Barry S. Orlek

1.1k citations

38 papers · 881 indexed · h-index 15

Co-authors: Peter G. Sammes V Knott-Hunziker Graham J. Riley Stephen G. Waley Harry J. Wadsworth Frank Brown Michael Clark Paul Wyman
Topics: Chemical Synthesis and Analysis (12 papers)Receptor Mechanisms and Signaling (9 papers)Antibiotic Resistance in Bacteria (5 papers)
Cited by: Molecular Medicine Organic Chemistry Pharmacology
Journals: Biochemical Journal FEBS Letters Journal of Medicinal Chemistry
Partner nations: United Kingdom United States South Africa

In The Last Decade

Barry S. Orlek

38 papers receiving 775 citations

Peers

Countries citing papers authored by Barry S. Orlek

Since Specialization

Citations

This map shows the geographic impact of Barry S. Orlek's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Barry S. Orlek with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Barry S. Orlek more than expected).

Fields of papers citing papers by Barry S. Orlek

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Barry S. Orlek. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Barry S. Orlek. The network helps show where Barry S. Orlek may publish in the future.

Co-authorship network of co-authors of Barry S. Orlek

This figure shows the co-authorship network connecting the top 25 collaborators of Barry S. Orlek. A scholar is included among the top collaborators of Barry S. Orlek based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Barry S. Orlek. Barry S. Orlek is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	A Practical Synthesis of Differentially Protected 4,4′-Dipiperidinyl Ethers: Novel Ligands of Pharmaceutical Interest 2009 ·Synlett ·James Bailey,Gordon Bruton,Anthony Huxley,(unknown),Peter H. Milner,Barry S. Orlek,Geoffrey Stemp	3
2	Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to α-ketoamide inhibitors 2003 ·European Journal of Medicinal Chemistry ·Gordon Bruton,Anthony Huxley,Peter J. O’Hanlon,Barry S. Orlek,Drake S. Eggleston,John Eric Humphries,Simon A. Readshaw,Andrew B. West,Stephen Ashman,Murray J. B. Brown,Keith M. Moore,Andrew J. Pope,Karen O’Dwyer,Wenxin Wang	47
3	Characterisation of SB-221420-A — a neuronal Ca2+ and Na+ channel antagonist in experimental models of stroke 2000 ·European Journal of Pharmacology ·Colin A. Campbell,Frank C. Barone,Christopher D. Benham,Sarah J. Hadingham,Mark H Harries,John D. Harling,(unknown),Victoria Lewis,Kenneth B. Mackay,Barry S. Orlek,Raymond F. White,Andrew A. Parsons,A. Jacqueline Hunter	12
4	Evaluation of a Series of Anticonvulsant 1,2,3,4-Tetrahydroisoquinolinyl-benzamides 2000 ·Bioorganic & Medicinal Chemistry ·Wai N. Chan,Michael S. Hadley,John D. Harling,Hugh J. Herdon,Barry S. Orlek,Graham J. Riley,(unknown),Tania O. Stean,Mervyn Thompson,Neil Upton,Robert W. Ward	8
5	A molecular mechanism for toxin block in N-type calcium channels 1998 ·Protein Engineering Design and Selection ·Stephen W. Doughty,Frank E. Blaney,Barry S. Orlek,W. Graham Richards	11
6	Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl- benzamides with potential anticonvulsant activity 1998 ·Bioorganic & Medicinal Chemistry Letters ·Wai N. Chan,Michael S. Hadley,John D. Harling,Hugh J. Herdon,Jeffrey C. Jerman,Barry S. Orlek,Tania O. Stean,Mervyn Thompson,Neil Upton,Robert W. Ward	12
7	Stereoselective construction of vicinal diamines. Part 3.1 Routes to the benz[ f ]indeno[1,7-bc] azepine and benz[e]indeno[2,1-b][1,4]diazepine ring systems 1997 ·Journal of the Chemical Society Perkin Transactions 1 ·Barry S. Orlek,(unknown)	1
8	Design of [R-(Z)]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the N-Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere 1997 ·Journal of Medicinal Chemistry ·Steven M. Bromidge,Frank Brown,Frederick Cassidy,Michael Clark,Steven Dabbs,Michael S. Hadley,Julie A. Hawkins,(unknown),Christopher Naylor,Barry S. Orlek,Graham J. Riley	22
9	Bridged 1,2,5,6-tetrahydropyridine esters and oxime ethers related to arecoline are novel and potent muscarinic agonists 1994 ·Bioorganic & Medicinal Chemistry Letters ·Steven M. Bromidge,Frederick Cassidy,Michael Clark,(unknown),Michael S. Hadley,Barry S. Orlek,Graham J. Riley,Geoffrey Stemp	1
10	Design and synthesis of novel muscarinic agonists containing the 1,2,4-triazine ring as an ester bioisostere 1994 ·Bioorganic & Medicinal Chemistry Letters ·Barry S. Orlek,Frederick Cassidy,Michael Clark,(unknown),(unknown),Julie A. Hawkins,Graham J. Riley	7
11	Steric acceleration of intramolecular cycloaddition reactions 1993 ·Tetrahedron ·Barry S. Orlek,Peter G. Sammes,(unknown)	18
12	A Convenient Synthesis of Masked β-Ketoaldehydes by the Controlled Addition of Nucleophiles to (Trimethylsilyl)ethynyl Ketones 1993 ·Synthetic Communications ·Steven M. Bromidge,David A. Entwistle,(unknown),Barry S. Orlek	16
13	Use of steric buttresses to enhance intramolecular cycloadditions 1993 ·Journal of the Chemical Society Chemical Communications ·Barry S. Orlek,Peter G. Sammes,(unknown)	12
14	Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives 1992 ·Journal of Medicinal Chemistry ·Harry J. Wadsworth,S. M. Jenkins,Barry S. Orlek,Frederick Cassidy,Michael Clark,Frank Brown,Graham J. Riley,(unknown),Julie A. Hawkins,Christopher Naylor	68
15	Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands 1992 ·Journal of Medicinal Chemistry ·S. M. Jenkins,Harry J. Wadsworth,Steven M. Bromidge,Barry S. Orlek,Paul Wyman,Graham J. Riley,Julie A. Hawkins	61
16	A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality 1992 ·Bioorganic & Medicinal Chemistry Letters ·Steven M. Bromidge,Frank Brown,Frederick Cassidy,Michael Clark,Steven Dabbs,Julie A. Hawkins,(unknown),Barry S. Orlek,Graham J. Riley	16
17	Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor 1991 ·Journal of Medicinal Chemistry ·Barry S. Orlek,Frank E. Blaney,Frank Brown,Michael Clark,Michael S. Hadley,(unknown),Graham J. Riley,(unknown),Harry J. Wadsworth,Paul Wyman	171
18	Stereoselective synthesis of protected amines and diamines from alkenes using N,N-Dichloro-t-butylcarbamate 1991 ·Tetrahedron Letters ·Barry S. Orlek,Geoffrey Stemp	30
19	Diastereoselective routes to and ethyl 1-azabicyclo[2.2.1] hept-3-YL carboxylates 1991 ·Tetrahedron Letters ·Barry S. Orlek,Harry Wadsworth,Paul Wyman,Michael S. Hadley	9
20	Kinetics of inactivation of β-lactamase I by 6 β-bromopenicillanic acid 1980 ·Biochemical Journal ·V Knott-Hunziker,Barry S. Orlek,Peter G. Sammes,S G Waley	33

About Barry S. Orlek

Barry S. Orlek is a scholar working on Molecular Medicine, Organic Chemistry and Physiology, having authored 38 papers that have together received 881 indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (12 papers), Receptor Mechanisms and Signaling (9 papers) and Antibiotic Resistance in Bacteria (5 papers). The work is most often cited by research in Molecular Medicine (181 citations), Organic Chemistry (459 citations) and Pharmacology (138 citations). Barry S. Orlek has collaborated with scholars based in United Kingdom, United States and South Africa. Frequent co-authors include Peter G. Sammes, V Knott-Hunziker, Graham J. Riley, Stephen G. Waley, Harry J. Wadsworth, Frank Brown, Michael Clark, Paul Wyman, Julie A. Hawkins and Michael S. Hadley. Their work appears in journals such as Biochemical Journal, FEBS Letters and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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