Standout Papers

I-TASSER: a unified platform for automated protein structure and func... 2004 2026 2011 2018 4.9k
  1. I-TASSER: a unified platform for automated protein structure and function prediction (2010)
    Ambrish Roy, Alper Küçükural et al. Nature Protocols
  2. I-TASSER server for protein 3D structure prediction (2008)
    Yang Zhang BMC Bioinformatics
  3. TM-align: a protein structure alignment algorithm based on the TM-score (2005)
    Yang Zhang Nucleic Acids Research
  4. I-TASSER server: new development for protein structure and function predictions (2015)
    Jianyi Yang, Yang Zhang Nucleic Acids Research
  5. Scoring function for automated assessment of protein structure template quality (2004)
    Yang Zhang, Jeffrey Skolnick Proteins Structure Function and Bioinformatics
  6. Complementary Sequence-Mediated Exon Circularization (2014)
    Xiao‐Ou Zhang, Haibin Wang et al. Cell
  7. Extensive translation of circular RNAs driven by N6-methyladenosine (2017)
    Yun Yang, Xiaojuan Fan et al. Cell Research
  8. Improving the Physical Realism and Structural Accuracy of Protein Models by a Two-Step Atomic-Level Energy Minimization (2011)
    Dong Xu, Yang Zhang Biophysical Journal
  9. Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? (2014)
    Justine M. Abais, Min Xia et al. Antioxidants and Redox Signaling
  10. Diverse alternative back-splicing and alternative splicing landscape of circular RNAs (2016)
    Xiao‐Ou Zhang, Rui Dong et al. Genome Research
  11. Protein–ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment (2013)
    Jianyi Yang, Ambrish Roy et al. Bioinformatics
  12. How significant is a protein structure similarity with TM-score = 0.5? (2010)
    Jinrui Xu, Yang Zhang Bioinformatics
  13. Ab initio protein structure assembly using continuous structure fragments and optimized knowledge‐based force field (2012)
    Dong Xu, Yang Zhang Proteins Structure Function and Bioinformatics
  14. LOMETS: A local meta-threading-server for protein structure prediction (2007)
    Sitao Wu, Yang Zhang Nucleic Acids Research
  15. BioLiP: a semi-manually curated database for biologically relevant ligand–protein interactions (2012)
    Jianyi Yang, Ambrish Roy et al. Nucleic Acids Research
  16. COFACTOR: an accurate comparative algorithm for structure-based protein function annotation (2012)
    Ambrish Roy, Jianyi Yang et al. Nucleic Acids Research
  17. Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice (2010)
    Qizhou Lian, Yuelin Zhang et al. Circulation
  18. The Biogenesis of Nascent Circular RNAs (2016)
    Yang Zhang, Wei Xue et al. Cell Reports
  19. COFACTOR: improved protein function prediction by combining structure, sequence and protein–protein interaction information (2017)
    Chengxin Zhang, Peter L. Freddolino et al. Nucleic Acids Research
  20. Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics (2017)
    Yinghong Li, Peng Zhang et al. Nucleic Acids Research
  21. Folding non-homologous proteins by coupling deep-learning contact maps with I-TASSER assembly simulations (2021)
    Wei Zheng, Chengxin Zhang et al. Cell Reports Methods
  22. I-TASSER-MTD: a deep-learning-based platform for multi-domain protein structure and function prediction (2022)
    Xiaogen Zhou, Wei Zheng et al. Nature Protocols
  23. US-align: universal structure alignments of proteins, nucleic acids, and macromolecular complexes (2022)
    Chengxin Zhang, Morgan Shine et al. Nature Methods
  24. Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles (2023)
    Zhuang Li, Haihua Liu et al. Cell Host & Microbe
  25. Improving deep learning protein monomer and complex structure prediction using DeepMSA2 with huge metagenomics data (2024)
    Wei Zheng, Qiqige Wuyun et al. Nature Methods
  26. Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer (2025)
    Ruifeng Yang, Yang Zhang et al. Molecular Biomedicine

Immediate Impact

50 by Nobel laureates 43 from Science/Nature 126 standout
Sub-graph 1 of 16

Citing Papers

Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Automated model building and protein identification in cryo-EM maps
2024 StandoutNature
22 intermediate papers

Works of Yang Zhang being referenced

Progressive assembly of multi-domain protein structures from cryo-EM density maps
2022
CR-I-TASSER: assemble protein structures from cryo-EM density maps using deep convolutional neural networks
2022
and 14 more

Author Peers

Author Last Decade Papers Cites
Yang Zhang 36046 7044 2623 5050 907 51.1k
Jeremy C. Smith 31235 7665 4114 3097 818 56.8k
David S. Wishart 47041 4793 2421 2954 537 73.1k
Tom L. Blundell 33473 7516 3474 1481 499 44.6k
Mark Gerstein 46809 3550 1761 7660 543 59.7k
Robert Huber 46461 11184 9122 6236 596 66.0k
Andrej Săli 49661 11352 4428 1286 375 64.9k
Ruth Nussinov 42884 10341 3405 1452 785 52.9k
Vladimir N. Uversky 50938 13737 2486 930 1.1k 71.7k
Peter G. Schultz 50248 6644 6777 2107 690 72.2k
Janet M. Thornton 69527 20209 4415 1458 480 90.5k

All Works

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2026