C. Lerner

1.3k citations

22 papers · 1.0k indexed · h-index 18

Impact in

Organic Chemistry top 5%
- Click Chemistry and Applications
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
Computational Theory and Mathematics top 2%
- Computational Drug Discovery Methods

Papers in ⓘ

Molecular Biology 17
- Chemical Synthesis and Analysis 6
- Protein Structure and Dynamics 5
- DNA and Nucleic Acid Chemistry 4
- Metabolomics and Mass Spectrometry Studies 2
Computational Theory and Mathematics 6
- Computational Drug Discovery Methods 6

Co-authors: Dionicio Siegel (2 shared papers)Jason D. Brubaker (2 shared papers)Mark G. Charest (2 shared papers)Andrew G. Myers (2 shared papers)François Diederich (14 shared papers)Roland Jakob‐Roetne (12 shared papers)Edilio Borroni (10 shared papers)G. Zürcher (7 shared papers)
Journals: Angewandte Chemie International Edition (3 papers)Helvetica Chimica Acta (3 papers)Journal of Medicinal Chemistry (2 papers)Scientific Reports (1 paper)Journal of the American Chemical Society (1 paper)
Partner nations: Switzerland United States France

In The Last Decade

C. Lerner

21 papers receiving 978 citations

Peers

Countries citing papers authored by C. Lerner

Since Specialization

Citations

This map shows the geographic impact of C. Lerner's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by C. Lerner with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites C. Lerner more than expected).

Fields of papers citing papers by C. Lerner

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by C. Lerner. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by C. Lerner. The network helps show where C. Lerner may publish in the future.

Co-authors

The 25 scholars most cited alongside C. Lerner, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with C. Lerner Line = papers co-authored together C. Lerner links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 22 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics Science ·Mark G. Charest, C. Lerner, Jason D. Brubaker, Dionicio Siegel, Andrew G. Myers	2005	248
2	A Robust Platform for the Synthesis of New Tetracycline Antibiotics Journal of the American Chemical Society ·Cuixiang Sun, Qiu Wang, Jason D. Brubaker, Peter M. C. Wright, C. Lerner, Kevin Noson, Mark G. Charest, Dionicio Siegel, Yiming Wang, Andrew G. Myers	2008	103
3	A Real-World Perspective on Molecular Design Journal of Medicinal Chemistry ·Bernd Kuhn, Wolfgang Guba, Jérôme Hert, David W. Banner, Caterina Bissantz, Simona Ceccarelli, Wolfgang Haap, Matthias Körner, A. Kuglstatter, C. Lerner, Patrizio Mattei, Werner Neidhart, Emmanuel Pinard, M.G. Rudolph, Tanja Schulz‐Gasch, Thomas J. Woltering, Martin Ståhl	2016	80
4	Machine learning-powered antibiotics phenotypic drug discovery Scientific Reports ·Sannah Zoffmann, Maarten Vercruysse, Fethallah Benmansour, Andreas Maunz, Luise Wolf, Rita Blum Marti, Tobias Heckel, Haiyuan Ding, Hoa Truong, Michael Prummer, Roland Schmucki, Clive Mason, Kenneth A. Bradley, Asha I. Jacob, C. Lerner, Andrea Araujo Del Rosario, Mark Burcin, Kurt E. Amrein, Marco Prunotto	2019	67
5	Synthesis of Novel Nonpeptidic Thrombin Inhibitors Helvetica Chimica Acta ·U. Obst, P. Betschmann, C. Lerner, Paul Seiler, François Diederich, Völker Gramlich, Lutz Weber, David W. Banner, Peter Schönholzer	2000	64
6	X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann–La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing. Angewandte Chemie International Edition ·C. Lerner, A. Ruf, Völker Gramlich, B. Masjost, G. Zürcher, Roland Jakob‐Roetne, Edilio Borroni, François Diederich	2001	57
7	Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity Organic & Biomolecular Chemistry ·C. Lerner, B. Masjost, A. Ruf, Völker Gramlich, Roland Jakob‐Roetne, G. Zürcher, Edilio Borroni, François Diederich	2002	49
8	A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro Antimicrobial Agents and Chemotherapy ·Jeremy C. Jones, Bindumadhav M. Marathe, C. Lerner, Lukas M. Kreis, Rodolfo Gasser, Philippe Noriel Q. Pascua, Isabel Nájera, Elena A. Govorkova	2016	49
9	X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity Angewandte Chemie ·C. Lerner, A. Ruf, Völker Gramlich, B. Masjost, G. Zürcher, Roland Jakob‐Roetne, Edilio Borroni, François Diederich	2001	49
10	Safety screening in early drug discovery: An optimized assay panel Journal of Pharmacological and Toxicological Methods ·Stefanie Bendels, Caterina Bissantz, Bernhard Fasching, Grégori Gerebtzoff, Wolfgang Guba, Manfred Kansy, Jacques Migeon, Susanne Mohr, Jens‐Uwe Peters, Fabien Tillier, R. Wyler, C. Lerner, Christian Krämer, Hans Richter, Sonia Roberts	2019	41
11	Molecular Recognition at the Active Site of Catechol‐O‐Methyltransferase: Energetically Favorable Replacement of a Water Molecule Imported by a Bisubstrate Inhibitor Angewandte Chemie International Edition ·Manuel Ellermann, Roland Jakob‐Roetne, C. Lerner, Edilio Borroni, Daniel Schlatter, Doris Roth, A. Ehler, M.G. Rudolph, François Diederich	2009	39
12	Molecular Recognition at the Active Site of Catechol‐O‐methyltransferase (COMT): Adenine Replacements in Bisubstrate Inhibitors Chemistry - A European Journal ·Manuel Ellermann, Ralph Paulini, Roland Jakob‐Roetne, C. Lerner, Edilio Borroni, Doris Roth, A. Ehler, W. Bernd Schweizer, Daniel Schlatter, M.G. Rudolph, François Diederich	2011	31
13	Bisubstrate Inhibitors of the Enzyme Catechol O‐Methyltransferase (COMT): Efficient Inhibition Despite the Lack of a Nitro Group ChemBioChem ·Ralph Paulini, C. Lerner, Roland Jakob‐Roetne, G. Zürcher, Edilio Borroni, François Diederich	2004	31
14	Catechol-O-methyltransferase in complex with substituted 3′-deoxyribose bisubstrate inhibitors Acta Crystallographica Section D Biological Crystallography ·Manuel Ellermann, C. Lerner, Guillaume Burgy, A. Ehler, Caterina Bissantz, Roland Jakob‐Roetne, Ralph Paulini, Oliver Allemann, Héloïse Tissot, Dan Grünstein, M. Stihle, François Diederich, M.G. Rudolph	2012	26
15	Bisubstrate Inhibitors of Catechol O‐Methyltransferase (COMT): the Crucial Role of the Ribose Structural Unit for Inhibitor Binding Affinity ChemMedChem ·Ralph Paulini, Christian Trindler, C. Lerner, Lukas Brändli, W. Bernd Schweizer, Roland Jakob‐Roetne, G. Zürcher, Edilio Borroni, François Diederich	2006	22
16	Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket Journal of Medicinal Chemistry ·C. Lerner, Roland Jakob‐Roetne, Bernd Buettelmann, A. Ehler, M.G. Rudolph, Rosa Marı́a Rodrı́guez Sarmiento	2016	21
17	Bisubstrate Inhibitors for the Enzyme Catechol O‐Methyltransferase (COMT): Dramatic Effects of Ribose Modifications on Binding Affinity and Binding Mode Helvetica Chimica Acta ·C. Lerner, Romain Siegrist, Eliane Schweizer, François Diederich, Völker Gramlich, Roland Jakob‐Roetne, G. Zürcher, Edilio Borroni	2003	17
18	Molekulare Erkennung in der aktiven Tasche der Catechol‐O‐ Methyltransferase: energetisch günstige Verdrängung eines von einem Bisubstratinhibitor importierten Wassermoleküls Angewandte Chemie ·Manuel Ellermann, Roland Jakob‐Roetne, C. Lerner, Edilio Borroni, Daniel Schlatter, Doris Roth, A. Ehler, M.G. Rudolph, François Diederich	2009	17
19	Synthesis and Biological Evaluation of Potent Bisubstrate Inhibitors of the Enzyme CatecholO-Methyltransferase (COMT) Lacking a Nitro Group Helvetica Chimica Acta ·Ralph Paulini, C. Lerner, François Diederich, Roland Jakob‐Roetne, G. Zürcher, Edilio Borroni	2006	15
20	Molecular Recognition with Biological Receptors: Structure-Based Design of Thrombin Inhibitors CHIMIA International Journal for Chemistry ·P. Betschmann, C. Lerner, S. Sahli, U. Obst, François Diederich	2000	4

About C. Lerner

C. Lerner is a scholar working on Molecular Biology, Computational Theory and Mathematics, Pharmacology, Organic Chemistry and Physiology, having authored 22 papers that have together received 1.0k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (6 papers), Chemical Synthesis and Analysis (6 papers), Protein Structure and Dynamics (5 papers), DNA and Nucleic Acid Chemistry (4 papers), Adenosine and Purinergic Signaling (3 papers), Mass Spectrometry Techniques and Applications (3 papers), Microbial Natural Products and Biosynthesis (2 papers) and Metabolomics and Mass Spectrometry Studies (2 papers). The work is most often cited by research in Organic Chemistry (431 citations), Computational Theory and Mathematics (203 citations), Pharmacology (209 citations), Molecular Medicine (61 citations) and Molecular Biology (515 citations). C. Lerner has collaborated with scholars based in Switzerland, United States and France. Frequent co-authors include Dionicio Siegel, Jason D. Brubaker, Mark G. Charest, Andrew G. Myers, François Diederich, Roland Jakob‐Roetne, Edilio Borroni, G. Zürcher, Völker Gramlich and M.G. Rudolph. Their work appears in journals such as Angewandte Chemie International Edition, Helvetica Chimica Acta, Journal of Medicinal Chemistry, Scientific Reports and Journal of the American Chemical Society.

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