Barbara Sedgwick

7.1k citations

43 papers · 4.6k indexed · 3 hit papers · h-index 30

Co-authors: Tomas Lindahl Sarah C. Trewick Peter Robins Yusaku Nakabeppu Timothy F. Henshaw Robert P. Hausinger Paul A. Bates Pertti Koivisto
Topics: DNA Repair Mechanisms (33 papers)Epigenetics and DNA Methylation (17 papers)Bacterial Genetics and Biotechnology (14 papers)
Cited by: Cancer Research Molecular Biology Genetics
Journals: Nature Cell Proceedings of the National Academy of Sciences
Partner nations: United Kingdom United States France

In The Last Decade

Barbara Sedgwick

43 papers receiving 4.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

2002 617 citations Sarah C. Trewick, Timothy F. Henshaw et al. Nature profile →
REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 562 citations Barbara Sedgwick, Yusaku Nakabeppu et al. Annual Review of Biochemistry profile →
Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations

2009 294 citations Barbara Sedgwick, Tomas Lindahl et al. profile →

Peers

Countries citing papers authored by Barbara Sedgwick

Since Specialization

Citations

This map shows the geographic impact of Barbara Sedgwick's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Barbara Sedgwick with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Barbara Sedgwick more than expected).

Fields of papers citing papers by Barbara Sedgwick

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Barbara Sedgwick. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Barbara Sedgwick. The network helps show where Barbara Sedgwick may publish in the future.

Co-authorship network of co-authors of Barbara Sedgwick

This figure shows the co-authorship network connecting the top 25 collaborators of Barbara Sedgwick. A scholar is included among the top collaborators of Barbara Sedgwick based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Barbara Sedgwick. Barbara Sedgwick is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Dynamic states of the DNA repair enzyme AlkB regulate product release 2008 ·EMBO Reports ·Boris Bleijlevens,(unknown),Emily Flashman,Yi Yang,P. J. Simpson,Pertti Koivisto,Barbara Sedgwick,Christopher J. Schofield,Stephen Matthews	52
2	Replacement of non-heme Fe(II) with Cu(II) in the α-ketoglutarate dependent DNA repair enzyme AlkB: Spectroscopic characterization of the active site 2007 ·Journal of Inorganic Biochemistry ·Boris Bleijlevens,(unknown),Barbara Sedgwick,Stephen E. J. Rigby,Stephen Matthews	15
3	Direct Removal of Alkylation Damage from DNA by AlkB and Related DNA Dioxygenases 2006 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Barbara Sedgwick,Peter Robins,Tomas Lindahl	22
4	Repair of alkylated DNA: Recent advances 2006 ·DNA repair ·Barbara Sedgwick,Paul A. Bates,Johanna Paik,Stacy L. Jacobs,Tomas Lindahl	253
5	Sensitization of Human Carcinoma Cells to Alkylating Agents by Small Interfering RNA Suppression of 3-Alkyladenine-DNA Glycosylase 2005 ·Cancer Research ·Johanna Paik,Tod Duncan,Tomas Lindahl,Barbara Sedgwick	50
6	Repairing DNA-methylation damage 2004 ·Nature Reviews Molecular Cell Biology ·Barbara Sedgwick	283
7	Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases 2004 ·Journal of Biological Chemistry ·Pertti Koivisto,Peter Robins,Tomas Lindahl,Barbara Sedgwick	87
8	Minimal Methylated Substrate and Extended Substrate Range of Escherichia coli AlkB Protein, a 1-Methyladenine-DNA Dioxygenase 2003 ·Journal of Biological Chemistry ·Pertti Koivisto,Tod Duncan,Tomas Lindahl,Barbara Sedgwick	69
9	Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damagebreakdown → 2002 ·Nature ·Sarah C. Trewick,Timothy F. Henshaw,Robert P. Hausinger,Tomas Lindahl,Barbara Sedgwick	617
10	Reversal of DNA alkylation damage by two human dioxygenases 2002 ·Proceedings of the National Academy of Sciences ·Tod Duncan,Sarah C. Trewick,Pertti Koivisto,Paul A. Bates,Tomas Lindahl,Barbara Sedgwick	320
11	Defective processing of methylated single-stranded DNA by E. coli alkB mutants 2000 ·Genes & Development ·(unknown),Sarah C. Trewick,Tomas Lindahl,Barbara Sedgwick	104
12	Nitrosated peptides and polyamines as endogenous mutagens in O6- alkylguanine-DNA alkyltransferase deficient cells 1997 ·Carcinogenesis ·Barbara Sedgwick	61
13	DNA base damage induced by ionizing radiation recognized byEscherichia coli UvrABC nuclease but not Nth or Fpg proteins 1996 ·Molecular Carcinogenesis ·Teresa Roldán‐Arjona,Barbara Sedgwick	11
14	Release of 5′-terminal deoxyribose-phosphate residues from incised abasic sites in DNA by theEscherichia coliRecJ protein 1994 ·Nucleic Acids Research ·Grigory L. Dianov,Barbara Sedgwick,Graham Daly,Monica Olsson,Susan T. Lovett,Tomas Lindahl	85
15	DNA repair 1993 ·Current Opinion in Cell Biology ·Deborah E. Barnes,Tomas Lindahl,Barbara Sedgwick	58
16	Induction of the adaptive response of Escherichia coli to alkylation damage by the environmental mutagen, methyl chloride 1993 ·Mutation Research/DNA Repair ·Patrick Vaughan,Tomas Lindahl,Barbara Sedgwick	19
17	Environmental mutagens that induce the adaptive response to alkylating agents in Escherichia coli 1991 ·Carcinogenesis ·P Vaughan,Barbara Sedgwick,J. Hall,Julian Gannon,Tomas Lindahl	38
18	Widespread adaptive response against environmental methylating agents in microorganisms 1991 ·Mutation research. Fundamental and molecular mechanisms of mutagenesis ·Barbara Sedgwick,Patrick Vaughan	38
19	REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTSbreakdown → 1988 ·Annual Review of Biochemistry ·(unknown),Barbara Sedgwick,(unknown),Yusaku Nakabeppu	562
20	The Inducible Repair of Alkylated DNA 1981 ·Progress in nucleic acid research and molecular biology ·John Cairns,Peter Robins,Barbara Sedgwick,Philippa J. Talmud	62

About Barbara Sedgwick

Barbara Sedgwick is a scholar working on Cancer Research, Molecular Biology and Genetics, having authored 43 papers that have together received 4.6k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (33 papers), Epigenetics and DNA Methylation (17 papers) and Bacterial Genetics and Biotechnology (14 papers). The work is most often cited by research in Cancer Research (973 citations), Molecular Biology (4.0k citations) and Genetics (1.1k citations). Barbara Sedgwick has collaborated with scholars based in United Kingdom, United States and France. Frequent co-authors include Tomas Lindahl, Sarah C. Trewick, Peter Robins, Yusaku Nakabeppu, Timothy F. Henshaw, Robert P. Hausinger, Paul A. Bates, Pertti Koivisto, Tod Duncan and Ian Teo. Their work appears in journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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