Christian Grütter

4.0k citations

30 papers · 2.0k indexed · h-index 25

Impact in

Virology top 5%
Molecular Biology top 5%
- Inflammasome and immune disorders
- Melanoma and MAPK Pathways

Papers in ⓘ

Molecular Biology 21
- Melanoma and MAPK Pathways 10
- Protein Kinase Regulation and GTPase Signaling 6
Organic Chemistry 11
- Quinazolinone synthesis and applications 4
- Synthesis and biological activity 4

Co-authors: Daniel Rauh (22 shared papers)Jeffrey R. Simard (14 shared papers)Matthias Rabiller (7 shared papers)Matthäus Getlik (9 shared papers)Markus G. Grütter (6 shared papers)Zhizhou Fang (1 shared paper)Sabine Klüter (5 shared papers)Haridas B. Rode (5 shared papers)
Journals: Journal of Medicinal Chemistry (6 papers)Journal of the American Chemical Society (3 papers)ACS Chemical Biology (3 papers)Bioorganic & Medicinal Chemistry (2 papers)Journal of Molecular Biology (2 papers)
Partner nations: Germany Switzerland United States

In The Last Decade

Christian Grütter

30 papers receiving 2.0k citations

Peers

Countries citing papers authored by Christian Grütter

Since Specialization

Citations

This map shows the geographic impact of Christian Grütter's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christian Grütter with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christian Grütter more than expected).

Fields of papers citing papers by Christian Grütter

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christian Grütter. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christian Grütter. The network helps show where Christian Grütter may publish in the future.

Co-authors

The 25 scholars most cited alongside Christian Grütter, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Christian Grütter Line = papers co-authored together Christian Grütter links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 30 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1β processing Cell Death and Differentiation ·Stéphanie Papin, Solange Cuenin, Laetitia Agostini, Fabio Martinon, Sabine Werner, Hans‐Dietmar Beer, Christian Grütter, Markus G. Grütter, Jürg Tschopp	2007	252
2	Natural-product-derived fragments for fragment-based ligand discovery Nature Chemistry ·Björn Over, Stefan Wetzel, Christian Grütter, Yasushi Nakai, Steffen Renner, Daniel Rauh, Herbert Waldmann	2012	233
3	Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features ACS Chemical Biology ·Zhizhou Fang, Christian Grütter, Daniel Rauh	2012	150
4	ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors Clinical Cancer Research ·Johannes M. Heuckmann, Michael Hölzel, Martin L. Sos, Stefanie Heynck, Hyatt Balke‐Want, Mirjam Koker, Martin Peifer, Jonathan M. Weiss, Christine M. Lovly, Christian Grütter, Daniel Rauh, William Pao, Roman K. Thomas	2011	147
5	Development of a Fluorescent-Tagged Kinase Assay System for the Detection and Characterization of Allosteric Kinase Inhibitors Journal of the American Chemical Society ·Jeffrey R. Simard, Matthäus Getlik, Christian Grütter, Vijaykumar Pawar, Sabine Wulfert, Matthias Rabiller, Daniel Rauh	2009	123
6	Hybrid Compound Design To Overcome the Gatekeeper T338M Mutation in cSrc Journal of Medicinal Chemistry ·Matthäus Getlik, Christian Grütter, Jeffrey R. Simard, Sabine Klüter, Matthias Rabiller, Haridas B. Rode, Armin Robubi, Daniel Rauh	2009	121
7	A new screening assay for allosteric inhibitors of cSrc Nature Chemical Biology ·Jeffrey R. Simard, Sabine Klüter, Christian Grütter, Matthäus Getlik, Matthias Rabiller, Haridas B. Rode, Daniel Rauh	2009	109
8	Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor Nature Chemical Biology ·Solveigh C. Koeberle, Johannes Romir, Stefan Fischer, Andreas Koeberle, Verena Schattel, Wolfgang Albrecht, Christian Grütter, Oliver Werz, Daniel Rauh, Thilo Stehle, Stefan Laufer	2011	106
9	Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components Journal of Clinical Investigation ·Martha R. Neagu, Patrick Ziegler, Thomas Pertel, Caterina Strambio‐De‐Castillia, Christian Grütter, G Martinetti, Luca Mazzucchelli, Markus G. Grütter, Markus G. Manz, Jeremy Luban	2009	100
10	Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR Bioorganic & Medicinal Chemistry ·Agnes Michalczyk, Sabine Klüter, Haridas B. Rode, Jeffrey R. Simard, Christian Grütter, Matthias Rabiller, Daniel Rauh	2008	76
11	Structure of the PRYSPRY‐domain: Implications for autoinflammatory diseases FEBS Letters ·Christian Grütter, Christophe Briand, Guido Capitani, Peer R. E. Mittl, Stéphanie Papin, Jürg Tschopp, Markus G. Grütter	2005	72
12	The Crystal Structure of Human Pyrin B30.2 Domain: Implications for Mutations Associated with Familial Mediterranean Fever Journal of Molecular Biology ·Christopher Weinert, Christian Grütter, Heidi Roschitzki‐Voser, Peer R. E. Mittl, Markus G. Grütter	2009	49
13	Fluorophore Labeling of the Glycine-Rich Loop as a Method of Identifying Inhibitors That Bind to Active and Inactive Kinase Conformations Journal of the American Chemical Society ·Jeffrey R. Simard, Matthäus Getlik, Christian Grütter, R. Schneider, Sabine Wulfert, Daniel Rauh	2010	45
14	A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions Proceedings of the National Academy of Sciences ·Christian Grütter, Trevor Wilkinson, Richard V. Turner, Sadhana Podichetty, Donna K. Finch, Matthew McCourt, Scott Loning, Lutz Jermutus, Markus G. Grütter	2008	43
15	A Biomimetic Chromanol Cyclization Leading to α‐Tocopherol Angewandte Chemie International Edition ·Christian Grütter, Emma Alonso, Antoinette Chougnet, Wolf‐D. Woggon	2006	42
16	Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance ChemBioChem ·Sabine Klüter, Jeffrey R. Simard, Haridas B. Rode, Christian Grütter, Vijaykumar Pawar, H.C.A. Raaijmakers, Tjeerd Barf, Matthias Rabiller, Willem A. L. van Otterlo, Daniel Rauh	2010	38
17	Identification of Type II and III DDR2 Inhibitors Journal of Medicinal Chemistry ·André Richters, Hoang Duc Nguyen, Trang Thi Phuong Phan, Jeffrey R. Simard, Christian Grütter, Julian Engel, Daniel Rauh	2014	32
18	Structure-based design, synthesis and biological evaluation of N-pyrazole, N′-thiazole urea inhibitors of MAP kinase p38α European Journal of Medicinal Chemistry ·Matthäus Getlik, Christian Grütter, Jeffrey R. Simard, Hoang Duc Nguyen, Armin Robubi, Beate Aust, Willem A. L. van Otterlo, Daniel Rauh	2011	31
19	Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase PLoS ONE ·Matthäus Getlik, Jeffrey R. Simard, Martin Termathe, Christian Grütter, Matthias Rabiller, Willem A. L. van Otterlo, Daniel Rauh	2012	31
20	Dibenzosuberones as p38 Mitogen-Activated Protein Kinase Inhibitors with Low ATP Competitiveness and Outstanding Whole Blood Activity Journal of Medicinal Chemistry ·Stefan Fischer, Heike K. Wentsch, Svenja Mayer‐Wrangowski, Markus O. Zimmermann, Silke M. Bauer, Kirsten Storch, Raimund Nieß, Solveigh C. Koeberle, Christian Grütter, Frank M. Boeckler, Daniel Rauh, Stefan Laufer	2012	29

About Christian Grütter

Christian Grütter is a scholar working on Molecular Biology, Organic Chemistry, Oncology, Immunology and Pharmacology, having authored 30 papers that have together received 2.0k indexed citations. Recurring topics across this work include Melanoma and MAPK Pathways (10 papers), Protein Kinase Regulation and GTPase Signaling (6 papers), HER2/EGFR in Cancer Research (5 papers), Quinazolinone synthesis and applications (4 papers), Synthesis and biological activity (4 papers), interferon and immune responses (4 papers), Computational Drug Discovery Methods (3 papers) and Microbial Natural Products and Biosynthesis (3 papers). The work is most often cited by research in Virology (125 citations), Molecular Biology (1.4k citations), Computational Theory and Mathematics (301 citations), Immunology (370 citations) and Organic Chemistry (483 citations). Christian Grütter has collaborated with scholars based in Germany, Switzerland and United States. Frequent co-authors include Daniel Rauh, Jeffrey R. Simard, Matthias Rabiller, Matthäus Getlik, Markus G. Grütter, Zhizhou Fang, Sabine Klüter, Haridas B. Rode, Stéphanie Papin and Jürg Tschopp. Their work appears in journals such as Journal of Medicinal Chemistry, Journal of the American Chemical Society, ACS Chemical Biology, Bioorganic & Medicinal Chemistry and Journal of Molecular Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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