Adrian Higginbottom

5.6k total citations · 2 hit papers
50 papers, 3.5k citations indexed

About

Adrian Higginbottom is a scholar working on Neurology, Molecular Biology and Genetics. According to data from OpenAlex, Adrian Higginbottom has authored 50 papers receiving a total of 3.5k indexed citations (citations by other indexed papers that have themselves been cited), including 29 papers in Neurology, 21 papers in Molecular Biology and 19 papers in Genetics. Recurrent topics in Adrian Higginbottom's work include Amyotrophic Lateral Sclerosis Research (29 papers), Neurogenetic and Muscular Disorders Research (18 papers) and Cell Adhesion Molecules Research (8 papers). Adrian Higginbottom is often cited by papers focused on Amyotrophic Lateral Sclerosis Research (29 papers), Neurogenetic and Muscular Disorders Research (18 papers) and Cell Adhesion Molecules Research (8 papers). Adrian Higginbottom collaborates with scholars based in United Kingdom, United States and Germany. Adrian Higginbottom's co-authors include Pamela J. Shaw, Peter N. Monk, Jane A. McKeating, Janine Kirby, Guillaume M. Hautbergue, Laura Ferraiuolo, Johnathan Cooper‐Knock, Mike Flint, Paul G. Ince and Shoshana Levy and has published in prestigious journals such as Journal of Biological Chemistry, The EMBO Journal and Blood.

In The Last Decade

Adrian Higginbottom

48 papers receiving 3.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The C9orf72 protein interacts with Rab1a and the ULK 1 complex to regulate initiation of autophagy

2016 301 citations Christopher P Webster, Emma F. Smith et al. The EMBO Journal profile →
CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection

2004 287 citations Adrian Higginbottom, Peter N. Monk et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Adrian Higginbottom United Kingdom	30	1.4k	1.3k	907	771	738	50	3.5k
Satoru Senju Japan	38	86 0.1×	3.1k 2.4×	191 0.2×	348 0.5×	290 0.4×	101	5.8k
S J Korsmeyer United States	23	144 0.1×	2.7k 2.1×	589 0.6×	251 0.3×	33 0.0×	29	4.7k
Giuseppe Giannini Italy	36	281 0.2×	2.7k 2.1×	110 0.1×	241 0.3×	49 0.1×	109	4.1k
Eun Joo Chung South Korea	31	387 0.3×	1.7k 1.3×	143 0.2×	155 0.2×	18 0.0×	102	3.4k
Avgi Mamalaki Greece	22	268 0.2×	606 0.5×	253 0.3×	98 0.1×	60 0.1×	56	1.5k
Gaetano Romano United States	27	183 0.1×	2.1k 1.6×	147 0.2×	239 0.3×	35 0.0×	80	3.3k
Elena V. Ivanova United States	26	166 0.1×	3.1k 2.4×	156 0.2×	252 0.3×	62 0.1×	80	4.7k
B. Nelson Chau United States	24	172 0.1×	3.1k 2.4×	268 0.3×	340 0.4×	40 0.1×	33	4.1k
Idit Shachar Israel	34	108 0.1×	804 0.6×	272 0.3×	169 0.2×	48 0.1×	83	3.6k
Bianca M. Conti‐Fine United States	34	1.2k 0.9×	1.2k 0.9×	227 0.3×	101 0.1×	10 0.0×	82	3.5k

Countries citing papers authored by Adrian Higginbottom

Since Specialization

Citations

This map shows the geographic impact of Adrian Higginbottom's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Adrian Higginbottom with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Adrian Higginbottom more than expected).

Fields of papers citing papers by Adrian Higginbottom

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Adrian Higginbottom. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Adrian Higginbottom. The network helps show where Adrian Higginbottom may publish in the future.

Co-authorship network of co-authors of Adrian Higginbottom

This figure shows the co-authorship network connecting the top 25 collaborators of Adrian Higginbottom. A scholar is included among the top collaborators of Adrian Higginbottom based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Adrian Higginbottom. Adrian Higginbottom is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Badger, Shirlene, Ian Coldicott, Adrian Higginbottom, et al.. (2025). A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests ‘space cadet syndrome’ on two FVB backgrounds. Disease Models & Mechanisms. 18(2).

Richardson, Connor D., Adrian Higginbottom, Fiona E. Matthews, et al.. (2024). Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort. Neuroscience Research. 204. 22–33. 3 indexed citations

Bauer, Claudia S., Christopher P Webster, Allan C. Shaw, et al.. (2022). Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation. Frontiers in Cellular Neuroscience. 16. 1061559–1061559. 9 indexed citations

Allen, Scott P., Lydia M. Castelli, Laura Francis, et al.. (2018). Inosine reverses motor neuron toxicity observed in amyotrophic lateral sclerosis patient astrocytes with an adenosine deaminase deficiency. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1859. e23–e23. 1 indexed citations

Iannitti, Tommaso, Shibi Likhite, Ian Coldicott, et al.. (2018). Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS. Molecular Therapy — Nucleic Acids. 12. 75–88. 35 indexed citations

Vogt, Miriam A., Philip Knuckles, Adrian Higginbottom, et al.. (2018). TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons. Scientific Reports. 8(1). 8097–8097. 40 indexed citations

Webster, Christopher P, Emma F. Smith, Claudia S. Bauer, et al.. (2016). The C9orf72 protein interacts with Rab1a and the ULK 1 complex to regulate initiation of autophagy. The EMBO Journal. 35(15). 1656–1676. 301 indexed citations breakdown →

Cooper‐Knock, Johnathan, Joanna J. Bury, Paul R. Heath, et al.. (2015). C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis. PLoS ONE. 10(5). e0127376–e0127376. 77 indexed citations

Cooper‐Knock, Johnathan, Adrian Higginbottom, Matthew J. Stopford, et al.. (2015). Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy. Acta Neuropathologica. 130(1). 63–75. 129 indexed citations

10.

Wang, X-L, M. Ismail, Chiara F. Valori, et al.. (2014). PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons. Cell Death and Disease. 5(2). e1096–e1096. 22 indexed citations

11.

Higginbottom, Adrian, et al.. (2014). Distinct Regions of the Large Extracellular Domain of Tetraspanin CD9 Are Involved in the Control of Human Multinucleated Giant Cell Formation. PLoS ONE. 9(12). e116289–e116289. 13 indexed citations

12.

Mead, Richard J., Adrian Higginbottom, Scott P. Allen, et al.. (2013). S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis. Free Radical Biology and Medicine. 61. 438–452. 55 indexed citations

13.

Allen, Scott P., et al.. (2013). Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis. Neurobiology of Aging. 35(6). 1499–1509. 69 indexed citations

14.

Buchman, Vladimir L., Johnathan Cooper‐Knock, Natalie Connor‐Robson, et al.. (2013). Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation. Molecular Neurodegeneration. 8(1). 12–12. 40 indexed citations

15.

Ferraiuolo, Laura, Adrian Higginbottom, Paul R. Heath, et al.. (2011). Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain. 134(9). 2627–2641. 154 indexed citations

16.

Cox, Laura, Laura Ferraiuolo, Gerald Goodall, et al.. (2010). Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS). PLoS ONE. 5(3). e9872–e9872. 198 indexed citations

17.

Parthasarathy, V., Adrian Higginbottom, Helen C. Murray, et al.. (2009). Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells. Immunology. 127(2). 237–248. 52 indexed citations

18.

Wright, Andrew, Adrian Higginbottom, Abhishek Upadhyay, et al.. (2007). Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response. Molecular Immunology. 44(10). 2507–2517. 30 indexed citations

19.

Cain, Stuart A., Adrian Higginbottom, & Peter N. Monk. (2003). Characterisation of C5a receptor agonists from phage display libraries. Biochemical Pharmacology. 66(9). 1833–1840. 10 indexed citations

20.

Higginbottom, Adrian, Yûji Takahashi, Laura Bolling, et al.. (2003). Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion. Biochemical and Biophysical Research Communications. 311(1). 208–214. 40 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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