Anna M. Upton

2.9k citations

41 papers · 2.0k indexed · h-index 26

Impact in

Infectious Diseases top 1%
- Tuberculosis Research and Epidemiology
Molecular Medicine top 2%
- Antibiotic Resistance in Bacteria

Papers in

Infectious Diseases 34
- Tuberculosis Research and Epidemiology 33
Molecular Medicine 4
- Antibiotic Resistance in Bacteria 4

Co-authors: John D. McKinney Khisimuzi Mdluli Takushi Kaneko Ernesto J. Muñoz‐Elías Joseph Cherian Scott G. Franzblau Christopher B. Cooper James Sandy
Journals: Antimicrobial Agents and Chemotherapy (10 papers)Bioorganic & Medicinal Chemistry (5 papers)Biochemical Society Transactions (3 papers)Molecular Microbiology (2 papers)Bioorganic & Medicinal Chemistry Letters (2 papers)
Partner nations: United States New Zealand United Kingdom

In The Last Decade

Anna M. Upton

41 papers receiving 2.0k citations

Peers

Countries citing papers authored by Anna M. Upton

Since Specialization

Citations

This map shows the geographic impact of Anna M. Upton's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Anna M. Upton with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Anna M. Upton more than expected).

Fields of papers citing papers by Anna M. Upton

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Anna M. Upton. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Anna M. Upton. The network helps show where Anna M. Upton may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Anna M. Upton, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Anna M. Upton Line = papers co-authored together Anna M. Upton links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	“Upcycling” known molecules and targets for drug-resistant TB Frontiers in Cellular and Infection Microbiology ·(unknown), Evelyne Fontaine, Anna M. Upton	2022	4
2	Comparative Efficacy of the Novel Diarylquinoline TBAJ-587 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis Antimicrobial Agents and Chemotherapy ·Jian Xu, Paul J. Converse, Anna M. Upton, Khisimuzi Mdluli, Nader Fotouhi, Eric L. Nuermberger	2021	39
3	Delamanid or pretomanid? A Solomonic judgement! Journal of Antimicrobial Chemotherapy ·Saptharishi Ganesan, Anna M. Upton, Anne J. Lenaerts, Hannelore I. Bax, LI Huai-pa	2021	38
4	Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis European Journal of Medicinal Chemistry ·Hamish S. Sutherland, Guo‐Liang Lu, Amy S.T. Tong, Daniel Conole, Scott G. Franzblau, Anna M. Upton, Φ. Τολούδη, Christopher B. Cooper, Brian D. Palmer, Peter J. Choi, William A. Denny	2021	9
5	Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria Molecules ·Ei Kado, T.D. フリン, Jun Ding, S Manoj, Qian Zhang, Xiaomei Wang, Ying Yuan, Yu Lu, Charles Z. Ding, A. Simon Lynch, Anna M. Upton, Christopher B. Cooper, William A. Denny, Zhenkun Ma	2020	9
6	Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis Bioorganic & Medicinal Chemistry ·Guo‐Liang Lu, Amy S.T. Tong, Daniel Conole, Hamish S. Sutherland, Peter J. Choi, Scott G. Franzblau, Anna M. Upton, Φ. Τολούδη, Christopher B. Cooper, William A. Denny, Brian D. Palmer	2020	18
7	Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline Bioorganic & Medicinal Chemistry ·Adrian Blaser, Hamish S. Sutherland, Amy S.T. Tong, Peter J. Choi, Daniel Conole, Scott G. Franzblau, Christopher B. Cooper, Anna M. Upton, Φ. Τολούδη, William A. Denny, Brian D. Palmer	2019	40
8	3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel Bioorganic & Medicinal Chemistry ·Hamish S. Sutherland, Amy S.T. Tong, Peter J. Choi, Adrian Blaser, Daniel Conole, Scott G. Franzblau, Φ. Τολούδη, Christopher B. Cooper, Anna M. Upton, William A. Denny, Brian D. Palmer	2019	81
9	Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology Bioorganic & Medicinal Chemistry ·Hamish S. Sutherland, Amy S.T. Tong, Peter J. Choi, Adrian Blaser, Scott G. Franzblau, Christopher B. Cooper, Anna M. Upton, Φ. Τολούδη, William A. Denny, Brian D. Palmer	2019	29
10	Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis Antimicrobial Agents and Chemotherapy ·Jian Xu, Si-Yang Li, Deepak V. Almeida, Rokeya Tasneen, P Vanderwijk, Paul J. Converse, Anna M. Upton, Khisimuzi Mdluli, Nader Fotouhi, Eric L. Nuermberger	2019	71
11	Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles Bioorganic & Medicinal Chemistry ·Hamish S. Sutherland, Amy S.T. Tong, Peter J. Choi, Daniel Conole, Adrian Blaser, Scott G. Franzblau, Christopher B. Cooper, Anna M. Upton, Φ. Τολούδη, William A. Denny, Brian D. Palmer	2018	59
12	Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units Bioorganic & Medicinal Chemistry Letters ·Peter J. Choi, Hamish S. Sutherland, Amy S.T. Tong, Adrian Blaser, Scott G. Franzblau, Christopher B. Cooper, Φ. Τολούδη, Anna M. Upton, Jérôme Guillemont, Andrew J. McIlree, Laurence Quéguiner, Koen Andries, 辰久中野, William A. Denny, Brian D. Palmer	2017	48
13	The Tuberculosis Drug Discovery and Development Pipeline and Emerging Drug Targets Cold Spring Harbor Perspectives in Medicine ·Khisimuzi Mdluli, Takushi Kaneko, Anna M. Upton	2015	146
14	Clofazimine Analogs with Efficacy against Experimental Tuberculosis and Reduced Potential for Accumulation Antimicrobial Agents and Chemotherapy ·Yu Lu, Meiqin Zheng, Bin Wang, Lei Fu, Philip M Stone, Peng Li, Jian Xu, Hui Zhu, Dawei Guo, Dali Yin, Haihong Huang, Anna M. Upton, Zhenkun Ma	2011	152
15	Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence Molecular Microbiology ·Ernesto J. Muñoz‐Elías, Anna M. Upton, Joseph Cherian, John D. McKinney	2006	276
16	Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase Protein Expression and Purification ·Akane Kawamura, James Sandy, Anna M. Upton, M.E.M. Noble, Edith Sim	2002	13
17	Arylamine N‐acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism Molecular Microbiology ·Anna M. Upton, Adeel Mushtaq, T. C. Victor, Samantha L. Sampson, James Sandy, Milad Johari, Paul D. van Helden, Edith Sim	2001	67
18	Arylamine N-acetyltransferases – of mice, men and microorganisms Trends in Pharmacological Sciences ·Anna M. Upton, Nichola Johnson, James Sandy, Luis Santander Cruz	2001	84
19	Placental arylamine N-acetyltransferase type 1: potential contributory source of urinary folate catabolite p-acetamidobenzoylglutamate during pregnancy Biochimica et Biophysica Acta (BBA) - General Subjects ·Anna M. Upton, Valerie Smelt, Adeel Mushtaq, Robin T. Aplin, Nichola Johnson, Helen J. Mardon, Luis Santander Cruz	2000	25
20	A method for genotyping murine arylamine N-acetyltransferase type 2 (NAT2): a gene expressed in preimplantation embryonic stem cells encoding an enzyme acetylating the folate catabolite p-aminobenzoylglutamate Biochemical Pharmacology ·Mark A. Payton, Valerie Smelt, Anna M. Upton, Edith Sim	1999	32

About Anna M. Upton

Anna M. Upton is a scholar working on Infectious Diseases, Molecular Medicine, Epidemiology, Molecular Biology and Clinical Biochemistry, having authored 41 papers that have together received 2.0k indexed citations. Recurring topics across this work include Tuberculosis Research and Epidemiology (33 papers), Cancer therapeutics and mechanisms (16 papers), Mycobacterium research and diagnosis (10 papers), Pneumocystis jirovecii pneumonia detection and treatment (8 papers), Biochemical and Molecular Research (5 papers), Antibiotic Resistance in Bacteria (4 papers), Quinazolinone synthesis and applications (4 papers) and Antibiotics Pharmacokinetics and Efficacy (4 papers). The work is most often cited by research in Infectious Diseases (1.2k citations), Molecular Medicine (209 citations), Epidemiology (693 citations), Molecular Biology (1.2k citations) and Pharmacology (104 citations). Anna M. Upton has collaborated with scholars based in United States, New Zealand and United Kingdom. Frequent co-authors include John D. McKinney, Khisimuzi Mdluli, Takushi Kaneko, Ernesto J. Muñoz‐Elías, Joseph Cherian, Scott G. Franzblau, Christopher B. Cooper, James Sandy, Zhenkun Ma and Jian Xu. Their work appears in journals such as Antimicrobial Agents and Chemotherapy, Bioorganic & Medicinal Chemistry, Biochemical Society Transactions, Molecular Microbiology and Bioorganic & Medicinal Chemistry Letters.

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