Alan C. Cheng

3.4k citations

45 papers · 1.8k indexed · 1 hit paper · h-index 24

Impact in

Computational Theory and Mathematics top 0.5%
- Computational Drug Discovery Methods
Molecular Biology top 5%
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Bioinformatics and Genomic Networks
- DNA and Nucleic Acid Chemistry

Papers in

Computational Theory and Mathematics 12
- Computational Drug Discovery Methods 12
Molecular Biology 37
- Protein Structure and Dynamics 13
- DNA and Nucleic Acid Chemistry 5
- RNA and protein synthesis mechanisms 5
- Protein purification and stability 4

Co-authors: Ryan G. Coleman Anna C. Salzberg Qing Cao Daniel R. Caffrey Enoch S. Huang Alan D. Frankel Patricia Soulard Elizabeth Joshi
Journals: Journal of Medicinal Chemistry (8 papers)Bioorganic & Medicinal Chemistry Letters (6 papers)Journal of Chemical Information and Modeling (5 papers)Journal of Molecular Biology (2 papers)Scientific Reports (1 paper)
Partner nations: United States Switzerland Germany

In The Last Decade

Alan C. Cheng

42 papers receiving 1.8k citations

Hit Papers

align trajectories log scale

Structure-based maximal affinity model predicts small-molecule druggability 2007 · 514 citations

Peers

Countries citing papers authored by Alan C. Cheng

Since Specialization

Citations

This map shows the geographic impact of Alan C. Cheng's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alan C. Cheng with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alan C. Cheng more than expected).

Fields of papers citing papers by Alan C. Cheng

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alan C. Cheng. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alan C. Cheng. The network helps show where Alan C. Cheng may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Alan C. Cheng, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Alan C. Cheng Line = papers co-authored together Alan C. Cheng links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Practically Significant Method Comparison Protocols for Machine Learning in Small Molecule Drug Discovery Journal of Chemical Information and Modeling ·Jeremy R. Ash, Ning Zheny, Raquel Rodríguez-Pérez, Matteo Aldeghi, Alan C. Cheng, Djork-Arné Clevert, Ola Engkvist, Cheng Fang, Daniel Pinheiro Moraes, Jacqueline M. Hughes‐Oliver, W. Patrick Walters	2025	6
2	AbLEF: antibody language ensemble fusion for thermodynamically empowered property predictions Bioinformatics ·A E CAREY, Nayanne Deusdará Escobar, Andrew B. Waight, Alan C. Cheng, เสก ประยงค์พันธ์	2024	0
3	Denoising Drug Discovery Data for Improved Absorption, Distribution, Metabolism, Excretion, and Toxicity Property Prediction Journal of Chemical Information and Modeling ·M. Adrian, Yunsie Chung, Alan C. Cheng	2024	2
4	A call for an industry-led initiative to critically assess machine learning for real-world drug discovery Nature Machine Intelligence ·Ning Zheny, Jeremy R. Ash, Matteo Aldeghi, Raquel Rodríguez-Pérez, Cheng Fang, Alan C. Cheng, Daniel Pinheiro Moraes, Djork-Arné Clevert, Ola Engkvist, W. Patrick Walters	2024	6
5	AbMelt: Learning antibody thermostability from molecular dynamics Biophysical Journal ·A E CAREY, Nayanne Deusdará Escobar, Alan C. Cheng, เสก ประยงค์พันธ์	2024	2
6	Exploring Deep Learning of Quantum Chemical Properties for Absorption, Distribution, Metabolism, and Excretion Predictions Journal of Chemical Information and Modeling ·Omotosho I. F, Agatha de Araújo Arruda Anzai Toledo, И В Тентелова, Alan C. Cheng	2022	16
7	Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction Antibodies ·Carl Mieczkowski, Alan C. Cheng, Thierry Fischmann, Amanda M. Saulenas, Jeanne Baker, Makiko Uchida, G. Raghunathan, Corey Strickland, Laurence Fayadat‐Dilman	2021	11
8	Improvement in ADMET Prediction with Multitask Deep Featurization Journal of Medicinal Chemistry ·Evan N. Feinberg, Elizabeth Joshi, Vijay S. Pande, Alan C. Cheng	2020	125
9	Experimental Error, Kurtosis, Activity Cliffs, and Methodology: What Limits the Predictivity of Quantitative Structure–Activity Relationship Models? Journal of Chemical Information and Modeling ·Robert P. Sheridan, Prabha Karnachi, Matthew Tudor, Yuting Xu, Andy Liaw, Falgun Shah, Alan C. Cheng, Elizabeth Joshi, Meir Glick, Juan C. Alvarez	2020	43
10	Structure-guided Discovery of Dual-recognition Chemibodies Scientific Reports ·Alan C. Cheng, Elizabeth M. Doherty, Sheree Johnstone, Erin F. DiMauro, Ebinezer Israel, Yanyan Sun (351971), Alice Atieno Juma, Jie Tang, Thomas Nixey, Xiaoshan Min, Philip Tagari, Les P. Miranda, Zhulun Wang	2018	4
11	Collaborating to improve the use of free-energy and other quantitative methods in drug discovery Journal of Computer-Aided Molecular Design ·Bradley Sherborne, Veerabahu Shanmugasundaram, Alan C. Cheng, Clara D. Christ, Renée L. DesJarlais, José S. Duca, Richard A. Lewis, Deborah A. Loughney, Eric S. Manas, Georgia B. McGaughey, Catherine E. Peishoff, Herman van Vlijmen	2016	38
12	Screening for lysine-specific demethylase-1 inhibitors using a label-free high-throughput mass spectrometry assay Analytical Biochemistry ·Matthew Plant, Ndeye Khady M. Diop, Alan C. Cheng, Alexander Long, Hao Chen, Kurt Morgenstern	2011	30
13	Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: Alleviating hERG interactions through structure based design Bioorganic & Medicinal Chemistry Letters ·Snahel Patel, Nate V. Powell, Alan C. Cheng, Elisa De La Cruz, Christine Loh, Natasha M. Kablaoui	2009	49
14	Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2 Bioorganic & Medicinal Chemistry Letters ·Erin F. DiMauro, John L. Buchanan, Alan C. Cheng, Renee Emkey, Stephen A. Hitchcock, Liyue Huang, Ming Huang, 洋行音, Josie H. Lee, Xingwen Li, Matthew W. Martin, F. Krombach, Ryan D. White, Вадим Владимирович Крамской, Vinod F. Patel, Robert T. Fremeau	2008	14
15	N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR Bioorganic & Medicinal Chemistry Letters ·Holly L. Deak, John Newcomb, Joseph J. Nunes, Christina Boucher, Alan C. Cheng, Erin F. DiMauro, Linda F. Epstein, Paul Gallant, Brian L. Hodous, Xin Huang, Josie H. Lee, Vinod F. Patel, Stephen E. Schneider, Susan M. Turci, Xiaotian Zhu	2007	9
16	An intuitive approach to measuring protein surface curvature Proteins Structure Function and Bioinformatics ·Ryan G. Coleman, 松永健嗣, Diane L. Souvaine, Alan C. Cheng	2005	29
17	Transformations and Algorithms for Least Sum of Squares Hypersphere Fitting Canadian Conference on Computational Geometry ·松永健嗣, Alan C. Cheng, Ryan G. Coleman, Diane L. Souvaine	2004	2
18	Recognition of Nucleic Acid Bases and Base-pairs by Hydrogen Bonding to Amino Acid Side-chains Journal of Molecular Biology ·Alan C. Cheng, William W. Chen, Cynthia N. Fuhrmann, Alan D. Frankel	2003	120
19	Structural Diversity and Isomorphism of Hydrogen-bonded Base Interactions in Nucleic Acids Journal of Molecular Biology ·Reda Abdel Samee Ahmed REZK, Alan C. Cheng, Alan D. Frankel	2003	29
20	Design of RNA-binding proteins and ligands Current Opinion in Structural Biology ·Alan C. Cheng	2001	71

About Alan C. Cheng

Alan C. Cheng is a scholar working on Computational Theory and Mathematics, Molecular Biology, Physical and Theoretical Chemistry, Radiology, Nuclear Medicine and Imaging and Instrumentation, having authored 45 papers that have together received 1.8k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (13 papers), Computational Drug Discovery Methods (12 papers), Monoclonal and Polyclonal Antibodies Research (7 papers), Machine Learning in Materials Science (7 papers), DNA and Nucleic Acid Chemistry (5 papers), RNA and protein synthesis mechanisms (5 papers), Protein purification and stability (4 papers) and Enzyme Structure and Function (4 papers). The work is most often cited by research in Computational Theory and Mathematics (737 citations), Molecular Biology (1.3k citations), Organic Chemistry (263 citations), Physical and Theoretical Chemistry (79 citations) and Pharmacology (143 citations). Alan C. Cheng has collaborated with scholars based in United States, Switzerland and Germany. Frequent co-authors include Ryan G. Coleman, Anna C. Salzberg, Qing Cao, Daniel R. Caffrey, Enoch S. Huang, Alan D. Frankel, Patricia Soulard, Elizabeth Joshi, Vijay S. Pande and Evan N. Feinberg. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Journal of Chemical Information and Modeling, Journal of Molecular Biology and Scientific Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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