Alan Eastman

15.0k citations

185 papers · 12.5k indexed · 2 hit papers · h-index 61

Impact in

Oncology top 0.2%
- Metal complexes synthesis and properties
- Cancer-related Molecular Pathways
Molecular Biology top 0.5%
- DNA Repair Mechanisms
- Cell death mechanisms and regulation
- DNA and Nucleic Acid Chemistry
- Cancer therapeutics and mechanisms
- RNA Interference and Gene Delivery

Papers in

Oncology 82
- Cancer-related Molecular Pathways 37
- Metal complexes synthesis and properties 31
Molecular Biology 148
- DNA Repair Mechanisms 52
- Cell death mechanisms and regulation 36
- DNA and Nucleic Acid Chemistry 33
- RNA Interference and Gene Delivery 18

Co-authors: Michael A. Barry Christine M. Sorenson Edward Bresnick Jason E. Reynolds Nancy A. Schulte Darcy Bates Jinfang Li Ronald J. Krieser
Journals: Journal of Biological Chemistry (9 papers)Biochemistry (8 papers)Biochemical and Biophysical Research Communications (7 papers)Chemico-Biological Interactions (6 papers)Carcinogenesis (6 papers)
Partner nations: United States United Kingdom Japan

In The Last Decade

Alan Eastman

185 papers receiving 12.2k citations

Hit Papers

align trajectories log scale

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia 1990 · 782 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1990 Biochemical Pharmacology
1987 Pharmacology & Therapeutics

Peers

Countries citing papers authored by Alan Eastman

Since Specialization

Citations

This map shows the geographic impact of Alan Eastman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alan Eastman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alan Eastman more than expected).

Fields of papers citing papers by Alan Eastman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alan Eastman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alan Eastman. The network helps show where Alan Eastman may publish in the future.

Co-authors

The 25 scholars most cited alongside Alan Eastman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Alan Eastman Line = papers co-authored together Alan Eastman links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction Scientific Reports ·蒋耀曦, Katelyn L. Donahue, Laura J. Tafe, Chris C Patterson, Alan Eastman	2021	7
2	Nuphar alkaloids induce very rapid apoptosis through a novel caspase-dependent but BAX/BAK-independent pathway Cell Biology and Toxicology ·Н. А. Адаменко, Andrés Moriel Gómez, Hui Li, Jimmy Wu, Alan Eastman	2019	5
3	Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477 Cell Death and Disease ·Н. А. Адаменко, Ryan S. Soderquist, Darcy Bates, Alan Eastman	2019	19
4	Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA -Mutant Breast Cancer Clinical Cancer Research ·Wei Yang, Joseph serge MBARGA EVOUNA, Lloye M. Dillon, Kevin Shee, Lisa Virliana, Matti Moosa, Laurent Salphati, Jodie Pang, Xiaolin Zhang, Michelle Nannini, Eugene Demidenko, Darcy Bates, Lionel D. Lewis, Jonathan D. Marotti, Alan Eastman, Todd W. Miller	2016	27
5	Total Syntheses and Biological Evaluation of Both Enantiomers of Several Hydroxylated Dimeric Nuphar Alkaloids Angewandte Chemie International Edition ·Andrés Moriel Gómez, Hui Li, Charles W. Chapman, Haoran Xue, John B. MacMillan, Alan Eastman, Jimmy Wu	2015	21
6	The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells Clinical Cancer Research ·Alexander Dorgham, Leigh Ann Humphries, Olga V. Danilova, Ping Yan, Jennifer R. Brown, Alan Eastman, Alexey V. Danilov	2014	109
7	Recurrent Low-Dose Chemotherapy to Inhibit and Oxygenate Head and Neck Tumors Advances in experimental medicine and biology ·Nadeem Khan, Huagang Hou, Dunja Melcic, M. Lakshmi Kuppusamy, Eunice Y. Chen, Alan Eastman, Periannan Kuppusamy, Harold M. Swartz	2014	6
8	Vinblastine Rapidly Induces NOXA and Acutely Sensitizes Primary Chronic Lymphocytic Leukemia Cells to ABT-737 Molecular Cancer Therapeutics ·Darcy Bates, Alexey V. Danilov, Christopher H. Lowrey, Alan Eastman	2013	29
9	Preclinical Development of the Novel Chk1 Inhibitor SCH900776 in Combination with DNA-Damaging Agents and Antimetabolites Molecular Cancer Therapeutics ·Dya Irawati, Injae Chung, K. Toyoda, David Parry, Alan Eastman	2011	100
10	High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors Cancer Research ·Marina Cewick, K. Toyoda, Kyung Il Kim, Sarah J. Freemantle, Alan Eastman, Ethan Dmitrovsky, Michael J. Spinella	2009	88
11	Conjugated Linoleic Acid (CLA) Inhibits Expression of the Spot 14 (THRSP) and Fatty Acid Synthase Genes and Impairs the Growth of Human Breast Cancer and Liposarcoma Cells Nutrition and Cancer ·Suarseh Suarseh, Arne Olsén, Lionel D. Lewis, Burton Eisenberg, Alan Eastman, William B. Kinlaw	2009	43
12	The role of Chk1 and Mre11/Nbs1/Rad50 in S phase arrest induced by DNA damage Cancer Research ·K. Toyoda, Aime A. Levesque, Alan Eastman	2008	1
13	Cell cycle checkpoints and their impact on anticancer therapeutic strategies Journal of Cellular Biochemistry ·Alan Eastman	2003	131
14	Intracellular Calcium Stores Are Not Required for Bcl-2-mediated Protection from Apoptosis Journal of Biological Chemistry ·Jason E. Reynolds, Alan Eastman	1996	33
15	Apoptosis in an Interleukin-2-dependent Cytotoxic T Lymphocyte Cell Line Is Associated with Intracellular Acidification Journal of Biological Chemistry ·Jinfang Li, Alan Eastman	1995	208
16	Kinetic and DNA-Binding Properties of Recombinant Human O6-Methylguanine-DNA Methyltransferase Archives of Biochemistry and Biophysics ·Chien‐Lung Chan, Zhanjun Wu, Thomas L. Ciardelli, Alan Eastman, Edward Bresnick	1993	46
17	Mechanisms of resistance to cisplatin Cancer treatment and research ·Alan Eastman	1991	39
18	Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation. Journal of Clinical Investigation ·R. J. Parker, Alan Eastman, Benjamín C. Bostick, E Reed	1991	250
19	Host-cell reactivation of cisplatin-damaged pRSVcat in a human lymphoid cell line Carcinogenesis ·Meenakshi Dabholkar, Alan Eastman, Eddie Reed	1990	10
20	Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II) Biochemistry ·Alan Eastman, Nancy A. Schulte	1988	269

About Alan Eastman

Alan Eastman is a scholar working on Oncology, Molecular Biology, Cancer Research, Toxicology and Cell Biology, having authored 185 papers that have together received 12.5k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (52 papers), Cancer-related Molecular Pathways (37 papers), Cell death mechanisms and regulation (36 papers), DNA and Nucleic Acid Chemistry (33 papers), Metal complexes synthesis and properties (31 papers), RNA Interference and Gene Delivery (18 papers), Carcinogens and Genotoxicity Assessment (18 papers) and Microtubule and mitosis dynamics (17 papers). The work is most often cited by research in Oncology (5.2k citations), Molecular Biology (9.0k citations), Cancer Research (1.8k citations), Toxicology (269 citations) and Cell Biology (1.1k citations). Alan Eastman has collaborated with scholars based in United States, United Kingdom and Japan. Frequent co-authors include Michael A. Barry, Christine M. Sorenson, Edward Bresnick, Jason E. Reynolds, Nancy A. Schulte, Darcy Bates, Jinfang Li, Ronald J. Krieser, Roderick T. Bunch and Margaretha Jennerwein. Their work appears in journals such as Journal of Biological Chemistry, Biochemistry, Biochemical and Biophysical Research Communications, Chemico-Biological Interactions and Carcinogenesis.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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