Christine B.F. Thien

3.4k citations

38 papers · 2.8k indexed · 1 hit paper · h-index 25

Molecular Biology top 5%
Immunology top 5%
Oncology top 5%
Hematology top 2%
Cell Biology top 5%

Co-authors: Wallace Y. Langdon Christopher E. Andoniou David D.L. Bowtell Maria A. Murphy Francesca Walker Deon J. Venter Ivan Bertoncello Louise Barnett
Topics: Protein Kinase Regulation and GTPase Signaling (7 papers)Ubiquitin and proteasome pathways (6 papers)Acute Myeloid Leukemia Research (6 papers)
Cited by: Immunology Hematology Immunology and Allergy
Journals: Journal of Biological Chemistry Journal of Clinical Investigation The Journal of Experimental Medicine
Partner nations: Australia United States Norway

In The Last Decade

Christine B.F. Thien

38 papers receiving 2.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Cbl: many adaptations to regulate protein tyrosine kinases

2001 521 citations Christine B.F. Thien, Wallace Y. Langdon Nature Reviews Molecular Cell Biology profile →

Peers

Countries citing papers authored by Christine B.F. Thien

Since Specialization

Citations

This map shows the geographic impact of Christine B.F. Thien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christine B.F. Thien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christine B.F. Thien more than expected).

Fields of papers citing papers by Christine B.F. Thien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christine B.F. Thien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christine B.F. Thien. The network helps show where Christine B.F. Thien may publish in the future.

Co-authorship network of co-authors of Christine B.F. Thien

This figure shows the co-authorship network connecting the top 25 collaborators of Christine B.F. Thien. A scholar is included among the top collaborators of Christine B.F. Thien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christine B.F. Thien. Christine B.F. Thien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice 2014 ·Experimental Hematology ·Samuel J. Taylor,Christine B.F. Thien,(unknown),(unknown),Carolyn Grove,Benjamin H. Lee,D. Gary Gilliland,Wallace Y. Langdon	13
2	Dasatinib Targets B-Lineage Cells but Does Not Provide an Effective Therapy for Myeloproliferative Disease in c-Cbl RING Finger Mutant Mice 2014 ·PLoS ONE ·(unknown),Samuel J. Taylor,(unknown),Marlene S. Orandle,Herbert C. Morse,Christine B.F. Thien,Wallace Y. Langdon	10
3	Incidence of c-Cbl mutations in human acute myeloid leukaemias in an Australian patient cohort 2011 ·Pathology ·Reza Ghassemifar,Christine B.F. Thien,(unknown),David Joske,Gavin Cull,Bradley Augustson,Wallace Y. Langdon	3
4	Essential Role of E3 Ubiquitin Ligase Activity in Cbl-b–Regulated T Cell Functions 2011 ·The Journal of Immunology ·Magdalena Paolino,Christine B.F. Thien,Thomas Gruber,Reinhard Hinterleitner,Gottfried Baier,Wallace Y. Langdon,Josef Penninger	77
5	c-Cbl Promotes T Cell Receptor-induced Thymocyte Apoptosis by Activating the Phosphatidylinositol 3-Kinase/Akt Pathway 2010 ·Journal of Biological Chemistry ·Christine B.F. Thien,(unknown),James H. Steer,Frank Köentgen,Elisa S. Jansen,Clare L. Scott,Wallace Y. Langdon	19
6	Unaltered negative selection and Treg development of self‐reactive thymocytes in TCR transgenic Fyn‐deficient mice 2009 ·European Journal of Immunology ·Alusha A. Mamchak,Christine B.F. Thien,(unknown),Julia Lyandres,Shuwei Jiang,Wallace Y. Langdon,Anthony DeFranco	2
7	The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells 2008 ·Genes & Development ·Chozhavendan Rathinam,Christine B.F. Thien,Wallace Y. Langdon,Hua Gu,Richard A. Flavell	83
8	The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells 2007 ·Molecular Immunology ·Morten P. Oksvold,(unknown),Christine B.F. Thien,Wallace Y. Langdon	21
9	Cbl-b Is a Negative Regulator of Inflammatory Cytokines Produced by IgE-Activated Mast Cells 2006 ·The Journal of Immunology ·Sonja E. Gustin,Christine B.F. Thien,Wallace Y. Langdon	31
10	Loss of c‐Cbl RING finger function results in high‐intensity TCR signaling and thymic deletion 2005 ·The EMBO Journal ·Christine B.F. Thien,(unknown),Yifan Zhan,Andrew M. Lew,Valentina Voigt,Christopher E. Andoniou,Wallace Y. Langdon	57
11	Mini ReviewNegative regulation of PTK signalling by Cbl proteins 2005 ·Growth Factors ·Christine B.F. Thien,Wallace Y. Langdon	59
12	UV-Radiation-Induced Internalization of the Epidermal Growth Factor Receptor Requires Distinct Serine and Tyrosine Residues in the Cytoplasmic Carboxy-Terminal Domain 2004 ·Radiation Research ·Morten P. Oksvold,Christine B.F. Thien,(unknown),Andrew Chantry,Henrik S. Huitfeldt,Wallace Y. Langdon	10
13	c-Cbl–deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action 2004 ·Journal of Clinical Investigation ·Juan Carlos Molero,Thomas E. Jensen,(unknown),Michelle Couzens,Herbert Herzog,Christine B.F. Thien,Wallace Y. Langdon,Ken Walder,Maria A. Murphy,David D.L. Bowtell,David E. James,Gregory J. Cooney	91
14	Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor 2003 ·Oncogene ·Morten P. Oksvold,Christine B.F. Thien,(unknown),Andrew Chantry,Henrik S. Huitfeldt,Wallace Y. Langdon	44
15	RING Finger Mutations that Abolish c-Cbl-Directed Polyubiquitination and Downregulation of the EGF Receptor Are Insufficient for Cell Transformation 2001 ·Molecular Cell ·Christine B.F. Thien,Francesca Walker,Wallace Y. Langdon	145
16	Cbl: many adaptations to regulate protein tyrosine kinasesbreakdown → 2001 ·Nature Reviews Molecular Cell Biology ·Christine B.F. Thien,Wallace Y. Langdon	521
17	The Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation 2000 ·Molecular and Cellular Biology ·Christopher E. Andoniou,Nancy L. Lill,Christine B.F. Thien,Mark Lupher,Satoshi Ota,David D.L. Bowtell,Robin M. Scaife,Wallace Y. Langdon,Hamid Band	105
18	Perturbed Regulation of ZAP-70 and Sustained Tyrosine Phosphorylation of LAT and SLP-76 in c-Cbl-Deficient Thymocytes 1999 ·The Journal of Immunology ·Christine B.F. Thien,David D.L. Bowtell,Wallace Y. Langdon	83
19	Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl 1997 ·Oncogene ·Christine B.F. Thien,Wallace Y. Langdon	51
20	EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene 1997 ·Oncogene ·Christine B.F. Thien,Wallace Y. Langdon	65

About Christine B.F. Thien

Christine B.F. Thien is a scholar working on Aging, Hematology and Immunology, having authored 38 papers that have together received 2.8k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (7 papers), Ubiquitin and proteasome pathways (6 papers) and Acute Myeloid Leukemia Research (6 papers). The work is most often cited by research in Immunology (809 citations), Hematology (417 citations) and Immunology and Allergy (179 citations). Christine B.F. Thien has collaborated with scholars based in Australia, United States and Norway. Frequent co-authors include Wallace Y. Langdon, Christopher E. Andoniou, David D.L. Bowtell, Maria A. Murphy, Francesca Walker, Deon J. Venter, Ivan Bertoncello, Louise Barnett, Richard A. Flavell and Chozhavendan Rathinam. Their work appears in journals such as Journal of Biological Chemistry, Journal of Clinical Investigation and The Journal of Experimental Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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