David C. Wedge

62.9k citations

72 papers · 5.0k indexed · 3 hit papers · h-index 29

Impact in

Cancer Research top 0.5%
- Cancer Genomics and Diagnostics
Molecular Biology top 2%
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- DNA Repair Mechanisms
- Single-cell and spatial transcriptomics
- CRISPR and Genetic Engineering

Papers in

Cancer Research 31
- Cancer Genomics and Diagnostics 29
Genetics 16
- Evolution and Genetic Dynamics 7

Co-authors: Peter J. Campbell Michael R. Stratton Ludmil B. Alexandrov Serena Nik‐Zainal Philip H. Jones Peter Van Loo Julian E. Sale José M. C. Tubío
Journals: Bioinformatics (5 papers)Nature Communications (4 papers)European Journal of Cancer (3 papers)Cancer Research (3 papers)Nature Genetics (3 papers)
Partner nations: United Kingdom United States Norway

In The Last Decade

David C. Wedge

70 papers receiving 4.9k citations

Hit Papers

align trajectories log scale

Clock-like mutational processes in human somatic cells 2015 · 569 citations

Peers

Countries citing papers authored by David C. Wedge

Since Specialization

Citations

This map shows the geographic impact of David C. Wedge's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David C. Wedge with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David C. Wedge more than expected).

Fields of papers citing papers by David C. Wedge

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David C. Wedge. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David C. Wedge. The network helps show where David C. Wedge may publish in the future.

Co-authorship network

The 25 scholars most cited alongside David C. Wedge, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David C. Wedge Line = papers co-authored together David C. Wedge links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	The landscape of microbial associations in human cancer Science Translational Medicine ·Abraham Gihawi, Henry M. Wood, J. W. Clark, Justin O’Grady, Rosalind A. Eeles, David C. Wedge, Ling Yang, Gkikas Magiorkinis, Andrew Schache, Liam Masterson, А. Ю. Зализко, Tim R. Fenton, Terence M. Jones, Adrienne M. Flanagan, М А Крымова, Alex Rubinsteyn, Rachel Hurst, Colin S. Cooper, Daniel Brewer	2025	2
2	Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival Science Advances ·Michael Haley, Hongliang Yan, Siyang Zhong, Murilo Henrique de Oliveira Scapim, 正坂口, Gareth Howell, David Coope, Federico Roncaroli, Andrew T. King, David C. Wedge, Stuart M. Allan, Omar Pathmanaban, David Brough, Kevin N. Couper	2024	23
3	Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer RevealsTP53Aneuploidy–driven Metabolic Reprogramming Cancer Research Communications ·Marni B. McClure, Yasunori Kogure, Naser Ansari‐Pour, Yuki Saito, Hann‐Hsiang Chao, Jonathan H. Shepherd, Mariko Tabata, Olufunmilayo I. Olopade, David C. Wedge, Katherine A. Hoadley, Charles M. Perou, Keisuke Kataoka	2023	11
4	The genomic landscape and clonal evolutionary trajectory of classical hairy cell leukemia Leukemia ·李发强, Violaine Anger, William Tapper, Nicola J. Weston-Bell, David C. Wedge, Naser Ansari‐Pour, Surinder S. Sahota	2023	4
5	Abstract 6463: Persistence of smoking mutational signatures in the non-small cell lung cancer genome Cancer Research ·Colin R. Lindsay, Pantelis Nicola, Andreas Gruber, Kate Brown, Mathew Carter, Helen Adderley, Shereen Rafee, 付云强, Andrew Wallace, George J. Burghel, Hélene Schlecht, Katie Baker, Tetyana Nagornyak, Jane Rogan, Jamie Weaver, Angeliki Malliri, William G. Newman, Fiona Blackhall, David C. Wedge, HL Lucas	2023	1
6	In utero origin of myelofibrosis presenting in adult monozygotic twins Nature Medicine ·Nikolaos Sousos, Máire Ní Leathlobhair, Christina Simoglou Karali, Eleni Louka, Nicola Bienz, Daniel Royston, Sally‐Ann Clark, Angela Hamblin, Ruel Cedeno, Vikram Mathews, Biju George, Anindita Roy, Bethan Psaila, David C. Wedge, Adam J. Mead	2022	33
7	Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity Nature Communications ·Annalise Katz‐Summercorn, Sriganesh Jammula, Anna Frangou, 木下晴雄, Michael O’Donovan, Monika Tripathi, Shalini Malhotra, Massimiliano di Pietro, Sujath Abbas, Ginny Devonshire, Władysław Januszewicz, Shiaki Ohsawa, Karol Nowicki-Osuch, Shona MacRae, Alex Northrop, Aisling M. Redmond, David C. Wedge, Rebecca C. Fitzgerald	2022	11
8	Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity Cancer Research ·Kirsi Ketola, Heidi Kaljunen, Sinja Taavitsainen, 刘刻, Mostafa Tavassolipour, Bernardo Rodríguez–Martín, Kerstin Haase, Dan J. Woodcock, José M. C. Tubío, David C. Wedge, Matti Nykter, G. Steven Bova	2021	8
9	Benchmarking small-variant genotyping in polyploids Genome Research ·P. Cameron, David C. Wedge, Gerton Lunter	2021	7
10	A Systematic Review of Prostate Cancer Heterogeneity: Understanding the Clonal Ancestry of Multifocal Disease European Urology Oncology ·Andrew Erickson, 邴绍献, Timothy Rajakumar, Clare Verrill, Richard J. Bryant, Freddie C. Hamdy, David C. Wedge, Dan J. Woodcock, Ian G. Mills, Alastair Lamb	2021	13
11	Genomic copy number predicts esophageal cancer years before transformation Nature Medicine ·Sarah Killcoyne, Coy Quej, David C. Wedge, Dan J. Woodcock, Matthew Eldridge, Rachel de la Rue, Ahmad Miremadi, Sujath Abbas, María Edelmira Calvar Fuentes, Nazim İsmayılov Nazim İsmayılov, Władysław Januszewicz, Loly Sandi F. Naibaho, Moritz Gerstung, Rebecca C. Fitzgerald	2020	77
12	Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy Nature Communications ·Dan J. Woodcock, Ping-Yang, Sinja Taavitsainen, Matti Kankainen, Gunes Gundem, Daniel Brewer, Pekka Ellonen, Maija Lepistö, Radar-Chafirovitch, Andrew Warner, Teemu Tolonen, مها ا عبدالله, William B. Isaacs, M R Emmert-Buck, Matti Nykter, Tapio Visakorpi, G. Steven Bova, David C. Wedge	2020	42
13	Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma Nature Communications ·Xing Hua, Zhao Wei, Angela Cecilia Pesatori, Dario Consonni, Neil E. Caporaso, Tongwu Zhang, Bin Zhu, Mingyi Wang, Kristine Jones, Belynda Hicks, Lei Song, Joshua N. Sampson, David C. Wedge, Jianxin Shi, Maria Teresa Landi	2020	80
14	Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2:ERG Fusion Status and Immune Cell Infiltration Journal of Molecular Diagnostics ·Srinivasa R. Rao, Nasullah Khalid Alham, V MOTILVA, Stacey McIntyre, Richard J. Bryant, Lucia Cerundolo, L. E. Dubins, Stephanie Jones, Molly Browne, Ian G. Mills, Alastair Lamb, Ian Tomlinson, David C. Wedge, Lisa Browning, Korsuk Sirinukunwattana, Claire Palles, Freddie C. Hamdy, Jens Rittscher, Clare Verrill	2020	7
15	The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma Cancer Research ·Vandana Sandhu, David C. Wedge, Inger Marie Bowitz Lothe, Knut Jørgen Labori, Stefan C. Dentro, Trond Buanes, Martina L. Skrede, Andrea Pohl, Else Munthe, Ola Myklebost, Ole Christian Lingjærde, Anne‐Lise Børresen‐Dale, Tone Ikdahl, Peter Van Loo, Silje Nord, Elin H. Kure	2016	27
16	High burden and pervasive positive selection of somatic mutations in normal human skin Science ·Iñigo Martincorena, Amit Roshan, Moritz Gerstung, Peter Ellis, Peter Van Loo, Stuart McLaren, David C. Wedge, Anthony Fullam, Ludmil B. Alexandrov, José M. C. Tubío, Lucy Stebbings, Andrew Menzies, Sara Widaa, Michael R. Stratton, Philip H. Jones, Peter J. Campbell Hit paper breakdown →	2015	1123
17	Clock-like mutational processes in human somatic cells Nature Genetics ·Ludmil B. Alexandrov, Philip H. Jones, David C. Wedge, Julian E. Sale, Peter J. Campbell, Serena Nik‐Zainal, Michael R. Stratton Hit paper breakdown →	2015	569
18	Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets Bioinformatics ·Marie Brown, David C. Wedge, Royston Goodacre, Douglas B. Kell, Philip N. Baker, Louise C. Kenny, Mamas A. Mamas, Ludwig Neyses, Warwick B. Dunn	2011	3
19	FDRAnalysis: A Tool for the Integrated Analysis of Tandem Mass Spectrometry Identification Results from Multiple Search Engines Journal of Proteome Research ·David C. Wedge, Ritesh Krishna, Peiliang Ren, Jennifer A. Siepen, Andrew R. Jones, Simon J. Hubbard	2011	15
20	Peptide detectability prediction following ESI mass spectrometry using genetic programming. Research Explorer (The University of Manchester) ·David C. Wedge, King Wai Lau, 彭湘云, Simon J. Hubbard, Douglas B. Kell, Claire E. Eyers	2007	2

About David C. Wedge

David C. Wedge is a scholar working on Cancer Research, Genetics, Molecular Biology, Hematology and Spectroscopy, having authored 72 papers that have together received 5.0k indexed citations. Recurring topics across this work include Cancer Genomics and Diagnostics (29 papers), Metabolomics and Mass Spectrometry Studies (7 papers), Evolution and Genetic Dynamics (7 papers), RNA and protein synthesis mechanisms (5 papers), Epigenetics and DNA Methylation (5 papers), Advanced Chemical Sensor Technologies (5 papers), Single-cell and spatial transcriptomics (4 papers) and Advanced Proteomics Techniques and Applications (4 papers). The work is most often cited by research in Cancer Research (2.0k citations), Molecular Biology (2.7k citations), Oncology (984 citations), Pathology and Forensic Medicine (570 citations) and Genetics (737 citations). David C. Wedge has collaborated with scholars based in United Kingdom, United States and Norway. Frequent co-authors include Peter J. Campbell, Michael R. Stratton, Ludmil B. Alexandrov, Serena Nik‐Zainal, Philip H. Jones, Peter Van Loo, Julian E. Sale, José M. C. Tubío, Andrew Menzies and Iñigo Martincorena. Their work appears in journals such as Bioinformatics, Nature Communications, European Journal of Cancer, Cancer Research and Nature Genetics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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