Akio Kakefuda

409 citations

26 papers · 341 · h-index 12

Impact in

Organic Chemistry top 10%
- Carbohydrate Chemistry and Synthesis
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Chemical synthesis and alkaloids
Infectious Diseases
- HIV/AIDS drug development and treatment

Papers in

Organic Chemistry 14
- Chemical synthesis and pharmacological studies 5
Molecular Biology 14
- Receptor Mechanisms and Signaling 5
- Ion channel regulation and function 5
- Pharmacological Receptor Mechanisms and Effects 3

Co-authors: Shuichi Sakamoto (11 shared papers)Akira Matsuda (5 shared papers)Takuma Sasaki (2 shared papers)Shin‐ichi Tsukamoto (6 shared papers)Satoshi Shuto (3 shared papers)Toshihiro Watanabe (7 shared papers)Junichi Seki (2 shared papers)Takemitsu Nagahata (2 shared papers)
Journals: Bioorganic & Medicinal Chemistry (8 papers)Chemical and Pharmaceutical Bulletin (4 papers)Tetrahedron (4 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)Journal of Medicinal Chemistry (2 papers)
Partner nations: Japan Norway United States

In The Last Decade

Akio Kakefuda

26 papers receiving 326 citations

Peers

Countries citing papers authored by Akio Kakefuda

Since Specialization

Citations

This map shows the geographic impact of Akio Kakefuda's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Akio Kakefuda with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Akio Kakefuda more than expected).

Fields of papers citing papers by Akio Kakefuda

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Akio Kakefuda. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Akio Kakefuda. The network helps show where Akio Kakefuda may publish in the future.

Co-authors

The 25 scholars most cited alongside Akio Kakefuda, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Akio Kakefuda Line = papers co-authored together Akio Kakefuda links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 26 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Nucleosides and nucleotides. 132. Synthesis and biological evaluations of ring-expanded oxetanocin analogues: Purine and pyrimidine analogues of 1,4-anhydro-2-deoxy-d-arabitol and 1,4-anhydro-2-deoxy-3-hydroxymethyl-d-arabitol Tetrahedron ·Akio Kakefuda, Satoshi Shuto, Takemitsu Nagahata, Junichi Seki, Takuma Sasaki, Akira Matsuda	1994	51
2	Welwitindolinone C synthetic studies. Construction of the welwitindolinone carbon skeleton via a transannular nitrone cycloaddition Tetrahedron ·David Freeman, A.A. Holubec, Matthew W. Weiss, Julie A. Dixon, Akio Kakefuda, Masami Ohtsuka, Munenori Inoue, Rishi G. Vaswani, Hidenori Ohki, Brian D. Doan, Sarah E. Reisman, Brian M. Stoltz, Joshua Day, Ran Tao, N.A. Dieterich, John L. Wood	2010	38
3	Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. III. Synthesis of (.+-.)-N-12-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1-yl)butyll-N-methylbenzamides and Evaluation of NK1-NK2 Dual Antagonistic Activities. Chemical and Pharmaceutical Bulletin ·Hirokazu Kubota, Akio Kakefuda, Yoshinori Okamoto, Masahiro Fujii, Osamu Yamamoto, Y Yamagiwa, Masaya Orita, Kazutaka Ikeda, Makoto Takeuchi, Tadao Shibanuma, Yoshikazu Isomura	1998	24
4	Discovery of 4,5-Diphenyl-1,2,4-triazole Derivatives as a Novel Class of Selective Antagonists for the Human V1A Receptor Bioorganic & Medicinal Chemistry ·Akio Kakefuda	2002	21
5	Synthesis and Pharmacological Evaluation of 5-(4-Biphenyl)-3-methyl-4-phenyl-1,2,4-triazole Derivatives as a Novel Class of Selective Antagonists for the Human Vasopressin V_1A Receptor Journal of Medicinal Chemistry ·Akio Kakefuda, Takeshi Suzuki, Takahiko Tobe, Junko Tsukada, Atsuo Tahara, Shuichi Sakamoto, Shin‐ichi Tsukamoto	2002	21
6	Nucleosides and Nucleotides. 104. Radical and Palladium-Catalyzed Deoxygenation of the Allylic Alcohol Systems in the Sugar Moiety of Pyrimidine Nucleosides^§,1 Nucleosides and Nucleotides ·Akira Matsuda, Hitomi Okajima, Akira Masuda, Akio Kakefuda, Yuichi Yoshimura, Tohru Ueda	1992	21
7	Synthesis and Pharmacological Evaluation of 1-Oxo-2-(3-piperidyl)-1,2,3,4- tetrahydroisoquinolines and Related Analogues as a New Class of Specific Bradycardic Agents Possessing I_f Channel Inhibitory Activity Journal of Medicinal Chemistry ·Hideki Kubota, Akio Kakefuda, Toshihiro Watanabe, Noe Ishii, Koichi Wada, Noriyuki Masuda, Shuichi Sakamoto, Shin‐ichi Tsukamoto	2003	17
8	Synthesis and pharmacological evaluation of N-acyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel specific bradycardic agents Bioorganic & Medicinal Chemistry ·Hideki Kubota, Toshihiro Watanabe, Akio Kakefuda, Noriyuki Masuda, Kouichi Wada, Noe Ishii, Shuichi Sakamoto, Shin‐ichi Tsukamoto	2004	14
9	Synthesis and structure–activity relationships of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study Bioorganic & Medicinal Chemistry ·Takahiro Kuramochi, Akio Kakefuda, Ippei Sato, Issei Tsukamoto, Taku Taguchi, Shuichi Sakamoto	2004	12
10	Nucleosides and nucleotides. 120. Stereoselective radical deoxygenation of tert-alcohols in the sugar moiety of nucleosides: synthesis of 2′,3′-dideoxy-2′-C-methyl- -2′-C-ethynyl-β-d-threo-pentofuranosyl pyrimidines and adenine as potential antiviral and antitumor agents Tetrahedron ·Akio Kakefuda, Yuichi Yoshimura, Takuma Sasaki, Akira Matsuda	1993	12
11	Synthesis and pharmacological evaluation of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel specific bradycardic agents Bioorganic & Medicinal Chemistry Letters ·Hideki Kubota, Toshihiro Watanabe, Akio Kakefuda, Noriyuki Masuda, Kouichi Wada, Noe Ishii, Shuichi Sakamoto, Shin‐ichi Tsukamoto	2004	11
12	Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. II. Syntheses and NK2 Receptor-Antagonistic Activities of N-(2-Aryl-4-(spiro-substituted piperidin-1'-yl)butyl)carboxamides. Chemical and Pharmaceutical Bulletin ·Hideki Kubota, Akio Kakefuda, Hitoshi Nagaoka, Osamu Yamamoto, Kazutaka Ikeda, Makoto Takeuchi, Tadao Shibanuma, Yoshikazu Isomura	1998	11
13	Synthesis and structure–activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: effects on heart failure Bioorganic & Medicinal Chemistry ·Takahiro Kuramochi, Akio Kakefuda, Hiroyoshi Yamada, Takashi Ogiyama, Taku Taguchi, Shuichi Sakamoto	2004	11
14	Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: A novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor Bioorganic & Medicinal Chemistry ·Kazushi Watanabe, Akio Kakefuda, Minoru Yasuda, Kentaro Enjo, Aya Kikuchi, Takashi Furutani, Yoichi Naritomi, Yukio Otsuka, Minoru Okada, Mitsuaki Ohta	2013	9
15	(±)-2-(3-Piperidyl)-1,2,3,4-tetrahydroisoquinolines as a new class of specific bradycardic agents Bioorganic & Medicinal Chemistry Letters ·Hideki Kubota, Akio Kakefuda, Toshihiro Watanabe, Yasuko Taguchi, Noe Ishii, Noriyuki Masuda, Shuichi Sakamoto, Shin-ichi Tsukamoto	2003	9
16	N-Methylbenzanilide derivatives as a novel class of selective V1A receptor antagonists Bioorganic & Medicinal Chemistry Letters ·Akio Kakefuda, Junko Tsukada, Toshiyuki Kusayama, Atsuo Tahara, Shin‐ichi Tsukamoto	2002	9
17	Synthesis and Pharmacological Evaluation of 2-(3-Piperidyl)-1,2,3,4-tetrahydroisoquinoline Derivatives as Specific Bradycardic Agents. Chemical and Pharmaceutical Bulletin ·Akio Kakefuda, Toshihiro Watanabe, Yasuko Taguchi, Noriyuki Masuda, Akihiro Tanaka, Isao Yanagisawa	2003	9
18	Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor Bioorganic & Medicinal Chemistry ·Takahiro Kuramochi, Akio Kakefuda, Hiroyoshi Yamada, Issei Tsukamoto, Taku Taguchi, Shuichi Sakamoto	2005	8
19	Synthesis and structure–activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium–calcium exchanger Bioorganic & Medicinal Chemistry ·Takahiro Kuramochi, Akio Kakefuda, Hiroyoshi Yamada, Ippei Sato, Taku Taguchi, Shuichi Sakamoto	2004	7
20	Synthesis and biological activity of novel 4,4-difluorobenzazepine derivatives as non-peptide antagonists of the arginine vasopressin V1A receptor Bioorganic & Medicinal Chemistry ·Yoshiaki Shimada, Nobuaki Taniguchi, Akira Matsuhisa, Hiroaki Akane, Noriyuki Kawano, Takeshi Suzuki, Takahiko Tobe, Akio Kakefuda, Takeyuki Yatsu, Atsuo Tahara, Yuichi Tomura, Toshiyuki Kusayama, Koh‐ichi Wada, Junko Tsukada, Masaya Orita, Takashi Tsunoda, Akihiro Tanaka	2005	6

About Akio Kakefuda

Akio Kakefuda is a scholar working on Organic Chemistry, Molecular Biology, Cardiology and Cardiovascular Medicine, Infectious Diseases and Cancer Research, having authored 26 papers that have together received 341 indexed citations. Recurring topics across this work include Cardiac electrophysiology and arrhythmias (7 papers), Chemical synthesis and pharmacological studies (5 papers), Receptor Mechanisms and Signaling (5 papers), Ion channel regulation and function (5 papers), HIV/AIDS drug development and treatment (5 papers), Synthesis and Biological Activity (4 papers), Pharmacological Receptor Mechanisms and Effects (3 papers) and HIV Research and Treatment (2 papers). The work is most often cited by research in Organic Chemistry (225 citations), Infectious Diseases (45 citations), Virology (11 citations), Molecular Biology (149 citations) and Pharmacology (16 citations). Akio Kakefuda has collaborated with scholars based in Japan, Norway and United States. Frequent co-authors include Shuichi Sakamoto, Akira Matsuda, Takuma Sasaki, Shin‐ichi Tsukamoto, Satoshi Shuto, Toshihiro Watanabe, Junichi Seki, Takemitsu Nagahata, Noriyuki Masuda and Yuichi Yoshimura. Their work appears in journals such as Bioorganic & Medicinal Chemistry, Chemical and Pharmaceutical Bulletin, Tetrahedron, Bioorganic & Medicinal Chemistry Letters and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Akio Kakefuda

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Akio Kakefuda

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