavior (10 papers)
Partner nations: United States United Kingdom Ireland

In The Last Decade

David E. Nichols

206 papers receiving 10.9k citations

Hit Papers

align trajectories log scale

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor 2020 · 306 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2020 Cell
2016 Pharmacological Reviews
2008 Chemical Reviews
2004 Pharmacology & Therapeutics

Peers

Countries citing papers authored by David E. Nichols

Since Specialization

Citations

This map shows the geographic impact of David E. Nichols's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David E. Nichols with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David E. Nichols more than expected).

Fields of papers citing papers by David E. Nichols

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David E. Nichols. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David E. Nichols. The network helps show where David E. Nichols may publish in the future.

Co-authorship network

The 25 scholars most cited alongside David E. Nichols, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David E. Nichols Line = papers co-authored together David E. Nichols links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	A proposed novel combined milling and combustion performance model for fuel selection Journal of the Energy Institute ·Orla Williams, David E. Nichols, Fatih Güleç, Joseph Perkins, Edward Lester	2025	0
2	Ligand and G-protein selectivity in the κ-opioid receptor Nature ·Jianming Han, Jingying Zhang, Cheryl Engels, Sarah M. Bernhard, B. Krumm, Lei Zhao, Jordy Homing Lam, 蒙蒙胡, Susruta Majumdar, David E. Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F. Fay, Tao Che	2023	43
3	Entactogens: How the Name for a Novel Class of Psychoactive Agents Originated Frontiers in Psychiatry ·David E. Nichols	2022	40
4	Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor Cell ·Kuglae Kim, Tao Che, Ouliana Panova, Jeffrey F. DiBerto, Jiankun Lyu, B. Krumm, Daniel Wacker, Michael J. Robertson, Alpay B. Seven, David E. Nichols, Brian K. Shoichet, Georgios Skiniotis, Bryan L. Roth Hit paper breakdown →	2020	306
5	Effects of Schedule I drug laws on neuroscience research and treatment innovation Nature reviews. Neuroscience ·David Nutt, Leslie A. King, David E. Nichols	2013	217
6	Ambient Temperature Effects on 3,4-Methylenedioxymethamphetamine-Induced Thermodysregulation and Pharmacokinetics in Male Monkeys Drug Metabolism and Disposition ·Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul W. Czoty, David E. Nichols, Michael A. Nader	2007	37
7	Serotonin 5‐HT_2A receptor activation induces 2‐arachidonoylglycerol release through a phospholipase c‐dependent mechanism Journal of Neurochemistry ·Jason C. Parrish, David E. Nichols	2006	49
8	Distinct Molecular Recognition of Psychostimulants by Human and Drosophila Serotonin Transporters Journal of Pharmacology and Experimental Therapeutics ·David L. Roman, Shannon N. Saldaña, David E. Nichols, F. Ivy Carroll, Eric L. Barker	2004	8
9	An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA Pharmacology Biochemistry and Behavior ·J. J. Cui, Ernieza Suhana Mokhtar, David E. Nichols, Jon E. Sprague	2002	29
10	Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT2A/2C receptor affinity Bioorganic & Medicinal Chemistry Letters ·James J. Chambers, Deborah Kurrasch‐Orbaugh, David E. Nichols	2002	19
11	A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties Bioorganic & Medicinal Chemistry Letters ·V Téllez-Sill, Deborah Kurrasch‐Orbaugh, Danuta Marona‐Lewicka, David E. Nichols	2001	12
12	Drug discrimination studies of the interoceptive cues produced by selective serotonin uptake inhibitors and selective serotonin releasing agents Psychopharmacology ·Danuta Marona‐Lewicka, David E. Nichols	1998	21
13	Complex stimulus properties of LSD: a drug discrimination study with α2-adrenoceptor agonists and antagonists Psychopharmacology ·Danuta Marona‐Lewicka, David E. Nichols	1995	19
14	Effect of the R(−) and S(+) isomers of MDA and MDMA on phosphotidyl inositol turnover in cultured cells expressing 5-HT2A or 5-HT2C receptors Neuroscience Letters ·J. Frank Nash, Bryan L. Roth, Jesse Brodkin, David E. Nichols, Gary A. Gudelsky	1994	64
15	Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections. Journal of Pharmacology and Experimental Therapeutics ·Jeffrey M. Witkin, David E. Nichols, Philip Terry, Jonathan L. Katz	1991	165
16	Combined administration of a non-neurotoxic 3,4-methylenedioxymethamphetamine analogue with amphetamine produces serotonin neurotoxicity in rats Neuropharmacology ·Michael P. Johnson, David E. Nichols	1991	22
17	2,3-Dihydrobenzofuran analogs of hallucinogenic phenethylamines Journal of Medicinal Chemistry ·David E. Nichols, Scott E. Snyder, Robert Oberlender, Michael P. Johnson, Xuemei Huang	1991	41
18	Studies of dioxole ring substituted 3,4-methylenedioxyamphetamine (MDA) analogues Pharmacology Biochemistry and Behavior ·David E. Nichols, Robert Oberlender, Kevin D. Burris, Andrew J. Hoffman, Michael P. Johnson	1989	10
19	MDMA transiently alters biogenic amines and metabolites in mouse brain and heart Pharmacology Biochemistry and Behavior ·Thomas Steele, David E. Nichols, G.K.W. Yim	1989	19
20	Hallucinogenic and stimulatory amphetamine derivatives: fingerprinting DOM, DOI, DOB, MDMA, and MBDB by spectral analysis of brain field potentials in the freely moving rat (Tele-Stereo-EEG) Psychopharmacology ·Wilfried Dimpfel, Laura Alejandra Lozano Salcedo, David E. Nichols	1989	34

About David E. Nichols

David E. Nichols is a scholar working on Toxicology, Cellular and Molecular Neuroscience, Clinical Psychology, Organic Chemistry and Biological Psychiatry, having authored 213 papers that have together received 11.2k indexed citations. Recurring topics across this work include Neurotransmitter Receptor Influence on Behavior (115 papers), Psychedelics and Drug Studies (100 papers), Chemical synthesis and alkaloids (49 papers), Neuroscience and Neuropharmacology Research (30 papers), Receptor Mechanisms and Signaling (30 papers), Forensic Toxicology and Drug Analysis (24 papers), Biochemical Analysis and Sensing Techniques (17 papers) and Analytical Chemistry and Chromatography (14 papers). The work is most often cited by research in Toxicology (2.1k citations), Cellular and Molecular Neuroscience (6.5k citations), Clinical Psychology (5.9k citations), Biological Psychiatry (450 citations) and Organic Chemistry (3.5k citations). David E. Nichols has collaborated with scholars based in United States, United Kingdom and Ireland. Frequent co-authors include Charles D. Nichols, Danuta Marona‐Lewicka, Richard B. Mailman, Andrew J. Hoffman, Michael P. Johnson, Jon E. Sprague, Robert Oberlender, G.K.W. Yim, Jason C. Parrish and David Nutt. Their work appears in journals such as Journal of Medicinal Chemistry, Journal of Pharmacology and Experimental Therapeutics, Psychopharmacology, European Journal of Pharmacology and Pharmacology Biochemistry and Behavior.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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