Standout Papers

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activa... 1995 2026 2005 2015 3.1k
  1. An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) (1995)
    Jürgen M. Lehmann, Linda B. Moore et al. Journal of Biological Chemistry
  2. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation (1998)
    Mercedes Ricote, Andrew C. Li et al. Nature
  3. Bile Acids: Natural Ligands for an Orphan Nuclear Receptor (1999)
    Derek J. Parks, Steven G. Blanchard et al. Science
  4. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ (1997)
    Steven A. Kliewer, Scott S. Sundseth et al. Proceedings of the National Academy of Sciences
  5. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation (1995)
    Steven A. Kliewer, Timothy M. Willson et al. Cell
  6. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ (1998)
    Robert T. Nolte, G. Bruce Wisely et al. Nature
  7. A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis (2000)
    Bryan Goodwin, Stacey A. Jones et al. Molecular Cell
  8. The PPARs:  From Orphan Receptors to Drug Discovery (2000)
    Timothy M. Willson, Peter J. Brown et al. Journal of Medicinal Chemistry
  9. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. (1998)
    J�rgen Lehmann, David D. McKee et al. Journal of Clinical Investigation
  10. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway (1998)
    Steven A. Kliewer, John T. Moore et al. Cell
  11. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity (2001)
    Jeff L. Staudinger, Bryan Goodwin et al. Proceedings of the National Academy of Sciences
  12. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ (2005)
    Gabriel Pascual, Sumito Ogawa et al. Nature
  13. Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway (1997)
    Jürgen M. Lehmann, Steven A. Kliewer et al. Journal of Biological Chemistry
  14. Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors (1999)
    H. Eric Xu, Millard H. Lambert et al. Molecular Cell
  15. A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport (2001)
    William R. Oliver, CAROLINE S. RUSSELL et al. Proceedings of the National Academy of Sciences
  16. Synthetic LXR ligand inhibits the development of atherosclerosis in mice (2002)
    Sean B. Joseph, Elaine McKilligin et al. Proceedings of the National Academy of Sciences
  17. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice (2006)
    Yanqiao Zhang, Hans C. Lee et al. Proceedings of the National Academy of Sciences
  18. Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase (1999)
    John S. Welch, Mercedes Ricote et al. Nature
  19. The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism (2002)
    Steven A. Kliewer, Bryan Goodwin et al. Endocrine Reviews
  20. Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice (2000)
    Andrew C. Li, Kathleen K. Brown et al. Journal of Clinical Investigation
  21. ApoE Promotes the Proteolytic Degradation of Aβ (2008)
    Qingguang Jiang, Shweta Mandrekar et al. Neuron
  22. Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor (2002)
    Heidi R. Kast-Woelbern, Bryan Goodwin et al. Journal of Biological Chemistry
  23. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor (2000)
    Linda B. Moore, Bryan Goodwin et al. Proceedings of the National Academy of Sciences
  24. Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands (2000)
    Linda B. Moore, Derek J. Parks et al. Journal of Biological Chemistry
  25. Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition (2002)
    Randy K. Bledsoe, Valerie G. Montana et al. Cell
  26. 6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity (2002)
    Roberto Pellicciari, Stefano Fiorucci et al. Journal of Medicinal Chemistry
  27. The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity (2001)
    Ryan E. Watkins, G. Bruce Wisely et al. Science
  28. The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones (1996)
    Timothy M. Willson, Jeffery E. Cobb et al. Journal of Medicinal Chemistry
  29. Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity (2000)
    Michèle Guerre-Millo, Philippe Gervois et al. Journal of Biological Chemistry
  30. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα (2002)
    H. Eric Xu, Thomas B. Stanley et al. Nature
  31. Peroxisome Proliferator–Activated Receptor γ and Metabolic Disease (2001)
    Timothy M. Willson, Millard H. Lambert et al. Annual Review of Biochemistry

Immediate Impact

77 from Science/Nature 237 standout
Sub-graph 1 of 17

Citing Papers

The gut metabolite indole-3 propionate promotes nerve regeneration and repair
2022 StandoutNature
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells
2020 StandoutNature

Works of Timothy M. Willson being referenced

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
2001 Standout
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
1999 StandoutScience

Author Peers

Author Last Decade Papers Cites
Timothy M. Willson 30944 13832 8176 10605 225 53.2k
Steven A. Kliewer 32561 14227 9700 10888 166 55.4k
David J. Mangelsdorf 39650 17627 14892 21964 221 69.2k
Bart Staels 40867 10111 4542 16704 781 77.2k
Peter Tontonoz 27078 6798 2579 13131 227 44.3k
David D. Moore 11701 7908 6386 5195 284 27.3k
Kristina Schoonjans 16265 8361 2343 7383 198 32.0k
Walter Wahli 28117 3014 4796 3649 325 41.2k
Masahiko Negishi 15545 5543 5643 2016 510 32.8k
Morris F. White 32584 4811 4432 12289 343 50.8k
Sten Orrenius 28265 5240 1647 2530 448 50.8k

All Works

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